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International Journal of Advance in Molecular Engineering Review Article

Revolutionizing Anti-Allergy Medications: A Comprehensive Review of Target Discovery and Medicinal Chemistry

  1. Neha Sahu Lingaya’s Vidyapeeth, Faridabad
  2. Rizwan Arif Lingaya’s Vidyapeeth, Faridabad

Abstract

Above the past few decades, the prevalence of allergy illnesses has been steadily rising, impacting 20–30% of the world's population. Multiple targets are involved in allergic reactions to infections of the skin, digestive tract, and respiratory system. Developing medications with a good curative efficacy and minimal side effects while utilizing novel multi-targets and processes in accordance with the clinical features of various allergic populations and allergens is the primary challenge facing research on anti-allergy therapies. The knowledge on possible therapeutic targets and the medicinal chemistry of synthetic anti-allergy small molecules are the main topics of this review. With reference to leukotriene production, wascium channel blockers, inhibitors of Th2 cytokines, histamine-1/4 receptor antagonists, and leukotrienes, the structure-activity relationship and the mechanism of compound-target interaction were highlighted. The investigation of chemical scaffold optimization and modification for various lead compounds, which is compiled in this review, should serve as a valuable resource for the drug design of related and promising research, such as allergy, in addition to improving the success rate and effectiveness of virtual screening for antiallergic drugs.

Keywords

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