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227 articles for “Genetics of the Disease”
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AI-Driven Pharmacogenomics and Precision Medicine: Future of Personalized Therapy
Abstract: Pharmacogenomics and artificial intelligence (AI) are emerging as important drivers of precision medicine, enabling healthcare systems to adopt individualized therapeutic approaches. Pharmacogenomics examines how genetic variations influence drug response, efficacy, metabolism, and toxicity, while AI provides advanced computational tools for analyzing complex genomic and clinical data. This review highlights the integration of AI-driven pharmacogenomics in personalized therapy and its potential to improve treatment outcomes. Machine learning, deep learning, natural language …
Published in Emerging Trends in Personalized Medicines · Vol. 3, Issue 2, 2026 · pp. 1–12 Read article
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Induction of Apoptosis using Gene Therapy in the Treatment of Cancer
Abstract: Gene therapy is the treatment of a genetic disease through the insertion of normal or genetically altered genes into cells in order to replace or make up for the non-functional or missing genes. A major application of gene therapy is the induction of apoptosis to inhibit metastases or cure cancer. Besides the identification of the target site, the choice of a suitable vector system for gene delivery is also critical …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 2, Issue 3, 2013 · pp. 6–10 Read article
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A Review on Clinical Aspects of Sickle Cell Anaemia
Abstract: Sickle cell anaemia is a genetic disorder in which there is a change in 6th position of Hb chain, i.e. replacement of glutamic acid by valine in the Hb chain. This disease was discovered in 1910 in United States by Dr. James B. Herrick. This disease was 1st affected to a young man named Walter Clement Noel from the island of Grenada, a dental student studying in Chicago. This article …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 7, Issue 2, 2017 · pp. 20–24 Read article
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Comprehensive Study and Triggering Factors of Alcoholic and Non-Alcoholic Fatty Liver
Abstract: Over the past few years, fatty liver disease has turned out to be a rather widespread phenomenon and has become a serious issue with the global population nowadays. It comprises alcoholic fatty liver disease and non-alcoholic fatty liver disease, which develop under the influence of various initiating factors, though frequently follow similar pathologies. The overloading of lipids in the hepatocytes in most cases will be the first sign of the …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 1, 2026 · pp. 43–52 Read article
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Gene Editing in Dairy Cows: Advancing Milk Yield, Health, and Resilience for Sustainable Dairy Development
Abstract: Gene editing has emerged as a transformative tool in dairy science, offering unprecedented opportunities to enhance productivity, improve animal health, and bolster resilience against environmental challenges. This study explores the potential of gene editing technologies, including CRISPR-Cas9, in advancing milk yield, optimizing milk composition, and addressing genetic disorders in dairy cows. Specific applications include targeting genes associated with mastitis resistance, improving feed efficiency, and introducing heat tolerance traits to adapt …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 2, 2025 Read article
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A Systematic Review on Leukemia Detection and Classification Techniques Using Gene Expression
Abstract: Early diagnosis of genetic diseases is crucial for effective treatment, especially in the case of Leukemia, a type of blood cancer characterized by abnormal proliferation of white blood cells. This paper presents a systematic review of recent computational techniques for the detection and classification of Leukemia using gene expression data obtained from DNA microarray analysis. The study explores diverse methodologies including machine learning (ML), deep learning (DL), and bio-inspired algorithms …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 2, 2025 Read article
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Precision Medicine for Neurofibromatosis Type 1: Progress and Prospects in Drug Discovery
Abstract: Objective: The development of neurofibromas, café-au-lait spots, and other neurological problems are the hallmarks of neurofibromatosis type 1 (NF1), a hereditary disorder. The dearth of efficacious pharmaceutical therapies underscores the need for novel therapeutic approaches, even in the face of clinical variability. Through very accurate prediction of the binding affinity of possible therapeutic drugs with the target protein, the computational technique known as “molecular docking” has become a potent tool …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 1, 2024 · pp. 01–15 Read article
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Drug Repurposing of Anticancer Agents JP-8g and REDX05358 Against the Target Protein Plectin 1a in Epidemolysis Bullosa Simplex with Muscular Dystrophy (EBS-MD)
Abstract: Epidermolysis Bullosa Simplex with Muscle Dystrophy is a genetic disease affecting the skin and muscles which can be seen at birth or start at adulthood due to the mutation in the protein Plectin 1a (PLEC gene) causing skin blisters and muscle weakness. This protein is seen in sarcolemma, Z disks in skeletal muscles, hemidesmosomes in skin and cardiac muscles giving stability to cytoskeleton, playing a crucial role in neuromuscular transmission …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 22–34 Read article
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Change of Capacitance in Cancerous Cell
Abstract: Cancer is a genetic disease. It is characterized by out of control growth of cell. It harms the body with its uncontrollable growth. Tumors that do not spread and show limited growth are generally considered to be benign. More dangerous are malignant tumors which can manage to divide and grow. They may be very dangerous and may cause death. Early detection of the disease helps in treatment and may save …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 4, Issue 1, 2015 · pp. 29–32 Read article
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To Develop Self-instructional Module on ‘Umbilical Cord Stem Cell Collection, Preservation and Utilization’ and Evaluate its Effectiveness on Improving the Knowledge of Operational Level Nurses
Abstract: Umbilical cord stem cell based regenerative and cellular medicine has now become a fascination for all. The umbilical cord blood, donated by mothers after the birth of newborn, has become an accepted source of hematopoietic stem cells for bone marrow reconstitution. They play an important role in the treatment of blood and immune system related genetic diseases, cancers, and blood disorders. This study is aimed to assess the knowledge of …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 9, Issue 3, 2020 · pp. 10–22 Read article
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Use of CRISPR/Cas9 in Delivery System with Nanotechnology Concept
Abstract: In this emerging era of science and technology development, the use of drug delivery concept has made possible to cure several health problems, but for certain genetic diseases like Sickle cell anemia, chronic diseases like cancers, Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)/CRISPR associated system (Cas) gene-editing system is here as a promising tool to cure them by doing certain gene manipulation in specific gene area causing the disease. However, …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 12, Issue 2, 2022 · pp. 16–23 Read article
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Indigenous Knowledge on Health Care in Tribes of Jharkhand and Odisha
Abstract: Health is multidimensional and influenced by plethora of factors such as habitat, religious attitude, political ideology, worldview, educational attainment, natural resource, food production, socio-cultural practices, hygiene and sanitation, environmental hazards, population structure, etc. in tribal societies of India. Indigenous people have the right to their traditional medicines and to maintain their health practices, including conservation of their vital medicinal plants, animals and minerals. Tribal areas in general are marked by …
Published in Research & Reviews : Journal of Herbal Science · Vol. 9, Issue 1, 2020 · pp. 29–35 Read article
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Bioinformatics in Veterinary Science: Unraveling Disease Patterns and Genomic Insights.
Abstract: Bioinformatics has emerged as a powerful tool in veterinary science, enabling the unraveling of disease patterns and providing valuable genomic insights. This article explores the application of bioinformatics in veterinary research, focusing on its impact on disease diagnosis, treatment, and prevention. By integrating large-scale data analysis, computational algorithms, and biological knowledge, bioinformatics has revolutionized our understanding of animal diseases, their genetic basis, and their interaction with the environment. The article …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 12, Issue 1, 2023 · pp. 21–26 Read article
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Assessing the impact of lifestyle factors on autoimmune risk and survival outcomes: A Population-based Study
Abstract: This study investigated the interplay between lifestyle factors and genetic regulation in autoimmune diseases, focusing on the role of human T-cell metabolic and proliferative control through C-REL gene transcription. This study combined CRISPR-Cas9 manipulation of C-REL in human T-cells with a longitudinal cohort of 100 adults (autoimmune patients and controls), investigating metabolic and proliferation dynamics via flow cytometry and assays. It assessed lifestyle impacts through surveys and medical records, ensuring …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 15, Issue 2, 2025 · pp. 10–19 Read article
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Efficient Identification of Complex Diseases Through Epistasis Computational Models: A Review
Abstract: AbstractGenome-Wide Association Studies (GWAS) identify and characterize the genes that are associated with human diseases. One of the significant ongoing researches in GWAS is to identify the disease susceptible genes through Epistasis. The gene that masks the effects of other genes is called Epistasis. The gene interacts with another gene is known as epistatic or genetic interactions (GGIs). GWAS identifies the genetic variants of Single Nucleotide Polymorphism and also the …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 7, Issue 2, 2020 · pp. 21–32 Read article
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The Power of Genetic Engineering in Revolutionizing Vaccines
Abstract: Genetic engineering techniques, including recombinant subunit, viral vector, and nucleic acid vaccines have transformed the landscape of vaccine development. These novel approaches offer precise antigen design, enhanced safety profiles, and rapid adaptability to emerging pathogens. Key advantages include improved efficacy through targeted immune responses, increased safety due to the absence of live pathogens, and the ability to modify vaccines to address new variants or diseases quickly. Notable success stories, such …
Published in International Journal of Vaccines · Vol. 2, Issue 1, 2025 · pp. 18–27 Read article
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Impact of PPAR-γ2 pro12Ala Gene Polymorphism and Susceptibility of Type 2 Diabetes Mellitus in Patients Visiting Gondar University Teaching Hospital
Abstract: Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia that can occur through mechanisms such as; impaired insulin secretion, insulin resistance in peripheral tissues and increased glucose output by liver. Type 2 diabetes clearly represents a multifactorial disease, and several findings indicate that multiple genetic and environmental factors are important contributing factor involved in the pathogenesis of this disease. Recently great emphasis has been given to genetical factors to combat …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 5, Issue 2, 2015 · pp. 21–28 Read article
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A Review on Advances in Personalized Medicine: from Genomics to Clinical Applications
Abstract: Personalised medicine, also known as precision medicine, is a revolutionary approach to healthcare that customises medical interventions and treatments for individual patients according to their distinct genetic, environmental, and lifestyle properties. The basic pillar of personalised medicine is genomics, and the area has seen an explosion of genetic information with the advent of high-throughput sequencing tools. Genomic data now provide unprecedented insights into the underlying genetic variations, mutations, and genetic …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 10, Issue 2, 2023 · pp. 13–17 Read article
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Genetic Variability and Statistical Methods: Key Insights for Computational Genetics Research
Abstract: Genetic variability, defined as the differences in DNA sequences among individuals, serves as the foundation of evolutionary biology and plays a pivotal role in species’ adaptability, resilience, and overall survival. Advances in genomic technologies, particularly high-throughput sequencing, have enabled unprecedented exploration of genetic diversity, fostering the growth of computational genetics. This interdisciplinary field combines statistical methods and computational tools to analyze genetic data, identify patterns, and link phenotypes to genotypes. …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 3, 2024 · pp. 19–23 Read article
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Multifactorial Diseases Becoming the Epigenetic Factor for the Genz
Abstract: This comprehensive paper investigates the complex interplay between multifactorial diseases, particularly obesity and cardiovascular disease (CVD), and their relationship with epigenetic mechanisms, highlighting the transgenerational implications of these interactions. The multifaceted nature of obesity and CVD, involving genetic predisposition, environmental influences, and epigenetic modifications, underscores the intricate pathways contributing to disease susceptibility and progression. Drawing upon a synthesis of diverse research findings, the paper elucidates the critical role of genetic …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 16–22 Read article