Use of CRISPR/Cas9 in Delivery System with Nanotechnology Concept

Maiolica Bandyopadhyay

Abstract

In this emerging era of science and technology development, the use of drug delivery concept has made possible to cure several health problems, but for certain genetic diseases like Sickle cell anemia, chronic diseases like cancers, Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)/CRISPR associated system (Cas) gene-editing system is here as a promising tool to cure them by doing certain gene manipulation in specific gene area causing the disease. However, significant challenges are still in hold in clinical and therapeutic applications to be fulfilled by this CRISPR technology. The safety and efficiency of delivery to target sites in vivo are the major challenges for it, and to solve these, nanotechnology is a new but a great concept which contributed towards many therapeutic applications by certain nanocarriers like in Cancer drug delivery. Due to the small size of different nanoparticles, they are becoming a major vehicle to carry and transfer certain drugs towards target site in safe and efficient way. This review will discuss in brief, how nanotechnology field made a huge impact in drug delivery system using CRISPR/Cas9 system and how interdisciplinary are these three domains in medical field with benefits and positive outcomes to society.

Abstract

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