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83 articles for “Formulated tablet”
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Formulation and Evaluation of Chewable Toothpaste Tablet Containing Cetylpyridinium Chloride
Abstract: The study’s goal was to create an effective formulation of Cetylpyridinium chloride chewable toothpaste pills. Cetylpyridinium chloride is a cationic quaternary ammonium chemical that has significant bactericidal, antiseptic, antiplaque, and anti-gingivitis effects. Cetylpyridinium chloride is an antiseptic with antimicrobial activities against a variety of oral bacteria and fungi. It has antiplaque and gingivitis properties. It is used therapeutically as an antiseptic agent; used alone or in combination with other drugs …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 9, Issue 2, 2022 · pp. 9–17 Read article
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Formulation and Development of Ibuprofen Floating Tablet
Abstract: The investigation focused on optimizing a gastric floating drug delivery system (GFDDS) for Ibuprofen tablets. It employed polymers like HPMC K4M and Carbopol 940 to improve Ibuprofen's bioavailability and therapeutic effectiveness. GFDDS, with lower bulk density than gastric fluids, remains buoyant in the stomach, extending gastric residence time. Compatibility assessments, via DSC analysis, indicated harmony between the polymers used, with no observed interaction between the polymer and the drug. The …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 10, Issue 3, 2023 · pp. 24–29 Read article
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Formulation And Evaluation Of Captopril Sustained Release Tablet By Qbd Approach.
Abstract: The purpose of present study was to formulation and evaluation of Captopril sustained release tablet by QbD approach using size expanding polymer and cross linker. Captopril is a ACE inhibitor use in treatment of mild to moderate hypertension. Captopril having biological half-life of 2 hrs. The drugs gets degrade as its goes to higher pH, so we selected size expanding GRDDS. In formulation development study by using QbD, we found …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 10, Issue 1, 2023 · pp. 64–73 Read article
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Formulation and Evaluation of Diltiazem Hydrochloride Sustained Release Matrix Tablets
Abstract: Tablets are the most popular and versatile formulations with wide acceptance when compared to other dosage forms due to ease of administration, storage and transport. Diltiazem HCl is a calcium channel blocker widely used for its peripheral and vasodilator properties in the treatment of hypertension and angina. The objective of the present study is to prepare and characterize novel sustained release tablets of freely water soluble drug Diltiazem HCl using …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 6, Issue 2, 2015 · pp. 17–27 Read article
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Design and Development of Sustained Release Tablets using Solid Dispersion of Beclomethasone Dipropionate
Abstract: In present study an attempt was made to enhance the solubility of beclomethasone dipropionate by solid dispersion method followed by formulating sustained release matrix tablet of beclomethasone dipropionate to improve the patient compliance. Beclomethasone dipropionate has poor water solubility and short elimination half-life hence solid dispersion of beclomethasone dipropionate were prepared with β-cyclodextrin and PEG 6000 as carrier by using physical mixture, solvent evaporation and kneading method. The prepared solid …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 2, Issue 3, 2015 · pp. 30–41 Read article
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Formulation and Evaluation of Buccal Mucoadhesive Bilayered Tablets of Enalapril Maleate
Abstract: The buccal mucoadhesive bilayered tablets of Enalapril Maleate were fabricated with objective of avoiding first pass metabolism and prolonging the duration of action. The tablets were prepared by wet granulation wherein, one layer comprised of drug and bio adhesive polymer, whereas second layer consisted of drug free backing layer of ethyl cellulose. Bioadhesive polymers like Carbopol 934P and one either of three HPMC K4M/ HPMC K15M/ HPMC K100M were employed …
Published in Trends in Drug Delivery · Vol. 1, Issue 1, 2014 · pp. 1–15 Read article
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Design And Evaluation Of Meloxicam Tablet For Colon Cancer
Abstract: Meloxicam, recognized as a preferential COX-2 inhibitor, has emerged as a promising chemopreventive agent for colorectal cancer. Leveraging its local and targeted action on the colon, Meloxicam proves to be a formidable component in the prevention of colorectal malignancies. This study aims to innovate by formulating and evaluating a targeted tablet delivery system for Meloxicam, emphasizing site-specific and instant drug release in the colon, thereby maximizing its therapeutic efficacy in …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 10, Issue 3, 2023 · pp. 1–7 Read article
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Factors Affecting Shear Stress on Tablet Hardness and Disintegration
Abstract: The quality and effectiveness of pharmaceutical tablets depend heavily on several factors influencing shear stress on tablet hardness and disintegration. These factors include formulation composition, wherein the selection and concentration of excipients and active ingredients affect how the tablet material responds to shear stress. Additionally, the compression force, speed, and duration during tablet compression are critical, impacting tablet hardness and disintegration properties. Tablet geometry and design, along with tablet press …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 1–19 Read article
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Effect of Starch CMC Blend on the Drug Release from the Tablet
Abstract: Starch is frequently used as a binder and disintegrate for immediate release tablet formulation and is also used to prepare sustained release formulations. Starches from various sources show different functional characteristics; while combining with other excipients. When starch blend from various sources is used in the combination with carboxy methyl cellulose (CMC), it shows different release properties. The aim of the present work is to investigate the influence of starch-CMC …
Published in Trends in Drug Delivery · Vol. 5, Issue 1, 2018 · pp. 10–16 Read article
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RP-HPLC Analytical Method Development and Validation for Quantitative Estimation of Metoclopramide Hydrochloride in Solid Oral Formulations
Abstract: RP-HPLC technique formulated for the numerical assessment of Metoclopramide Hydrochloride in tablet formulation has been confirmed for reliability. A C18 column facilitated the chromatographic separation using a mobile phase comprising 60:40 (v/v) potassium dihydrogen phosphate buffer: meth anol mixture. Such method was used to detect, where the retained time was 6.78 minutes and Metoclo pramide Hydrochloride produced a clear peaked at 273 nm. Results were in agreement with ICH Q2 …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 · pp. 07–15 Read article
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Simultaneous Estimation of Irbesartan and Hydrochlorothiazide in Bulk and Tablet Dosage Form by UV-Spectrophotometry
Abstract: The present study describes a simple, accurate, precise and cost-effective UV Spectrophotometric method for the simultaneous estimation of irbesartan and hydrochlorothiazide in bulk and tablet dosage form. The solvent used was methanol and the absorption maxima for irbesartan and hydrochlorothiazide were found to be 250 nm and 270 nm respectively. A linear response was observed in the range of 4–20 µg/mL with a correlation coefficient of 0.998 for irbesartan and …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 3, Issue 3, 2012 · pp. 9–17 Read article
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Combination of Withania somnifera and Centella asiatica for the Management of Anxiety and Stress: Promise for the Future
Abstract: Aim: the aim of the present study is to evaluate the anxiolytic effect of Aforte tablet formulated with the combination of Withania somnifera and Centella asiatica. Method: The anxiolytic effect of Aforte tablet was studied by ethogram and other conventional pharmacological studies such as Despair Swim test (DST), Elevated Plus Maze (EPZ) and Skeletal Muscle Relaxant Activity. Result: The study of ethogram of mice evaluated by focal animal sampling showed …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 9, Issue 1, 2019 · pp. 24–28 Read article
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A Comprehensive Exploration of Method Validation and Development in Pharmaceutical Analysis: Focus on Vortioxetine Analysis
Abstract: The pharmaceutical industry relies on rigorous method validation to ensure the accuracy, precision, and reliability of analytical techniques employed in drug testing and quality control. This comprehensive exploration delves into the validation parameters and guidelines essential for method validation, emphasizing accuracy, precision, linearity, detection and quantitation limits, specificity, range, robustness, and ruggedness. Validation plays a pivotal role in guaranteeing high-quality products, adhering to good manufacturing practices (GMP), and optimizing manufacturing …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 11, Issue 1, 2024 · pp. 46–52 Read article
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Formulation Development and In Vitro Evaluations of Trimetazidine and Clopidogrel Bilayered Tablets
Abstract: The Bilayered tablets consisting of Trimetazidine SR as well as Clopidogrel IR were efficiently prepared by damp granulation technique as well as straight compression approach specifically. The prepared powdered mix (SR) were also preserved the physiochemical residential or commercial properties of tablet computers such as thickness, firmness, weight variant, friability and drug material. The enhanced formula consists of the average thickness of 3.1 ± 0.034, average firmness of 4.2 ± …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 8, Issue 3, 2023 · pp. 29–40 Read article
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Analytical Method Development and Validation for Simultaneous Estimation of Paracetamol and Piroxicam by UV Method
Abstract: A new establishment and validation of a simple, precise, accurate and cost effective UV-Visible spectrophotometric method was developed to estimate both Paracetamol and Piroxicam simultaneously in conjoined pharmaceutical dosage forms. This technique was founded on simultaneous equation method of absorbances recorded at 252.0 nm and 282.0 nm of Paracetamol and Piroxicam in methanol respectively and an isosbestic point could be observed at 265.0 nm. It showed very good linearity over …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 3, 2025 · pp. 14–21 Read article
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Development and Validation of RP-HPLC Method for Estimation Ertugliflozin in Its Bulk and Tablet Dosage Form
Abstract: Background: This study developed and validated a new, sensitive, appropriate, clear, accurate, and robust reversed-phase high-performance liquid chromatography (RP-HPLC) method for determining safinamide in bulk medication and tablet formulations. An HPLC procedure using a UV detector and the Openlab EZchrome workstation programme was used to separate the samples, as well as a Kromasil C18 (250 mm × 4.6 mm i.d.) 5 μm. At a flow rate of 1.0 mL/min, methanol …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 9, Issue 1, 2022 · pp. 8–20 Read article
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Enhancement of Solubility and Dissolution of Ibuprofen by Solid Dispersion Technique with the Help of Box-Behnken Design
Abstract: This study aims to develop a stable solid dispersion of ibuprofen by solvent evaporation technique with increased solubility, dissolution, and stability. Solid dispersion of ibuprofen with PEG-6000 and poloxamer 407 in different weight ratios was prepared using solvent evaporation technique. The saturation solubility study showed a significant effect of all polymers on the solubility of ibuprofen in batch F6, which showed a maximum solubility of 97.99 g/mL in water. The …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 9, Issue 2, 2022 · pp. 25–31 Read article
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Development and Validation of Spectrophotometric and Colorimetric Method for the Determination of Ritonavir in its Bulk and Pharmaceutical Dosage Form
Abstract: A straightforward, exact, precise and sensitive UV spectrophotometric assay technique and a basic and sensitive colorimetric assay method have been created and validated for the quantitative estimation of Ritonavir from bulk drug and tablet formulations. UV spectrophotometric strategy which includes the assurance of Ritonavir in bulk medication and pharmaceutical dosage forms and has an assimilation greatest at 240 nm in methanol. The Beer's law was obeyed over the concentration range …
Published in Trends in Drug Delivery · Vol. 4, Issue 3, 2017 · pp. 32–41 Read article
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In-Vitro Evaluation of Extended Release Atorvastatin Tablets by using Natural Gums
Abstract: The present research is the formulation of extended-release tablets Atorvastatin is used as a hypoglycemic agent; it is HMG CoA Reductase inhibitor. All the formulation were prepared with using different grades of xanthan gum, guar gum, sodium alginate, then all the formulations were subjected to pre-compression and post-compression parameters such as angle of repose, bulk density, tapped density, Carr’s index, Hausner's ratio, weight variation, thickness, hardness, friability and drug content. …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 6, Issue 2, 2019 · pp. 55–62 Read article
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Development and Characterization of 5-Fluorouracil Cubosomal Nanosponge Tablet for Colon Targeting
Abstract: The objective of this study was to develop nano-scale delivery system to improve nanometric size range, percentage drug entrapment efficiency, controlled release of the incorporated drug and the protection against degradation. 5-FU loaded cubosomal dispersion was prepared by the bottom up technique and formulation was characterized. From this, 5-FU cubosomal nanosponges were prepared by the emulsion solvent diffusion method using various pH dependent polymers and evaluated, encapsulation of this formulation …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 10, Issue 2, 2019 · pp. 9–18 Read article