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383 articles for “evaluation strategies”
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Pharmacokinetics of Levothyroxine and Factors Influencing Its Therapeutic Efficacy in Hypothyroidism: A Comprehensive Review
Abstract: Levothyroxine (LT4) remains the standard therapy for hypothyroidism due to its effectiveness in restoring normal thyroid hormone levels and improving physiological functions. However, its pharmacokinetic profile exhibits considerable variability, which may influence therapeutic outcomes in clinical practice. This review aims to comprehensively evaluate the pharmacokinetics of levothyroxine, including its absorption, distribution, metabolism, and elimination, along with factors affecting its therapeutic efficacy. A structured literature search was conducted using electronic databases, …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 Read article
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Comprehensive Evaluation of Quercetin from Bauhinia purpurea for Its Anti-Acne and Anti-Inflammatory Potential, Including Advances in Quercetin-Loaded Nanogel Formulation
Abstract: Acne vulgaris is among the most prevalent chronic inflammatory dermatoses in clinical dermatology, afflicting a substantial proportion of the global adolescent and adult population. Conventional pharmacotherapies — including topical retinoids, benzoyl peroxide, and systemic antibiotics — remain the therapeutic mainstay; however, their long-term utility is progressively undermined by adverse cutaneous reactions, systemic toxicity, and the rising prevalence of antibiotic-resistant Cutibacterium acnes strains. These limitations have intensified scientific interest in plant-derived …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 2, 2026 Read article
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Effective Strategies for Sustainable Soil and Water Management: Enhancing Agricultural Productivity and Environmental Conservation
Abstract: Soil and water are essential natural resources, and their degradation due to erosion, overgrazing and other factors is ongoing. Water erosion is influenced by climate, topography, vegetation and soil, while wind erosion is affected by wind characteristics, surface features, topography and soil properties. Unsustainable land and water management practices lead to reduced soil fertility, soil loss, lower crop yields, water depletion, deforestation, and diminished biomass. Of the 1386 million cubic …
Published in International Journal of Land · Vol. 1, Issue 1, 2024 · pp. 11–36 Read article
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Exploring the Genetic and Environmental Factors Contributing to Ovarian Cancer in Women in Mumbai, India
Abstract: Background: Ovarian cancer incidence in Mumbai has risen by 30% over the past decade, with an age-standardized rate of 9.1 per 100,000 women, contrasting stable trends in Western nations. This study investigates the interplay of genetic and environmental factors driving this disparity in Mumbai’s diverse population. Methods: A hospital-based case-control study was conducted at a hospital, enrolling 200 epithelial ovarian cancer cases (aged 30–70 years) and 400 age-matched controls. Germline …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 3, 2025 · pp. 12–17 Read article
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Automated Intelligence, Machine Learning, and Big Data in Education: A Practical Framework, Synthetic Demonstration, and Deployment Guidance
Abstract: Artificial intelligence (AI), machine learning (ML), and big-data methods are increasingly used to improve educational decision making through personalization, early-warning systems, scalable feedback, and operational analytics. This manuscript proposes a practical end-to-end framework for educational AI/ML projects, covering problem definition, data engineering, modeling, evaluation, intervention design, and responsible governance. To provide a complete and reproducible template without exposing sensitive student data, we present a synthetic demonstration study that mirrors typical …
Published in Journal of Computer Technology & Applications · Vol. 17, Issue 1, 2026 Read article
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Status and Distribution of Major Invasive Plant Species in the Dehradun Region of the Uttarakhand Himalaya
Abstract: Invasive alien plant species are widely recognized as one of the major threats to global biodiversity and ecosystem stability. Their rapid spread and ability to adapt to different environmental conditions allow them to dominate natural habitats and disrupt ecological balance. The present study examines the status and distribution of major invasive plant species in the Dehradun region of Uttarakhand, which is situated in the Himalayan foothills of northern India. Field …
Published in International Journal of Trends in Horticulture · Vol. 3, Issue 1, 2026 · pp. 17–23 Read article
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Enhancement in Biomedical Polymer Nanocomposites: Biocompatibility and Mechanical Property Predictions using Machine Learning
Abstract: A machine learning (ML)-based framework is developed and validated through experimental analysis and comparative modeling to enhance system dependability and improve prediction performance. The proposed framework includes key stages such as data preprocessing, feature evaluation, model training, and performance benchmarking to determine the most effective prediction technique. Several machine learning models were evaluated, including Ensemble models, Artificial Neural Networks (ANN), Decision Tree (DT), Random Forest (RF), Support Vector Machine (SVM), …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 275–296 Read article
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Investigating The Alkalizing Potential of Chandanasava For Restoring Acid-Base Homeostasis in Renal Tubular Acidosis: A Computational and In Silico Pharmacological Study
Abstract: Chandanasava, a traditional Ayurvedic formulation, is recognized for its potential alkalizing properties, which may help restore acid-base homeostasis in conditions such as renal tubular acidosis (RTA). This study aims to investigate the active components of Chandanasava and their interactions with key renal target proteins, Pendrin and Carbonic Anhydrase II, which are essential for maintaining acid-base balance. An in silico approach was utilized to explore the pharmacological potential of the phytochemicals …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 2, 2025 · pp. 28–52 Read article
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Safe Routes to School: Best Practice and their Applicability to Urban Context
Abstract: Safe routes to school (SRTS) programs aim to encourage active transportation for children through enhanced safety, accessibility, and infrastructure within the areas surrounding schools. SRTS has become increasingly popular worldwide as a method of promoting public health, decreasing traffic, and promoting community cohesion. Yet bringing SRTS to urban environments comes with special challenges. Urban locations often have high traffic volumes, inadequate pedestrian facilities, socioeconomic inequities, and variable policy backing that …
Published in Trends in Transport Engineering and Applications · Vol. 13, Issue 1, 2026 · pp. 31–35 Read article
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Neuro-Symbolic Agentic AI for Autonomous Scientific Discovery: Integrating Deep Reinforcement Learning, Quantum Simulation, and XAI-Audited LLM Hypothesis Generation in Drug Target Identification
Abstract: The exponential growth of multi-omics data and the increasing complexity of disease-associated protein interactomes have rendered conventional drug target identification pipelines computationally and epistemologically inadequate. This paper presents the Neuro-Symbolic Agentic AI for Scientific Discovery (NS-AASD) framework, a unified architecture that cohesively integrates deep reinforcement learning (DRL) exploration strategies, variational quantum simulation (VQS) of protein conformational dynamics, and XAI-audited large language model (LLM) hypothesis generation within an autonomous scientific discovery …
Published in Research and Reviews : Journal of Computational Biology · Vol. 15, Issue 2, 2026 Read article
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Student Academic Achievement Forecast Based on Emotional Intelligence, Personality, Demographic Characteristics and Attitude Towards Education and Future Career
Abstract: This study was aimed at predicting students' academic achievement based on emotional intelligence of personality traits, attitudes to education and future career. The present study was a correlational-analytical study. The statistical population of Zanjan University students in the academic year of 1395-1395 was the sample of 489 people selected by cluster random sampling method. Academic Resilience Scale (ARI) and Schotte Emotional Intelligence Questionnaire and Researcher Attitude Questionnaire were used to …
Published in International Journal of Education Sciences · Vol. 1, Issue 2, 2024 · pp. 25–36 Read article
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CB₁ Reverse Agonists: A Cheminformatic and Patent Landscape Study
Abstract: The endocannabinoid system plays a crucial role in numerous physiological functions, making cannabinoid receptor 1 (CB1) an attractive target for therapeutic development. This review provides a systematic analysis of patent filings from 2019 to 2023 that focus on small-molecule CB1 reverse agonists. It begins with an overview of the endocannabinoid system, highlighting CB1’s involvement in energy balance, pain regulation, and neuroinflammatory processes The main section of the review examines fifteen …
Published in International Journal of Cheminformatics · Vol. 3, Issue 2, 2025 · pp. 33–36 Read article
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Assessment of Spatial Variations in Water Quality and Environmental Impacts on Freshwater Ecosystems A Case Study of Lakes Around Puducherry
Abstract: This study examines the water quality of Kanagan Lake, Osuteri Lake, and the Chunnambar River to evaluate environmental changes and their significance to Puducherry's ecosystem. A multidisciplinary approach was employed to assess key water quality parameters, including pH, dissolved oxygen, nutrient levels, and pollutant concentrations, providing a comprehensive understanding of the ecological health of these water bodies. The analysis revealed significant spatial variations in water quality across the sites, driven …
Published in Journal of Water Resource Engineering and Management · Vol. 12, Issue 1, 2025 · pp. 1–15 Read article
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Reinforcement Learning for Adaptive Sensing with Shape Memory Polymer-Based IoT Nodes
Abstract: The rapid expansion of intelligent sensing in the Internet of Things (IoT) has revealed the pressing need for materials and algorithms capable of self-adaptation in volatile environments. Conventional polymer-based sensors and static control strategies often fail to capture nonlinear thermo-mechanical dynamics, leaving them unsuitable for unpredictable operating conditions. Although prior studies have improved polymer composites or introduced algorithmic optimization independently, few attempts have coupled the adaptability of smart materials with …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 370–391 Read article
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Targeting Vasopressin 2 Receptor (V2R) in Renal Cystogenesis by Exploring the Nephroprotective Potential of “Terminalia arjuna”
Abstract: Objectives: Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disorder, leading to the formation of multiple cysts in the kidneys. It is a major cause of end-stage renal disease (ESRD), which often requires dialysis or a kidney transplant for survival. This research focuses on identifying potential bioactive compounds derived from natural sources that show promise for drug development targeting the V2R gene. Methods: The naturally occurred …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 2, 2024 · pp. 14–24 Read article
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Impact of Counseling on Cancer Patient’s Depression Level
Abstract: Introduction: When given the dreaded and possibly fatal cancer diagnosis, patients go through a great deal of pain. Depression is one of the psychiatric problems that can arise after a cancer diagnosis. The purpose of the current research is to evaluate how well counseling therapy can lower depression levels in cancer patients. Methodology: Geetanjali Hospital in Udaipur provided the data for this study, which utilized a single-group, quasi-experimental analysis employing …
Published in International Journal of Oncological Nursing and Practices · Vol. 1, Issue 1, 2023 · pp. 1–5 Read article
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A Sustainable and Green Prototyping Framework for Low-carbon and Resource-efficient Virtual Product Development
Abstract: The increasing emphasis on sustainable manufacturing has intensified the need for environmentally responsible design and development methodologies for polymer and polymer-composite materials, where material selection, processing routes, and waste generation play a critical role in overall environmental impact. This paper presents a Sustainable and Green Prototyping (SGP) framework that integrates Virtual Prototyping (VP), Life Cycle Assessment (LCA), and multi-objective optimization to systematically reduce carbon footprint, energy consumption, and material waste …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 459–471 Read article
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A Study to Evaluate the Impact of Health Education on Awareness of Long-term Complications of Hypertension Among Hypertensive Patients in A Selected Hospital, Bengaluru
Abstract: The rising burden of non-communicable diseases, particularly hypertension, poses significant public health challenges, especially in developing nations. This study aimed to assess the effectiveness of a health education program focused on lifestyle modifications to prevent hypertension-related complications among patients at selected hospitals in Bengaluru. Employing a quasi-experimental design, we recruited 60 hypertensive patients through purposive sampling. Initial knowledge was evaluated using a structured questionnaire, followed by an educational intervention provided …
Published in International Journal of Evidence Based Nursing And Practices · Vol. 2, Issue 2, 2024 · pp. 31–63 Read article
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Recent Advances in Content-based Image Retrieval: Techniques and Applications
Abstract: Content-based image retrieval (CBIR) plays a vital role in computer vision, driven by the increasing need for fast and accurate image retrieval across fields like healthcare, e-commerce, and digital libraries. This study offers a detailed review of CBIR methodologies, charting their progression from traditional feature extraction techniques, such as Local Binary Patterns (LBP), to contemporary deep learning-driven methods. The transformative impact of convolution neural networks (CNNs) is highlighted, emphasizing their …
Published in Journal of Computer Technology & Applications · Vol. 16, Issue 1, 2025 · pp. 67–71 Read article
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Comparative Study of Time Slice Windows Analysis and Impacted As-Planned Analysis for Data Center Construction Projects Using Primavera P6 24.12 Version
Abstract: Data centers are IT infrastructure that needs to be precisely scheduled and coordinated. Significant financial losses and operational failures may result from building delays. Stakeholders can assign blame and comprehend the reasons behind delays with the aid of forensic delay analysis. Because of their unique approaches and legal acceptability, TSWA, and IAPA are commonly used among the many strategies. These methods provide various ways to analyze project schedules and pinpoint …
Published in Journal of Construction Engineering, Technology & Management · Vol. 16, Issue 1, 2026 · pp. 33–51 Read article