Search
698 articles for “Pro drugs”
-
Design and Assessment of Fixed Dose Combination Containing Fenofibrate and Pravastatin Sodium in Tablet Formulation: A Bioinformatics Approach
Abstract: The aim of this is study is to formulate and evaluate fixed dose combination of Fenofibrate and Pravastatin sodium in tablet dosage for the treatment of Dyslipidemia. For the formulation and optimization of fenofibrate layer, two factor three level factorial design was used as experimental design for optimization with a minimum of nine run. All the nine trial (F1–F9) has been formulated according to the experimental design by wet granulation …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 11, Issue 1, 2024 · pp. 1–20 Read article
-
Advancements in Polymer Chemistry for Biomedical Applications: A Focus on Injection Guides
Abstract: Polymers have revolutionized biomedical applications, offering versatility, biocompatibility, and cost-effective manufacturing. This paper explores the role of polymer chemistry in the development of an advanced injection guide for precise drug delivery, aiming to enhance both safety and efficiency in clinical settings. Emphasis is placed on polymer selection, structural design, and functional modifications to improve injection procedures. By leveraging biodegradable and biocompatible polymers, the guide minimizes adverse tissue reactions while ensuring …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 129–136 Read article
-
Strategies for the Development and Optimization of Orally Disintegrating Tablets (ODTs) to Improve Bioavailability and Patient Compliance
Abstract: Background: Pharmaceutical scientists have developed Orally Disintegrating Tablets (ODTs) to advance patient drug acceptance and biological system availability through simplified medi-cation delivery especially for children and senior citizens and people who cannot swallow pills regularly. The oral disintegrating tablets dissolve in the mouth within thirty seconds or less (USP 701) while needing no additional liquid thus making them suitable for both emergency treatments. Objective: The research examines ODT development strategies …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 Read article
-
Characterization of Cellulose Producing Bacterial Isolates from Rotten Fruits
Abstract: Cellulose, the most abundant natural polymer, is predominantly sourced from plant wood but can also be synthesized by certain bacteria in the form of bio-cellulose. The potential applications of bio-cellulose are extensive, particularly in the biomedical field for tissue engineering, drug delivery, and more. The distinct properties and purity of bacterial cellulose, in contrast to plant-derived cellulose, underscore its importance and drive further research in the area. This study focuses …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 1, 2024 · pp. 38–45 Read article
-
Role of Artificial Intelligence in Simulation and Therapeutics in Neurodegenerative Diseases
Abstract: Neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, etc., are a cause of significant mortality rates due to a lack of curative treatments and their complex nature. Traditional therapeutic methodologies have several disadvantages such as slow diagnosis and a lack of effective treatments. They mainly focused on the management of the disease rather than curing it. The integration of artificial intelligence in the simulation and therapeutics of neurodegenerative …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 16, Issue 1, 2026 · pp. 19–29 Read article
-
AI-Driven Pharmacogenomics and Precision Medicine: Future of Personalized Therapy
Abstract: Pharmacogenomics and artificial intelligence (AI) are emerging as important drivers of precision medicine, enabling healthcare systems to adopt individualized therapeutic approaches. Pharmacogenomics examines how genetic variations influence drug response, efficacy, metabolism, and toxicity, while AI provides advanced computational tools for analyzing complex genomic and clinical data. This review highlights the integration of AI-driven pharmacogenomics in personalized therapy and its potential to improve treatment outcomes. Machine learning, deep learning, natural language …
Published in Emerging Trends in Personalized Medicines · Vol. 3, Issue 2, 2026 · pp. 1–12 Read article
-
A Comprehensive Exploration of Method Validation and Development in Pharmaceutical Analysis: Focus on Vortioxetine Analysis
Abstract: The pharmaceutical industry relies on rigorous method validation to ensure the accuracy, precision, and reliability of analytical techniques employed in drug testing and quality control. This comprehensive exploration delves into the validation parameters and guidelines essential for method validation, emphasizing accuracy, precision, linearity, detection and quantitation limits, specificity, range, robustness, and ruggedness. Validation plays a pivotal role in guaranteeing high-quality products, adhering to good manufacturing practices (GMP), and optimizing manufacturing …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 11, Issue 1, 2024 · pp. 46–52 Read article
-
Computational Study of Sombor Index on Generalized Abid–Waheed Graphs for Polymer Modeling
Abstract: This study investigates the topological properties of generalized Abid Waheed graphs. Development of theoretical models in chemistry, reducing computational complexity while analysing large molecules or networks Abid Waheed graphs play a significant role. Motivated by these findings, the research was extended to encompass generalized Abid Waheed graphs, characterized by r cycles of order s. A notable similarity between Abid Waheed graphs and Jahangir graphs was observed. The potential applications of …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 267–274 Read article
-
Evaluation of the anti diabetic effects of ethanolic root extract from polyalthania longifora in diabetic rats induced by streptozotin and nicotinamide with considaertion of toxocological aspects
Abstract: The root of Polialthia Longifolia was selected for the evaluation of antidiabetic potential in STZ-nicotinamide induced diabetic rat model.The root extract was extracted by hot percolation using ethanol as a solvent in soxhlet apparatus and the preliminary phytochemical screening was performed and it shows that the ethanolic root extract of Polialthia Longifolia contains alkaloids, glycosides, flavonoids and tannins. Safety profile is essential for the drugs obtained from the plant origin. …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 1, 2024 · pp. 37–50 Read article
-
Non-Small Cell Lung Cancer: Types, Pathogenesis, Diagnosis, and Novel Therapeutic Strategies
Abstract: Non-small cell lung cancer (NSCLC) is the most prevalent type of lung cancer, accounting for over 85% of all cases globally. It remains one of the primary causes of cancer-related death due to its rapid progression, few early symptoms, and late detection. The three main forms of non-small cell lung cancer (NSCLC) are adenocarcinoma, squamous cell carcinoma, and giant cell carcinoma; each has a unique histology, prognosis, and response to …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article
-
The Power of Persuasion: How Social Engineers Exploit Social Media Dynamics
Abstract: Social engineering, the strategic manipulation of individualities through cerebral tactics, thrives on social media platforms, where specific dynamics enhance its impact. This study delves into the styles social masterminds employ to exploit social media, assaying common strategies like phishing, impersonation, misinformation, and emotional prayers. Social media provides rich ground for these tactics through features similar as algorithmic modification, stoner obscurity, and echo chambers, which allow social masterminds to reach and …
Published in Journal Of Network security · Vol. 13, Issue 1, 2025 · pp. 37–44 Read article
-
Scientific Appraisal of Unani Drugs Used in Neurological Disorders
Abstract: Background: Neurological disorders are prevalent and are increasing. The Unani system of medicine provides insights into the pathogenesis, prevention, and treatment of these diseases. Objective: This study explores the Unani perspective on neurological disorders, focusing on therapies and the pharmacodynamics of related medicines. Methods: A comprehensive review of Unani literature was conducted using digital and traditional sources. Unani texts, like “Al Qanoon Fil Tib” by Ibn Sina and “Al Jami …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 13, Issue 1, 2026 · pp. 34–44 Read article
-
Dasatinib Induced Pulmonary Hypertension
Abstract: Dasatinib (Das) is a second-generation tyrosine kinase inhibitor that is used in the treatment of chronic myelogenous leukemia (CML) in patients who are resistant or intolerant to imatinib, as well as in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) patients. Dasatinib-induced pulmonary arterial hypertension (PAH) is a known but rare adverse effect of dasatinib and is grouped under Group-1 PAH. The mechanism of PAH development is not fully known, but …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 92–95 Read article
-
Biodegradable and Natural Fiber-Reinforced Polymer Composites for Co-Delivery of Multiple Therapeutic Agents
Abstract: The co-delivery of multiple drugs using advanced nanocarriers has revolutionized targeted therapy in various diseases, particularly in cancer, infectious diseases, and neurological disorders. Multi-layered polymeric nanocarriers (MLPNs) offer a sophisticated platform to encapsulate multiple therapeutic agents with precise control over drug release, bioavailability, and synergistic effects. These nanocarriers are designed with distinct polymer layers that enable sequential or simultaneous drug release based on stimuli-responsive mechanisms such as pH, temperature, and …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 406–419 Read article
-
Crystallographic Studies on The Stability of Pharmaceutical Compound
Abstract: Crystallographic studies provide detailed insights into the molecular structure and intermolecular interactions within a crystal lattice, which are key determinants of a compound's stability. By analyzing crystal structures, researchers can identify potential polymorphs, solvates, and hydrates that may impact the physical and chemical stability of the drug. This knowledge helps in optimizing formulation strategies, predicting shelf life, and ensuring consistent drug performance. Advanced techniques like X-ray diffraction and neutron diffraction …
Published in International Journal of Crystalline Materials · Vol. 1, Issue 1, 2024 · pp. 38–42 Read article
-
Investigating the Impact of Viral Infections on Pharmacokinetics and Pharmacodynamics of Antiviral Drugs
Abstract: The emergence and re-emergence of viral infections pose significant challenges to public health, necessitating a comprehensive understanding of how these infections impact the pharmacokinetics and pharmacodynamics of antiviral drugs. This review explores the intricate interactions between viral pathophysiology and the pharmacological effects of antiviral agents. Factors such as viral replication dynamics, host immune responses, and the genetic variability of both viruses and hosts significantly influence drug absorption, distribution, metabolism, and …
Published in International Journal of Virus Studies · Vol. 1, Issue 2, 2024 · pp. 23–30 Read article
-
Tiryaq-E-Arba (A Poly Herbal Unani Formulation) in Fighting Against COVID-19 Like Conditions–Unani Perspective
Abstract: Coronavirus disease 2019 (COVID-19) is a pandemic disease of modern time with unique and rapid transmission rate and affected almost all the nations without respecting any border. World Health Organization stated it is an infective disease and pandemic. The coronavirus disease 2019 (COVID- 19) which created in Wuhan, China, has now spread to 192 countries and organizational regions infecting nearly 800,000 persons of all ages as of 31 March 2020. …
Published in Research & Reviews : Journal of Herbal Science Read article
-
Effect of Snehpana (Lipid Based Drug Delivery System) with Shatpala Ghrit in Non-Alcholic Fatty Liver Diseases
Abstract: Among all the Drug Delivery Systems, Snehpana (~Lipid Based Drug Delivery System) is being widely used because this facilitates uniform distribution and absorption of fat and water-soluble chemical constituents. Due to their effective size-dependent properties and challenges related to the solubility and bioavailability of water-soluble drugs, this system holds a significant advantage. Numerous studies have highlighted the potential of lipid-based formulations in managing chronic and life-threatening diseases. Shatpala ghrit (SG) …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 12, Issue 1, 2025 · pp. 1–11 Read article
-
“DEVELOPMENT AND CHARACTERIZATION OF PHYTOSOMES FOR THE TREATMENT OF ANTI-CANCER ACTIVITY BY USING THE Spirulina (Arthospira Plantesis) EXTRACT”
Abstract: This study aims to investigate and evaluate spirulina's anticancer properties.The current research is centred on obtaining a Spirulina-containing drug. The goal is to design and create Phytosomes, characterizing them based on relevant and crucial parameters. The process of solvent evaporation was utilized in the creation of Phytosomes. Various parameters such as zeta potential, particle size, infra-red spectral analysis, % drug content, encapsulation efficiency, and % drug release (% DR) were …
Published in International Journal of Antibiotics · Vol. 1, Issue 1, 2024 · pp. 10–22 Read article
-
Evaluation Of Anti Obesity Activity Of Citrus Sinensis & Citrus Limon By High Fat Diet Induced Model Using Danio Rerio
Abstract: Obesity, defined by the World Health Organization (WHO) as an abnormal or excessive fat accumulation that may impair health, is becoming one of the greatest challenges to global health in this millennium, with more than 300 million men and nearly 450 million women obese globally in 2018. Obesity turns into serious problem globally. Zebrafish model can be used extensively for drug screening due to its low maintenance cost, comparatively short …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 1, 2024 · pp. 24–31 Read article