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395 articles for “Promising approach”
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Understanding Leukemogenesis: Challenges and Advancements in Diagnostic Approaches
Abstract: Leukaemia development, or leukemogenesis, is a multifactorial process driven by a complex interplay of environmental, genetic, and epigenetic factors. Despite substantial advancements in technology and medicine, which have enhanced our understanding of the contributing factors, early and accurate diagnosis remains a major challenge due to the overlapping clinical features shared by the various leukaemia subtypes. This study explores the molecular and cellular mechanisms underlying leukemogenesis, while also addressing the difficulties …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 3, Issue 1, 2025 · pp. 11–22 Read article
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Design, Synthesis, and Spectroscopic Elucidation of 3-Methyl-1-Phenylpyrazol-5-One: A Cheminformatics-Aided Approach to Heterocyclic Drug Scaffolds
Abstract: Pyrazolone, a notable heterocyclic compound, has drawn increasing interest due to its broad pharmacological profile and structural versatility. The synthesis, characterisation, and biological assessment of new pyrazolone derivatives are examined in this work. A comprehensive review of existing synthetic strategies is presented, emphasizing green and efficient methodologies. Novel derivatives were synthesized using varied starting materials and catalytic systems, followed by structural confirmation through spectroscopic analyses, including NMR, IR, and mass …
Published in International Journal of Cheminformatics · Vol. 3, Issue 1, 2025 · pp. 29–40 Read article
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A Split and Merge UNet: A Deep Learning Assisted UNet Model to Segment Corpus Callosum of Brain for Automatic Autism Detection
Abstract: In recent years, deep learning techniques have shown remarkable performance in various image analysis applications, particularly in the domain of medical image processing. Among these, image segmentation plays a critical role, as it helps in isolating and analyzing specific regions within medical images. The proposed study focuses on segmenting the corpus callosum, a vital structure in the human brain, using a novel optimization technique known as the Split and Merge …
Published in Journal of Multimedia Technology & Recent Advancements · Vol. 11, Issue 3, 2024 · pp. 1–9 Read article
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RNA- Based Drug Delivery, Current Advances, Pharmaceutical Applications, and Future Perspectives
Abstract: RNA-based therapeutics have emerged as a transformative approach in modern medicine due to their ability to regulate gene expression with high specificity and precision. Advances in molecular biology, RNA chemistry, and nanotechnology have accelerated the development of diverse RNA modalities, including messenger RNA (mRNA), small interfering RNA (siRNA), microRNA (miRNA), antisense oligonucleotides (ASOs), and RNA aptamers. These therapeutics offer promising strategies for the treatment of cancer, genetic disorders, infectious diseases, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 Read article
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Improving Polymer Composite Properties Through Reinforcement Learning Guided Prototyping A Novel Approach for Material Engineering
Abstract: Innovative approaches integrating reinforcement learning (RL) and machine learning (ML) into the fields of polymer composite prototyping and soft actuator manufacturing for applications. This new an algorithm utilizing RL optimizes polymer composite fabrication parameters to enhance material properties efficiently. By iteratively adjusting parameters based on predefined objectives, the RL agent guides the prototyping process, promising to revolutionize polymer composite engineering. A finest control method for locked loop control of Shape …
Published in Journal of Polymer & Composites · Vol. 12, Issue 4, 2024 · pp. 208–218 Read article
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A Comprehensive Review of Alternative Medicine: Biological Plausibility, Testability, Repeatability, and Effectiveness
Abstract: Alternative medicine, encompassing practices, such as acupuncture, herbal remedies, homeopathy, chiropractic care, Ayurveda, and Traditional Chinese Medicine (TCM), has gained global popularity as patients seek non-conventional healthcare solutions. Despite its widespread use, scientific evaluation of its biological plausibility, testability, repeatability, and effectiveness remains a significant challenge. This review critically examines these four criteria to assess the validity and reliability of alternative therapies. Acupuncture demonstrates partial plausibility, with evidence suggesting its …
Published in International Journal of Membranes · Vol. 2, Issue 1, 2025 · pp. 32–46 Read article
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Artificial Intelligence in Early Diagnosis and Personalized Treatment of Alzheimer’s Disease
Abstract: Artificial intelligence (AI) has become a disruptive technology in the medical care industry, with potential solutions to early diagnosis and customized treatment of Alzheimer’s disease (AD), a progressive neurodegenerative disease and the most prevalent cause of dementia globally. Conventional diagnostic techniques, such as cognitive, neuroimaging and biomarker techniques, are usually limited in the ability to detect disease at its most susceptible stage when treatment interventions are most effective. The recent …
Published in International Journal of Brain Sciences · Vol. 3, Issue 2, 2026 · pp. 15–27 Read article
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Real-Time Gesture Recognition with Convolutional Neural Networks
Abstract: Sign language detection plays a pivotal role in bridging communication barriers for the deaf and hard of hearing community. An extensive investigation on the use of convolutional neural networks (CNNs) for sign language recognition is presented in this article. Leveraging the power of deep learning, our research aims to develop an accurate and efficient system capable of recognizing and classifying sign language gestures in real-time. The report begins with an …
Published in Journal of Electronic Design Technology · Vol. 15, Issue 2, 2024 · pp. 12–18 Read article
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Polymer Composite-Assisted Crystal Engineering for Drug Synthesis and Property Control through Solid Solutions and Co-Crystals
Abstract: The long-standing problem of low aqueous solubility, which affects about 90% of all new drug molecules under development, requires an immediate need for alternative approaches apart from the usual practice of crystallization. Polymer-composite-assisted crystal engineering is a novel technique for overcoming the aforementioned problem. This involves the addition of accepted pharmaceutical polymers, such as HPMC, PVP, PEG, and Eudragit copolymers in a single process, which can promote nucleation, stabilize the …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 172–189 Read article
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In Silico Exploration of Podophyllum Hexandrum-Derived Phytocompounds as Potential Therapeutics Against Small Cell Lung Cancer (SCLC): A Molecular Docking Approach
Abstract: Small Cell Lung Cancer (SCLC) is a fast-growing and aggressive type of lung cancer that spreads quickly strongly associated with smoking. It is characterized by symptoms, such as persistent cough, breathing difficulties, or hoarseness, though it can sometimes be asymptomatic which makes early detection challenging. The tumor suppressor gene TP53 is critical in regulating the cell cycle and preventing uncontrolled cell division. Mutations in TP53 result in the loss of …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 1–11 Read article
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Nutrient-Mediated Activation of Cellular Signaling Pathways: Mechanistic Insights into Attenuation of Toxin Induced Inflammation in Food Animals
Abstract: Dietary and environmental toxins remain a persistent challenge in food animal production, where subclinical and clinical inflammation compromises health, productivity, and food safety. Toxin induced inflammation is driven by oxidative stress, mitochondrial dysfunction, and dysregulated immune signaling, resulting in impaired metabolic efficiency and increased disease susceptibility. Recent advances in nutritional science have revealed that nutrients act not only as substrates for growth but also as signaling molecules capable of modulating …
Published in International Journal of Toxins and Toxics · Vol. 3, Issue 1, 2026 · pp. 1–12 Read article
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Drug-Induced Liver Injury: Hepatotoxicity and Treatment - A Literature Review
Abstract: Drug-induced liver injury (DILI) is a major clinical and regulatory challenge, posing risks to patient safety and drug development worldwide. As the primary organ responsible for xenobiotic metabolism, the liver is particularly susceptible to toxic injury from prescription drugs, over-the-counter medications, herbal products, and dietary supplements. Drug-induced liver injury (DILI) accounts for a substantial proportion of acute liver failure cases and remains a leading cause of post-marketing drug withdrawal. Its …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 1, 2026 · pp. 1–17 Read article
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Role of Dried Allogenic Amniotic Membrane in Second degree Scald Burns
Abstract: Burn injuries represent a significant portion of common injuries, stemming from thermal, scalding, or electrical incidents. Among these, scald injuries stand out as the predominant type in children under five years old, constituting a majority, with over 65% of cases falling under this category. Currently, various scaffolds are employed to enhance the healing process and mitigate scar formation. Collagen plays a crucial role as a scaffold, facilitating tissue regeneration and …
Published in Research and Reviews : Journal of Surgery · Vol. 13, Issue 1, 2024 · pp. 25–30 Read article
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Review And Analysis of Application of Conductive Polymer Composites in Power-Efficient RF Circuits For 5G PAPR Reduction
Abstract: The need for low power RF circuits has gained more importance in the background of fifth-generation (5G) wireless communication systems, since the inherent PAPR characteristic of 5G signals—especially when using orthogonal frequency division multiplexing (OFDM) based techniques—becomes high. This high PAPR limits the efficiency of RF power amplifiers, increases power consumption, and induces thermal management challenges. In this context, conductive polymer composites (CPCs), based on advanced polymer matrices integrated with …
Published in Journal of Polymer & Composites · Vol. 13, Issue 3, 2025 · pp. 111–125 Read article
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Monitoring and Safety of Aircraft using Wireless Technology
Abstract: Traditional aircraft sensor networks, burdened by wire complexity and high-power demands, struggle with scalability and real-time data acquisition. This paper proposes Bluetooth Low Energy advertising as a transformative solution, leveraging its lightweight, energy-efficient, and secure nature within tree network architecture. Sensors broadcast data packets picked up by strategically placed gateways, enabling efficient data dissemination through multi-hop relaying. The approach boasts scalability due to minimal hardware and power requirements, leading to …
Published in International Journal of Satellite Remote Sensing · Vol. 1, Issue 2, 2023 · pp. 14–21 Read article
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Optimization of Process Parameters for Cu90Ni10 Alloy Processed by Wire Arc Additive Manufacturing (WAAM) Using an L9 Orthogonal Array
Abstract: Abstract Wire Arc Additive Manufacturing (WAAM) has gained significant attention in recent years as a promising technique for producing complex metallic components. This study focuses on the processing of Cu90Ni10 alloy using WAAM and employs an L9 orthogonal array to optimize the mechanical properties of the resulting components. Cu90Ni10 alloy is known for its excellent corrosion resistance and electrical conductivity, making it a critical material in various industries, including aerospace …
Published in Journal of Polymer & Composites · Vol. 11, Issue 8, 2023 · pp. 292–301 Read article
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Android Voting System Using Face Recognition
Abstract: This work investigates a novel authentication approach for online voting systems that includes facial recognition verification. The goal is to create an automated voting system that increases election security and voter convenience. Voters prefer to cast their ballots in designated areas, such as polling booths, resulting in long lines and the majority of people missing out on the chance to vote. Ineligible voters may potentially fabricate their ballots, generating a …
Published in International Journal of Mechanical Dynamics and Systems Analysis · Vol. 2, Issue 1, 2024 · pp. 15–20 Read article
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Targeting TNFSF4 in the Management of Systemic Lupus Erythematosus
Abstract: Systemic lupus erythematosus (SLE) is a multifaceted autoimmune disorder that remains a significant challenge for both healthcare providers and researchers. Despite advances in understanding its mechanisms, finding effective therapies is still difficult. This review highlights a potential therapeutic target in SLE research: tumor necrosis factor superfamily member 4 (TNFSF4), also referred to as OX40L. We explore how TNFSF4 contributes to SLE development, looking at its role in immune system regulation …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 3, 2024 · pp. 6–14 Read article
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Experimental and CFD Investigation of an Epoxy-Based Thermally Conductive Polymer Composite U-Tube Shell-and-Tube Heat Exchanger: A Lightweight Alternative to Conventional Metal Systems
Abstract: Shell-and-tube heat exchangers continue to play a critical role in industrial thermal systems; however, their conventional design based on fully metallic materials often leads to challenges related to weight, corrosion, and cost. In recent years, thermally conductive polymer composites have emerged as promising alternatives, offering improved corrosion resistance and design flexibility. In this study, the thermo-hydraulic performance of a U-tube shell-and-tube heat exchanger is investigated by partially replacing conventional metallic …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 685–700 Read article
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To Rule Out the Efficacy of Haridradi Drugs in Respiratory Allergic Disorders in the Childrens.
Abstract: Allergic diseases in children have increased significantly in recent years and they are a major cause of morbidity in the children. Although there is a genetic predisposition, exposure to allergens i.e pollens, irritants, infections, diets and inhalant will determine the sensitization. At present, the best approach to the children who are at high risk for the development of allergies is to introduce environmental and dietary control and adopt early measures …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 13, Issue 2, 2024 · pp. 53–60 Read article