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41 articles for “various malignancies”
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Selective Inhibitors of Nuclear Exports—A Novel Anti-Cancer Drug Class: The Review Study
Abstract: For the maintenance of cell homeostasis nucleus-cytoplasmic transport is of great concern. The transport is basically depending on a size of molecule. In different hematological and solid malignancies, the CRM1 is overexpressed so the agents are requiring that particularly inhibit the exportins of nuclear export. This concept favors the SINEs development. The objective of this review study is to understand all about the novel anticancer drugs and their uses in …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 5, Issue 1, 2018 · pp. 29–36 Read article
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Oncolytic Viruses (OV) Mediated Targeted Therapy to Eradicate Chronic Myeloid Leukemia (CML): A Review
Abstract: With the recent advances in scientific scenarios globally, an innovative introduction of cancer vaccines and a much safer and more effective way to eradicate cancer has been evolved. The viruses that are not severely harmful to the humans and do not recognize the human as their natural host can be deployed as an oncolytic virus to eradicate the malignancy either by killing or lysing the oncogenic cells or indirectly stimulating …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 12, Issue 2, 2022 · pp. 27–36 Read article
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Inhibition of PI3K/Akt/mTOR Signaling Pathway by Vitis Vinifera Phytocompounds: A Promising Strategy for Supressing Colorectal Cancer Growth and Metastasis
Abstract: Objectives: Colorectal cancer was not typically identified a few decades ago. Today, with almost 900 000 fatalities each year, it is the fourth most dangerous cancer in the world. Colorectal cancer is responsible for about 10% of all cancer diagnoses annually and cancer-related deaths worldwide. It is the second most common type of cancer in women and the third most common type in men. Incidence and death are roughly 25% …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 · pp. 64–75 Read article
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An Effective Convolutional Neural Network for Identifying Cancer Blood Disorder Cells Using Microscopic Images
Abstract: Blood, bone marrow, and lymphatic systems are all impacted by hematological cancer is known as a cancer blood disorder. Blood malignancies and various blood disorders pose significant health challenges across all age groups. Early disease detection is essential for effective cancer blood disorder treatment and management. If a blood cancer is not identified in time, it may be hazardous. It results in abnormal white blood cell production by the bone …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 2, 2024 · pp. 29–35 Read article
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Role of Gastric Receptors in Gastrointestinal Disorder
Abstract: The established and potential roles of cholecystokinin1 and cholecystokinin2 receptors in gastrointestinal and metabolic diseases are analyzed, along with findings from human studies involving agonists and antagonists. While there is considerable evidence implicating cholecystokinin1R in various diseases such as pancreatic disorders, motility disorders, tumor growth, satiety regulation, and cholecystokinin-deficient states, its specific role in these conditions remains ambiguous. Conversely, the role of cholecystokinin2R in physiological (e.g., atrophic gastritis) and pathological …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 2, 2024 · pp. 37–49 Read article
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Harnessing Nature: Formulations for Colon Cancer Prevention and
Abstract: Colon cancer, a rapidly advancing disease worldwide, involves the carcinogenesis of the distal part of the intestine. This malignancy progresses through various developmental stages necessitating diverse treatment approaches. Traditional treatments include drug therapy and chemotherapy; however, emerging methods, such as the use of phytochemical compounds offer promising mechanisms for combating this disease. Phytochemical compounds derived from natural food sources, including flavonoids, tannins, resveratrol, and epigallocatechin-3-gallate, exhibit potent anti-cancer properties. They …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 3, 2024 · pp. 11–23 Read article
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Current Trends in Crossing the Blood–Brain Barrier: A Review
Abstract: The blood-brain barrier (BBB) is a protective barrier that protects the central nervous system (CNS) from toxins and pathogens in the blood. However, the existence of BBB challenges therapy for CNS diseases and disorders as most pharmaceuticals (drugs) are restricted to enter brain. The review article focuses on the approaches involved to cross BBB with various advanced technology such as nanoparticles, intraventricular injection, chemical modifications, virus mediated distribution, exosome mediated …
Published in Trends in Drug Delivery · Vol. 10, Issue 2, 2023 · pp. 25–38 Read article
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Investigation on Plant Heparanase and its Inhibitors
Abstract: Heparanase is an endoglycosidase which cleaves heparan sulfate (HS) and hence participates in degradation and remodelling of extracellular matrix (ECM). It further regulates multiple biological activities that enhance tumour growth, angiogenesis and metastasis. Heparanase expression is enhanced in almost all cancers examined including various carcinomas, sarcomas and haematological malignancies. In the present article, heparanase enzyme in plants and its activity against inhibitors was described. Here the heparanase enzyme and the …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 10, Issue 3, 2020 · pp. 19–27 Read article
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Stilbenes: A Molecular Docking and ADMET Analysis Approach on an Emerging Resource for Scavenging Reactive Oxygen Species in the Field of Colon Malignancy
Abstract: Objective: Colon malignancy, also referred to as colon cancer, originates as precancerous polyps in the colon or rectum, which have the potential to thrive and progress into cancerous tumors over time. This study delves into various bioactive compounds (from natural sources like plants) to assess their potential efficacy in inhibiting colon malignancy as compared to conventional methods. Methods: The objective of this study was to employ computational methodologies to evaluate …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 3, 2024 · pp. 29–38 Read article
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CHARACTERIZATION, VIRULENCE TESTING AND ANTIFUNGAL SUSCEPTIBILITY PATTERN OF VARIOUS CANDIDA SPECIES AT TERTIARY CARE CENTRE, AMRITSAR
Abstract: IntroductionSerious fungal infections particularly Candida infection have increased in recent years as a consequence of increased immunosuppression associated with HIV infection, organ and tissue transplant and aggressive treatment for malignancies and autoimmune diseases. Present study was conducted to Characterize various Candida species isolated from various clinical samples, their virulence testing by biofilm production and antifungal susceptibility pattern.Settings and Design:A prospective observational study was conducted from September 2014 to June 2016 …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 9, Issue 2, 2019 · pp. 1–5 Read article
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Role of Food Supplements in Premalignant Lesions: A Literature Review
Abstract: Premalignant lesions of the oral cavity are histopathological alterations in the oral epithelium linked to a higher likelihood of malignant transformation. These lesions frequently present as leukoplakia (white patches), erythroplakia (red patches), oral lichen planus, and oral submucous fibrosis. Oral cancer, categorized among head and neck malignancies, is considered the sixth most common cancer globally. While tobacco and alcohol consumption remain the primary etiological factors, increasing evidence underscores the significant …
Published in Research and Reviews: A Journal of Dentistry · Vol. 16, Issue 3, 2025 · pp. 17–26 Read article
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Examining Connective Tissue Changes Across Various Grades of Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma: A Histochemical Polymeric Investigation
Abstract: Oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC) represent a spectrum of potentially malignant disorders posing significant challenges in diagnosis and management. The tumor microenvironment, particularly alterations in the connective tissue, plays a crucial role in the progression of these lesions. This histochemical investigation comprised with embedded polymers aimed to examine connective tissue changes across various grades of oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC). …
Published in Journal of Polymer & Composites · Vol. 12, Issue 3, 2024 · pp. 124–137 Read article
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A Review Article on Oroxylum indicum: A Versatile Medicinal Tree
Abstract: Oroxylum indicum, commonly known as the Indian trumpet tree or Shyonaka, is a medicinal plant belonging to the Bignoniaceae family. It is widely used in traditional medicine systems such as Ayurveda for treating various ailments including neurodegenerative diseases, cardiovascular conditions, arthritis, hepatitis, malignancies, diarrhea, fever, and jaundice. The plant's therapeutic properties are primarily attributed to its rich content of bioactive flavonoids, which exhibit notable anti-cancer, anti-inflammatory, and analgesic effects. Found …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 13, Issue 2, 2026 · pp. 01–07 Read article
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Is Tissue Platelet Count an Important Diagnostic Tool for Oral Cancer?
Abstract: Metastasis is the main cause of cancer-related deaths and a major challenge in today’s cancer management. Although many new therapies against malignant tumors have been developed over the last few years, the prognosis of most malignancies remains unfavorable, once metastatic spread has occurred. There are plethora of studies indicating that the interaction of tumor cells with platelets within the bloodstream is essential during this early phase of metastasis. Ironically, however, …
Published in Research and Reviews: A Journal of Dentistry · Vol. 5, Issue 1, 2014 · pp. 5–10 Read article
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Comparative Study of Machine Learning Algorithms for Detection of Breast Cancer
Abstract: Breast cancer continues to be the most commonly diagnosed cancer among women, with more than 2.3 million new cases diagnosed yearly worldwide. It is stated as the leading cause of cancer-related deaths. Therefore, this emphasizes the dire necessity for early diagnosis with a view to improving survival. Early diagnosis elevates the effectiveness of prediction and treatment. This research carries out a structured and analytical evaluation of various machine learning algorithms, …
Published in Journal of Artificial Intelligence Research & Advances · Vol. 12, Issue 2, 2025 · pp. 113–129 Read article
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Antioxidants in Dentistry: Clinical Significance and Controversies
Abstract: Antioxidants are extensively used in routine general clinical practice in the present era. Oxidative stress plays an important role in the etiology of various oral lesions. Increased incidence of oral cancer and potentially malignant disorders, where the oral environment is damaged by the production of free radicals warrants the need for research and evidence in the use of antioxidants in the field of dentistry. Keywords: Antioxidants, free radicals, oxidative stress
Published in Research and Reviews: A Journal of Dentistry · Vol. 4, Issue 3, 2013 · pp. 1–5 Read article
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Change of Capacitance in Cancerous Cell
Abstract: Cancer is a genetic disease. It is characterized by out of control growth of cell. It harms the body with its uncontrollable growth. Tumors that do not spread and show limited growth are generally considered to be benign. More dangerous are malignant tumors which can manage to divide and grow. They may be very dangerous and may cause death. Early detection of the disease helps in treatment and may save …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 4, Issue 1, 2015 · pp. 29–32 Read article
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Thyroid Disorders in Regard to Aetiology, Clinical Patterns, Management
Abstract: Thyroid disorders are one of the important and common endocrine problems encountered in clinical and occupational practice in all age groups more frequently in women and in adult population. Amongst all the functional thyroid disorders, hypothyroidism is far more common than hyperthyroidism. Recognition of this condition at an early stage can delay the progression to overt disease. Appropriate use of biochemical test, i.e., thyroid function test can delineate practically all …
Published in Journal of Energy, Environment & Carbon Credits · Vol. 6, Issue 3, 2016 · pp. 34–42 Read article
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Spontaneous Perforation of Uterus in Pyometra
Abstract: Accumulation of pus in the uterine cavity is known as Pyometra. Any cause that obstructs the flow of menstrual blood and endometrial secretions can lead to development of Pyometra. Various factors have been implicated in development of this condition which includes any benign or malignant growth that obstructs cervical canal, any age related stenosis, previous radiotherapy, previous surgeries on cervix. Spontaneous Rupture of Pyometra is a rare event and can …
Published in Research and Reviews : Journal of Surgery · Vol. 3, Issue 3, 2014 · pp. 16–18 Read article
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Mandible reconstruction following resection of gingival squamous cell carcinoma with peroneal artery perforator based fibular osteocutaneous free flap
Abstract: Reconstructing soft tissue defect resulting from resection of malignant tumor in face is crucial in esthetic and functional point of view. To address this condition, various surgical flaps are used, including the free vascularized osteocutaneous flap. In this case, we used a free fibular osteocutaneous flap to reconstruct both the bone (osseous) and soft tissue (mucosal) defects. These defects were caused by the removal (resection) of a lesion in a …
Published in Research and Reviews: A Journal of Dentistry · Vol. 16, Issue 2, 2025 · pp. 12–18 Read article