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Trends in Drug Delivery

Current Trends in Crossing the Blood–Brain Barrier: A Review

  1. Chenna M Shalini
  2. Komati Manasa
  3. Zafar Khan
  4. Manga Meghana
  5. Rama Rao T

Abstract

The blood-brain barrier (BBB) is a protective barrier that protects the central nervous system (CNS) from toxins and pathogens in the blood. However, the existence of BBB challenges therapy for CNS diseases and disorders as most pharmaceuticals (drugs) are restricted to enter brain. The review article focuses on the approaches involved to cross BBB with various advanced technology such as nanoparticles, intraventricular injection, chemical modifications, virus mediated distribution, exosome mediated transport, drug penetration enhancers, liposome based strategies, brain permeability enhancers, micro emulsions and micelles, cell penetrating peptides dendrimers and colloidal active ingredients. This study's objective is to provide a broad overview of recent developments in the delivery of brain medications as well as related subjects. We hope that this review will encourage readers to think about new approaches to brain drug delivery. Traditional oral or systemic administrations of therapeutic medications are limited in their ability to treat some central nervous system illness, including various types of cerebral malignances due to potential serious side effects and/or lack of brain penetration of medications decreases.

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