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19 articles for “metabolite profile”
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Exploring the Bioactive Potential of Himalayan Lichens: Phytochemical and Antimicrobial Profiling of Xanthoparmelia tinctina and Pyxine subcinerea Extracts
Abstract: The symbiotic association that develops between cyanobacteria, algae, and fungi results in the composite organism known as lichens, which has traits similar to those of plants but differs in its separate parent organisms. Lichens can have a variety of morphological characteristics, including foliose structures that resemble flat leaves, crustose structures that resemble flake crystals, fruticose branches that have short, leafless branches, and leprose-powder-like appearances. Due to their therapeutic potential, lichens …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 2, 2024 · pp. 21–28 Read article
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Metabolites in Modern Medicine: Decoding the Future of Health and Diseases
Abstract: The end products of many metabolic processes in cells are called metabolites. Each reaction contributes a specific metabolite. Metabolites act as fingerprints of on-going biological processes. Constant changes in cellular composition due to both environmental and internal factors. By analysing the types and presence of metabolites, scientists can effectively reconstruct the inner workings of a cell or organism. In the past, analysing metabolites was a slow and tedious process, often …
Published in Emerging Trends in Metabolites · Vol. 1, Issue 2, 2024 · pp. 1–13 Read article
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A Comprehensive Review of Metabolite
Abstract: Metabolites, tiny chemicals, are essential to physiology, signalling, and biological function. This extensive review classifies metabolites into primary and secondary categories by biological relevance. Alkaloids, flavonoids, and terpenoids contribute to ecological interactions and defence systems, while amino acids, nucleotides, and carbohydrates directly affect development and cellular function. The article examines metabolic pathways, mass spectrometry, NMR, and metabolomics, a growing field. Metabolites play a crucial role in various scientific and practical …
Published in Emerging Trends in Metabolites · Vol. 2, Issue 2, 2025 Read article
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Advancing Asthma Management: The Synergy of Systems Biology, Artificial Intelligence, and Next-Generation Therapeutics
Abstract: Asthma is an inflammatory disorder of the respiratory tract that is chronic and heterogeneous in nature and has various effects on millions of people. Being a chronic inflammatory disease, asthma remains incurable and the major conventional treatments offer limited success due to the mask nature of its pathophysiology. Systems biology/(AI), and next-generation has greatly enhanced knowledge and the management of asthma. The approaches based on gene, transcript, protein, and metabolite …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 14, Issue 2, 2024 · pp. 1–12 Read article
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Clinical metabolomics: Useful insights, perspectives, and challenges.
Abstract: Metabolomics provides a comprehensive snapshot of smallmolecule intermediates and end products of cellular processes and thereby links genotype, environment, and phenotype in human disease . Over the last decade, advances in liquid chromatography–mass spectrometry (LC–MS) and nuclear magnetic resonance (NMR) spectroscopy have enabled high-throughput profiling of thousands of metabolites from microliter volumes of clinical samples . Clinical metabolomics is now emerging as a tool for disease diagnosis, risk prediction, therapeutic …
Published in Emerging Trends in Metabolites · Vol. 3, Issue 1, 2026 · pp. 29–37 Read article
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A Conceptual Framework for AI-Integrated Metabolomics in Predictive Health Systems for Resource-Constrained Environments
Abstract: The increasing prevalence of non-communicable diseases (NCDs) continues to place a significant strain on healthcare systems, particularly in low- and middle-income regions where access to early diagnostic infrastructure is limited. Conventional healthcare approaches remain largely reactive, often detecting diseases at advanced stages when treatment effectiveness is reduced. This challenge underscores the need for predictive, cost-effective, and data-driven healthcare solutions. This study presents a conceptual framework that integrates metabolomics with artificial …
Published in Emerging Trends in Metabolites · Vol. 3, Issue 2, 2026 Read article
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Marine Fungi – An Expandable Source for Production of Novel Bioactive Metabolites: A Comprehensive Review
Abstract: The marine environment, representing the largest and most extreme biome on Earth, serves as an unparalleled reservoir of biodiversity. Within this vast ecosystem, marine fungi have emerged as a prolific source of structurally diverse and pharmacologically active secondary metabolites. Dwelling in habitats characterized by extreme high salinity, high hydrostatic pressure, and low temperatures, these microorganisms have evolved unique biochemical and metabolic pathways to synthesize novel compounds, including pyrrole-imidazole alkaloids, cyclic …
Published in International Journal of Fungi · Vol. 3, Issue 1, 2026 · pp. 30–37 Read article
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The Parasitic Fingerprint: Tracing Infection to Host Illness
Abstract: Parasitic infections remain a major global health burden, causing significant morbidity and mortality, particularly in tropical and subtropical regions. A critical aspect of disease pathogenesis is the unique molecular and cellular imprint left by parasites in their hosts, termed the “parasitic fingerprint.” These fingerprints encompass parasite-derived proteins, nucleic acids, metabolites, extracellular vesicles, and host responses, including gene expression changes, cytokine profiles, and metabolic adaptations. Advances in multi-omics technologies, which integrate …
Published in Recent Trends in Infectious Diseases · Vol. 3, Issue 1, 2026 · pp. 29–50 Read article
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Gut Microbial Metabolites in Inflammatory, Metabolic, and Neurologic Disorders.
Abstract: The human gut microbiota transforms dietary and hostderived substrates into a diverse array of metabolites—including shortchain fatty acids (SCFAs), hydrogen sulfide (H₂S), bile acid derivatives, indoles, trimethylamine Noxide (TMAO), branchedchain amino acid (BCAA) derivatives, and lipopolysaccharide (LPS)—that act as key signaling mediators along epithelial, immune, endocrine, and neural axes. These metabolites regulate barrier integrity, energy homeostasis, inflammation, and gut–brain communication and are increasingly implicated in the pathogenesis of inflammatory bowel …
Published in Emerging Trends in Metabolites · Vol. 3, Issue 1, 2026 · pp. 58–64 Read article
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A Review on Phytochemistry and Pharmacology of Macaranga peltata
Abstract: Macaranga peltata, categorized within the Euphorbiaceae family, represents a prevalent pioneer arboreal species across Southeast Asia, specifically in regions such as India and Sri Lanka. This review scrutinizes the phytochemical properties and pharmacological profiles of Macaranga peltata, underscoring both its historical medicinal applications and prospective therapeutic roles. The plant exhibits a rich composition of secondary metabolites, encompassing flavonoids, stilbenes, tannins, and terpenes, with the majority of these compounds being extracted …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 1, 2025 · pp. 50–59 Read article
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Comprehensive Evaluation of Quercetin from Bauhinia purpurea for Its Anti-Acne and Anti-Inflammatory Potential, Including Advances in Quercetin-Loaded Nanogel Formulation
Abstract: Acne vulgaris is among the most prevalent chronic inflammatory dermatoses in clinical dermatology, afflicting a substantial proportion of the global adolescent and adult population. Conventional pharmacotherapies — including topical retinoids, benzoyl peroxide, and systemic antibiotics — remain the therapeutic mainstay; however, their long-term utility is progressively undermined by adverse cutaneous reactions, systemic toxicity, and the rising prevalence of antibiotic-resistant Cutibacterium acnes strains. These limitations have intensified scientific interest in plant-derived …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 2, 2026 Read article
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Application of Metabolomics in Pharmacognosy
Abstract: In the field of pharmacognosy, the identification, quality control, and bioactivity evaluation of medicinal plants and natural products have become significantly more effective thanks to the development of a strong tool known as metabolomics, which is the complete study of small-molecule metabolites in biological systems. Metabolomics offers more in-depth insights into phytochemical composition, plant metabolism, and the mechanisms that underlie medicinal benefits. It does this by enabling high-throughput analysis and …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 3, 2025 · pp. 01–07 Read article
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Acetaminophen: Current Understanding and Future Directions in Pharmacology
Abstract: In this review, acetaminophen is described as one of the most widely used analgesic and antipyretic medications worldwide due to its effectiveness and reduced gastrointestinal toxicity compared with traditional NSAIDs. Its precise mode of action is still unclear despite widespread therapeutic use. Acetaminophen has little peripheral anti-inflammatory effect and largely acts within the central nervous system, in contrast to NSAIDs, which mainly block peripheral cyclooxygenase (COX) enzymes and lower inflammation. …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 2, 2026 Read article
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A brief survey on Alternative and Complementary Medicine with special reference to safety, toxins and toxicological concerns
Abstract: Alternative and Complementary Medicine (ACM) is a wide range of healthcare practices that may be used within or alongside conventional medicine, and many of these practices are rapidly becoming accepted and integrated into the modern healthcare system. In addition to traditional medicine systems (e.g. Ayurveda, Unani Medicine, Traditional Chinese Medicine, and Homeopathy), ACM includes practices that utilize natural remedies including herbal medicine, phytotherapy, naturopathy, acupuncture, yoga, and meditation. While these …
Published in International Journal of Toxins and Toxics · Vol. 3, Issue 1, 2026 · pp. 30–45 Read article
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Phytoconstituents of Ticanto crista (L.) R. Clark & Gagnon (Caesalpiniaceae): A Review
Abstract: Ticanto crista (L.) R. Clark & Gagnon (= Caesalpinia crista L.), a member of the Leguminosae family, is a medicinally important plant traditionally used in various systems of medicine, including Ayurveda, for treating a wide range of ailments. It has attracted increasing scientific interest due to its rich phytochemical profile and therapeutic potential. This review serves as a comprehensive index of the chemical structures of common and medicinal compounds isolated …
Published in Research & Reviews : Journal of Botany · Vol. 14, Issue 3, 2025 · pp. 38–59 Read article
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Fungal-derived Nutraceuticals & Bioactive Compounds with Physiotherapeutic and Health- promoting Properties: A Comprehensive Review
Abstract: Fungal-derived nutraceuticals represent a rapidly expanding field in biomedical research, offering a rich source of bioactive compounds with diverse therapeutic applications. This comprehensive review examines the physiotherapeutic and health-promoting properties of fungal metabolites, including polysaccharides, terpenes, proteins, peptides, alkaloids, fatty acids, vitamins, and minerals. Fungi produce over 9,000 bioactive compounds from approximately 22,500 microbial metabolites, with less than 5% of the fungal kingdom explored [1] . The major bioactive constituents …
Published in International Journal of Fungi · Vol. 2, Issue 2, 2025 Read article
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Assessing the Efficacy of Carica Papaya Leaf Extract in Preventing Thrombocytopenia: A Review
Abstract: A clinical condition known as thrombocytopenia is characterized by a low platelet count (less than 150 × 103/μL) in the blood, which leads to an imbalance in hemostasis and can result in multiple deadly consequences. Although the exact causes are not always known, they always lead to death by interfering with the formation of platelets and encouraging their destruction. Research demonstrates that Carica papaya leaf has special medicinal and therapeutic …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 11, Issue 2, 2024 · pp. 25–33 Read article
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Extracellular Vesicle-Based Liquid Biopsies: Decoding the Tumor Microenvironment for Precision Oncology
Abstract: The tumor microenvironment (TME) plays a pivotal role in cancer initiation, progression, and therapeutic response. Decoding the TME is, therefore, essential for advancing precision oncology. Extracellular vesicles (EVs), including exosomes and microvesicles, are nanoscale lipid bilayer particles secreted by tumor and stromal cells. They transport a wide range of bioactive molecules, such as DNA, RNA, proteins, lipids, and metabolites, which reflect the dynamic state of the TME. Recent advances in …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 15, Issue 1, 2026 · pp. 43–62 Read article
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Hydroponics Culture Regulated Metabolic Variations in Plants of Medicinal Value
Abstract: The current review chiefly brings to light the importance of alternative cultivation strategies for medicinal plants about the effective enhancement of the bioactive substances. The fast-paced society is favoring the need for its cost-effective cultivation and studying the effects thereafter. The mis-steps while collecting the plant from the wild lead to identification issues, genetic and phenotypic variations, variable bioactive substances/secondary metabolites, and toxic compounds. So, cultivation happening in controlled environments, …
Published in Research & Reviews : Journal of Herbal Science · Vol. 13, Issue 2, 2024 · pp. 14–20 Read article