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75 articles for “meta-analysis”
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Role of Organizational Culture in Mediating AI-Induced Social Alienation: A Meta-Analysis
Abstract: The fast adoption of artificial intelligence (AI) in the workplace has raised worries about its influence on employee well-being, particularly social alienation. Social alienation is characterised by feelings of detachment and estrangement at work. It can harm job satisfaction, staff engagement, and organisational performance. Existing literature suggests that organizational culture is crucial in shaping employee experiences with AI technologies. This meta-analysis investigates how organizational culture mediates the relationship between AI …
Published in Recent Trends in Social Studies · Vol. 2, Issue 1, 2025 · pp. 28–33 Read article
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Evaluating Epidemiological and Physical Risk Factors in the Development of Chemotherapy-induced Peripheral Neuropathy (CIPN): An In-depth Systematic Review and Meta-analysis
Abstract: Background of study: Chemotherapy-induced peripheral neuropathy (CIPN) encompasses a range of adverse effects caused by various cytotoxic medications and stands as a primary source of pain among individuals who have survived cancer. In instances of pronounced and sudden CIPN, it might become necessary to diminish chemotherapy dosages or discontinue their application. Currently, no efficacious strategy exists for proactively preventing CIPN, managing established chronic CIPN is constrained, and the risk factors …
Published in International Journal of Oncological Nursing and Practices · Vol. 1, Issue 2, 2023 · pp. 10–21 Read article
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Therapeutic Potential of Plant-Derived Phytochemicals in Targeting Receptor Pathways Related to Non-Enzymatic Glycation: A Meta-Analysis
Abstract: Background: Non-enzymatic glycation, where reducing sugars react with proteins, lipids, and nucleic acids, contributes to various pathological conditions, such as diabetic complications and cardiovascular diseases. This process is facilitated by the receptor for advanced glycation end-products (RAGE), which is pivotal in driving inflammation and causing tissue damage. Objective: This meta-analysis evaluates the effects of plant-derived phytochemicals on RAGE expression and associated signaling pathways, assessing their therapeutic potential in glycation-related diseases. …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 1, 2025 · pp. 60–73 Read article
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Crack Propagation Analysis in Metallic Alloys: A Comparative Study of Traditional and Advanced Materials
Abstract: A vital component of materials science and engineering, crack propagation analysis is essential to determining the structural integrity and dependability of materials. Designing safe and long-lasting structures for a variety of sectors required an understanding of how cracks begin, spread, and interact with a material's microstructure. To guarantee the performance, safety, and dependability of materials in a variety of applications, crack propagation analysis is essential. It offers insightful information about …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 1, Issue 1, 2023 · pp. 33–41 Read article
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Evaluation of Metal Coupons Corrosions in Fresh Water Environment at Different Water Depths Using Finite Element Analysis
Abstract: This research addressed the effects of water depths and quality on corrosion of submerged metal structures in the water body considering environmental conditions. The depths considered were 30cm to 150cm. Four different metal coupons were selected (Mild Steel, Copper Steel, Carbon Steel and Stainless Steel] Galerkin`s finite element techniques was applied to evaluate the relationship between diffusion and weight loss, also velocity and weight loss at different water depths. The …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 3, Issue 1, 2025 · pp. 27–50 Read article
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Analyzing the Sheet Metal Extrusion Process Using Finite Element Analysis
Abstract: A wide range of sheet metal forming techniques has been developed to make it easier to produce intricate 3D objects. However, the knowledge still isn't sufficient. The sheet metal extrusion method was examined in this research as one of the common sheet-bulk metal manufacturing technologies. Consideration of the flow-stress curve's impact across a broad range of plastic strain and ductile damage played a pivotal role in constructing a realistic finite …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 1, Issue 1, 2023 · pp. 13–25 Read article
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Antimicrobial Resistance and AI-Based Strategies for Rapid Pathogen Detection
Abstract: Antimicrobial resistance (AMR) has become a major global health threat, significantly reducing the effectiveness of antimicrobial therapies and increasing the burden of infectious diseases worldwide. The rapid emergence of multidrug-resistant pathogens has created an urgent need for faster, more accurate, and scalable diagnostic approaches to support timely treatment and effective infection control. Artificial intelligence (AI) has emerged as a promising technology capable of transforming pathogen detection and AMR surveillance through …
Published in Recent Trends in Infectious Diseases · Vol. 3, Issue 2, 2026 · pp. 26–36 Read article
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Differential Gene Expression Analysis of Human Atrial Fibroblasts Reveals Dysregulation of RNA Metabolism and Translational Machinery in Atrial Fibrillation
Abstract: Atrial fibrillation (AF) is a complex cardiac arrhythmia characterized by extensive structural remodeling and the activation of atrial fibroblasts, which drive the progression of fibrosis. To identify the underlying transcriptomic alterations, we analyzed six human atrial fibroblast RNA-Seq datasets (three control and three AF) retrieved from the Sequence Read Archive. After performing rigorous quality control and adapter trimming, we aligned the reads to the GRCh38 human reference genome using a …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 4, Issue 2, 2026 · pp. 15–25 Read article
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Prime Editing and Base Editing in Human Hematopoietic Stem Cells Toward Scarless Correction of Monogenic Blood Disorders
Abstract: Monogenic hematological disorders – such as sickle cell disease (SCD), β-thalassemia, and X-linked chronic granulomatous disease (X-CGD) – affect >400, 000 newborns worldwide each year, with a considerable burden in low-resource settings . Although donor-derived allogeneic hematopoietic stem-cell transplantation (HSCT) is widely regarded as curative, its application is limited due to issues of donor availability and graft-versus-host disease (GVHD) and conditioning-related toxicity. DSB-based conventional CRISPR-Cas9 strategies are limited by inefficient …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 4, Issue 1, 2026 Read article
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Evaluation of Critical MMAW Welding Defects Using Computer Simulation in Industrial Manufacturing Systems
Abstract: Manufacturing is one of the key sectors of any countries GDP and welding is one of the prime manufacturing processes of the manufacturing sector. Welding has several notable advantages over mechanical joining techniques, including higher structural integrity, design flexibility, and cost and weight lowers. Welded products/structures are subjected to serious issues of residual stresses and distortions. The performance and sturdiness of the welded structures are severely impacted by weld remaining …
Published in International Journal of Industrial and Product Design Engineering · Vol. 3, Issue 2, 2025 · pp. 18–26 Read article
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Exploring Potential Phytochemicals for Myasthenia Gravis Treatment: A Molecular Docking and ADME Analysis Approach
Abstract: Objective: Muscle feebleness and exhaustion derived from a disruption in neuromuscular transference are hallmarks of the crippling autoimmune disease myasthenia gravis (MG). The drawbacks of the current MG therapy options are frequently partial efficacy and adverse effects. To investigate the potential of phytochemicals in MG control, in this work we integrated molecular docking with ADME (absorption, distribution, metabolism, and excretion) analysis using a computer method. We identified molecules exhibiting favorable …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 1–13 Read article
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QSAR Modeling of a Novel Series of Methoxylated Chalcones as Antioxidant Agents Against Gram-Positive Bacteria Staphylococcus aureus
Abstract: Background: Chalcones are aromatic ketones belonging to the flavonoid family. They are plant-based compounds and are widely found in nature. For centuries, these bioactive molecules have been utilized in various traditional medicines for the treatment of several ailments. Chalcones have antibacterial, antiviral, antimalarial, antifungal, antioxidant, and antileishmanial properties. They are also used to treat inflammation and cancer. Chalcones act as angiogenesis inhibitors, an important factor in cancer progression and metastasis. …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 1, 2025 · pp. 28–34 Read article
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Investigating The Alkalizing Potential of Chandanasava For Restoring Acid-Base Homeostasis in Renal Tubular Acidosis: A Computational and In Silico Pharmacological Study
Abstract: Chandanasava, a traditional Ayurvedic formulation, is recognized for its potential alkalizing properties, which may help restore acid-base homeostasis in conditions such as renal tubular acidosis (RTA). This study aims to investigate the active components of Chandanasava and their interactions with key renal target proteins, Pendrin and Carbonic Anhydrase II, which are essential for maintaining acid-base balance. An in silico approach was utilized to explore the pharmacological potential of the phytochemicals …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 2, 2025 · pp. 28–52 Read article
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Ag₂S–Ag Nanocomposites: A Bottom-Up Approach to Enhance Thermoelectric Power Factor at Near Room Temperature
Abstract: The intrinsic ductility, low toxicity, and naturally occurring abundance of silver sulphide (Ag₂S) have made it a potential thermoelectric material in recent years. However, high electrical resistance severely limits its practical application. Here, we present a thorough analysis of how metallic Ag nanoinclusions affect the structural, electrical, and thermoelectric characteristics of Ag₂S nanocomposites made using a simple bottom-up polyol approach. (Ag₂S)₁₋ₓAgₓ nanocomposites with an Ag content ranging from 0 to …
Published in International Journal of Electro-Mechanics and Material Behaviour · Vol. 4, Issue 1, 2026 · pp. 40–55 Read article
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Genomic Characterization of Emerging Arboviruses in Rural India
Abstract: Arboviruses (arthropod-borne viruses) represent a rapidly evolving group of pathogens responsible for significant morbidity and mortality, particularly in tropical and subtropical regions. Rural India, characterized by dense vector populations, changing ecological patterns, and limited healthcare infrastructure, has become a hotspot for the emergence and re-emergence of arboviral diseases such as dengue, chikungunya, Japanese encephalitis, and more recently, Zika virus infections. Advances in genomic technologies, including next-generation sequencing (NGS), metagenomics, and …
Published in International Journal of Pathogens · Vol. 3, Issue 2, 2026 · pp. 1–8 Read article
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A Structure-based Design Approach to Catharanthus roseus Phytoconstituents as Potential Inhibitors of B-Cell Lymphoma 6 Protein
Abstract: Objectives: Lymphoma is a cancerous disease. It develops into millions of people worldwide. Identify the naturally active compounds from Catharanthus roseus, they have multiple values in the medicinal field of Siddha, and Indian Ayurveda are used as a disease-preventing agent. Drug illness prediction, toxicity prediction, statistical information, molecular docking, as well as absorption, distribution, metabolism, and excretion (ADME) analysis are used to predict the fit ligand as a drug. Methods: …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 2, 2023 · pp. 14–34 Read article
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Precision Medicine for Neurofibromatosis Type 1: Progress and Prospects in Drug Discovery
Abstract: Objective: The development of neurofibromas, café-au-lait spots, and other neurological problems are the hallmarks of neurofibromatosis type 1 (NF1), a hereditary disorder. The dearth of efficacious pharmaceutical therapies underscores the need for novel therapeutic approaches, even in the face of clinical variability. Through very accurate prediction of the binding affinity of possible therapeutic drugs with the target protein, the computational technique known as “molecular docking” has become a potent tool …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 1, 2024 · pp. 01–15 Read article
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Screening Phytocompounds of Tinospora cordifolia to Find Potential Drug Targets for Cystic Fibrosis
Abstract: This study aimed to evaluate the therapeutic potential of phytocompounds derived from Tinospora cordifolia in treating cystic fibrosis (CF), a genetic disorder caused by mutations in the CFTR gene that lead to severe respiratory and digestive complications. Phytocompounds were retrieved from the IMPPAT database and subjected to molecular docking simulations using PyRx to assess their binding affinity to the CFTR protein. The top-scoring compounds – sterol, magnoflorine, tembetarine, kaempferol, and …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 1, 2025 · pp. 16–24 Read article
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Phubbing, Social Anxiety and Perceived Control in Young Adults
Abstract: This study examines the complex interactions among ten empirical studies on social anxiety, phubbing (phone snubbing), and perceived control. Psychological research has focused a great deal of attention on social anxiety, which is characterized by the fear of being negatively evaluated in social situations. Phubbing, the practice of people prioritizing their phones over interpersonal interactions, has become more common in recent years due to the widespread use of smartphones. This …
Published in International Journal of Behavioral Sciences · Vol. 2, Issue 2, 2025 · pp. 18–25 Read article
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A Study on Fracture Sem Analysis by Optimization of FSW When a Composite Material Al 6061 Mixed with Fly Ash is Done with Cooper Using Anova Method
Abstract: The current study aims to examine how different parameters in friction stir spot welding influence hardness and tensile strength, while identifying the most suitable parameter combinations to enhance the overall quality of the fabricated components. The experimental work involves joining dissimilar materials, where one specimen consists of Aluminum alloy 6061 reinforced with 10% fly ash, and the other is a copper alloy. Various process conditions are altered during testing to …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 4, Issue 1, 2026 · pp. 1–5 Read article