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19 articles for “drug permeability”
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Bio-Inspired Membranes in Oral Drug Delivery: A Pathway to Enhanced Permeability and Targeted Therapy
Abstract: Bio-inspired membranes in oral drug delivery represent a significant advancement in pharmaceutical technology, harnessing principles of natural biological systems to improve drug permeability, bioavailability, and targeted release. This review discusses the design, materials, and fabrication techniques used in bio-inspired membranes, with a focus on materials like chitosan, silk fibroin, and synthetic polymers that mimic biological structures. By exploring the mechanisms of drug permeation, such as mucoadhesion and selective permeability, bio-inspired …
Published in International Journal of Membranes · Vol. 1, Issue 2, 2024 · pp. 39–52 Read article
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Polymer-Coated Composite Granules of Clarithromycin: Design, Characterization, and Functional Evaluation for Taste Masking and Antibacterial Performance
Abstract: Background: Masking the unpleasant taste of clarithromycin is essential to improve patient adherence, especially among pediatric and elderly groups. However, enhancing palatability while maintaining its antibacterial effectiveness remains a significant formulation challenge. This study focused on developing polymer-coated clarithromycin granules (B1–B10) using novel non-sugar-based polymers and assessing their antibacterial activity against Staphylococcus aureus Methods: Clarithromycin granules were produced using a fluidized bed coating technique with non-saccharide polymers, specifically Eudragit E-100 …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 1042–1050 Read article
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Biodegradable Polymer Nano Composites for Enhanced Drug Bioavailability
Abstract: Polymer-based nanoparticles have emerged as a revolutionary approach in drug delivery systems, particularly in enhancing the bioavailability of poorly soluble and unstable drugs. These nanoparticles, composed of both natural and synthetic polymers, serve as effective vehicles for encapsulating a wide range of therapeutic agents. Their surface characteristics can also be modified to enable targeted drug delivery, increasing the concentration of drugs at the site of action while minimizing side effects. …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 433–443 Read article
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Synthesis and Characterization of PF-127 Stabilized Metformin Encapsulated Chitosan-TPP Nanoparticles
Abstract: Metformin is widely used to manage Type 2 Diabetes, but its effectiveness is limited by low intestinal absorption, high dose requirements, and a short half-life. To tackle these challenges, several nano-drug delivery systems have been designed to optimize the delivery of metformin and enhance its therapeutic efficacy. Nanoparticles (NPs) have emerged as key players in medicine, biology, and pharmacology, gaini considerable attention for their potential applications. Polymeric NPs are among …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 27, Issue 1, 2025 · pp. 34–38 Read article
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Amlodipine induced peripheral edema and gingivitis – A case report.
Abstract: Calcium channel a group of drugs used to treat heart disorders are called blockers. These drugs dilate blood vessels and improve blood flow to heart, these works by preventing calcium flow through ion -specific (L- type) calcium channels in the cell membrane. Amlodipine, a calcium channel blocker in the dihydropyridine class, can cause peripheral edema and drug-induced gingivitis in some patients. In this case, the patient experienced swelling in the …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 1, 2025 · pp. 45–49 Read article
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Recent Trends in Ocular Drug Delivery: Challenges and Approaches
Abstract: Drug topically regulation can be accessed most easily in the eye. When given topically as eye drops, medication ocular bioavailability is quite low. Drug entry into specific ocular locations is complicated by the complex anatomy and physiology of the human eye. Research has long been interested in the topical administration of successful treatments. To provide a suitable ocular penetration and extend the duration of drug residence is their challenging task. …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 3, 2024 · pp. 22–38 Read article
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A Comprehensive Review: Emerging Nanotechnology in Cancer Drug Delivery
Abstract: Nanotechnology has become a groundbreaking strategy in cancer therapy, especially in drug delivery systems, offering improved treatment effectiveness while minimizing the adverse effects associated with traditional methods. This review presents an in-depth analysis of recent progress in nanotechnology for cancer drug delivery, emphasizing the design, mechanisms, and practical applications of nanoparticle-based systems. Nanoparticles, such as liposomes, dendrimers, and gold nanoparticles, offer unique advantages, including improved drug solubility, targeted delivery to …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 27, Issue 1, 2025 · pp. 24–33 Read article
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Review On: Liquid Crystal Cream for Topical Drug Delivery
Abstract: A Liquid crystal creams represent a novel approach in skincare formulations, leveraging the unique properties of liquid crystal technology to improve skin hydration and barrier function. An overview of current developments in liquid crystal cream formulations is given in this article, with an emphasis on the benefits they offer for skincare and their composition and structure. Liquid crystal creams mimic the lipid bilayers of the skin, offering enhanced compatibility and …
Published in Trends in Drug Delivery · Vol. 11, Issue 1, 2024 · pp. 1–8 Read article
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Toxicological Optimization and Assessment of Buccal Films Containing Felodipine Co-crystals to Enhance Bioavailability
Abstract: The preformulation study of felodipine was carried out and it was found that the drug is poorly water soluble. The co-crystals were prepared using three different co-formers sorbitol, ascorbic acid and oxalic acid. The solublity enhancement was observed in combination with sorbitol compared to other co-formers used. The characterization of co crystals was performed like PXRD, FTIR, SEM Analysis. XRD results indicates the amorphous form of the drug. The co-crystals …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 2, 2024 · pp. 10–29 Read article
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Advanced Ointment Formulation: An Insightful Review of Innovation and Efficacy
Abstract: This review provides an in-depth exploration of the evolution of ointment formulations, particularly considering the increasing prevalence of fungal infections and the growing demand for effective antifungal treatments. Traditional ointment formulations, while useful, often face significant challenges, such as inadequate penetration into the skin, poor bioavailability, and undesirable textures that limit their efficacy. As a result, there has been a shift toward more advanced, innovative formulations that aim to address …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 27, Issue 1, 2025 · pp. 14–23 Read article
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Evaluation of Mucoadhesive Polymers for Nasal Delivery of Herbal Bioactives
Abstract: A study assessed mucoadhesive polymers for intranasal herbal bioactive administration with higher residence time and mucosal permeability. Chitosan, Carbopol® 934P, and HPMC K15M were utilized to manufacture mucoadhesive nasal gels with standardized herbal bioactive fractions. Formulations were examined for pH, viscosity, spreadability, drug content, mucoadhesive strength, in-vitro release, ex-vivo penetration, and short-term stability. All formulations demonstrated a suitable pH for nasal usage and uniform drug content (97.48 ± 1.12% to …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1680–1689 Read article
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An Ayurveda Management of High Level of Fecal Calprotectin – A Single Case Study
Abstract: Calprotectin is protein found in leucocytes. Calprotectin plays a crucial role in various physiological processes, including cell differentiation, immune modulation, tumor development, programmed cell death, and inflammatory responses. Gut inflammation due to various cause like genetic inheritance, changes in microbiota within intestine, defective immune regulation. Also, some infective such as salmonella, E. coli, Cytomegalovirus, Amoebiasis etc., and Non-infective such as Ischaemic colitis, Non-steroidal anti-inflammatory drugs, Colonic carcinoma etc., can mimic …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 11, Issue 3, 2024 · pp. 19–25 Read article
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Nano‑Enabled CT for Cancer Imaging: From Molecular Targeting to Image‑Guided Therapy
Abstract: Nano‑enabled computed tomography (CT) exploits high‑atomic‑number (high‑Z) nanomaterials engineered with targeting ligands and therapeutic payloads to enhance contrast, enable molecular imaging, and support image‑guided interventions in oncology. Tumor‑specific nanoprobes such as RGD‑modified gold nanorods, polymer‑coated bismuth nanoparticles, and peptide, antibody, or aptamer‑functionalized platforms can intensify tumor conspicuity, allow early lesion detection and staging, and provide real‑time treatment monitoring. Integration of CT visibility with photothermal, photodynamic, chemo‑, radio‑, and immunotherapeutic functions …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 28, Issue 1, 2025 · pp. 40–49 Read article
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Ocular Films as a Drug Delivery System Against Fungal Infections: Current Insights and Future Directions
Abstract: Fungal infections of the eye, including keratitis, endophthalmitis, and blepharitis, represent a challenging class of ocular diseases due to their potential for vision loss and the limited efficacy of existing treatments. These infections are caused by a range of pathogenic fungi, such as Aspergillus, Candida, and Fusarium species, and often require long-term therapeutic intervention. Conventional topical antifungal therapies, such as eye drops and ointments, suffer from poor ocular bioavailability due …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 101–109 Read article
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Bioenhancer to Boost Herbal Drug Efficacy
Abstract: Bioenhancers are natural substances that significantly improve the absorption, bioavailability, and therapeutic efficacy of drugs when co-administered, without showing notable pharmacological activity of their own. In herbal medicine, the concept of bioenhancement has received growing attention as many phytoconstituents exhibit low oral bioavailability due to poor solubility, limited permeability, and extensive first-pass metabolism. The traditional Ayurvedic system first introduced this concept through the discovery of Piperine, the active alkaloid from …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 2, 2026 Read article
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A Comprehensive Study on Improving Contact Lens Performance Through Various Approaches
Abstract: Contact lenses improve vision quality by correcting refractive errors and thus provide a convenient alternative to traditional eyeglasses. Apart from vision enhancement, they have multiple applications in cosmetics, drug delivery, and therapeutic use. The performance of these lenses depends on various factors such as material, design, fitting, and interaction between the lens and the eye. The selection of appropriate materials is crucial for maintaining optimal eye health. Properties like oxygen …
Published in Journal of Polymer & Composites · Vol. 13, Issue 3, 2025 · pp. 211–222 Read article
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Advances in Nanocellulose-Enhanced Polymers and Composites: Structure, Performance, and Applications
Abstract: The most common biopolymer is cellulose, which can be converted into nanocellulose (NC) the sustainable nanomaterial possessing the outstanding characteristic of biodegradability, renewability, low density, high aspect ratio, and excellent mechanical performance. Such distinctive features make NC a promising filler in polymer and composite systems. Recent developments in the preparation of nanocellulose using various natural and artificial sources have facilitated scalable production processes that have less energy requirements and are …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1610–1623 Read article
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A study on Antibiotic Resistance: An Analysis of Molecular Mechanisms and Therapeutic Implications
Abstract: Antibiotic resistance (AR) represents one of the most critical existential threats to global public health, rapidly eroding the efficacy of established antimicrobial therapies and portending a return to the pre-antibiotic era. This analysis explores the intricate molecular landscape defining this crisis, focusing specifically on the primary mechanisms of action (MoA) utilized by major antibiotic classes—including cell wall inhibitors, protein synthesis inhibitors, and nucleic acid synthesis inhibitors—and the corresponding, diverse mechanisms …
Published in International Journal of Antibiotics · Vol. 3, Issue 1, 2026 · pp. 9–21 Read article
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Biodegradable Polymer Nanocarriers Composites for Biomedical Applications
Abstract: Smart polymeric nanocarriers, or SPNs, have evolved into a fascinating means of delivering medications especially to cancer cells. By improving the efficacy of chemotherapeutic treatments while lowering their negative effects, they have achieved a significant progress in exact medicine. Made to respond to certain elements in the tumours microenvironment, such as enzymes, temperature, pH, and redox conditions, these nanocarriers this reaction to triggers guarantees the release of the medicine at …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 293–305 Read article