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Nano Trends – A Journal of Nano Technology & Its Applications Original Research

Synthesis and Characterization of PF-127 Stabilized Metformin Encapsulated Chitosan-TPP Nanoparticles

  1. Sakshi Tyagi Centre for Emerging Diseases, Department of Biotechnology, Jaypee Institute of Information Technology, Noida
  2. Shalini Mani Department of Biotechnology, Jaypee Institute of Information Technology, Noida

Abstract

Metformin is widely used to manage Type 2 Diabetes, but its effectiveness is limited by low intestinal absorption, high dose requirements, and a short half-life. To tackle these challenges, several nano-drug delivery systems have been designed to optimize the delivery of metformin and enhance its therapeutic efficacy. Nanoparticles (NPs) have emerged as key players in medicine, biology, and pharmacology, gaini considerable attention for their potential applications. Polymeric NPs are among the most commonly utilized nanomaterials in nanomedicine due to their diverse applications. Chitosan (CS)-based polymeric NPs offer several key benefits, includingm biodegradability, biocompatibility, non-toxicity, bioactivity, ease of synthesis, and targeted delivery, making them highly suitable as drug carriers. CS NPs formed through ionic gelation are amongst the most studied nanosystems for drug delivery. Chitosan is also widely recognized as an effective nmucoadhesive polymer, capable of enhancing the bioavailability of drugs and improving cellular permeability. In this study, metformin-loaded chitosan TPP nanoparticles, stabilized by PF-127, were formulated, and characterized. We have incorporated the Ionic Gelation method for the formulation of nanoparticles. Physiochemical analyses such as FTIR and DLS were conducted. From the FTIR results, the successful synthesis of nanoparticles was confirmed. Also, the formulated nanoparticles showed mean hydrodynamic size of 188.8 nm, a zeta potential of -18.3 mV, and a drug entrapment efficiency of up to 41%.

Keywords

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