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40 articles for “direct compression”
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Development and Optimization of Orally Disintegrating Tablets (ODTs) Containing Standardized Curcumin Extract for Enhanced Bioavailability and Patient Compliance
Abstract: This research centers on creating and perfecting orally disintegrating tablets with standardized curcumin extract to both increase its bioavailability and promote better patient adherence. Although curcumin has numerous therapeutic applications. It remains clinically ineffective due to its poor aqueous solubility and bioavailability constraints. The development of orally disintegrating tablets involved direct compression with various levels of superdisintegrants including sodium starch glycolate and cross povidone to address existing challenges. Research teams …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 3, 2025 · pp. 1–06 Read article
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Zolmitriptan Mouth Dissolving Tablets: Development of Formulas and Invitro Evaluation
Abstract: Pharma Burst ODT super disintegrants were used in different concentrations to manufacture Zolmitriptan fast dissolving tablets by a direct compression method. With a 28° angle of repose, there is good flow. The densities for bulk and tapped materials are 0.410 (g/ml) and 0.500 (g/ml), respectively. The compressibility index and Hausner ratio have values of 19.05 and 1.24, correspondingly. According to IP standard, weight variation test results range from 121.4 mg …
Published in Emerging Trends in Personalized Medicines · Vol. 1, Issue 2, 2024 · pp. 1–15 Read article
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Design and Assessment of Fixed Dose Combination Containing Fenofibrate and Pravastatin Sodium in Tablet Formulation: A Bioinformatics Approach
Abstract: The aim of this is study is to formulate and evaluate fixed dose combination of Fenofibrate and Pravastatin sodium in tablet dosage for the treatment of Dyslipidemia. For the formulation and optimization of fenofibrate layer, two factor three level factorial design was used as experimental design for optimization with a minimum of nine run. All the nine trial (F1–F9) has been formulated according to the experimental design by wet granulation …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 11, Issue 1, 2024 · pp. 1–20 Read article
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Improving Black Cotton Soil with Sodium Hydroxide and Fly Ash: An Assessment of Optimum Moisture Content, Dry Density, and California Bearing Ratio
Abstract: This study investigates the stabilization of Black Cotton Soil (BCS), an expansive clayey soil primarily composed of montmorillonite minerals, using sodium hydroxide (NaOH) and fly ash. Due to its high plasticity and significant volume changes with moisture, BCS is challenging for construction purposes. Adding NaOH and fly ash can potentially improve the soil's moisture tolerance, compressibility, and reduce its plasticity, making it more suitable for structural applications. The research evaluates …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 192–201 Read article
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Strategies for the Development and Optimization of Orally Disintegrating Tablets (ODTs) to Improve Bioavailability and Patient Compliance
Abstract: Background: Pharmaceutical scientists have developed Orally Disintegrating Tablets (ODTs) to advance patient drug acceptance and biological system availability through simplified medi-cation delivery especially for children and senior citizens and people who cannot swallow pills regularly. The oral disintegrating tablets dissolve in the mouth within thirty seconds or less (USP 701) while needing no additional liquid thus making them suitable for both emergency treatments. Objective: The research examines ODT development strategies …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 Read article
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Review on Sustained Released Matrix Tablet
Abstract: Pharmaceuticals often use sustained release dose forms to prolong the therapeutic agent’s presence in the bloodstream and maintain a consistent plasma profile. The matrix governs the drug’s release rate. Hydroxypropyl methyl cellulose, a release retardant, is a key excipient in formulations due to its ability to promote sustained release. Techniques that include wet granulation, direct compression, or the dispersion of solid particles within a porous matrix, integrating polymers, like polymethyl …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 60–69 Read article
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Swift Solutions: The Science and Innovation Behind Fast-Dissolving Tablets
Abstract: Swift solutions in the context of fast dissolving tablets (FDTs) represent an innovative breakthrough in pharmaceutical science, aiming to provide rapid and effective drug delivery for patients who face difficulty swallowing conventional dosage forms. The science and innovation behind FDTs are rooted in advanced formulation techniques, material science, and drug delivery mechanisms that prioritize speed, convenience, and patient compliance. These tablets are formulated to dissolve quickly in the mouth, removing …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 26–36 Read article
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Rapid-On-Tongue Delivery: A Review of ODT Technologies, Taste Masking and Compliance
Abstract: Orodispersible Tablets (ODTs), another name for Fast Dissolving Drug Delivery Systems (FDDS), are innovative drugs that dissolve in the mouth rapidly without requiring water. These will be especially helpful for kids, the elderly, and others who have difficulty swallowing ordinary tablets or capsules. Superdisintegrants are used in these pills to break down quickly in the mouth, while flavorings or sweeteners are used to cover up any harsh or unpleasant taste. …
Published in Trends in Drug Delivery · Vol. 13, Issue 1, 2026 · pp. 01–08 Read article
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Comparative Study on Oro Dispersible Tablets of Candesartan Cilexetil Formulated with Natural and Synthetic Disintegrants
Abstract: Candesartan cilexetil, a BCS class II drug with low aqueous solubility and poor bioavailability (15%), poses challenges for oral delivery. To address this limitation, the present study focuses on polymer-based inclusion complexation and composite formulation strategies to enhance solubility and dissolution behavior. The drug was incorporated into β-cyclodextrin (β-CD), a cyclic oligosaccharide polymer, by the kneading method in different drug-to-carrier ratios. Among these, the 1:1 molar ratio complex exhibited the …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 687–695 Read article
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Application of Natural and Synthetic Polymer-Based Disintegrants in the Design of Fast Dissolving Cefuroxime Axetil Tablet Composites
Abstract: The current paper examines how natural and synthetic polymer-based disintegrants can be used to design fast-soluble types of tablet composites. A model drug was chosen and tablets were prepared by the direct compression method using different polymeric excipients, such as guar gum, locust bean gum, sodium starch glycolate (SSG) and cross povidone. Eight formulations were prepared and tested on the basis of critical material and performance characteristics including thickness, hardness, …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 1348–1360 Read article
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Advancements in Engine Oil Durability, Performance, and Diagnostics
Abstract: The depletion of fossil fuels and environmental concerns have driven the search for alternative fuels and enhanced lubricants. This article explores advancements in machine oil durability, focusing on vegetable oil modifications, synthetic lubricants, and diagnostic methods for marine engine oils. A study comparing Karanja oil blends with mineral diesel in direct injection compression ignition engines revealed comparable wear characteristics and reduced metallic debris for Karanja oil-fueled engines. Investigations on synthetic …
Published in Journal of Petroleum Engineering & Technology · Vol. 14, Issue 3, 2024 · pp. 39–45 Read article
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Numerical Studies on Deep Drawability of the Aluminium Alloy, AA6082 and Parameters Affecting It
Abstract: Deep drawing is a metal forming operation used for manufacturing sheet-metal components for application in the automobile, aerospace, and packaging industries. The objective of the present work was to study the various parameters influencing the drawability of AA6082. The deep-drawing process was modeled and simulated in Ls-Dyna Pre-Post(R) V4.6.17 software. The tensile test was performed according to the ASTM-E8M standard on AA6082-T6 material and subsequently annealed to attain higher ductility. …
Published in Journal of Polymer & Composites Read article
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Design and Mathematical Quantification of a Compressed-Air Vehicle
Abstract: Compressed-air technology is emerging as a promising alternative mode of transportation, offering significant advantages over conventional fuel-operated vehicles. Unlike fossil fuel systems, compressed-air propulsion produces no direct emissions, making it an eco-friendly solution to rising concerns about air pollution and environmental degradation. Owing to its sustainability potential, this technology has attracted considerable attention from researchers, engineers, and energy enthusiasts worldwide, who have conducted extensive studies to improve its efficiency, feasibility, …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1026–1035 Read article
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Deep Plate: A Deep Learning Approach to Recipe Generation from Food Images
Abstract: In the deep learning era, image understanding is advancing in sophistication, encompassing both semantic interpretation and the generation of meaningful image descriptions. To achieve this, deep neural networks must undergo specific cross-model training; these networks must be both simple enough to handle a wide range of inputs and complex enough to encode the fine contextual information associated with the image. An appropriate example of the previously described picture comprehension problem …
Published in Journal of Operating Systems Development & Trends · Vol. 11, Issue 2, 2024 · pp. 15–22 Read article
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Surface Level and Underwater Waste Removal System
Abstract: The paper introduces novel approach for surface and underwater waste collection, impact of water pollution can be devastating, affecting aquatic ecosystems, human health, and economies. Pollutants can harm aquatic plants and animals, disrupt ecosystems, and degrade water quality, making it unsafe for drinking, swimming, and other activities. Waterborne illnesses can also spread because of contaminated water, impacting groups of people who depend on tainted water supplies for hygiene and drinking. …
Published in Recent Trends in Fluid Mechanics · Vol. 11, Issue 2, 2024 · pp. 30–35 Read article
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Pneumatic Operated Engine
Abstract: The increasing awareness of fossil fuel depletion & environmental pollution has accelerated the need for the development of sustainable & eco-friendly alternatives to traditional internal combustion engines. Pneumatically operated engines have been identified as a potential alternative for small-scale mechanical power generation owing to their advantages of zero exhaust emissions, noise reduction & operational safety. This paper describes the design, development & performance analysis of a pneumatically operated engine, which …
Published in International Journal of Mechanical Dynamics and Systems Analysis · Vol. 4, Issue 1, 2026 · pp. 1–7 Read article
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Innovative Approaches to Reducing Data Traffic in IoT Networks Using Deep Learning and Compressive Sensing
Abstract: The exponential growth of internet of things (IoT) devices has posed unprecedented challenges in managing the massive data generated by real-time monitoring, automation, and analytics. Existing network infrastructures lack scalability, bandwidth, and suffer from latency problems, further making data transmission less efficient. This study surveys innovative approaches using deep learning and compressive sensing to reduce IoT data traffic. Deep learning is able to upgrade data processing by means of very …
Published in International Journal of Satellite Remote Sensing · Vol. 2, Issue 2, 2024 · pp. 46–62 Read article
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An Investigative Study on Cache-Oblivious Data Structures
Abstract: Cache-oblivious data structures and data management systems have emerged as critical components in modern computing environments, aiming to optimize memory access patterns across different levels of the memory hierarchy without explicit knowledge of cache sizes or configurations. This study presents an overview of cache-oblivious techniques, including adaptive data structures, compression, parallel processing, and security considerations. The workexplores future directions in cache-oblivious systems, such as non-volatile memory support, graph processing, edge …
Published in International Journal of Data Structure Studies · Vol. 1, Issue 2, 2023 · pp. 33–37 Read article
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A Review on Using Recycled Aggregate with Various Pozzolans in Geopolymer Concrete
Abstract: Reducing the use of natural resources is crucial to solving the global issue of CO2 emissions. Concrete can be produced sustainably by using recycled aggregates and geopolymer binders, which are environmentally benign alternatives to traditional components. Carbon footprints can be reduced by using these materials instead of ordinary Portland cement and natural aggregates. Among all the combinations, recycled coarse aggregates (RCA) and geopolymer concrete have garnered attention as a viable …
Published in Journal of Polymer & Composites · Vol. 13, Issue 3, 2025 · pp. 486–493 Read article
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Investigation of the independent and combined roles of Gr and ZrO₂ on strengthening behaviour of Al-7075 Composites
Abstract: This study investigates the effect of individual and hybrid reinforcements on the mechanical and microstructural behaviour of Al7075 composite fabricated using the 2-step stir-casting technique. Four compositions were made with the base Al-7075, Al-7075 3 weight % ZrO2, and Al-7075 3 weight % Gr as well as a hybrid composite Al7075 with 3 wt.% Gr, 3 wt.% ZrO2. 2-step stir-casting was used to increase the wettability of the particles, decrease …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1060–1075 Read article