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Journal of Polymer & Composites Original Research Special issue

Application of Natural and Synthetic Polymer-Based Disintegrants in the Design of Fast Dissolving Cefuroxime Axetil Tablet Composites

  1. Mallikarjuna BP Department of Pharmaceutical Chemistry, Shridevi Institute of Pharmaceutical Sciences, Tumkur
  2. G. Swarna Latha Department of Pharmaceutical chemistry, Mahathi College of Pharmacy, Annamayya Dist
  3. Durga Ganesh Jami Department of Pharmaceutical Sciences, Shri Jagadish Prasad Jhabarmal Tibrewala University, Jhunjhunu
  4. G. Uma Rani Department of Pharmaceutics, RBVRR Women’s college of Pharmacy, Barkatpura, Hyderabad
  5. Prasanthi Samathoti Department of Pharmaceutics, RBVRR Women’s College of Pharmacy, Barkatpura, Hyderabad

Abstract

The current paper examines how natural and synthetic polymer-based disintegrants can be used to design fast-soluble types of tablet composites. A model drug was chosen and tablets were prepared by the direct compression method using different polymeric excipients, such as guar gum, locust bean gum, sodium starch glycolate (SSG) and cross povidone. Eight formulations were prepared and tested on the basis of critical material and performance characteristics including thickness, hardness, friability, disintegration time, in-vitro drug release, and drug content uniformity.

The findings showed that the use of polymeric super disintegrants had a considerable effect on the composite matrix structure and functional behaviour of the pills. It is notable that locust bean gum, a natural polysaccharide, had similar or better disintegration performance and release performances in comparison with the synthetic polymers, including SSG and cross povidone. This brings out its promise as an environmentally friendly and efficient polymeric excipient in pharmaceutical blends.

In general, the work shows that the performance of the fast-dissolving drug delivery system is determined by the physicochemical interactions of natural and synthetic disintegrant polymers. The results also indicate that biodegradable gums such as locust bean gum can be useful to replace synthetic polymers in the creation of environmentally-friendly and effective composite arrangements.

Keywords

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