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117 articles for “clinical trial”
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Review article on Quality Control in Clinical Trials
Abstract: Quality control (QC) is a critical component in the conduct of clinical trials, ensuring the accuracy, reliability, and credibility of data collected throughout the study. It encompasses a systematic set of procedures designed to monitor trial conduct and data integrity, thus safeguarding the rights, safety, and well-being of participants. This review explores the principles, implementation, and evolving practices of quality control in clinical trials, highlighting its importance across all phases …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 3, 2025 · pp. 01–07 Read article
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Emerging Therapies for Diabetes Mellitus: Efficacy and Safety of USFDA-Approved Drugs and Late-Stage Clinical Trials
Abstract: This review provides a comprehensive analysis of drugs approved by the U.S. Food and Drug Administration (USFDA) for managing diabetes mellitus (DM) from 2013 to 2022, including emerging treatments from phase 3 clinical trials during this period. Over the past decade, the treatment landscape for diabetes has evolved significantly, with new therapies not only improving blood sugar control but also targeting broader health outcomes like heart and kidney health. In …
Published in International Journal of Toxins and Toxics · Vol. 2, Issue 2, 2025 · pp. 11–23 Read article
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Neuroimaging in Clinical Trials for Huntington’s Disease: Emerging Research Findings: The Advancement Directions and Implications
Abstract: Neuroimaging is very important in coordinating and conducting Huntington’s disease clinical trials as a tool in selecting patients, managing safety concerns, and assessing the benefits of interventions. This review presents the current uses and potential future uses of structural and functional magnetic resonance imaging (MRI), diffusion imaging, positron emission tomography (PET), proton magnetic resonance spectroscopy (MRS), perfusion imaging, and magneto encephalography (MEG) in HD trials. We describe how these modalities …
Published in International Journal of Brain Sciences · Vol. 2, Issue 2, 2025 · pp. 32–44 Read article
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Clinical Trial to Find the (Asbab) Aetiology and (Ilaj) Treatment of (Marz-e-Akyās Khusyat-ur-Rahim) Polycystic Ovarian Syndrome (PCOS)
Abstract: Introduction: Polycystic Ovarian Syndrome (PCOS) is common endocrine disorder. It is clinically defined as the syndrome characterized by amenorrhoea, hirsutism and obesity associated with polycystic ovaries. Diagnosis is made on the Rotterdam criteria, established in 2003. The criteria require the presence of 2 of the following 3 criteria: 1. Oligo-ovulation or an ovulation. 2. Hyperandrogenism. 3. Polycystic ovaries through ultrasound evaluation. Methods: Diagnosed patients were enrolled in the trial into …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 12, Issue 3, 2025 · pp. 30–37 Read article
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An Open Labelled Parallel Arm Randomized Clinical Trial of Tuvaraka Oil Prepared By Two Different Method In The Management of Pama
Abstract: In Ayurveda, all skin diseases have classified mainly into two groups i.e., Mahakushtha (major skin diseases) and Kshudrakushtha (minor skin diseases). Tuvaraka [Hydnocarpus laurifolia (Dessnt).Sleumer] is one among the most useful drugs for the treatment of Kushtha (Various skin diseases) and Madhumeha (Diabetes Melitus). Pama is described under Kshudra Kushtha. which can be correlates with scabies. Aim: To evaluate the clinical efficacy of Tuvaraka oil prepared by modified method and …
Published in Research & Reviews : Journal of Herbal Science · Vol. 13, Issue 1, 2024 · pp. 29–36 Read article
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Impact of Pre-Operative Nebulized Lidocaine–Dexmedetomidine Combination Versus Monotherapy on Incidence, Severity, and Patient Comfort Scores of Post-Operative Sore Throat: A Randomized Controlled Clinical Trial
Abstract: Post-operative sore throat (POST) is a common issue after endotracheal intubation and can reduce patient comfort and hinder recovery. This randomized, double-blind clinical study investigated how effective pre-operative nebulized lidocaine, dexmedetomidine, and their combination are in minimizing POST. Eligible adult patients classified as ASA I–II and scheduled for elective surgery under general anesthesia were randomly assigned to three groups. Nebulization was administered 15–20 minutes before induction using standardized dosing and …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 4, Issue 1, 2026 · pp. 29–35 Read article
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A Study to Assess the Add-on Impact of Ayurvedic Management along with Ongoing Conventional Treatment of Diabetes Mellitus: A Randomized Clinical Trial
Abstract: Diabetes affects millions and thus is a major public health disease among with adults aged 30+. Available treatment although helps but many develop other side effects to complicate the issue. Ayurveda offers options to manage diabetes without complications. Present study is to see the add-on effect of Ayurveda therapy among persons on modern medicines. Ayurveda D4 combination is Jamunbeej and Gudmarpatra 5 gm churna each before breakfast and dinner and …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy Read article
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Caries-Preventive Effects of Self-Applied Subacidic 0.5% NaF-HF Gel via Toothbrushing in 7–8-Year-Old Schoolchildren: A Randomized Controlled Clinical Trial
Abstract: To assess the caries-preventive effectiveness of self-applied subacidic 0.5% sodium fluoride–hydrofluoric acid (NaF-HF) gel used during toothbrushing in children aged 7–8 years Objective: To assess the caries-preventive effectiveness of self-applied subacidic 0.5% sodium fluoride–hydrofluoric acid (NaF-HF) gel used during toothbrushing in children aged 7–8 years. Methods: This 1-year, multi-arm, double-blind, placebo-controlled, parallel-group randomized study evaluated the caries-preventive efficacy of self-applied 0.5% NaF-HF gel among primary schoolchildren. A total of 1200 …
Published in Research and Reviews: A Journal of Dentistry · Vol. 17, Issue 1, 2026 · pp. 14–19 Read article
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Development of Zinc Gluconate Vitamin C Effervescent Tablet for Immunity Improvement and Management of Corona Virus Disease (COVID-19)
Abstract: The global pandemic of coronavirus disease- 2019 (COVID-19) continues to pose a threat to people, societies, and economic and healthcare systems. COVID-19s progression and lethality are determine by the host immune system, as is the case with many other diseases. revolutionary idea that has been used to treat other diseases is the control of inflammatory response and cytokine production based on immunonutrition. Some COVID-19 clinical trials are now using zinc, …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 1, 2024 Read article
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NanoBioAI: Utilizing Python to Investigate Magnetocaloric Effects in Magnetotactic Bacteria and Optimized Conditions for Thermotherapy
Abstract: The study presented in the research work represents a multidisciplinary approach, integrating biology, nanotechnology, and artificial intelligence. It specifically highlights the use of python computational power to investigate magnetocaloric effect (MCE) in magnetotactic bacteria (MTB), a phenomenon yet to be fully understood, characterized by reversible heating and cooling effects induced by magnetic fields. MTB are unique in that they contain embedded magnetic nanoparticles ranging from 10–100 nm in diameters. These …
Published in Journal of Artificial Intelligence Research & Advances · Vol. 11, Issue 2, 2024 · pp. 122–131 Read article
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AI Application in the Creation of Medications for COPD
Abstract: The crippling lung condition known as chronic obstructive pulmonary disease (COPD) is typified by a continuous restriction of airflow, which results in increased respiratory dysfunction and a reduced quality of life. The rising incidence of COPD worldwide emphasizes the pressing need for innovative pharmaceutical approaches to address the illness. Even though COPD care has advanced significantly, most current medications concentrate on symptom relief rather than disease change. This gap in …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 01–05 Read article
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Ovarian Cancer: Understanding Risk Factors, Diagnosis, and Advances in Treatment
Abstract: Ovarian cancer is a leading cause of cancer-related mortality among women worldwide, often diagnosed at advanced stages due to its subtle early symptoms. Ovarian cancer develops due to a combination of factors, including genetics, environmental influences, and hormonal changes. This article explores the pathophysiology of ovarian cancer, highlighting the genetic mutations, such as BRCA1 and BRCA2, that contribute to its development. It also discusses current diagnostic methods, including imaging techniques …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 2, 2025 Read article
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Role of Artificial Intelligence in Simulation and Therapeutics in Neurodegenerative Diseases
Abstract: Neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, etc., are a cause of significant mortality rates due to a lack of curative treatments and their complex nature. Traditional therapeutic methodologies have several disadvantages such as slow diagnosis and a lack of effective treatments. They mainly focused on the management of the disease rather than curing it. The integration of artificial intelligence in the simulation and therapeutics of neurodegenerative …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 16, Issue 1, 2026 · pp. 19–29 Read article
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Innovations in Gene Therapy: Revolutionizing Treatment for Genetic Disorders and Diseases
Abstract: Gene therapy is a revolutionary intervention in the treatment of genetic diseases since it is an intervention that aims at the very source of diseases, through editing and modification of genes. More recent innovations in gene editing systems, such as CRISPR-Cas9, CRISPR-Cas12, and prime editing, have greatly increased the accuracy and effectiveness of gene therapies, enabling more specific therapies. The opportunities of personalized medicine are also extended by the creation …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 16, Issue 1, 2026 Read article
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FDA Drug Approvals 2024: A Comprehensive Review
Abstract: The year 2024 has been pivotal for the pharmaceutical industry, with the U.S. Food and Drug Administration (FDA) granting approval to a diverse array of new drugs. These approvals highlight significant strides in therapeutic innovation, targeting a spectrum of diseases from rare genetic disorders to prevalent chronic conditions. This article provides a detailed examination of the FDA-approved drugs of 2024, focusing on their therapeutic indications, mechanisms of action, and the …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 28–46 Read article
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Efficacy of Combination Therapy with Osimertinib and Afatinib in epidermal growth factor receptor-mutant non-small-cell lung cancer Patients
Abstract: Treatment options for patients with non-small-cell lung cancer who have epidermal growth factor receptor mutations are constrained by the emergence of resistance to epidermal growth factor receptor tyrosine kinase inhibitors. Osimertinib or afatinib alone, when tested in a laboratory model, led to the formation of drug-resistant clones harboring epidermal growth factor receptor secondary mutations. However, combining these drugs prevented the emergence of such mutations. In a Phase II clinical trial, …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 1, 2024 · pp. 13–24 Read article
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A Novel Frontier On Biofeedback Enhanced Psychological Wellbeing For Metabolic Health In Human
Abstract: This article explores the emerging field of biofeedback and its application in optimizing metabolic health. Biofeedback involves the use of technology to monitor physiological processes and provide real-time feedback to individuals, empowering them to regulate their bodily functions. We delve into various biofeedback modalities and their potential benefits in managing metabolic disorders such as diabetes, obesity, and metabolic syndrome. Additionally, we discuss the underlying mechanisms of biofeedback, its effectiveness in …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 1, 2025 · pp. 56–69 Read article
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Review of Atorvastatin As A Potent Drug For Cardio-Vascular Disease(CVD)
Abstract: Cardiovascular disease (CVD), particularly atherosclerosis, remains the leading cause of death worldwide, significantly burdening public health, especially in Western societies. Metabolic syndrome and arrhythmic complications further exacerbate cardiovascular morbidity and mortality. Among restorative specialists, statins particularly atorvastatin have gotten to central in both the essential and auxiliary anticipation of coronary heart infection (CHD) due to their strong lipid-lowering properties and additional pleiotropic impacts. Atorvastatin, a selective HMG-CoA reductase inhibitor, not …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 3, 2025 · pp. 8–18 Read article
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Evaluation of Safety of Unani Pharmacopieal Majoon-e-Lana in Cases of Neurasthenia
Abstract: Neurasthenia, referred to as Zof-e-Asaab in the Unani system of medicine, is a functional disorder characterized by generalized weakness of the nervous system. Individuals suffering from this condition commonly experience persistent fatigue, reduced physical and mental performance, low mood, irritability, disturbed sleep, and, in some cases, elevated blood pressure. Although various conventional treatment options are available for symptom management, no specific curative therapy has been established. Furthermore, long-term use of …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 13, Issue 2, 2026 Read article
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Pharma Tech: Leveraging Software for Drug Development & Clinical Research
Abstract: The pharmaceutical sector is progressively adopting software solutions to enhance the drug development process and optimize clinical research results. Drug development is a time-consuming, expensive, and intricate process that traditionally requires extensive laboratory research, preclinical testing, and several stages of clinical trials. Software tools are revolutionizing these stages by improving efficiency, minimizing errors, and speeding up timelines. During preclinical testing, predictive software tools are used to model toxicological effects and …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 1, 2025 · pp. 11–19 Read article