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9 articles for “buccal mucoadhesion”
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Sumatriptan Succinate Mucoadhesive Buccal Tablets: Formulation Design, Optimization and Evaluation
Abstract: The main aim of present investigation was to develop and study mucoadhesive buccal tablets of sumatriptan succinate using different bioadhesive polymer. Nine formulations were prepared by using direct compression method with varying concentration of polymer as HPMC (Metolose SR 90SH-15000), xanthan gum (XTGM) and sodium carboxy methyl cellulose (sodium CMC). Fourier transform infrared spectroscopy was used to identify drug excipient interaction. Micromeritic properties of lubricated blend, physical properties and chemical …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 13, Issue 2, 2022 · pp. 1–20 Read article
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Formulation and Evaluation of Buccal Mucoadhesive Bilayered Tablets of Enalapril Maleate
Abstract: The buccal mucoadhesive bilayered tablets of Enalapril Maleate were fabricated with objective of avoiding first pass metabolism and prolonging the duration of action. The tablets were prepared by wet granulation wherein, one layer comprised of drug and bio adhesive polymer, whereas second layer consisted of drug free backing layer of ethyl cellulose. Bioadhesive polymers like Carbopol 934P and one either of three HPMC K4M/ HPMC K15M/ HPMC K100M were employed …
Published in Trends in Drug Delivery · Vol. 1, Issue 1, 2014 · pp. 1–15 Read article
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Preparation and Evaluation of Mucoadhesive Bilayered Buccal Patch using HPMC and Gelatin
Abstract: The buccal drug delivery system has gained more popularity than other drug delivery systems owing to its ease and safe administration. The high permeability of the buccal mucosa allows the drug to reach the systemic circulation and gives rapid onset of action. The buccal route also helps to avoid drug degradation from first-pass hepatic metabolism and improves drug bioavailability. The present study is designed to develop and evaluate the mucoadhesive …
Published in Trends in Drug Delivery · Vol. 8, Issue 1, 2023 · pp. 5–13 Read article
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Buccal Drug Delivery System: A Review
Abstract: The occurrence of interfacial molecular attracting force into the surface of biologically known substrates and naturally or synthetically occurring polymer, that in turn permits the polymer to cling to the biologically known surfaces for a prolonged length of time, is known as bio adhesion. Bio adhesive polymerizing system has employed into creation of goods for a variety of biomedical applicability, including surgical glue and denture adhesive, for a long time. …
Published in Trends in Drug Delivery · Vol. 9, Issue 2, 2022 · pp. 16–27 Read article
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Toxicological Optimization and Assessment of Buccal Films Containing Felodipine Co-crystals to Enhance Bioavailability
Abstract: The preformulation study of felodipine was carried out and it was found that the drug is poorly water soluble. The co-crystals were prepared using three different co-formers sorbitol, ascorbic acid and oxalic acid. The solublity enhancement was observed in combination with sorbitol compared to other co-formers used. The characterization of co crystals was performed like PXRD, FTIR, SEM Analysis. XRD results indicates the amorphous form of the drug. The co-crystals …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 2, 2024 · pp. 10–29 Read article
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A Comprehensive Review on Buccal Drug Delivery System
Abstract: Buccal delivery involves the running of the desired drug through the buccal mucosal membrane lining of the oral cavity. The buccal region of the oral cavity is a striking target for administration of the drug of choice because it offers some discrete advantages over all other routes. However, the mucosal lining of the oral cavity drugs which undergo rigorous firstpass metabolism, for those drugs, buccal route are excellent. Buccal drug …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 8, Issue 2, 2017 · pp. 20–32 Read article
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Formulation Development of Antihypertensive Buccal Patches and Characterisation
Abstract: Buccal patches containing atenolol and nifedipine were fabricated from mucoadhesive polymers like chitosan and hydroxypropyl methylcellulose (HPMC) 15CPS for the purpose of prolonging drug release and improving their bioavailability. The fabricated films were smooth, uniform and the colour was brown with good flexibility. The weight and thickness of all the formulations were found to be uniform. The drug content was in the range of 95–98%, indicating drug uniformity. Swelling index …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 2, Issue 2, 2015 · pp. 15–27 Read article
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A Novel Approach of Protein Peptide Drug Delivery System
Abstract: Protein and peptides perform vital functions in body and are essential for life. They show various roles as therapeutic agents in treatment of cancer and diabetes. Various routes are available for the delivery of proteins and peptides such as oral route, transdermal route, pulmonary route, parenteral route, ocular route, nasal route, buccal route. However physicochemical properties of protein and peptides make them challenging for exogenous administration, especially in oral administration. …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 7, Issue 2, 2020 · pp. 44–59 Read article
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Oral Thin Films of Ondanetron Hcl: Formulation and Performance Evaluation
Abstract: This study had the goal to formulate oral polymeric thin film that would dissolve and disintegrate instantly, while also having high mechanical features. These are the most advanced forms of solid dosage forms. Solvent casting was the technique employed to create oral thin films. These are additionally referred to as buccal films/strip, mouth dissolving films, oral thin films, as well as oral strips of paper. These films are suitable for …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 3, 2024 · pp. 1–6 Read article