Buccal Drug Delivery System: A Review

Gayatri Bedarkar; R. T Dolas

Abstract

The occurrence of interfacial molecular attracting force into the surface of biologically known substrates and naturally or synthetically occurring polymer, that in turn permits the polymer to cling to the biologically known surfaces for a prolonged length of time, is known as bio adhesion. Bio adhesive polymerizing system has employed into creation of goods for a variety of biomedical applicability, including surgical glue and denture adhesive, for a long time. The buccal area of the oral mucosa provides an adorable channel of systemic medication distribution within the mouth mucosa. Drugs are delivered via oral mucosal layer, that has a higher first-pass metabolism and degrades gastrointestinal. The medication is immediately transmitted via the systemic circulation via the buccal drug delivery mechanism, which allows for painless administration, quick enzymatic action, high bioavailability, and reduced liver metabolism. The disadvantages of the oral drug delivery route include substantial presystemic metabolism, which causes medicines to a break down in an acidic environment due to poor absorption. This review paper provides a comprehensive overview of the oral mucosa, mucoadhesion, variables influencing the whole process, assessment methodologies, and how to eliminate obstacles when formulating buccal drug delivery formulations.

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