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13 articles for “Partition coefficient.”
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Studies on Phytochemical analysis of Citrus sinensis
Abstract: Citrus sinensis, also known as sweet orange, is an extensively grown fruit with extensive nutritional and medicinal significance. The present study focussed on the phytochemical analysis of C. sinensis, aiming to identify and quantify the bioactive compounds present in its various plant parts. The investigation encompassed the extraction, isolation, and characterization of secondary metabolites, including flavonoids, alkaloids, terpenoids, phenolic compounds, and essential oils. The research employed a combination of classical …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 13, Issue 3, 2023 · pp. 9–14 Read article
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Application of Prodrug to Improve Skin Permeability: A Review
Abstract: Administration of drug via skin has some limitations such as skin barrier, solubility of drug and partition coefficient etc. Stratum corneum which is an outer skin layer, acts as a barrier to the skin. Thus, prodrug has some applications to improve skin permeability. Prodrugs are defined as the compounds which are initially inactive but covert into their active form when reacted with several chemicals or enzymes at particular active site …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 8, Issue 1, 2023 · pp. 1–11 Read article
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Aceclofenac and Diclofenac Sodium Conjugates with Amino Acids to Overcome Acidity
Abstract: This research work was based on a conjugate approach with some non-steroidal anti-inflammatory drugs (NSAIDs) to overcome the side effects like gastric irritation, solubility behavior, and some other effects of NSAIDs. Almost all the NSAIDs have undesirable reactions as well as they cause some types of major adverse reactions. Here the prodrugs conjugates are the approaches that increase the lipophilicity of the drug and decrease the solubility in water by …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 12, Issue 2, 2022 · pp. 19–25 Read article
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Application of Aqueous Two-Phase Systems in the Extraction of Bovine Serum Albumin
Abstract: Protein partitioning in an aqueous two-phase system (ATPS) has been found to be a powerful method for extracting and separating mixtures of biomolecules. In ATPS, many factors influence the partition coefficient K (which is the ratio of protein concentration in the top phase to that in the bottom phase) and the recovery percent (Rec%). Two systems of ATPS were used: first, polyethylene glycol (PEG4000)/sodium phosphate, and second, PEG4000/dextran. The behavior …
Published in Journal of Polymer & Composites · Vol. 11, Issue 1, 2023 · pp. 41–50 Read article
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Analytical Method Development and Validation of Simultaneous Estimation of Natural Active Constituents Andrographolide and Piperine by UV Method.
Abstract: A simple, accurate, precise, and robust UV-Visible spectrophotometric method was developed and validated for the simultaneous estimation of Andrographolide and Piperine in bulk and combined pharmaceutical dosage forms. Preformulation studies confirmed favorable physicochemical properties for both drugs, including acceptable solubility profiles, melting points, pH values, and partition coefficients. The method development involved determination of λmax values at 224 nm for Andrographolide and 288 nm for Piperine using ethanol as solvent. …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 3, 2025 · pp. 33–41 Read article
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Development and Characterization of a Solid Dispersion of an Anti-Diabetic Drug Using Pectin as a Natural Polymer
Abstract: Aim: The current study sought to improve the solubility and oral bioavailability of gliclazide by creating solid dispersions and oral dispersible tablets (ODTs) with enhanced physicochemical characteristics and maintained antidiabetic action. Methods: Preformulation studies were conducted to evaluate the physicochemical properties of gliclazide, including physical appearance, melting point, solubility, and partition coefficient. Solid dispersions were prepared using hydrophilic carriers-pectin and PVP K30, and subsequently characterized by Fourier Transform Infrared Spectroscopy …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 2, 2026 · pp. 01–12 Read article
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Soil Adsorption Study of Thiram on Four Indian Soils by Extractive Spectrophotometry
Abstract: Concern about the environmental impact of an extensive use of pesticides has prompted research into the environmental fate of these agents which is strongly influenced by the interactions between the pesticides and soil. With a view to studying the fate of thiram fungicide in soil and the extent of surface and groundwater contamination, the soil-adsorption of thiram on four Indian soils of different soil characteristics has been studied by an …
Published in Research and Reviews: A Journal of Toxicology · Vol. 1, Issue 1-3, 2011 · pp. 56–62 Read article
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3D QSAR Studies of 2,3-Disubstituted Quinazolin Phenyl Acetic Acid Derivatives as Antimicrobial Agents
Abstract: Quantitative structure activity relationship (QSAR) studies have been performed on series of31 compounds of 2,3-disubstituted quinazolin phenyl acetic acid derivatives withantimicrobial activity using Chemoffice version 8.0 software. The QSAR models have beendeveloped by using multiple linear regressions in order to identify descriptors, which areactually focusing towards the biological activity. Leave one out (LOO) method was employedin cross validation analysis to validate the developed model. The best predictive QSAR modelderived, had …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 8, Issue 2, 2017 · pp. 4–7 Read article
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In Silico Assessment of Drug like Properties of Some Thiadiazole and Oxadiazole Derivatives as HDAC Inhibitors
Abstract: Purpose: To investigate in silico the drug-like properties of some thiadiazole and oxadiazole derivatives as HDAC inhibitors. Methods: We used Chemdraw Ultra 11.0 to redraw all chemical structures. Furthermore, some applications, such as Bio-Loom for Windows - version 1.5, Molinspiration Property Calculator, and ACD/I-LAB, were used to forecast the drug-like properties of thiadiazole and oxadiazole derivatives, including relative molecular mass (MW), partition coefficient log P (cLog P), number of hydrogen …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 9, Issue 2, 2022 · pp. 1–13 Read article
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Mechanistic Studies on Aziridinyl-Benzoquinones in Cultured Tumour Cells
Abstract: This study compares the anti-tumour effects of NQO1 activated drug RH1 (2, 5-diaziridinyl-3 - hydoxymethyl-6-methyl-1, 4-benzoquinone) with a lipophilic ester derivative Es5 on the isogenic cell lines MDA 468 and MDA 468 NQO1 which differs only in expression of wtNQO1. A 39- fold enhancement of growth inhibitory activity was seen in NQO1 expressing cells compared the NQO1 null cells for the Es5 compared to the 25- fold increase seen for …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 11, Issue 2, 2023 · pp. 37–45 Read article
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Development and Performance Evaluation of Efficient Low-Complexity SPIHT Image Coder
Abstract: Wavelet transform is one of the advanced, effective and computationally fast methods for image data as well as video compression. The wavelet based image compression is particularly a nonreversible method that has been growing computationally more complicated as they getting more accurate and reliable. In this work we have developed an image compression technique based on main concepts related to partial ordering of the coefficients of image matrix elements by …
Published in Journal of Advanced Database Management & Systems · Vol. 2, Issue 3, 2015 · pp. 5–10 Read article
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Fractional Riemannian Fuzzy C-Means with Time-Series Regularization for Economic Manifold Forecasting
Abstract: A fractional Riemannian fuzzy c-means framework is proposed for uncertain economic forecasting on non-Euclidean data domains. Observations are represented on a Riemannian manifold, cluster centres are intrinsic prototypes, and a latent fuzzy regime signal is regularised by both autoregressive and fractional-memory penalties. The resulting objective couples geometric clustering with time-series consistency, thereby discouraging partitions that are locally plausible but temporally incoherent. Closed-form membership updates, exponential-map centre updates, normal equations for …
Published in Recent Trends in Mathematics · Vol. 3, Issue 2, 2026 · pp. 49–55 Read article
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Modified Listless Set Partitioning in Hierarchical Trees (MLS) for Memory Constrained Image Coding Applications
Abstract: SPIHT image coding algorithm is a very effective state-of-art technique for compression of wavelet transformed images. However, the use of three continuously growing linked lists, limit its applications to achieve high quality images in memory constrained environments.The No List SPIHT (NLS) is an attempt to implement SPIHT algorithm without lists, but it uses 4 bits per coefficient state markers to keep track of significant/insignificant information of pixels/sets. This paper presents …
Published in Current Trends in Signal Processing · Vol. 2, Issue 1-3, 2012 · pp. 56–66 Read article