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103 articles for “Mechanisation”
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Nutrient-Mediated Activation of Cellular Signaling Pathways: Mechanistic Insights into Attenuation of Toxin Induced Inflammation in Food Animals
Abstract: Dietary and environmental toxins remain a persistent challenge in food animal production, where subclinical and clinical inflammation compromises health, productivity, and food safety. Toxin induced inflammation is driven by oxidative stress, mitochondrial dysfunction, and dysregulated immune signaling, resulting in impaired metabolic efficiency and increased disease susceptibility. Recent advances in nutritional science have revealed that nutrients act not only as substrates for growth but also as signaling molecules capable of modulating …
Published in International Journal of Toxins and Toxics · Vol. 3, Issue 1, 2026 · pp. 1–12 Read article
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Catalytic Trends of OsO4 for the Taurine-Bromamine-T Redox System: Kinetic and Mechanistic Chemistry of Catalyzed and Uncatalyzed Reactions
Abstract: Taurine (2-ethane aminosulfonic acid) facilitates as a building block for protein synthesis, also possessing various other vital biological functions. Literature survey revealed that there was no report available on the oxidation of taurine with any oxidants from its kinetic, mechanistic and catalytic aspects. A detailed comparative mechanistic study of its Os(VIII) catalyzed and uncatalyzed oxidation kinetics by bromamine-T (BAT) in NaOH medium at 313 K revealed the rate law to …
Published in Journal of Catalyst & Catalysis · Vol. 4, Issue 3, 2017 · pp. 5–19 Read article
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Immune Dysregulation and Cytokine Circuitry in Genital Endometriosis: Mechanistic Insights and Next-Generation Immunotherapeutic Strategies
Abstract: Genital endometriosis is increasingly recognized as an immune-mediated inflammatory disorder driven by complex interactions between dysregulated immune cells, cytokine hubs, and microbiome-derived modulators. This review introduces a novel “immune–cytokine circuitry” framework that unifies innate and adaptive immune abnormalities with key cytokine loops sustaining chronic inflammation, angiogenesis, neuroinflammation, and immune tolerance. Within this circuitry, macrophage polarization, dendritic cell immaturity, NK-cell anergy, Treg expansion, Th17 amplification, and B-cell–mediated autoimmunity converge to establish …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 1, 2026 · pp. 06–16 Read article
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Mechanistic and Catalytic Behavior of Os(VIII) for the Chlorpheniramine Maleate and Bromamine-B Redox System: A Kinetics Based Approach
Abstract: Chlorpheniramine maleate (CPM) is an important antihistamine agent. To the best of our knowledge there is no report in the literature about the oxidation of CPM with halogen + 1 oxidant from the stand point of its kinetics and mechanistic chemistry. Hence, a systematic kinetics and mechanistic study on the oxidation of CPM with bromamine-B (BAB) in the presence of NaOH and Os(VIII) catalyst has been carried out at 303 …
Published in Journal of Catalyst & Catalysis · Vol. 2, Issue 1, 2015 · pp. 18–31 Read article
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Integrated Computational and Bio-catalytic Transformations: DFT-Guided Mechanistic Insights, Machine Learning, and Nano-biocatalyst Engineering for Sustainable Catalysis
Abstract: Computational catalysis has emerged as a transformative scientific discipline that integrates quantum chemistry, molecular modeling, machine learning, and density functional theory (DFT) to understand catalytic mechanisms and design highly efficient catalytic systems for sustainable industrial applications. The increasing global demand for environmentally responsible chemical manufacturing has accelerated research on advanced catalytic materials including transition metal catalysts, metal–organic frameworks (MOFs), homogeneous catalysts, heterogeneous systems, and bimetallic catalysts involving nickel and iron. …
Published in Journal of Catalyst & Catalysis · Vol. 13, Issue 2, 2026 · pp. 36–44 Read article
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Diet-Driven Enhancement of Immune Resilience, Disease Resistance, and Performance: Mechanistic Insights, Nutritional Interventions, and Implications for Sustainable Dairy Development
Abstract: This review synthesizes current knowledge on how dietary strategies can strengthen immune resilience, improve disease resistance, and enhance productive performance in dairy systems while advancing sustainable development. Immune function in dairy cattle is profoundly influenced by nutrition, with energy, protein, essential amino acids, fatty acids, vitamins, minerals, and bioactive compounds playing critical roles in shaping both innate and adaptive immune responses. Suboptimal nutrition impairs immune competence, increases susceptibility to infectious …
Published in Research and Reviews : A Journal of Immunology · Vol. 16, Issue 2, 2026 · pp. 15–24 Read article
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Ru(III)-Catalyzed Oxidative Cleavage of Ritodrine Hydrochloride: A Kinetic and Mechanistic Study
Abstract: A systematic kinetic and mechanistic study of the oxidation of ritodrine hydrochloride (RTH) with chloramine-T (CAT) in both HClO4 and NaOH media has been carried out at 303 K. In acid medium, the reaction rate is very sluggish to be measured kinetically. Ruthenium (III) chloride ([Ru(III)]) was found to be an efficient catalyst. The reaction rate exhibits a first-order dependence on [CAT]0 in both media. It shows a fractional-order on …
Published in Journal of Catalyst & Catalysis · Vol. 1, Issue 1, 2014 · pp. 29–40 Read article
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Postbiotics Unveiled: Mechanistic Insights and Therapeutic Implications in Obesity.
Abstract: The burgeoning global obesity epidemic necessitates innovative therapeutic approaches, and postbiotics, bioactive compounds arising from microbial fermentation, have emerged as promising contenders in reshaping obesity management. This comprehensive review explores the multifaceted mechanisms by which postbiotics impact obesity, from modulating gut microbiota composition to influencing metabolic pathways and enhancing energy expenditure. The exploration of postbiotics is rooted in a deeper understanding of the gut–brain axis and bidirectional communication between gut …
Published in Emerging Trends in Metabolites · Vol. 3, Issue 1, 2026 · pp. 11–28 Read article
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Activation Energy in Photochemical and Thermally Driven Reactions: Mechanistic Insights, Kinetic Modelling and Photocatalytic Applications
Abstract: Chemical reactions constitute fundamental processes in which reactants are transformed into products through the breaking and formation of chemical bonds. In photochemical systems, these transformations are initiated or influenced by the absorption of light, making energy transfer mechanisms particularly significant. A key parameter governing reaction kinetics is activation energy, defined as the minimum energy required for reactant molecules to undergo a successful transformation. This article focuses on the role of …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 4, Issue 1, 2026 · pp. 21–26 Read article
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Solid-State Reactions: Mechanistic Insights, Kinetic Behavior and Emerging Applications in Advanced Materials
Abstract: Solid-state reactions are fundamental to the synthesis and transformation of inorganic materials, playing a crucial role in the development of ceramics, semiconductors, catalysts, and energy storage systems. Unlike reactions in liquid or gaseous phases, they are limited by restricted atomic mobility and typically require elevated temperatures to enhance diffusion and overcome activation energy barriers. These reactions proceed through interfacial contact between solid reactants, followed by nucleation of product phases and …
Published in International Journal of Crystalline Materials · Vol. 3, Issue 1, 2026 · pp. 10–14 Read article
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Thermodynamic, Kinetic and Mechanistic Investigations of Ruthenium(III) Catalyzed Methylparaben Oxidation by Diperiodatocuprate(III) in Aqueous Alkaline Medium
Abstract: The kinetics of ruthenium(III) catalyzed degradative oxidation of methylparaben by the copper complex, diperiodatocuprate(III) in alkaline medium is studied at 25ºC and at a ionic strength of 8.0 × 10−2 mol dm−3. In the presence of catalyst ruthenium(III), the reaction between methylparaben and diperiodatocuprate(III) in aqueous alkaline medium exhibits 1:1 stoichiometry. The oxidation products were identified by UV-visible, GC-MS and IR spectroscopy. The reaction exhibited unit order in case of …
Published in Journal of Catalyst & Catalysis · Vol. 2, Issue 1, 2015 · pp. 4–17 Read article
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Dental Pulp Stem Cells Derived from Wisdom Teeth as Multitarget Biological Modulators of Alzheimer’s and Parkinson’s Disease: Mechanistic Insight and Translational Perspective
Abstract: Alzheimer’s disease and Parkinson’s disease are chronic, progressive neurodegenerative disorders with complex pathogenic pathways such as neuroinflammation, oxidative stress, mitochondrial dysfunction, synaptic degeneration, and reduced neurotrophic signalling. Despite the large amount of research, the pharmacological treatments in use offer only symptomatic relief and cannot significantly prevent or slow down disease progression sufficiently; new pathogenetic treatment strategies are necessary. In recent years, stem cell-based approaches have gained interest as potential therapeutic …
Published in Research and Reviews: A Journal of Dentistry · Vol. 17, Issue 2, 2026 · pp. 7–28 Read article
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Systemic Lupus Erythematosus Revisited: A Milestones in Classification, Mechanistic Insights on Pathogenesis, Diagnosis, and Evolving Treatment Paradigms
Abstract: Systemic lupus erythematosus (SLE) is a prototypic, multi-systemic chronic inflammatory autoimmune disorder characterized by extreme clinical heterogeneity and the potential to involve virtually any organ or tissue. The condition is driven by a fundamental breakdown in immune tolerance, resulting in the overproduction of pathogenic autoantibodies and the formation of immune complexes that precipitate widespread inflammation and organ damage. This review aims to provide an exhaustive synthesis of recent developments in …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 3, 2026 Read article
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Mechanistic Studies on Aziridinyl-Benzoquinones in Cultured Tumour Cells
Abstract: This study compares the anti-tumour effects of NQO1 activated drug RH1 (2, 5-diaziridinyl-3 - hydoxymethyl-6-methyl-1, 4-benzoquinone) with a lipophilic ester derivative Es5 on the isogenic cell lines MDA 468 and MDA 468 NQO1 which differs only in expression of wtNQO1. A 39- fold enhancement of growth inhibitory activity was seen in NQO1 expressing cells compared the NQO1 null cells for the Es5 compared to the 25- fold increase seen for …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 11, Issue 2, 2023 · pp. 37–45 Read article
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HINDRANCES FOR DEVELOPMENT OF AGRICULTURAL SECTOR IN INDIA: A MINOR STUDY
Abstract: In India, agriculture is primarily responsible for maintaining food and nutrition security. Agriculture's contribution to the country's output fell from 53% in 1950–1951 to 18% in 2019–2020. Roughly 50% of the workforce still makes their living from it. Many hindrances of the agriculture sector in India are lying behind its growth and development. The objective of the study is to evaluate the barriers preventing India's agricultural development to its full …
Published in Research and Reviews : Journal of Crop science and Technology · Vol. 12, Issue 3, 2023 · pp. 26–33 Read article
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A Review on Structural Evaluation of Flexible Pavements using Falling Weight Deflectometer
Abstract: For rehabilitation design processes, the new Mechanistic-Empirical Pavement Design approach relies heavily on the material stiffness, back calculated from the deflection measurements taken from existing pavements. These measurements are typically made using Falling Weight Deflectometer (FWD) or Heavy Weight Deflectometer (HWD) units. In order to provide high quality and consistent material stiffness data for the Mechanistic-Empirical Pavement Design the deflection results obtained at radial distance in between 0 and 1800 …
Published in Trends in Transport Engineering and Applications · Vol. 2, Issue 1, 2015 · pp. 1–10 Read article
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Statistical Modeling for Climate Matching between Some Saudi Cities and Some Cities in the United States of America
Abstract: In a research project entitled "Structural Pavement Design for Saudi Arabian Roads", the researchers aimed to suggesting a complete structural pavement design system for the highway network of The Kingdom of Saudi Arabia (KSA). This main objective took into consideration changes of the materials along with prevailing environmental and traffic loading in various regions of KSA. The importance of this research project came from the fact that structural design techniques …
Published in Research & Reviews : Journal of Statistics · Vol. 8, Issue 3, 2019 · pp. 32–40 Read article
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Design, Synthesis, and Spectroscopic Elucidation of 3-Methyl-1-Phenylpyrazol-5-One: A Cheminformatics-Aided Approach to Heterocyclic Drug Scaffolds
Abstract: Pyrazolone, a notable heterocyclic compound, has drawn increasing interest due to its broad pharmacological profile and structural versatility. The synthesis, characterisation, and biological assessment of new pyrazolone derivatives are examined in this work. A comprehensive review of existing synthetic strategies is presented, emphasizing green and efficient methodologies. Novel derivatives were synthesized using varied starting materials and catalytic systems, followed by structural confirmation through spectroscopic analyses, including NMR, IR, and mass …
Published in International Journal of Cheminformatics · Vol. 3, Issue 1, 2025 · pp. 29–40 Read article
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Role of Quantum Chemistry in Catalysis: A Comprehensive Review
Abstract: Catalysis plays a crucial role in modern chemical manufacturing, energy conversion, and environmental protection by enabling chemical reactions to occur more rapidly, selectively, and with reduced energy consumption. A fundamental understanding of catalytic processes at the atomic and electronic levels is essential for the rational design and optimization of catalysts. Quantum chemistry has emerged as a powerful theoretical and computational framework that enables detailed investigation of electronic structure, reaction energetics, …
Published in Journal of Catalyst & Catalysis · Vol. 13, Issue 1, 2026 · pp. 01–16 Read article
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Pharmacodynamics and Drug–Receptor Interactions: Integrating PK/PD Modeling with Modern Drug Development
Abstract: Understanding drug action requires an integrated perspective of pharmacodynamics and pharmacokinetics, which together determine therapeutic efficacy and safety. This review provides a comprehensive overview of the mechanisms underlying drug action, with particular emphasis on drug–receptor interactions and their role in modulating physiological responses. Drugs exert their effects primarily through interactions with specific biological targets, including receptors, enzymes, ion channels, and transporters, resulting in a spectrum of desired and adverse outcomes. …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 · pp. 33–47 Read article