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61 articles for “Malignancies”
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An Insight into Childhood Malignancy
Abstract: Childhood cancers represent a significant public health concern, affecting a vulnerable population with unique biological and developmental characteristics. The aim of this article is to describe the main causes and different types of malignancies in childhood. By understanding the contributing factors towards malignancy in childhood one can plan for the preventive measures and early diagnosis and treatment modalities can be adopted. Even though the treatment patterns have improved, people are …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 1, 2024 · pp. 07–12 Read article
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Stilbenes: A Molecular Docking and ADMET Analysis Approach on an Emerging Resource for Scavenging Reactive Oxygen Species in the Field of Colon Malignancy
Abstract: Objective: Colon malignancy, also referred to as colon cancer, originates as precancerous polyps in the colon or rectum, which have the potential to thrive and progress into cancerous tumors over time. This study delves into various bioactive compounds (from natural sources like plants) to assess their potential efficacy in inhibiting colon malignancy as compared to conventional methods. Methods: The objective of this study was to employ computational methodologies to evaluate …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 3, 2024 · pp. 29–38 Read article
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Hidradenocarcinoma: A Rare Skin Disease
Abstract: Hidradenocarcinoma (HAC) also known as ‘‘sweat gland tumor” is an aggressive, uncommon, highly malignant, adnexal tumor derived from the intradermal duct of eccrine sweat glands. It is said to be aggressive as it has a high risk of local recurrence (50%–75%) and a high potential to metastasize to nearby lymph nodes or to other distant sites. Hidradenocarcinoma has other recognized variants which are known by different names such as Malignant …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 2, Issue 1, 2024 · pp. 1–12 Read article
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Mystic Malignant Melanoma Modalities
Abstract: Melanoma is a highly aggressive form of cancer with four recognized subtypes. In about 90% of cases, melanoma is diagnosed as a primary tumor, without signs of spreading. If caught early, the survival rate is quite high, reaching around 94%. However, for metastatic melanoma, the survival rate drops significantly to about 40%. Diagnosing melanoma can be tricky, as it shares features with benign conditions like seborrheic keratosis, benign moles, blue …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 3, 2024 · pp. 1–10 Read article
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Evaluation of Mammographic Breast Density in Benign and Malignant Breast Disease Patients
Abstract: The purpose of the study was to compare the breast density in benign breast disease and carcinoma of the breast and to evaluate the association between breast density and the Breast Imaging Reporting and Data Systems (BIRADS) score to investigate the potential of breast density as a prognostic indicator. In this study, histologically proven cases of 30 benign breast disease patients and 30 breast carcinoma patients were included. Breast density …
Published in Research and Reviews : Journal of Surgery · Vol. 14, Issue 3, 2025 Read article
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Role of Food Supplements in Premalignant Lesions: A Literature Review
Abstract: Premalignant lesions of the oral cavity are histopathological alterations in the oral epithelium linked to a higher likelihood of malignant transformation. These lesions frequently present as leukoplakia (white patches), erythroplakia (red patches), oral lichen planus, and oral submucous fibrosis. Oral cancer, categorized among head and neck malignancies, is considered the sixth most common cancer globally. While tobacco and alcohol consumption remain the primary etiological factors, increasing evidence underscores the significant …
Published in Research and Reviews: A Journal of Dentistry · Vol. 16, Issue 3, 2025 · pp. 17–26 Read article
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A Rare Case Of Symplastic Leiomyoma Of Uterus : A case Report
Abstract: Uterine smooth muscle tumors (USMT) are of mesenchymal origin and develop from the smooth muscle cells of the uterus. Leiomyomas and their subtypes are the most commonly occurring USMT’s. Symplastic Leiomyoma is an unusual histologic subtype of Benign Leiomyoma, hence also known as atypical or Bizarre leiomyoma. It is often difficult to differentiate it from Leiomyosarcoma because of its bizarre looking nuclei on histology. However it’s malignant transformation is rare. …
Published in International Journal of Toxins and Toxics · Vol. 1, Issue 2, 2024 · pp. 26–31 Read article
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Examining Connective Tissue Changes Across Various Grades of Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma: A Histochemical Polymeric Investigation
Abstract: Oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC) represent a spectrum of potentially malignant disorders posing significant challenges in diagnosis and management. The tumor microenvironment, particularly alterations in the connective tissue, plays a crucial role in the progression of these lesions. This histochemical investigation comprised with embedded polymers aimed to examine connective tissue changes across various grades of oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC). …
Published in Journal of Polymer & Composites · Vol. 12, Issue 3, 2024 · pp. 124–137 Read article
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Use of the Computer Statistics in Oncology
Abstract: Currently, the use of computer statistics and computer statistical modeling in oncology for obtaining an accurate diagnosis, determination of the choice of treatment method and its correction in the process of ongoing treatment, prediction of the outcome of the disease, and evaluation of the effectiveness of the chosen treatment tactics is a decisive factor. The use of computer statistics, based on an adapted scientific and statistical package of the SSP …
Published in Research & Reviews : Journal of Statistics Read article
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Recent Development Technique in Management of Cancer
Abstract: Cancer develops when a change in one's genetic makeup leads to the development of tumour cells. These clusters of malignant cells eventually develop into tumours. Tumours can shed cancerous cells, which can then travel through the lymphatic system or the circulatory system to other organs. In the medical field, this occurrence is referred to as metastasis. Cancer cells proliferate even when they have no instructions to do so. Despite the …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 1, 2024 · pp. 25–41 Read article
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Role of Gastric Receptors in Gastrointestinal Disorder
Abstract: The established and potential roles of cholecystokinin1 and cholecystokinin2 receptors in gastrointestinal and metabolic diseases are analyzed, along with findings from human studies involving agonists and antagonists. While there is considerable evidence implicating cholecystokinin1R in various diseases such as pancreatic disorders, motility disorders, tumor growth, satiety regulation, and cholecystokinin-deficient states, its specific role in these conditions remains ambiguous. Conversely, the role of cholecystokinin2R in physiological (e.g., atrophic gastritis) and pathological …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 2, 2024 · pp. 37–49 Read article
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Uterine Leiomyosarcoma: A Diagnostic Dilemma
Abstract: Tumours that fall under the category of uterine malignancies include carcinosarcomas, leiomyosarcomas, endometrial stromal sarcomas, and undifferentiated sarcomas. Of them, leiomyosarcoma is the most common subtype, while still quite uncommon—it accounts for 1% to 2% of uterine cancers. Since postmenopausal bleeding is typically present in leiomyosarcomas, prompt detection is essential for successful treatment. This case study features a 50-year-old female patient who had postmenopausal bleeding, which is a common sign …
Published in International Journal of Pathogens · Vol. 1, Issue 1, 2024 · pp. 38–42 Read article
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Precision Medicine for Neurofibromatosis Type 1: Progress and Prospects in Drug Discovery
Abstract: Objective: The development of neurofibromas, café-au-lait spots, and other neurological problems are the hallmarks of neurofibromatosis type 1 (NF1), a hereditary disorder. The dearth of efficacious pharmaceutical therapies underscores the need for novel therapeutic approaches, even in the face of clinical variability. Through very accurate prediction of the binding affinity of possible therapeutic drugs with the target protein, the computational technique known as “molecular docking” has become a potent tool …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 1, 2024 · pp. 01–15 Read article
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Machine Learning Approaches in Breast Cancer Diagnosis: Current Trends and Future Perspectives
Abstract: Since cancer is still one of the world's top causes of death, precise and effective detection techniques must be developed. Machine learning (ML) approaches have shown promise in recent years for enhancing cancer prognosis and detection. This paper presents a comprehensive review of the application of ML in cancer detection, focusing on various modalities including medical imaging, genomic data, and clinical records. We highlight the challenges associated with traditional cancer …
Published in International Journal of Radio Frequency Innovations · Vol. 2, Issue 1, 2024 · pp. 14–20 Read article
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Assessment of Women's Knowledge of Mastitis at Indus International Hospital, Punjab
Abstract: Mastitis is a non-cancerous inflammatory condition of the breast, often resulting from infection, which can impact the mammary gland's structures. It is a relatively frequent condition, affecting between 5% and 33% of women during lactation at some point in their lives. Typical clinical signs include pain in one breast, redness (erythema), and swelling, often accompanied by flu-like symptoms such as fever, chills, and body aches. Upon examination, the affected breast …
Published in Research and Reviews: A Journal of Health Professions · Vol. 14, Issue 3, 2024 Read article
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An Immunohistochemical Study to Assess the Role of Myofibroblasts in Diagnosing and Predicting the Outcome of Oral Squamous Cell Carcinoma
Abstract: Background: Squamous cell carcinoma (SCC) accounts for approximately 94% of all oral malignancies, hence establishing oral squamous cell carcinoma (OSCC) as one of the top 10 most prevalent malignant tumors. Cells with several functions, such as macrophages and myofibroblasts, play a vital role in the biological behavior of tumors. This study aimed to assess and evaluate the prevalence of myofibroblasts (MF) and macrophages in SCCs occurring in the oral region. …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 2, Issue 1, 2024 · pp. 13–17 Read article
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Fuzzy C-Means Clustering for Effective Segmentation and Classification of Brain Tumors in MRI Scans
Abstract: The paper discusses the importance of detecting and classifying brain tumors via MRI for effective treatment. It proposes a framework utilizing the Fuzzy C-means clustering algorithm for segmentation, demonstrating improved performance through real dataset validation. The model is trained on a large, annotated MRI dataset to identify and classify different tumor types, enabling machine learning-based classification into benign and malignant tumors. The MATLAB-based solution automates brain tumor feature extraction, aiding …
Published in Journal of Microwave Engineering and Technologies · Vol. 11, Issue 2, 2024 · pp. 23–28 Read article
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An Effective Convolutional Neural Network for Identifying Cancer Blood Disorder Cells Using Microscopic Images
Abstract: Blood, bone marrow, and lymphatic systems are all impacted by hematological cancer is known as a cancer blood disorder. Blood malignancies and various blood disorders pose significant health challenges across all age groups. Early disease detection is essential for effective cancer blood disorder treatment and management. If a blood cancer is not identified in time, it may be hazardous. It results in abnormal white blood cell production by the bone …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 2, 2024 · pp. 29–35 Read article
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Comparison of a Human Papillomavirus Test with the Hybrid Capture 2 and a Real-Time PCR Method for 18 High-Risk and Low-Risk Human Papillomavirus Infections in Women
Abstract: Squamous intraepithelial lesions (SILs), which are a kind of cancer, and HUMAN papillomavirus (HPV) viral load have frequently been investigated as a risk factor in findings that were in dispute. These studies made use of several HPV viral quantitation assays [including the commercially available hybrid capture 2 (HC2) assays], which vary in their capacity to consider variations in cervical cell collection, linear dynamic range of viral load quantitation, and identified …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 15, Issue 1, 2025 · pp. 10–16 Read article
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Exploring Abies grandis phytocompounds potential by in silico analysis targeting on the 5P9J Protein
Abstract: Blood Cancer, also popular with name ‘Hematologic cancer’ have variety of types: Leukaemia, Lymphoma, Myeloma, uncontrolled multiplication of blood cells mainly affecting to bone marrow and blood cells (White Blood Cells). Lymphoma, originating from lymphatic system resulted in uncontrolled growth and instead of normal apoptosis development of tumor. Myeloma, uncontrolled formation of malignant plasma cells leads disrupting production of healthy blood cells. This situation creates variety of diseases like anaemia, …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 2, 2025 Read article