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20 articles for “Invitro”
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Zolmitriptan Mouth Dissolving Tablets: Development of Formulas and Invitro Evaluation
Abstract: Pharma Burst ODT super disintegrants were used in different concentrations to manufacture Zolmitriptan fast dissolving tablets by a direct compression method. With a 28° angle of repose, there is good flow. The densities for bulk and tapped materials are 0.410 (g/ml) and 0.500 (g/ml), respectively. The compressibility index and Hausner ratio have values of 19.05 and 1.24, correspondingly. According to IP standard, weight variation test results range from 121.4 mg …
Published in Emerging Trends in Personalized Medicines · Vol. 1, Issue 2, 2024 · pp. 1–15 Read article
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Comparison of Bond Strengths of Nano and Microhybrid Flowable Composites for Orthodontic Bonding: An Invitro Study
Abstract: Introduction: When the orthodontic brackets are bonded to the etched enamel, the ideal orthodontic adhesive should have optimal bond strength and be able to withstand masticatory forces as well as orthodontic forces. At the same time, when the treatment is completed, the bracket should debond without causing any damage to the enamel. There have been many recent advances in composites in general and their applications in orthodontic use is questionable. …
Published in Journal of Polymer & Composites · Vol. 10, Issue 3, 2022 · pp. 1–8 Read article
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Invitro Evaluation of a Herbal Soap Formulation as an Antifungal Agent
Abstract: During the past few decades, there is a rise in the resistance of bacterial and fungal pathogens. In this accord, lot of research is being carried out and many studies are focused on the use of plant extracts as fungicides. There is archaeological evidence that the betel leaves have been chewed since very ancient times, for its activity towards bacteria and fungi. Hydroxychavicol, a phenolic substance isolated as an aqueous …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 1, Issue 3, 2011 · pp. 1–6 Read article
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Role of Vanadium Salicylic acid coordination Complex in Diabetic cataract induced InVitro in Goat lens
Abstract: Diabetes is one of the major health problems that affect a large number of human populations. Diabetic cataract is one of the most frequent ocular complications rising secondarily to diabetes Vanadium and its various coordination metal complex plays a significant role in reduction of diabetes as well as cataract. We had tried to find out that the synthesized complex of Vanadium –Salicylic acid had a role on diabetic cataract induced …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 5, Issue 1, 2018 · pp. 25–28 Read article
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Enhancing Abiotic Stress Tolerance in Banana (Musa spp.) Using In Vitro Methods and Conserving Germplasm
Abstract: Both biotic and abiotic stressors are the main factors limiting banana output. Research on biotic stressors in bananas has received enough attention globally, whereas abiotic stressors receive less attention. Water availability, salinity, and a wide variety of temperatures are the main problems that must be resolved to maintain banana farming in the twenty-first century. Samples were introduced with water, salt and heat stresses in invitro condition. Under different stress and …
Published in Research and Reviews : Journal of Crop science and Technology · Vol. 14, Issue 1, 2025 · pp. 9–15 Read article
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An Extensive In vitro Approach in Development of Next Generation Drugs Against Trehalose-6-Phosphate Phosphatases Involved in Pathogenicity of Many Microorganisms
Abstract: Normal 0 false false false EN-IN X-NONE X-NONE MicrosoftInternetExplorer4 AbstractTrehalose-6-phosphate phosphatase (TPP) enzymes implicated in pathogenecity of number of bacteria, fungi and nematodes causing serious diseases such as tuberculosis, candedemias, aspergillosis, elephantiasis and parasitic ones. This study is an effort to target a common pathway critical to pathogenicity of different microbes but entirely absent in vertebrates and to come out with new generation drugs by an extensive in vitro approach. …
Published in Research & Reviews : Journal of Herbal Science · Vol. 7, Issue 1, 2018 · pp. 32–43 Read article
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Formulation and Evaluation of Hybrid Polymer Films using Metformin as Model Drug
Abstract: The present work was to formulate transdermal films which can produce a constant and prolonged release of drug using Chitosan and polyethylene oxide. In the present study high molecular weight Chitosan (300 K) and Polyethylene oxide (600 K) were used.initially, pre-formulation studies were performed to check the solubility of drug and polymers. A suitable method was developed for the estimation of absorption maxima of the drug by UV double beam …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 5, Issue 1, 2018 · pp. 1–15 Read article
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Comparative Evaluation of Corneal Permeation of Indomethacin Using Different Vegetable Oil
Abstract: Topical administration of drugs is the most favoured route for management of ocular inflammation. About 90% of dose applied topically from such solutions is lost due to precorneal losses (nasolacrimal drainage) and tearing results in poor availability as contact time is less between drug and ocular tissue. An increased ocular contact time of the drug may be achieved by formulating the drug as an oil solution. In this study, invitro …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 12, Issue 2, 2025 · pp. 7–12 Read article
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Raktmokshana in Sharad Ritucharya: Answer to Various Diseases Disturbing Haematology
Abstract: Changes in the external environment bring various changes in the human body that cause various diseases, protection from whom requires a continuous conscious effort. These changes with their adaptation have been mentioned in Ayurvedic Samhita’s. This study aims to understand and check the curative and preventive relevance of one such regimen of Sharad ritu (~Autumn season), namely, Raktamokshanam (~bloodletting) as mentioned in classical texts of Ayurveda in context to modern …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 13, Issue 3, 2024 · pp. 26–36 Read article
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Development of Sodium Alginate Beads of Telmisartan Using Emulsion Gelation Method: Formulation and In-Vitro Characterization
Abstract: Introduction: The antihypertensive medication Telmisartan (TEL) is a member of BCS class II, which is distinguished by limited oral rate and extent and water solubility. By localizing the medication release in the stomach, gastro-retentive floating bead devices may be able to address the issues related to partial absorption and the low solubility of TEL. The preparation of TEL floating alginate beads was the aim of this investigation. The current work …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 11, Issue 3, 2024 · pp. 13–21 Read article
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Protective Role of Sulforaphane against Multiorgan Toxicity in Rats: An In-vivo and In-vitro Review Study
Abstract: Sulforaphane [1-isothiocyanate-(4R) -(methylsulfinyl) butane] is a natural dietary isothiocyanate produced by the enzymatic accomplishment of the myrosinase on glucopharanin, a 4-methylsulfinylbutyl glucosinolate contained in cruciferous vegetables such as broccoli, brussel sprouts, and cabbage. Exploring of this compound against various oxidative degenerative diseases such as hepatic, nephro and cardiac diseases is growing because of its anticarcinogenic and cytoprotective properties. In several invivo and invitro experimental paradigms proved SFN and its compounds …
Published in Research and Reviews: A Journal of Toxicology · Vol. 8, Issue 1, 2018 · pp. 1–8 Read article
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Formation of hygiene and cosmetic wipes using herbal formulation
Abstract: Increase in the awareness among the consumers against the health and hygiene products has increase the demand of nonwovens. There is huge increase in hygiene products in the recent COVID-19 pandemics. The hygiene products help the control the moisture as well as acts as a good disinfectant against the pathogens present on the skin. In the present study wet wipes formulations are being done using herbal formulations. Xanthum gum is …
Published in Research and Reviews: A Journal of Toxicology · Vol. 11, Issue 3, 2024 · pp. 1–8 Read article
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Screening of Phytochemical Constituents Towards Antimicrobial Potency of Hygrophila schulli
Abstract: The present study was carried out to determine the invitro antibacterial and antifungal and phytochemical activity of Hygrophila schulli. In this study antimicrobial activity of leaves of Hygrophila schulli was studied by analyzing in different concentrations ranging from 100-500µg. We observed that at higher concentrations (>300 µg) ethanolic extract of Hygrophila schulli showed certain significant antimicrobial effect. Antimicrobial activities against Escherichia coli, Fusarium verticillioides, Klebsiella sp., Aspergillus flavus, Pseudomonas aeruginosa, …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 1, Issue 1, 2011 · pp. 1–5 Read article
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Free Radical Scavenging Activity of Zanthoxylum rhetsa (Roxb) DC
Abstract: The leaves of Zanthoxylum rhetsa (Roxb) DC are used in Indian system of medicine. Thepresent study deals with the physicochemical, phytochemical investigation, and in vitroantioxidant activity on various extracts of the plant. The leaf extracts of Z. rhetsa wereprepared with five different solvents such as hexane, chloroform, ethyl acetate, ethanol andwater. The results of this study showed that leaves powder of Z. rhetsa is rich in secondarymetabolites and contain many …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 7, Issue 2, 2017 · pp. 17–26 Read article
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Extraction of Essential Oil and Anti-bacterial Activity Determination of Cassia tora Seed on some Selected Microorganisms (Staphylococcus aureus, Trichophyton rubrum and Streptococcus species)
Abstract: Essential oils have been used for extensive applications of variety of wellness throughout documented history. With massive advancement in science, essential oils today have undergone numerous refining methods to give an improved effect. The aim of this study was to extract and investigate the functional properties of Cassia tora seed oil through analytical profiling using gas chromatography. In the gas chromatographic analysis two chromatographic conditions used were the same except …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 10, Issue 3, 2020 · pp. 12–20 Read article
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In vitroAntioxidant and Antidiabetic Activity of Regional Chemotypes of three Curcuma species from Chhattisgarh
Abstract: Phytoconstituents and nutritional rich Curcuma species playsan important role in medication. In the present study rhizomes of Curcuma longa, Curcuma caesia and Curcuma aromatica from different regions of Chhattisgarh, Indiawere chosen for best chemotype identification on the basis of antioxidant and antidiabetic potential. Curcuminoids found in Curcuma rhizomes vary often with varieties, locations, sources, and cultivation conditions, while there are significant variations in varieties and geographical locations as well as …
Published in Research & Reviews : Journal of Herbal Science · Vol. 7, Issue 1, 2018 · pp. 13–22 Read article
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The Research Outline for Performing in vitro Cataract Research on Goat Eyes
Abstract: Cataract could be defined as opacification of the lens. It is one the most common complications related with growing age, diabetes, hypertension, nicotine consumption, alcohol abuse and sedentary life style. The current approach in management of cataract is the surgical removal of the cataract, but there are certain complications that arises pre-operatively, post operatively and during the surgical phase, that’s why there is a dire need in development of a …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 1, 2018 · pp. 37–39 Read article
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Formulation And Evaluation of Domperidone Medicated Jelly Using Solvent Deposition Method For Solubility Enhancement
Abstract: Objective: The purpose of this study is to develop and characterize medicated jelly of Domperidone. Domperidone is associated with poor aqueous solubility and dissolution rate and thus exhibit a poor bioavailability. Solvent deposition is a promising method to improve the solubility of poor water soluble drugs.Methods: Solvent depositions were prepared for optimization and evaluated for percentage drug content, invitro dissolution, solubility analysis. Optimization of Domperidone solvent deposition was done using …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 4, Issue 2, 2017 · pp. 40–53 Read article
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Design Approach based Formulation of Deformable Liposomes and their In vitro Skin Permeation
Abstract: Leukemia is the common cause of disease and its worldwide incidence is increasing. Cytarabine pyrimidine nucleoside analogs most widely used for the treatment of leukemia, but the major obstacles to existing treatments are adverse effect and poor patient’s compliances. To provide sustained drug release with minimum side effects and to develop more patients affable formulation, the authors investigated the transdermal delivery of cytarabine through deformable liposomes. The present work demonstrated …
Published in Trends in Drug Delivery · Vol. 4, Issue 3, 2017 · pp. 14–25 Read article
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Formulation and Evaluation of Transdermal Drug Delivery of Piroxicam
Abstract: The aim of the present study was to formulate transdermal films loaded with Piroxicam (PX). Transdermal films were prepared by using sodium alginate (SA) and xanthan gum (XG) as biopolymers by varying the blend ratios viz., 10:0, 8:2, 6:4, 4:6 and 2:8 (w/w %) through solution casting method. The drug loaded membranes were evaluated for thickness, tensile behaviours, and content uniformity. In-vitro diffusion was determined by Franz diffusion cell. Piroxicam …
Published in Trends in Drug Delivery · Vol. 1, Issue 2, 2014 · pp. 8–13 Read article