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68 articles for “In vivo evaluation.”
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Formulation and Evaluation of Gastroretentive Bilayered Floating Tablets of Famotidine: Effect of Formulation Variables and in vitro in vivo Evaluation
Abstract: The present investigation concerns the development of bilayered floating tablets of famotidine for prolongation of gastric residence time. An attempt was made to prepare bilayered floating tablets of famotidine by direct compression method. Two layered formulations were designed with an immediate release layer (IR) comprising of the drug, the super disintegrant Croscarmellose sodium along with the other diluents like microcrystalline cellulose and dicalcium phosphate. Three batches of immediate release layer …
Published in Trends in Drug Delivery · Vol. 2, Issue 3, 2015 · pp. 1–17 Read article
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Formulation and Evaluation of Gastro retentive Effervescent Floating Tablets of Famotidine: Effect of Formulation Variables and In Vitro In Vivo Evaluation
Abstract: Gastro retentive effervescent floating tablets of famotidine were developed in an attempt to sustain the drug release as well as to prolong the presence of dosage form in the stomach or upper small intestine until drug is completely released in desired period of time from the formulation with special emphasis to the effect and concentration of different polymers on drug release and floatation. Tablets were prepared by direct compression method …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 2, Issue 3, 2015 · pp. 13–29 Read article
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Formulating Self Phospholipids Dispersion of Poorly Water-Soluble Drug to Enhance Oral Bioavailability
Abstract: In present study, self-nano phospholipid dispersion (SNPD) of Simvastatin (SIM) was prepared based on Phosal 53 MCT to improve the oral bioavailability. Ternary phase diagrams were constructed to evaluate the efficient nanoemulsion regions and also for the optimum concentrations of lipid (Phosal 53 MCT) and surfactant (Cremophore RH 40), co-surfactant (Gelucire 50/13) and water in the formulation. The globule size of SNPD batch A was found to be 115.7 nm, …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 10, Issue 3, 2019 · pp. 24–33 Read article
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In vitro and in vivo Anti-Oxidant and Anti-Diabetic Evaluation of cladodes Crude Extract and Solvent fractions of Opuntia elatior mill (Cactaceae)
Abstract: Objective: Ariel part of Opuntia elatior (Cactaceae) has been used in folklare remedies to treat diabetes in America, Mexico and India. However, the anti-diabetic potential of cladodes of this medicinal plant is not scientifically validated and authenticated. The present study aimed to evaluate in vitro and in vivo anti-oxidant and anti-diabetic potential of methanol extracts and solvent fractions of O. elatior cladodes. Methods: Phytochemical analysis performed according to standard procedure. …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 12, Issue 2, 2025 · pp. 77–88 Read article
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Synthesis and Characterization of Polymer-Based Benzamide Derivatives with Potential Biomedical Applications
Abstract: The present study explores the synthesis and characterization of polymer-supported benzamide derivatives, focusing on their potential biomedical applications. The use of polymer-supported synthesis offers several advantages, including improved reaction efficiency, ease of purification, and reusability of the support material, making it an environmentally friendly and cost-effective approach. The synthesis involved a stepwise reaction sequence, with polymeric supports facilitating controlled functionalization and ensuring high product purity. These materials have been widely …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 Read article
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Protagonist of Aspirin in Primary Treatment of Cardiovascular Disease: An Overview
Abstract: AbstractAspirin (ASA) is the most used medication on the globe. The benefits of aspirin therapy for the secondary prevention of cardiovascular disease clearly outweigh the risks of bleeding, and low- dose aspirin is uniformly recommended in this condition. While the clinical use of aspirin in secondary cardiovascular disease (CVD) prevention remains undisputed, its role in primary prevention is controversial. Recently, three trials of primary prevention reported neutral net benefit results …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 9, Issue 2, 2020 · pp. 12–30 Read article
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Design and Development of Novel Floating Drug Delivery Systems
Abstract: Recent advances in science and technology have greatly aided in the creation of novel drug delivery methods, especially in addressing physiological issues including irregular stomach emptying times and brief stomach residence periods. Long-term stomach absorption is the goal of gastro-retentive dosage forms (GRDF). Floating drug delivery systems, expanding or swelling systems, polymer-based bioadhesive systems, high-density systems, and other ways that postpone stomach emptying are just a few of the techniques …
Published in International Journal of Membranes · Vol. 1, Issue 2, 2024 · pp. 1–22 Read article
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Revolutionizing Diabetes Management: Nanostructured Biosensors for Real-time Monitoring
Abstract: Chronic metabolic disease known as diabetes mellitus, which is characterized by dysregulated blood glucose levels, is becoming a major global health concern. The implementation of automated insulin administration systems and continuous glucose monitoring (CGM) has shown promise in the management of diabetes. Nanostructured biosensors, leveraging the unique properties of nanomaterials, offer enhanced sensitivity, selectivity, and biocompatibility, making them ideal candidates for real-time monitoring and personalized treatment. This article delves into …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 14, Issue 1, 2024 · pp. 49–70 Read article
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Antipsoriatic Potential of Polyherbal Paste
Abstract: AbstractPsoriasis is a common dermatitis affecting 1-3% of the population. Several attempts have been made in overcoming psoriasis with prolonged treatment duration. The oral anti-psoriatic agents though quite effective are associated with renal, hepatic and hematological toxicities. The topical treatments have also been described in the classical Unani literature. This work aims in evaluating antipsoriatic potential of Barg-e-Neem, Barg-e-Henna, and Kamela that exhibit anti-inflammatory activity and are used in traditional …
Published in Research & Reviews : Journal of Herbal Science · Vol. 8, Issue 3, 2019 · pp. 20–32 Read article
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In Vivo Hypoglycemic Activity of Aqueous Leaf and Root Extracts of Macaranga Barteri Müll. Arg. (Euphorbiaceae) In Swiss Albino Mice
Abstract: Background: Macaranga barteri Müll. Arg. is a perennial plant in the family Euphorbiaceae and is used in African traditional medicine for the management of several ailments, including diabetes. Although the leaves and stem bark have been studied for various pharmacological activities, little is known about the therapeutic value of the roots. Objective: This study evaluated the in vivo hypoglycemic activity of aqueous leaf and root extracts of M. barteri in …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 15, Issue 2, 2026 · pp. 60–78 Read article
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Stomach Mimicry of A-Forte for Pharmacokinetic Insight
Abstract: Drug absorption from solid dosage forms after oral administration depends on the release of the drug substance from the drug product, the dissolution or solubilization of the drug under physiological conditions, and the permeability across the gastrointestinal tract. In vitro dissolution may be relevant to the prediction of in vivo performance. To evaluate the in vitro dissolution of A-forte, a siddha proprietary medicine and the influencing factors, a study of …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 2, Issue 2, 2015 · pp. 8–12 Read article
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Anti-tuberculosis Effects of the Extracts from Humulus japonicus and Humulus lupulus in in vitro and ex-vivo TB Models
Abstract: AbstractObjectives: Anti-tuberculosis effects of Humulus japonicus and Humulus lupulus were evaluated in in vitro direct killing ability and in ex-vivo indirect killing ability through human macrophages. Methods: H37Rv or XDR strain or NTM was treated with Crude extracts of Humulus japonicas and Humulus lupulus to estimate the MIC(Minimal Inhibitory Concentration) or MKC(Minimal Killing Concentration). Results: The MIC or MKC of the extracts of Humulus japonicus was 31.2 µg/ml for H37Rv …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 9, Issue 3, 2022 · pp. 40–49 Read article
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Computational Examination of Curcumin Derivatives as Promising Inhibitors for BRCA1 and BRCA2 Proteins in Breast Cancer Treatment
Abstract: Objective: Breast cancer is a major problem for global health and one of the most popular and dangerous diseases. Data from the National Cancer Registry Program (NCRP) of the National Center for Disease Informatics and Research (NCDIR), an arm of the Indian Council of Medical Research (ICMR) in Bangalore, India, shows that an estimated 1,461,427 new cancer cases will occur… Conditions in India by 2022. Among these conditions, breast cancer …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 3, 2023 · pp. 68–87 Read article
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Exclusion of Seed Sprouts Salmonella Pathogens Through Bacteriophages
Abstract: Foodborne pathogens are contamination in foods; it results in poisoning conditions that reach to the consumers. Food poisoning responsible microbial inhabitants are progressive within a short duration and it is difficult to control their ascendancy. In practice, many chemical-based antimicrobial agents are used to control the foodborne pathogenic bacteria, subsequently with some drawbacks. Hence, we urgently need an attractive alternative to reduce bacterial food contamination. The lytic bacteriophages are the …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 9, Issue 1, 2019 · pp. 73–80 Read article
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Formulation, Optimization and Evaluation of Flurbiprofen Liposomal Gel
Abstract: The present study deals with effect of various combinations of lecithin, cholesterol, chloroform-methanol and tween-80 on liposomes of flurbiprofen. Optimization of the flurbiprofen liposomes by Design Expert software was done. Vesicle size, drug content, SEM and entrapment efficiency were evaluated. Flurbiprofen gel with optimized liposome using Carbopol 934 as gelling agents, were formulated. pH, spreadability and drug content in the gel were evaluated. Results of skin irritation study showed that …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 8, Issue 2, 2017 · pp. 33–42 Read article
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In vitro and In vivo Trypanocidal Activity of Methanolic Extract of Lantana camara leaves on Trypanosoma brucei in Laboratory Mice
Abstract: In this study, the methanol extract of Lantana camara leaves were tested for their trypanocidal activity in vitro in a microtiter plate and in vivo using male laboratory mice. Five different concentrations 10mg/ml, 20 mg/ml, 30 mg/ml, 40mg/ml, and 50mg/ml of the extract were prepared and the time taken to immobilize the parasites were recorded. The in vitro results showed that the leave extract at concentrations of 50 mg/ml had …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 2, 2024 · pp. 32–41 Read article
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A Novel Liquid Crystal Drug Delivery for Transdermal Application
Abstract: The present study was aimed at the formulation of liquid crystals of acyclovir that will be incorporated into a transdermal patch. Liquid crystals serve as drug carrier and have a good penetration-enhancer property, due to the extensive similarity of these colloidal systems with the intercellular lipids in the stratum corneum. The liquid crystals were prepared using tween 80 as emulsifier, cetosteryl alcohol as emulsion stabilizer and double-distilled water. Liquid crystals …
Published in Trends in Drug Delivery · Vol. 2, Issue 2, 2015 · pp. 28–37 Read article
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Formulation Development of Anti-psoriatic Topical Babchi Oil Emulgel
Abstract: AbstractPsoriasis is an inflammatory condition associated with painful, itchy, scaly skin and disfiguring skin lesions. It is an autoimmune disease that appears on the skin. The immune system plays a key role in psoriasis. The lack of possible cure and associated disadvantages in allopathic medicines has led to extensive research in natural products with anti-psoriatic activity. Psoralea corilyfolia (Babchi oil) was found to be efficacious and cheap anti-psoriatic drug with …
Published in Research & Reviews : Journal of Herbal Science · Vol. 2, Issue 2, 2013 · pp. 12–25 Read article
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Inhibition of Ehrlich Ascites Carcinoma by Crotalaria verrucosa L. Leaf in Swiss Albino Mice
Abstract: Objective: The objective of the present study was to evaluate the antitumor activity of Crotalaria verrucosa L. leaf against Ehrlich ascites carcinoma (EAC) in Swiss albino mice. Methods: The in vivo antitumour activity of the ethanol extract of leaf of C. verrucosa L. (ELCV) was evaluated at 50, 100 and 200 mg/kg bw against EAC, using mean survival time. After administration of the extract of C. verrucosa, viable EAC cell …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 5, Issue 2, 2018 · pp. 5–10 Read article
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Advanced Ointment Formulation: An Insightful Review of Innovation and Efficacy
Abstract: This review provides an in-depth exploration of the evolution of ointment formulations, particularly considering the increasing prevalence of fungal infections and the growing demand for effective antifungal treatments. Traditional ointment formulations, while useful, often face significant challenges, such as inadequate penetration into the skin, poor bioavailability, and undesirable textures that limit their efficacy. As a result, there has been a shift toward more advanced, innovative formulations that aim to address …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 27, Issue 1, 2025 · pp. 14–23 Read article