Objective: The objective of the present study was to evaluate the antitumor activity of Crotalaria verrucosa L. leaf against Ehrlich ascites carcinoma (EAC) in Swiss albino mice. Methods: The in vivo antitumour activity of the ethanol extract of leaf of C. verrucosa L. (ELCV) was evaluated at 50, 100 and 200 mg/kg bw against EAC, using mean survival time. After administration of the extract of C. verrucosa, viable EAC cell count and body weight in the EAC tumour hosts were observed. The animal was also observed for improvement in the haematological parameters (e.g., heamoglobin content, red and white blood cells count) after ELCV treatment. Results: Intraperitoneal administration of ELCV reduced viable EAC cells, increased the survival time, and restored altered haematological parameters. Significant efficacy was observed for ELCV at 100 mg/kg dose (P<0.05). Conclusions: It can be concluded that the ethanol extract of leaf of C. verrucosa L. possesses significant antitumour activity. Keywords: Crotalaria verrucosa L., Ehrlich ascites carcinoma, antitumour property, ethanol extractCite this ArticleRamesh Kannan N, Agnel Arul John, Natarajan E. Inhibition of Ehrlich Ascites Carcinoma by Crotalaria verrucosa L. Leaf in Swiss Albino Mice. Research and Reviews: A Journal of Ayurvedic Science, Yoga and Naturopathy. 2018; 5(2): 5–10p.
