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227 articles for “Genetics of the Disease”
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Gene Therapy in Modern Medicine: Promises and Challenge in Treating Genetic Diseases
Abstract: Gene therapy is a medical approach that focuses on altering or adjusting an individual’s genes to treat or prevent illnesses. The aim is to repair faulty genes or insert new ones into the body to combat diseases. Gene therapy can involve directly introducing modified or new genes into a patient’s cells or altering the genes already present in the patient’s body. This approach shows potential for treating a range of …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 2, 2024 · pp. 27–32 Read article
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Breeding and Genetics of Disease Resistance in Poultry and Farm Animals: A Review
Abstract: Disease resistance is one of the most essential parameters that is now getting consideration in the animal selection along with production traits. Development and rearing of genetically disease resistant stocks is the newer face of animal husbandry at present. The increasing microbial resistance, increased drug residues in animal products, ever increasing cost of therapeutic treatment, and consumer’s preference towards organic products are all giving bright signal to the development of …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 10, Issue 1, 2021 · pp. 1–7 Read article
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Statistical Models for Predicting Genetic Variability and Disease Susceptibility
Abstract: Differences in genetics are key to understanding why some individuals are more prone to certain diseases than others. Recent advancements in genomic research, combined with statistical modeling techniques, have made significant strides in predicting disease risk based on genetic factors. This review explores the application of statistical models for predicting genetic variability and their role in disease susceptibility. We discuss traditional methods like linear regression and genome-wide association studies (GWAS), …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 1, 2025 · pp. 30–34 Read article
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Innovations in Gene Therapy: Revolutionizing Treatment for Genetic Disorders and Diseases
Abstract: Gene therapy is a revolutionary intervention in the treatment of genetic diseases since it is an intervention that aims at the very source of diseases, through editing and modification of genes. More recent innovations in gene editing systems, such as CRISPR-Cas9, CRISPR-Cas12, and prime editing, have greatly increased the accuracy and effectiveness of gene therapies, enabling more specific therapies. The opportunities of personalized medicine are also extended by the creation …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 16, Issue 1, 2026 · pp. 19–25 Read article
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A Comprehensive Analysis of Alzheimer’s Disease
Abstract: Alzheimer's disease, the most prevalent form of dementia, is a progressive neurological disorder characterized by cognitive decline, particularly in memory function. The condition manifests in two primary forms: familial Alzheimer’s disease, affecting individuals under the age of 65 years, and sporadic Alzheimer’s disease, which constitutes the majority of cases and primarily afflicts adults aged 65 years and older. The prevalence of Alzheimer’s disease is influenced by various factors, such as …
Published in Research and Reviews: A Journal of Toxicology · Vol. 13, Issue 2, 2023 · pp. 26–32 Read article
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Genetic Testing: An Intervention of Biotechnology for Healthy Motherhood
Abstract: The journey from a woman to a mother had been one of the sweetest of its kind. Having a child with a chronic illness has a major impact on the family as a whole, especially mothers. Mothers of a child with chronic disease experience difficulties in dealing with feelings which may subsequently lead to a dysfunctional family. Usually parenting stress is more on mothers caused by having their more affectionate …
Published in Research and Reviews: A Journal of Health Professions · Vol. 8, Issue 3, 2018 · pp. 87s–90s Read article
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Immunological and Genetic Markers of Rheumatoid Arthritis Among Women in North India: A Case-Control Study
Abstract: Background: Rheumatoid arthritis (RA) is an autoimmune disease systemically afflicting women marked by chronic inflammation around the involved joints leading to joints destruction. It has both endocrinological and immunological associations as well as genetic associations but data pertaining to women of North India is scanty.Objective: This case-control study was done to evaluate the presence and significance of major immunological and genetic markers of RA in North Indian women with the …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 2, 2025 · pp. 1–10 Read article
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A review on Design of Gene Therapy and Its Potential for Craniofacial Regeneration
Abstract: One of the most talked-about topics of the 21st century is gene therapy, which holds the promise of treating many diseases. Current gene therapy research explores a wide range of potential treatments, such as enhancing the body’s immune response to tumors, promoting the formation of new blood vessels in the heart to mitigate heart attacks, and preventing HIV replication in AIDS patients. Gene therapy involves the introduction, alteration, or replacement …
Published in Emerging Trends in Personalized Medicines · Vol. 2, Issue 2, 2025 · pp. 6–12 Read article
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A Review Article on Genetic Testing, Types and Their Applications in Diseases
Abstract: Genetic testing, a medical test identifies changes in chromosomes, genes or proteins. The result of a genetic test result helps us to confirm or rule out any suspected genetic disorder and determine susceptibility of a person for a genetic disorder. Prenatal testing can be used to diagnose the changes which include neural tube defect and genetic disorders like Down’s syndrome that may occur in a zygote’s gene or chromosome even …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 7, Issue 3, 2017 · pp. 34–41 Read article
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Deciphering Neuroinformatics in the Gene Profiling of Mental Retardation using the Tool Geneious Pro and Cytoscape Software
Abstract: Mental retardation (MR) is defined as an overall intelligence quotient lower than 70, associated with functional deficit in adaptive behavior, such as daily-living skills, social skills and communication. Genetic abnormalities frequently give rise to a mental retardation phenotype. The prevalence of mental disability in India was found to be 2.3%. The prevalence was higher among females (3.1%) than among males (1.5%) with a higher finding among the elderly age group …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 2, Issue 2, 2015 · pp. 25–48 Read article
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The Future of Camelids in South America: Recent Developments and Prospects
Abstract: Camelids, including llamas, alpacas, vicuñas, and guanacos, have been central to South American culture, economy, and ecosystems for centuries. Known for their adaptability to harsh Andean climates, these species provide valuable resources, such as luxurious fiber, nutritious meat, and durable leather. In modern times, their importance has grown due to increasing demand for sustainable and ethically sourced products, coupled with their minimal environmental impact and significant contributions to rural livelihoods. …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 14, Issue 2, 2025 · pp. 35–38 Read article
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Infant Examination India's Case of Sickle Cell Disease
Abstract: From the present work, it is evident that sickle cell disease causes a huge impact on health care status in many countries. The review also examines the historical background of the complications of the disease and drug development since the last few decades from the present work, it is evident that the sickle cell disease causes a huge impact on health care status in many countries. The review also examines …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 12, Issue 2, 2022 · pp. 17–26 Read article
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CRISPR-Cas9: Revolutionizing the Genetic Frontier
Abstract: The rapid development of CRISPR/CRISPR-associated enzyme (Cas) technology has enabled truly customised treatment of human genetic disorders, paving the way for recent developments in the field of gene therapy. Because CRISPR/Cas can accurately target and edit individual genes within a genome, it has established itself as a formidable tool for genetic manipulation. CRISPR/Cas9 technology allows for precise editing of specific DNA sequences in an organism's genome. This method uses three …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 2, 2025 Read article
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Challenges of Upgrading Local Cattle with Exotic Breeds: Genetic, Environmental, Economic, and Sustainability Trade-offs
Abstract: The practice of upgrading local cattle with exotic breeds has gained popularity as a strategy to enhance milk and meat production. While this approach holds potential for improving productivity, it also presents a range of challenges that need careful consideration. This study examines the genetic, environmental, economic, and sustainability trade-offs associated with upgrading local cattle with exotic breeds. From a genetic perspective, upgrading can result in the dilution of traits …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 2, 2025 · pp. 38–53 Read article
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Calf Mortality in the Tropics: Multidimensional Challenges and Implications for Sustainable Dairy Development
Abstract: Calf mortality remains a significant challenge in tropical dairy farming, posing threats to productivity and sustainability. This review explores the multifactorial factors contributing to calf mortality in the tropics, including environmental stress, infectious diseases, nutritional deficiencies, management practices, genetic factors, and social dynamics. Tropical climates, characterized by extreme temperature variations, humidity, and poor shelter, exacerbate stress and compromise calf health. Infectious diseases, such as bacterial, viral, and parasitic infections, coupled …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 14, Issue 3, 2025 · pp. 7–23 Read article
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Genomic Medicine Revolutionizes Heart Care: A New Standard of Practice
Abstract: The integration of genomic and precision medicine into cardiovascular healthcare represents a transformative advancement in addressing the global burden of cardiovascular diseases (CVDs). Precision medicine leverages genomic, proteomic, and metabolomic data to provide personalized care, optimizing treatment outcomes while minimizing adverse effects. Over the past decade, extensive research has highlighted its potential to revolutionize the management of major CVDs, including myocardial infarction, hypertension, and heart failure, which significantly contribute to …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 2, 2025 · pp. 30–37 Read article
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Next-Generation mRNA Vaccines: Applications Beyond COVID-19
Abstract: Messenger RNA (mRNA) vaccine technology has become a paradigm shift in contemporary medicine and, with remarkable success in the COVID-19 pandemic, has opened the door to a new wave of vaccines development. In contrast to the traditional vaccine methods, mRNA vaccines are based on the synthetic genetic code that allows host cells to express target antigens, thus eliciting strong humoral and cellular immunity. The speed of development, efficacy, scalability of …
Published in International Journal of Vaccines · Vol. 3, Issue 2, 2026 · pp. 15–26 Read article
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A Review on Junk DNA
Abstract: For many years, although being incredibly catchy, the term junk DNA discouraged mainstream scientists from exploring noncoding genetic material. Among humans, the DNA that actually codes for protein synthesis is 2% only. Hence, the noncoding region of genome is then termed Junk DNA. The junk DNA component is drastically different. Hence at the time of investigating the role of satellite DNA for the fertility and survival in pure species, the …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 13, Issue 2, 2023 · pp. 6–9 Read article
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Laboratory Animals: Usages in Genetic Research
Abstract: Laboratory animals are one on which advanced research is conducted and validated in labs for better understanding the natural phenomenon of biological system, genetics and disease models. Laboratory animals include mice, rat, hamster, guinea pig, gerbil, monkey etc. Lab animals play a vital role in biomedical research and genetic studies as they share common physiology and genetics, which resemble to a large extent with humans and thus make them excellent …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 7, Issue 1, 2017 · pp. 14–21 Read article
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Leveraging Genome-Wide Association Studies for Precision Medicine in Cardiovascular Diseases
Abstract: Cardiovascular diseases (CVDs) are the leading cause of death globally, with complex etiologies involving genetic, environmental, and lifestyle factors. Genome-wide association studies (GWAS) have significantly advanced the understanding of genetic underpinnings of CVDs by identifying numerous risk loci and variants associated with various cardiovascular conditions. This review explores the potential of GWAS to drive precision medicine in cardiovascular diseases by linking genetic data with clinical outcomes, providing insights into disease …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 1, 2025 · pp. 35–39 Read article