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Research and Reviews : Journal of Computational Biology Review Article

Leveraging Genome-Wide Association Studies for Precision Medicine in Cardiovascular Diseases

  1. Amartya Kumar Department of Biotechnology, Dronacharya groups of institutions,Greater Noida

Abstract

Cardiovascular diseases (CVDs) are the leading cause of death globally, with complex etiologies involving genetic, environmental, and lifestyle factors. Genome-wide association studies (GWAS) have significantly advanced the understanding of genetic underpinnings of CVDs by identifying numerous risk loci and variants associated with various cardiovascular conditions. This review explores the potential of GWAS to drive precision medicine in cardiovascular diseases by linking genetic data with clinical outcomes, providing insights into disease pathogenesis, and enabling the development of personalized therapeutic strategies. Although GWAS has provided extensive insights, challenges persist in applying these discoveries to clinical practice due to the intricate interplay between genes and the environment, as well as the multifaceted polygenic nature of CVDs. The review also highlights the importance of integrating GWAS data with other omics technologies, including transcriptomics and proteomics, to provide a more comprehensive understanding of cardiovascular health and disease. Finally, we discuss the need for diverse population representation in GWAS, emphasizing the importance of reducing health disparities through the inclusion of underrepresented ethnic groups. The future of precision medicine in CVDs relies on overcoming current challenges, incorporating multi-omics approaches, and ensuring equity in genomic research.

Keywords

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