Search
15 articles for “Cytotoxicity assay”
-
Reference of Circadian Rhythm in the Treatment of Psoriasis: A Novel Insight
Abstract: The objective of the present study was to establish the needs for different products in the treatment of psoriasis with reference to circadian rhythm. The events like proliferation of keratinocytes and elastase activity are influenced by circadian rhythm. The proliferation of the keratinocytes occurs more during early hours of the day however, the enzymatic activities occur post to that. Psorolin ointment and Psorolin oil were studied for the cell proliferation …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 2, Issue 2, 2015 · pp. 1–7 Read article
-
Evaluation of Antioxidant and Cytotoxic activities of Mycelia Biomass and Culture broth of three Edible Mushrooms, Morchella conica, Hericium erinaceus and Pleurotus florida Grown in Submerged Culture
Abstract: Mycelia biomass of three edible mushrooms namely, Morchella conica, Pleurotus florida and Hericium erinaceus were grown as submerged culture in potato dextrose broth supplemented with yeast extract, potassium dihydrogen orthophosphate and magnesium sulphate. The mycelia biomass was extracted with 70% ethanol and culture broth with ethyl acetate. The solvents were evaporated to dryness at low temperature using a rotary vacuum evaporator and the residues thus obtained were used for the …
Published in International Journal of Fungi · Vol. 1, Issue 1, 2024 · pp. 37–50 Read article
-
Valorization of Human and Cattle Dental Waste into Functional Composite Biomaterials: A Detailed Comparative Analysis
Abstract: This study investigates the conversion of human and cattle (goat and cow) teeth into bioactive hydroxyapatite-based composites and presents a detailed comparative evaluation of these biogenic materials with laboratory-synthesised (synthetic) hydroxyapatite (HAp). In this work, hydroxyapatite was extracted from human and bovine teeth through controlled calcination and milling, while synthetic HAp was prepared using a standard wet chemical precipitation route. All materials were subsequently sintered at 900 °C and fabricated …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 340–354 Read article
-
Review on Unveiling the Shadow of Hyperpigmentation
Abstract: Natural products offer promising solutions for treating skin pigmentation disorders due to their non-toxic properties and effective mechanisms of action. Studies highlight their safety and efficacy through methods such as cytotoxicity tests, tyrosinase activity assays, and melanogenesis inhibition evaluations. Advanced delivery systems like liposomes and nanoparticles further enhance their performance by improving solubility and skin penetration. Skin pigmentation disorders, influenced by factors such as UV radiation, hormonal changes, and inflammation, …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 2, 2025 · pp. 59–66 Read article
-
Neuroinflammation Is Aggravated by the Aqueous Extract of Myrmecodia Platytyrea Tuber
Abstract: Myrmecodia platytyrea, commonly known as the ant plant, is a medicinal epiphyte traditionally used in Southeast Asia for its purported health benefits, including anti-inflammatory, antioxidant, antimicrobial, and anticancer activities. Its tuber contains abundant secondary metabolites, including flavonoids, tannins, phenolic compounds, and saponins. While these phytochemicals are generally associated with therapeutic effects, the biological activity of Myrmecodia extracts varies depending on the type of extract, dosage, and route of administration. In …
Published in International Journal of Brain Sciences · Vol. 3, Issue 1, 2026 · pp. 5–14 Read article
-
Arsenic Induced Cytotoxicity Study Against Human Epithelial Carcinoma (HeLa) Cell
Abstract: The present investigation was undertaken to find out the cytotoxic effects of various amounts of arsenic exposure to human epithelial carcinoma (HeLa) cell. Cells were treated with a final concentration (0, 10, 20, 30, 40 and 50 µg/l) of arsenite in 5 ml MEM for 24 h where 0 concentration was considered as control. Cell viability was determined by the trypan blue (TB) exclusion test using hematocytometer and automated BIO-RAD …
Published in Research and Reviews: A Journal of Toxicology · Vol. 5, Issue 1, 2015 · pp. 1–8 Read article
-
Cyto-toxicity of Silver Nanoparticles on A Bacterial Population Isolated From Lakewater
Abstract: Due to the increased industrial and consumer applications, there is growing concern regarding the possible risk associated with their environmental exposure. Silver nanoparticles are considered to be toxic both to environment and human beings after a permissible limit. The aim of the present study was to explore the difference in toxicity mechanism of Silver nanoparticles (NPs) at low concentrations (≤1 μg/mL), in a lake-water bacterial consortia containing Bacillus marisflavi and …
Published in Research and Reviews: A Journal of Toxicology · Vol. 4, Issue 1, 2014 · pp. 22–25 Read article
-
Excoecaria agallocha Extract from Leaves Encounters Antifungal, Antibacterial, and Cytotoxic Activity – In Vitro Studies
Abstract: Mangroves contain a wide range of bioactive substances, certain of and these have been used as solutions for a variation of conditions for thousands of years. Excoecaria agallocha leaf application components have been extracted in the presence of organic solvents along with water-based with a Soxhlet apparatus and antibacterial research properties employing diffusion agar well assays towards nine different kinds of culture infectious agents, six clinical trials isolated compounds, as …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 15, Issue 2, 2025 · pp. 1–7 Read article
-
In vitro Evaluation of Kigelia pinnata Leaves for Its Antioxidative and Anticancer Activity
Abstract: Previous studies suggest that the Kigelia pinnata leaves have useful effects against diseases mediated through oxidative stress and cancers. In this study, leaves of Kigelia pinnata were studied for presence of different phytochemical constituents, anti-oxidant and anti-cancer activities.Crude methane extracts of Kigelia pinnata leaves showed cytotoxic activity in vitro against non-small cell lung cancinoma (A-549) cells using the MTT assay. Phytochemical evaluation showed the existence of alkaloids, terpenoids, flavonoids, tannins …
Published in Research and Reviews: A Journal of Health Professions · Vol. 9, Issue 1, 2019 · pp. 26–30 Read article
-
Phyto-bioefficiency of Vijaya Extract for Normal Cell Protection and Its Anticancer Efficiency Against Breast Cancer Xenograft
Abstract: Cannabis is an annual, dioecious, flowering herb. Its leaves are palmately compound by serrate leaflets. Cannabis sativa maximum phytochemicals are soluble in organic solvent. The Cannabis plant has been historically used due to its medicinal properties since thousands of years through several beliefs. In India, the department of narcotics has sanction that Cannabis can be grown in a monitored way with proper approval and license. The present study concludes that …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 11, Issue 3, 2022 · pp. 15–21 Read article
-
Phytochemical Screening and Biological Activity of Pomegranate Extracts
Abstract: Pomegranates are renowned for their abundance of bioactive compounds that exhibit potent antioxidant, anti-inflammatory, and antimicrobial properties, making them a subject of growing interest in natural medicine. This study aimed to compare the biological activities of ethanolic extracts derived from different parts of the pomegranate plant—specifically, the bark, peel, and leaves. A comprehensive investigation was conducted to evaluate their phytochemical composition and assess their antimicrobial, antioxidant, and anticancer properties. The …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 2, 2025 · pp. 64–79 Read article
-
Nitric Oxide Synthase (NOS) in Breast Carcinoma
Abstract: Breast cancer is the most alarming problem of the current time. Nitric oxide, a free radical gas is synthesized by isoenzymes called nitric oxide synthase. Nitric oxide synthase consists of three isoforms; Nitric oxide produced is cytotoxic which is known to inhibit the DNA synthesis causing its damage. Keeping this in mind, nitric oxide synthase was determined in breast cancer and normal breast tissue. For this tissue from 60 breast …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 7, Issue 1, 2018 · pp. 23–28 Read article
-
Antibacterial, Cytotoxicity Studies of Azukia mungo (L.) Masam and Correlation with in silico Docking Studies
Abstract: Introduction and Background: Azukia genus plants rich in proteinaceous anti-nutrients like tannins (especially condensed tannins) has been shown to have anti-bacterial activity against Staphylococcus aureus and antineoplastic activity against lung and liver cancer cells. Five types of procyanidins (condensed tannins) have already been isolated from Azukia mungo and structurally elucidated. But its activity against the Methicillin resistant Staphylococcus aureus (MRSA) has not yet been shown. Hence we focus our work …
Published in Research and Reviews: A Journal of Toxicology · Vol. 7, Issue 2, 2017 · pp. 21–31 Read article
-
Cytogenotoxicity Assessment of Asphalt Plant Discharge Water using Plant Assay
Abstract: The Allium cepa assay test was used to evaluate cytogenotoxic effects of asphalt plant discharge water at the concentrations of 10, 20, 30, 40, 50, 60, 70, 80, 90 and 100% (v/v) asphalt plant discharge water/distilled water. The distilled water served as the negative control. The analysis of the physicochemical properties and heavy metals concentrations showed that most parameters were higher than the established standards of WHO and FMENV. The …
Published in Journal of Water Pollution & Purification Research · Vol. 12, Issue 3, 2025 · pp. 100–110 Read article
-
Chemical Profile and Toxicity of Fresh and Dry leaves of the Essential Oils of Vetiveria zizanioides (L.) Nash. From Southwest Nigeria
Abstract: The fresh and dry leaves of Vetiveria zizanioides (L.) Nash (Gramineae) plant was collected, air dried and authenticated at the University of Ibadan Herbarium with voucher number: UIH-23237. The plant's dried, fresh leaves were hydro distilled in a Clevenger device to extract the essential oils. The oils were characterized by Gas Chromatography-Mass Spectrometry (GC – MS) while the toxicity of the essential oils was tested using brine shrimps’ lethality assay. …
Published in Recent Trends in Cosmetics · Vol. 1, Issue 1, 2024 · pp. 44–49 Read article