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163 articles for “Clinical efficacy”
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Clinical Efficacy of Laxadi Taila Janubasti in the Management of Janusandhigata Vata (Knee Osteoarthritis): A Case Report
Abstract: Background: Janusandhigata Vata, described under Sandhigata Vata in Ayurvedic classics, characterized by pain, swelling, crepitus, stiffness, and restricted movement of the knee joint. Clinically, it resembles Knee Osteoarthritis (OA), a common degenerative Musculoskeletal disorder affecting the quality of life of elderly individuals. Janubasti is a localized oleation therapy widely employed for managing degenerative knee disorders. Laxadi Taila possesses Vatahara, Balya, and Asthi-Sandhana properties that may help restore joint function and …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 15, Issue 2, 2026 Read article
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Assessing the Clinical Efficacy and Safety of Semaglutide: A Comprehensive Study
Abstract: Semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), has emerged as a versatile therapeutic agent with significant potential in managing a range of diseases. Extensive research has demonstrated its efficacy in treating obesity, type 1 and type 2 diabetes, and even neurodegenerative disorders like Parkinson’s disease. This comprehensive review examines the principal outcomes derived from clinical trials that incorporate semaglutide alongside other GLP-1 agonists, with particular emphasis on the mechanisms underlying …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 96–104 Read article
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Clinical Evaluation of Efficacy of a Polyherbal Unani Formulation (Mentioned in Makhzan-Ul-Ilaj) in the Management of Warm-e-Lauzatain-Haad (Acute Tonsillitis)
Abstract: Background: Warm-e-Lauzatain-Haad (Acute Tonsillitis) is an inflammatory condition of the palatine tonsils characterized by throat pain, fever, odynophagia and general discomfort. It is particularly common among adolescents and young adults and contributes substantially to outpatient visits and missed academic or workdays. In Unani medicine Warm-e-Lauzatain is described as a hot inflammatory swelling arising from deranged humors, exposure to irritants or descending catarrhal matter. Classical Unani texts including Makhzan-ul-Ilaj, advocate the …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 15, Issue 1, 2026 · pp. 13–22 Read article
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Pharmacological Comparison of Turmeric and Non-Steroidal Anti-Inflammatory Drugs in Pain Relief
Abstract: Pain is one of the most frequently encountered clinical symptoms affecting millions globally and is typically treated pharmacologically with nonsteroidal anti-inflammatory drugs (NSAIDs). However, long-term use of NSAIDs is associated with adverse effects such as gastrointestinal, renal, and cardiovascular issues. In recent years, turmeric and its main active compound, curcumin, have received considerable attention for their reported anti-inflammatory, analgesic, and antioxidant properties as natural therapeutic options. This review seeks to …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 13, Issue 1, 2026 · pp. 19–28 Read article
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Review on Clinical Safety and Efficacy of Giant Calotropis in the 21st Century
Abstract: Calotropis gigantea, a highly valued plant in traditional Indian pharmacology, has emerged as a promising candidate for therapeutic innovation. This review delves into the clinical safety and efficacy of C. gigantea in the 21st century, examining its historical use, phytochemical composition, and pharmacological properties. While traditional medicine has long utilized C. gigantea for various ailments, modern research has sought to validate these claims through scientific investigation. This review critically analyzes …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 1, 2025 · pp. 26–34 Read article
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Efficacy of Combination Therapy with Osimertinib and Afatinib in epidermal growth factor receptor-mutant non-small-cell lung cancer Patients
Abstract: Treatment options for patients with non-small-cell lung cancer who have epidermal growth factor receptor mutations are constrained by the emergence of resistance to epidermal growth factor receptor tyrosine kinase inhibitors. Osimertinib or afatinib alone, when tested in a laboratory model, led to the formation of drug-resistant clones harboring epidermal growth factor receptor secondary mutations. However, combining these drugs prevented the emergence of such mutations. In a Phase II clinical trial, …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 1, 2024 · pp. 13–24 Read article
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A Clinical Study on Comparing the Efficacy of Areca Catechu Mother Tincture with Areca Tea in Control of Blood Sugar Level Among Healthy Individuals
Abstract: Areca tea of Nivedan Nimpe is trending among diabetic group as preventive and curative diet. Areca Catechu is one of the Indian homoeopathic drugs. There is no authentic literature source to indicate the action of Areca against diabetes, so authors have investigated immediate action on blood sugar level among healthy individuals. Selection of volunteers was done on the basis of inclusion and exclusion criteria. Volunteers were randomly divided into three …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy Read article
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Homeopathy: A Comprehensive Review of Efficacy, Mechanisms, and Controversies
Abstract: Homeopathy is a widely used alternative medical system based on principles established by Samuel Hahnemann, including “like cures like” and potentization Despite its popularity, homeopathy remains controversial due to the highly diluted nature of its remedies, which often contain no detectable molecules of the original substance. This article provides a comprehensive review of the clinical efficacy, proposed mechanisms, and ongoing controversies surrounding homeopathy Clinical studies yield mixed results, with some …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 12, Issue 1, 2025 · pp. 25–32 Read article
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Formulation and Evaluation of Saliva Substitute
Abstract: The development and evaluation of saliva substitutes play a vital role in managing xerostomia, a condition marked by insufficient saliva production that adversely affects oral health and overall well-being. This study investigates various formulations of saliva substitutes intended to replicate the functionality of natural saliva. The key goals are to assess their moisturizing effectiveness, physical and chemical properties, and in vitro performance. These formulations generally incorporate hydrators, lubricants, thickeners, and …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 11, Issue 3, 2024 · pp. 32–47 Read article
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Comparative Efficacy and Safety of Safinamide and Rasagiline in the Treatment of Parkinson’s Disease: A Meta-Analysis and Systematic Review
Abstract: Background: Recent studies have suggested Rasagiline and Safinamide monotherapy as potential management options for Parkinson’s disease. Parkinson’s disease, a neurological disorder characterized by tremors and movement difficulties, necessitates treatments aimed at managing clinical symptoms. Levodopa remains the primary effective treatment for Parkinson’s disease symptoms; however, its long-term use often leads to motor complications in many patients. Additional therapeutic drugs, such as dopamine agonists and monoamine oxidase B inhibitors, including Safinamide …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 74–91 Read article
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Kisunla (Donanemab): A Novel Breakthrough Illuminating a Path to Better Alzheimer’s Outcomes
Abstract: Background: Alzheimer’s disease (AD) is a progressive neurodegenerative condition marked by cognitive decline, memory loss, and loss of independence. Despite decades of extensive research, disease-modifying treatments have been limited in success. Recent therapeutic advancements have led to the development of monoclonal antibodies targeting amyloid-beta (Aβ) plaques, particularly the pyroglutamate-modified variant, a key pathological hallmark of AD. Objectives: This review aims to explore the therapeutic potential of Donanemab (Kisunla), a novel …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 15, Issue 3, 2025 · pp. 37–45 Read article
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Effect of Dashamoola Niruha Basti in the Management of Gridhrasi (Sciatica): A Case Study
Abstract: Gridhrasi is one of the Nanatmaja Vata Vyadhis described in Ayurvedic literature and is characterized by radiating pain, stiffness, pricking sensation, and restricted movement of the lower limb. Clinically, it closely resembles Sciatica caused by compression or irritation of the Sciatic Nerve. Basti Chikitsa is regarded as the most effective therapeutic modality for Vata disorders. Dashamoola, owing to its Vata-Kapha Shamaka, Shothahara, and Vedanasthapana properties, may play a significant role …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 13, Issue 2, 2026 Read article
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Pathways in Drug Discovery and Development: From Molecular Targets to Market Approval
Abstract: A complicated, multidisciplinary, and resource-intensive process, the discovery and development of new pharmacological drugs is essential to the advancement of contemporary medicine. Finding and optimising lead chemicals comes after a disease-relevant biological target has been identified and validated. Through preclinical research in animal models, these leads are thoroughly assessed for toxicity, pharmacokinetics, safety, and efficacy. Clinical trials, which are carried out in several stages to evaluate safety, efficacy, ideal dosage, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 1, 2026 · pp. 01–04 Read article
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Engineering Anti-Tau Monoclonal Antibodies for Alzheimer’s Disease and Parkinsonian Tauopathies: A Biotechnological Perspective
Abstract: Neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease are characterized by progressive neuronal loss associated with abnormal protein aggregation. Among these, tauopathies are defined by the accumulation of hyperphosphorylated tau protein, which plays a central role in disease progression. Advances in biotechnology have enabled the development of anti-tau monoclonal antibodies (mAbs) as promising therapeutic agents aimed at neutralizing pathological tau species and inhibiting their propagation. This review provides a …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 16, Issue 1, 2026 Read article
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An Open Labelled Parallel Arm Randomized Clinical Trial of Tuvaraka Oil Prepared By Two Different Method In The Management of Pama
Abstract: In Ayurveda, all skin diseases have classified mainly into two groups i.e., Mahakushtha (major skin diseases) and Kshudrakushtha (minor skin diseases). Tuvaraka [Hydnocarpus laurifolia (Dessnt).Sleumer] is one among the most useful drugs for the treatment of Kushtha (Various skin diseases) and Madhumeha (Diabetes Melitus). Pama is described under Kshudra Kushtha. which can be correlates with scabies. Aim: To evaluate the clinical efficacy of Tuvaraka oil prepared by modified method and …
Published in Research & Reviews : Journal of Herbal Science · Vol. 13, Issue 1, 2024 · pp. 29–36 Read article
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GLP-1 Receptor Agonists: A Dual Therapeutic Strategy for the Management of Type 2 Diabetes Mellitus and Obesity
Abstract: For the treatment of obesity and type 2 diabetes mellitus (T2DM), glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have become a revolutionary class of pharmaceutical drugs. These drugs were first created as glucose-lowering treatments, but they have now shown other advantages, such as notable weight loss, better cardiovascular results, and general metabolic control. The objective of this narrative review is to assess the pharmacological mechanisms, clinical efficacy, safety profile, and therapeutic …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 1, 2026 · pp. 69–75 Read article
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Tribological Characteristics of Dental Crowns
Abstract: Dental tribology is an emerging field that focuses on improving the design and material choices for artificial dental systems. This paper looks at different dental crown materials, their clinical efficacy and the consequences of tribological wear on teeth due to interfacial movement. Ceramics are commonly utilized in fixed dental restorations because of their superior mechanical and cosmetic qualities, which include exceptional fracture resistance and clinical endurance. Ceramic crowns, often used …
Published in Journal of Polymer & Composites · Vol. 13, Issue 2, 2025 · pp. 550–559 Read article
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Horizon Scanning and Early Assessment of Health Technologies for the Treatment of Orphan Diseases
Abstract: The theoretical foundations and regulatory framework of the processes of the formation of an effective health technology assessment (HTA) system at the early stages of the life cycle of medicines are analyzed in the article. Particular attention is paid to horizon scanning (HS) and early assessment of expensive innovative drugs utilized for treating rare diseases. In order to inform policymakers, purchasers, and providers (to prioritize MT research, financial, and operational …
Published in International Journal of Brain Sciences · Vol. 1, Issue 1, 2024 · pp. 32–39 Read article
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Panoramic review on Sida rhombifolia L.
Abstract: Sida Rhombifolia is also called Bala and is a well-known Ayurvedic herbal preparation used to treat inflammation, pain and neurological disorders. Literature calls Bala as Sida cordifolia, Sida, root powder acute, Sida cordata or Sida Rhombifolia subsp. retusa to achieve clinical efficacy of standardization of ksheerBala thailam Balamulacherna is essential.The objective of the study is to authenticate the pharmacognostic standards of Sida Rhombifolia root powder. Sida Rhombifolia was standardized with …
Published in International Journal of Pathogens · Vol. 1, Issue 1, 2024 · pp. 20–32 Read article
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Screening of Pharmaceutically Significant Methioninase-Producing Fungi from the Satpura Range of Hoshangabad District and Its Large-Scale Production
Abstract: L-methioninase, an enzyme with notable anticancer properties, has emerged as a promising therapeutic agent due to its ability to selectively degrade methionine, a critical amino acid for the survival of methionine-dependent cancer cells. Methionine dependency, observed in many tumor cells, is a metabolic vulnerability that can be exploited for targeted cancer therapy. The Satpura Range in the Narmadapuram District, India, with its diverse microbial ecosystems, offers a rich reservoir for …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 12, Issue 2, 2025 · pp. 33–43 Read article