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31 articles for “Biofilm”
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Quorum Sensing and Biofilm Dynamics in Pathogens: An Evolving Frontier in Infectious Disease
Abstract: Bacterial and fungal pathogens rarely act as solitary invaders. Instead, they engage in sophisticated chemical communication known as quorum sensing (QS) to coordinate population-wide behaviours and construct structured, multicellular biofilm communities. These biofilms, composed of extracellular polymeric substances, not only facilitate microbial persistence on biotic and abiotic surfaces but also confer remarkable protection against host immune defenses and antimicrobial therapies. QS systems act as central regulators of biofilm dynamics, orchestrating …
Published in International Journal of Pathogens · Vol. 3, Issue 1, 2026 · pp. 18–23 Read article
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Pharmacokinetic Profiling and Molecular Docking of Carvacrol and Structural Analogs: Targeting Quorum Sensing Proteins to Disrupt Biofilm-Mediated Antimicrobial Resistance in Multidrug-Resistant Bacterial Pathogen
Abstract: Antibiotic resistance, particularly in Pseudomonas aeruginosa, has become a major global health threat, exacerbated by the organism's ability to form biofilms and regulate virulence through quorum sensing (QS). The LuxR and LasR receptors are key regulators in this process, influencing both pathogenicity and antibiotic resistance. This study investigates potential QS inhibitors targeting these receptors as a strategy to mitigate antibiotic resistance. The primary objective was to identify novel ligands that …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 2, 2025 · pp. 43–61 Read article
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Effect of Cell Carrier Loading on Phenol Degradation in Association with Production of Exopolymeric Substances and Biofilm Characteristics during Start up and Steady State in a Pulsed Plate Bioreactor
Abstract: Biodegradation of phenol in a continuous pulsed plate bioreactor (PPBR) using immobilized bacterial cells has been shown to be a highly efficient process. The present paper reports the studies on the effect physical characteristics of biofilm (biofilm thickness, attached dry biomass and biofilm dry density) and chemical characteristics in terms of exopolymers viz. protein, carbohydrate and humic substance produced by Pseudomonas desmolyticum (NCIM 2112) bacterial cells immobilized on granular activated …
Published in International Journal of Pollution: Prevention & Control · Vol. 2, Issue 2, 2024 · pp. 24–30 Read article
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Characterization of Antibacterial and Biofilm Inhibition in Tin and Zinc Oxide Nanoparticle-Doped Orthodontic Composites
Abstract: Background: This study investigated the antibacterial effectiveness of orthodontic adhesive enhanced with stannous oxide (SnO₂) nanoparticles against Lactobacillus acidophilus and Streptococcus mutans, in comparison to traditional adhesives without nanoparticle infusion. Methods: A modified orthodontic adhesive was prepared by incorporating 1% w/w of tin dioxide and zinc oxide nanoparticles (SnO₂ + ZnO₂ NPs) into Transbond XT. This nanoparticle-enhanced composite was used to fabricate discs for assessing antibacterial activity against Lactobacillus acidophilus …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 230–239 Read article
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Fabrication and Analysis of PBAT/Cyperus Rotundus Micro Crystalline Cellulose Biofilms for Food Packaging Applications
Abstract: Global plastic waste crisis has gained an increasing attention and many efforts have been made recently to develop biodegradable polymers as food packaging alternatives. Solution casting is used for fabrication and characterization of reinforced polybutylene adipate-co-terephthalate (PBAT) biofilm with Cyperus rotundus microcrystalline cellulose (CRC). PBAT-CRC biofilms with different CRC loadings (1%, and 2%) had been prepared and their structural, mechanical, thermal and morphological properties of fabricated biofilms were analyzed to …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 591–599 Read article
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Impact of Therapeutics on Carbapenem-Resistant Acinetobacter baumannii
Abstract: Acinetobacter baumannii, a formidable pathogen in healthcare settings, poses a significant threat due to its propensity to cause nosocomial infections. This bacterium exhibits several attributes that enable it to evade the human body's natural defenses. A. baumannii's remarkable adaptability is highlighted by its ease in acquiring antibiotic resistance determinants, rendering it challenging to treat. Its ability to thrive in hospital environments underscores the urgent need for stringent infection control practices …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 14, Issue 2, 2024 · pp. 1–11 Read article
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Overview of Virulence Factor of Staphylococcus sp.
Abstract: Staphylococcus is a highly virulent genus of bacteria that can cause a range of infections in humans and animals. The production of toxins, enzymes, and biofilms contributes to its ability to establish infections and evade host defenses. Understanding the characteristics and virulence factors of Staphylococcus is crucial for the development of effective prevention strategies and treatment options. Staphylococcus aureus is a significant etiological agent of nosocomial infections on a global …
Published in International Journal of Toxins and Toxics · Vol. 1, Issue 1, 2024 · pp. 25–31 Read article
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Whispers of the Microbial World: Unveiling Bacterial Dialogues through Quorum Sensing
Abstract: Quorum sensing is a special way of bacteria by which they can regulate their own gene expression as per the population density of the bacteria. It is basically a type of cell-to-cell communication pathway used by the microbes. The signal molecule which helps in this mechanism are called auto inducer(AI). As the mechanism depends by changes in the cell density, so when the cell density reaches to the threshold cell …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 14, Issue 3, 2024 · pp. 1–8 Read article
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Antimicrobial Peptides and Bacteriophages as Next-Generation Alternatives to Conventional Antibiotics
Abstract: The growing threat of antibiotic-resistant bacteria has underscored the urgent need for innovative alternatives to conventional antibiotics. Antimicrobial peptides (AMPs) and bacteriophages are gaining recognition as next-generation therapeutics due to their distinct mechanisms of action and ability to target resistant pathogens effectively. AMPs, which can be natural or synthetic, disrupt microbial membranes and offer broad-spectrum antimicrobial activity with a reduced likelihood of resistance development. Bacteriophages, as bacteria-specific viruses, provide precise …
Published in International Journal of Antibiotics · Vol. 2, Issue 1, 2025 · pp. 9–27 Read article
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Heterocyclic Compounds in Thin Film Coatings: A Review on Anticorrosion and Antimicrobial Properties.
Abstract: Heterocyclic compounds have gained significant attention in thin film coatings due to their exceptional chemical versatility and functional properties. These compounds, characterized by the presence of heteroatoms in their ring structures, play a crucial role in enhancing the anticorrosion and antimicrobial performance of protective coatings. This review explores the recent advancements in the application of heterocyclic compounds for corrosion resistance and microbial inhibition, emphasizing their mechanisms of action, effectiveness, and …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 12, Issue 1, 2025 · pp. 16–21 Read article
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Adaptive Mechanisms of Rumen Microbiota to High-Fiber Diets: Mystery of Fiber Degradation and Nutrient Utilization for Improved Host Performance
Abstract: The rumen microbiota plays a critical role in the digestion of plant fibers, enabling herbivores to derive essential nutrients from fibrous feed sources. The adaptation of these microbial communities to high-fiber diets is crucial for optimizing fiber degradation and nutrient utilization. This study explores the mechanisms by which rumen microbes adjust to handle the complex structure of fibrous materials such as cellulose, hemicellulose, and lignin. Through an integrated approach, we …
Published in Research and Reviews : Journal of Dairy Science and Technology · Vol. 15, Issue 1, 2026 · pp. 7–17 Read article
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Copper Sulfide Semiconducting Nanoparticles for Antibacterial Applications: Synthesis Strategies, Mechanisms and Performance – A Review
Abstract: Copper sulfide nanoparticles (CuS NPs) have drawn growing attention as a next-generation antibacterial platform, owing to their tunable structural, optical, and catalytic properties. This review consolidates current evidence on CuS NP synthesis, mechanisms, and antibacterial performance, comparing chemical and green synthesis routes alongside the effects of morphology, doping, and surface modification. Mechanistically, CuS NPs act through several overlapping pathways, including reactive oxygen species generation, bacterial membrane disruption, ion release, and …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 Read article
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Inhibition of Quorum Sensing to Mitigate the Risks of Membrane Biofouling in Biological Wastewater Treatment
Abstract: Membrane-based systems play a pivotal role in various applications, providing efficient separation, purification, and filtration processes across diverse industries such as water purification and desalination. However, this system faces major challenge of membrane biofouling impacting the efficiency and sustainability of such systems. Biofouling occurs when various microorganisms like bacteria, fungi, etc. adheres to the surface of membrane and form biofilm which results in reducing membrane permeability and increasing its operational …
Published in Research & Reviews : Journal of Ecology · Vol. 13, Issue 1, 2024 · pp. 18–26 Read article
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The Effects of Physiochemical Parameters and Microbial Counts on Metal Coupons Corrosions in Freshwater Environment at Different Water Depths
Abstract: The effect of water quality on metal coupon corrosion was investigated at the New Calabar River in Choba. The study examined metal corrosion rates at five different depths: 30 cm, 60 cm, 90 cm, 120 cm, and 150 cm in a freshwater environment. Water samples were collected at each depth and analyzed for physicochemical and microbial parameters to understand their impact on metal degradation. Key parameters measured included pH, Electrical …
Published in Journal of Water Pollution & Purification Research · Vol. 12, Issue 2, 2025 · pp. 31–51 Read article
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Chemical Composition and Antimicrobial Efficacy of Ferula persica Extracts: A Phytochemical and Bioactivity Assessment in Iraq
Abstract: The research presented in the tables focuses on analyzing the chemical content of extracts from the Ferula persica plant, a wild species in Iraq with significant medical and therapeutic importance dating back to ancient times. This study involved testing some chemical and physical properties of the alcoholic extract of the plant's aerial parts and evaluating its antimicrobial activity, specifically against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). The …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 1, 2025 · pp. 10–22 Read article
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Plant Bioactive Metabolites and Their Role in the Prevention and Control of Dental Diseases and Infections.
Abstract: The oral diseases, including dental caries and periodontitis, affect masses worldwide, and have historically been managed with synthetic antimicrobials that cause deleterious side effects, leading to mounting bacterial resistance. Consequently, contemporary dentistry is rapidly shifting toward phytomedicine using plant bioactive molecules, such as polyphenols, terpenes, anthraquinones (berberin, eugenol, curcumin, catechins, allicin, and azadirachtin. These compounds offer potent antimicrobial, anti-inflammatory, and tissue-regenerative properties that are crucial for preventing and curing dental …
Published in Emerging Trends in Metabolites · Vol. 3, Issue 1, 2026 · pp. 47–66 Read article
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Infective Endocarditis, Result of Chronic Periodontal Disease: A Real and Present Danger
Abstract: Introduction: Endocarditis is an inflammation of the endocardium, the inner lining of the heart and heart valves. It is usually caused by bacteria and is associated with high mortality and morbidity. It can result from transient bacteremia from the oral cavity. Streptococci are the primary colonizers of tooth surface and are instrumental in development of the complex oral biofilm, dental plaque. Streptococcus sanguinis is one of the abundant oral commensals …
Published in Research and Reviews: A Journal of Dentistry Read article
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A Descriptive Exploration of Children’s Understanding of Dental Caries in a Chosen School Setting
Abstract: Dental caries is a microbial condition that impacts the calcified tissues of the teeth, marked by the demineralization of the inorganic component and the degradation of the organic substance within the tooth. It is a persistent, contagious infection involving the modification of tooth structure due to the depletion of chemicals resulting from metabolic activities, along with the presence of dental biofilm on the tooth surface. The study employed a descriptive …
Published in Journal of Nursing Science & Practice · Vol. 14, Issue 1, 2024 Read article
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Disease: A Major Stumbling Block in the Growth of Aquaculture
Abstract: Aquaculture plays a crucial role in ensuring food security, fostering economic development, and providing recreational opportunities worldwide. However, the intensification of aquaculture practices has led to a surge in environmental challenges, including water pollution, soil acidification, eutrophication, chemical contamination, and the spread of diseases. Among these, diseases caused by bacteria, viruses, fungi, and parasites pose significant threats to the sustainability of global aquaculture. Despite the implementation of various diagnostic methods …
Published in International Journal of Marine Life · Vol. 1, Issue 1, 2024 · pp. 25–28 Read article
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Concern for Public Health: Periodontitis
Abstract: Periodontitis, a severe form of gum disease, erodes the bone that supports teeth and results in tooth loss. It is caused by bacterial infection and inflammation of the soft tissues around the teeth. About 70% of people 65 years of age and older are affected, on average. Red, bleeding, sensitive gums, foul breath, and receding gums are hallmark indications. Depending on the severity, a full dental examination, the insertion of …
Published in Research and Reviews: A Journal of Dentistry · Vol. 15, Issue 1, 2024 · pp. 22–26 Read article