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56 articles for “Accelerated Stability study”
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A Comparative Accelerated Stability Study of Jivantyadi Yamaka and Jivantyadi Malahara
Abstract: Background: Saviryata Avadhi of different Ayurvedic dosage forms is described in various Ayurvedic treatises after 12th century. Though the concepts have strong background, it is needed to re-validate the age old concepts by following contemporary standards. Jivantyadi Yamaka is a polyherbal medicated Sneha (Ghrita and Taila) used externally for curing Vipadika and other skin disorders. However, till date stability study of Jivantyadi Yamaka and its developed dosage form Jivantyadi Malahara …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 9, Issue 2, 2022 · pp. 18–24 Read article
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Design, Formulation, and Evaluation of Topical Meloxicam Emulgel
Abstract: AbstractThe study has the objective to formulate and evaluate meloxicam (MLX)-loaded nanoemulgel for topical drug delivery. Nanoemulsion is prepared by spontaneous emulsification technique. Nanoemulgel is prepared by adding nanoemulsion into the gel matrix. The characterization of meloxicam loaded nanoemulgel was performed. The formulations werecharacterized/evaluated for homogenicity, clarity, viscosity, pH, and drug release. In the present investigation, topical gel of MLX was formulated using pectin, polyethylene glycol (PEG), propylene glycol (PPG), …
Published in Trends in Drug Delivery · Vol. 9, Issue 3, 2022 · pp. 30–41 Read article
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Formulation, Optimization and Evaluation of Flurbiprofen Liposomal Gel
Abstract: The present study deals with effect of various combinations of lecithin, cholesterol, chloroform-methanol and tween-80 on liposomes of flurbiprofen. Optimization of the flurbiprofen liposomes by Design Expert software was done. Vesicle size, drug content, SEM and entrapment efficiency were evaluated. Flurbiprofen gel with optimized liposome using Carbopol 934 as gelling agents, were formulated. pH, spreadability and drug content in the gel were evaluated. Results of skin irritation study showed that …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 8, Issue 2, 2017 · pp. 33–42 Read article
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Formulation and Evaluation of Diltiazem Hydrochloride Sustained Release Matrix Tablets
Abstract: Tablets are the most popular and versatile formulations with wide acceptance when compared to other dosage forms due to ease of administration, storage and transport. Diltiazem HCl is a calcium channel blocker widely used for its peripheral and vasodilator properties in the treatment of hypertension and angina. The objective of the present study is to prepare and characterize novel sustained release tablets of freely water soluble drug Diltiazem HCl using …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 6, Issue 2, 2015 · pp. 17–27 Read article
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Formulation and Evaluation of Verapamil Solid Dispersion Tablets for Solubility Enhancement
Abstract: This study was mainly designed to solve the drawbacks of conventional verapamil solid dosage form, low bioavailability and limited clinical efficacy, by preparing solid dispersion. Verapamil solid dispersion was developed by kneading method, melt solvent method and co-precipitation method to modify the release and enhance solubility of the drug. The physical state of the dispersed verapamil in the polymer matrix was characterized by differential scanning calorimetry, powder X-ray diffraction, scanning …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 7, Issue 1, 2016 · pp. 39–54 Read article
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Formulation and Development of Soft Chewable Palm Tree Jaggery Based Cough Lozenges
Abstract: Lozenges are used for treatment of relief from severe cough, Phargnitis, throat infections, and the common cold. Comparative studies were carried of the herbal lozenges with two different sweetening agents, jaggery and crystal sugar. Herbal Lozenges were prepared using Aloe vera gel, pepper powder, dry ginger powder, clove powder, dried powder of tulasi, mint leaves, Liquorice powder and turmeric as major medicament and palm tree jaggery or crystal sugar served …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 12, Issue 3, 2022 · pp. 47–52 Read article
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Formulation and Evaluation of Buccal Mucoadhesive Bilayered Tablets of Enalapril Maleate
Abstract: The buccal mucoadhesive bilayered tablets of Enalapril Maleate were fabricated with objective of avoiding first pass metabolism and prolonging the duration of action. The tablets were prepared by wet granulation wherein, one layer comprised of drug and bio adhesive polymer, whereas second layer consisted of drug free backing layer of ethyl cellulose. Bioadhesive polymers like Carbopol 934P and one either of three HPMC K4M/ HPMC K15M/ HPMC K100M were employed …
Published in Trends in Drug Delivery · Vol. 1, Issue 1, 2014 · pp. 1–15 Read article
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Formulation Evaluation and Optimization of Orodispersible Tablets of Pantoprazole Sodium by the using of Different Superdisintigrants
Abstract: The objective of this study was to formulate and optimize an orodispersible formulation of pantoprazole sodium using a 32 factorial design for optimized the superdisintigrant concentration. Various concentration (2%,4%,6%) of superdisintegrants (SSG, CP) were added in formulation, all processing steps are carried out at temperature below 250C and relative humidity less than 35%. Procedure to manufacture orodispersible tablets by direct compression was established. The results show that the presence of …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 7, Issue 3, 2017 · pp. 11–20 Read article
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Formulation and Evaluation of Transungual Drug Delivery of Fluconazole Using Permeation Enhancers Screened by Hydration of Nail Plate
Abstract: The objective of the work was to formulate nail lacquer containing fluconazole an antifungual drug for the treatment of onychomycosis. Onychomycosis, a common fungal nail infection affects the people. Topical and ungual therapy is limited because of the poor permeation of the drug through nail plate. Film base was prepared using varying concentration of cellulose acetate and ethyl cellulose as polymers. The permeation enhancers were screened by nail plate hydration. …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 8, Issue 3, 2017 · pp. 32–45 Read article
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Regulatory Requirements for Registration of Generic Drug Products in Japan
Abstract: Drug registration is a procedure of expertise of the pharmaceutical product quality, efficacy and safety by regulatory authority. The emergence of various formats has enabled the manufacturers of drugs to easily gain access into various markets and thus, was able to place their products in the market. The choice of Japan as one of the destinations for the market of the Drug products ensures the manufacturer a good market value. …
Published in Trends in Drug Delivery · Vol. 2, Issue 2, 2015 · pp. 19–27 Read article
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Development and Fabrication of Biohydrogel for Targeted Delivery of Delafloxacin for Bacterial Skin Infections
Abstract: The escalating challenge of bacterial resistance necessitates innovative drug delivery systems to enhance the efficacy of antibiotics. This study focuses on the development and optimization of a biohydrogel formulation for the targeted delivery of Delafloxacin, aiming to improve its therapeutic outcomes against resistant bacterial strains. Utilizing a 3² factorial design, biohydrogel formulations incorporating Poly(N-isopropylacrylamide) (PNIPAM) and Genipin were synthesized. The optimization process was guided by Design Expert software, focusing on …
Published in Research & Reviews: A Journal of Drug Design & Discovery Read article
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Formulation, Evaluation, and Stability Studies of a Topical Clotrimazole and Zinc Oxide Suspension with Enhanced Skin Protective Properties
Abstract: Background: Clotrimazole is a well-known antifungal agent frequently used in the treatment of various superficial fungal infections, while Zinc Oxide is a widely accepted skin protectant with soothing, astringent, and antimicrobial properties. Combining these agents in a topical suspension offers a dual therapeutic approach, enhancing both antifungal efficacy and skin protection. Objective: The objective of this study was to formulate, evaluate, and conduct stability studies on topical suspensions containing Clotrimazole …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 3, 2025 · pp. 22–31 Read article
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Formulation and Evaluation of a Polyherbal Lip Scrub Containing Beetroot, Licorice, and Aloe Vera
Abstract: The current research is aimed at developing and assessing a polyherbal lip scrub which contains beetroot extract, licorice extract and aloe vera gel to enhance better exfoliation, nutritional and depigmentation. The fusion method was applied to the herbal extract formulations by varying systematically the concentration of the herbal extracts to develop the 4 formulations (F1-F4) each of 15 g. These prepared formulations were tested on their important physicochemical and functional …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 2, 2026 · pp. 47–55 Read article
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Assessment of the Reinforced Slope Stability Under Earthquake Loading
Abstract: Failure of the soil slopes by dynamic excitation is one of the most vital geotechnical earthquake hazards which may lead to serious destruction to the bridge abutments, dams, embankment, and structures resting on the slope. Moreover, due to deficient space available for the construction of slopes in urban areas, high and steep slope is constructed by geotextile reinforcement slopes. In this study, numerical modelling is made to study the behaviour …
Published in Journal of Geotechnical Engineering · Vol. 8, Issue 2, 2021 · pp. 29–37 Read article
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Seismic Analysis of G+10 Building With and Without Zipper Brace Frame
Abstract: This paper presents a seismic analysis of a G+10 building with and without Zipper Brace Frame (ZBF). The research begins with a detailed literature review, investigating the existing seismic-resistant techniques employed in high-rise buildings. The Zipper Brace Frame is introduced as an innovative system that has shown promising results in enhancing seismic performance while maintaining architectural aesthetics. Two analytical models are created: one without bracing systems and the other incorporating …
Published in Journal of Structural Engineering and Management · Vol. 10, Issue 3, 2023 · pp. 27–34 Read article
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Corn Husk Fiber–Reinforced PLA Biocomposites: Mechanical, Thermal, and Biodegradation Performance
Abstract: The increasing environmental burden caused by conventional petroleum-based plastics has driven significant interest in the development of sustainable polymer composites reinforced with renewable natural fibers. In the present work, corn husk fiber (CHF), an agricultural waste by-product, was utilized as a reinforcing phase in a polylactic acid (PLA) matrix to fabricate eco-friendly biocomposites. Composite samples with varying fiber loadings (0–40 wt.%) were produced through twin-screw melt blending followed by compression …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 312–327 Read article
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Formulation and Evaluation of a Natural Excipients-Based Diclofenac Sodium Topical Ointment
Abstract: The present study reports the formulation and evaluation of a diclofenac sodium topical ointment incorporating natural excipients to improve skin compatibility and formulation sustainability. Conventional topical non-steroidal anti-inflammatory drug (NSAID) formulations frequently rely on synthetic excipients that may cause dermal irritation and pose environmental concerns. To address these limitations, a 1% w/w diclofenac sodium ointment was developed using aloe vera gel, glycerin, xanthan gum, peppermint oil, vitamin E, and isopropyl …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 2, 2026 · pp. 14–26 Read article
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Simplified Solution to Analysis Risk Assessment of Reinforcement type Soil Wall Considering Seismic Waves with Uniform Surcharge
Abstract: Due to failure of reinforced soil wall in various country the various risk factor are associated to these failure. In the present pseudo-static analysis some risk factor analysis have been done by considering the seismic waves with uniform surcharge and also consider surcharge’s inertial behavior at risk factor of horizontal and vertical coefficients of accelerations at kh = 0.24, 0.36 and kv = 0.12, 0.18 taking into account. The earlier …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 452–458 Read article
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Integrated Computational and Bio-catalytic Transformations: DFT-Guided Mechanistic Insights, Machine Learning, and Nano-biocatalyst Engineering for Sustainable Catalysis
Abstract: Computational catalysis has emerged as a transformative scientific discipline that integrates quantum chemistry, molecular modeling, machine learning, and density functional theory (DFT) to understand catalytic mechanisms and design highly efficient catalytic systems for sustainable industrial applications. The increasing global demand for environmentally responsible chemical manufacturing has accelerated research on advanced catalytic materials including transition metal catalysts, metal–organic frameworks (MOFs), homogeneous catalysts, heterogeneous systems, and bimetallic catalysts involving nickel and iron. …
Published in Journal of Catalyst & Catalysis · Vol. 13, Issue 2, 2026 · pp. 36–44 Read article
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Biomedical Approach to Developing and Characterizing Chitosan Nanoparticles Encapsulating Urapidil for Hypertension Management
Abstract: The aim of this study was to create Chitosan Nanoparticles loaded with Urapidil to achieve controlled drug release, enhance solubility, and reduce dosing frequency to improve patient adherence to therapy for hypertension. Urapidil was formulated into nanoparticles via the ionic-gelation method using Chitosan as a polymer, Sodium tripolyphosphate as a cross-linking agent, and filled into hard gelatin capsules after lyophilization. Pre-formulation studies, including melting point analysis and determination of the …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 1, 2024 · pp. 43–51 Read article