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394 articles for “diabetics”
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Computational Identification of Protein Tyrosine Phospatase-1B (PTP-1B) Inhibitors for Checking Type II Diabetes
Abstract: Protein tyrosine phosphatases (PTPs) are a family of enzyme that comprises of about 100 proteins which catalyze dephosphorylation of phosphotyrosine residues in protein substrates. Phosphotyrosine is a central element in cell signaling, and its activity is essential for cellular homeostasis and for appropriate responses to extracellular signals. PTP-1B antagonizes insulin signaling by reducing the activation state of the insulin receptor kinase, thereby inhibiting post-receptor signaling in insulin responsive tissue. The …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 6, Issue 3, 2017 · pp. 21–25 Read article
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Patient Teaching for Cardiac Rehabilitation in Cardio Diabetes
Abstract: Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide, and are a significant contributor to morbidity and health-related costs. Coronary artery disease (CAD)—the most common type of CVDs—is considered as a chronic condition and, therefore, requires a careful medical management with multiple recommendations for patients to achieve optimal secondary prevention. As a consequence, patient education is a necessary step to promote patient understanding of the recommended therapies and behavior …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 7, Issue 2, 2017 · pp. 29–35 Read article
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Synthesis and Evaluation of Novel Peroxisome Proliferator Activated Receptor-γ (PPAR-γ) Agonists for the Treatment of Diabetes
Abstract: A series of novel thiazolidinedione derivatives as peroxisome proliferator activated receptor-gamma (PPAR-gamma) agonists bearing different fatty acid esters and amides as substituents in the positions 3 and 4 of the benzylidene moiety have been designed, synthesized and tested as potential antihyperglycemic agents. The compounds containing stearic acid (A1TU, A2TU, A3TU, A2TS and A3TS) exhibited the maximum activity (64.7-70.3 % BG reduction) among all the synthesized compounds. The capric acid containing …
Published in Research and Reviews: A Journal of Toxicology · Vol. 6, Issue 2, 2016 · pp. 1–12 Read article
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Anti-hyperglycemia Effects of Plant Secondary Metabolites Towards PKA/CREB Pathway Activation in Diabesity
Abstract: Objective: Diabesity, the amalgamation of diabetes and obesity, presents a significant global health challenge. This research carefully examines how plant secondary metabolites influence glucose regulation in diabetes using the PKA/CREB pathway, paying particular attention to diabesity—the combination of diabetes and obesity. Understanding the complex ways in which these metabolites affect metabolic health will help to identify new treatment approaches for managing diabetes and its associated problems. By conducting a thorough …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 33–50 Read article
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Development and Characterization of a Solid Dispersion of an Anti-Diabetic Drug Using Pectin as a Natural Polymer
Abstract: Aim: The current study sought to improve the solubility and oral bioavailability of gliclazide by creating solid dispersions and oral dispersible tablets (ODTs) with enhanced physicochemical characteristics and maintained antidiabetic action. Methods: Preformulation studies were conducted to evaluate the physicochemical properties of gliclazide, including physical appearance, melting point, solubility, and partition coefficient. Solid dispersions were prepared using hydrophilic carriers-pectin and PVP K30, and subsequently characterized by Fourier Transform Infrared Spectroscopy …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 2, 2026 · pp. 01–12 Read article
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Management of RCT Treated Fractured Teeth with Lack of Interocclusal Space in Diabetic and Hypertensive Patient
Abstract: Multi-disciplinary levels of care, including repairing failed treatments that negatively affect the mouth and smile, treatment of maxillofacial (jaw and face) abnormalities, treatment of cases stemming from congenital disorders as well as cases stemming from oral/maxillofacial trauma or neglect and advanced dental care for complex anatomical features of the teeth, gums and supporting bone structure. Prosthodontists work closely with their patients to develop a comprehensive treatment plan and to help …
Published in Research and Reviews: A Journal of Dentistry · Vol. 3, Issue 3, 2012 · pp. 7–13 Read article
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Medicinal Plants with Potent Antidiabetic and Wound Healing Activity: A Review
Abstract: Wound healing is impaired in diabetic patient with infection or hyperglycemia, and because of the increasing incidence of diabetes worldwide wound healing occupies an important and developing fields of research in modern biomedical sciences. As such process of wound healing is highly complicated and becomes more complex when associated with a condition like diabetes which itself is a substantial socioeconomic and quite serious life burden. As a consequence of its …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 4, Issue 1, 2015 · pp. 21–36 Read article
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Antidiabetic Potential of Bryophyllum pinnatum: A Study on its Pharmacological Effects and Synergistic Action with Glibenclamide
Abstract: Diabetes is a long-term metabolic disorder that profoundly impacts an individual’s overall health, social interactions, and quality of life. While significant progress has been made in diabetes management with the use of medications such as insulin and oral hypoglycemic agents, the limitations of these existing treatments highlight the need for new therapeutic alternatives. Moreover, the high cost of current diabetes medications makes them inaccessible to many, particularly in rural areas …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 2, 2025 · pp. 18–30 Read article
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Covid-19 Associated Mucormycosis: Urgency To Reconsider The Uncontrolled Use Of Prophylactic Drugs
Abstract: Mucormycosis, a lethal mycosis, has affected hundreds of COVID-19 sufferers in India. Mucormycosis, previously known as zygomycosis, is due to the diverse fungi that belong to the family "Mucorales." These molds are normally determined in soil, air, and damp partitions and often colonize oral mucosa, nose, paranasal sinuses, and throat. The pathophysiological results of diabetes mixed with the intense inflammatory surge in COVID-19 and steroid remedy weaken a person's immunity …
Published in Research and Reviews: A Journal of Medicine · Vol. 11, Issue 3, 2021 · pp. 12–17 Read article
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Development of a Polymeric Detection System for Salivary Annexin-1: A Potential Tool for Point-of-Care Diagnostics in Periodontal Disease
Abstract: Salivary annexin-1, a protein with anti-inflammatory properties, has emerged as a potential biomarker for periodontal disease. However, current detection methods, like ELISA, are often complex and require laboratory settings. This study explores the development of a novel polymeric detection system for the rapid and sensitive identification of salivary annexin-1. This system could leverage the unique properties of polymers to create a point-of-care diagnostic tool for: (1) early detection and monitoring …
Published in Journal of Polymer & Composites · Vol. 12, Issue 5, 2024 · pp. 101–110 Read article
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Effect of Glycemic Control on Sputum Conversion at the End of Intensive Phase of Category I DOTS Therapy among Patients with Pulmonary Tuberculosis
Abstract: India is an endemic country of tuberculosis and diabetic capital of the world. A patient with diabetes has more chance of occurrence tuberculosis. Many studies pointed out the merging epidemic of diabetes and tuberculosis. Rifampicin and Isoniazid are the most prominent drugs in anti-TB treatment. These drugs disrupt the metabolism of many anti-hypoglycemic agents and lower the plasma levels, leading to hypogycemia. In non-diabetics, it impairs the release and action …
Published in Journal of Nursing Science & Practice · Vol. 10, Issue 1, 2020 · pp. 13–17 Read article
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Hydroxylated Chalcone Derivatives as Future Aldose Reductase Inhibitors: Discovery through Docking Technique
Abstract: The research endeavors molecular docking assisted exploration of ALR inhibitory perspectives of some B-ring substituted hydroxyl group (A-ring) containing chalcone compounds against human aldose reductase in complex with NADP+ and the inhibitor IDD594 (PDB ID: 1US0) by utilizing the iGEMDOCK (Genetic Evolutionary Method for Molecular Docking) software. The present investigation immensely focused on the human aldose reductase inhibitory perspectives of some hydroxylated chalcone compounds. The inhibition of the enzyme by …
Published in Research and Reviews : Journal of Computational Biology · Vol. 8, Issue 1, 2019 · pp. 8–12 Read article
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Exploring The Multitarget Pharmacological Mechanism of Diabex for T2dm by Combining Network Pharmacology and Molecular Docking Techniques
Abstract: Objective: Hyperglycemia brought on by an absolute or relative absence of insulin synthesis or action characterises a set of illnesses known as diabetes mellitus. Chronic hyperglycemia in diabetes mellitus has been linked to organ damage, heart, and blood vessels. The persistent metabolic condition Diabetes is a severe global issue with negative social, health, and economic effects. It is a type of metabolism disorder that interferes with food digestion in the …
Published in International Journal of Bioinformatics and Computational Biology Read article
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Recombinant Insulin
Abstract: Recombinant insulin, a revolutionary product of biotechnology, has transformed the landscape of diabetes treatment. Developed through genetic engineering techniques, recombinant insulin offers a safer, more consistent alternative to traditional animal-derived insulin. Its production involves the insertion of the human insulin gene into host organisms such as Escherichia coli or Saccharomyces cerevisiae, which serve as efficient factories for insulin synthesis. Recombinant insulin is used to treat diabetic patients who are allergic …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 39–43 Read article
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In Vivo Hypoglycemic Activity of Aqueous Leaf and Root Extracts of Macaranga Barteri Müll. Arg. (Euphorbiaceae) In Swiss Albino Mice
Abstract: Background: Macaranga barteri Müll. Arg. is a perennial plant in the family Euphorbiaceae and is used in African traditional medicine for the management of several ailments, including diabetes. Although the leaves and stem bark have been studied for various pharmacological activities, little is known about the therapeutic value of the roots. Objective: This study evaluated the in vivo hypoglycemic activity of aqueous leaf and root extracts of M. barteri in …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 15, Issue 2, 2026 · pp. 60–78 Read article
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Image Preprocessing And Analysis On Eye Fundus Images Segmentation By Using Density Clustering Methods
Abstract: Abstract: In order to do an automated evaluation of various retinal illnesses such as Diabetic retinopathy, Glaucoma, and Macular Edema, fundus images must be pre-processed first. For many reasons, it's difficult to accurately detect the optic disc. Many blood vessels cross the optic disc, making it difficult to discern the disc's boundaries in fundus images. Lesion regions in diabetic retinopathy look very much like an optic disc's colour and texture, …
Published in Recent Trends in Sensor Research & Technology · Vol. 8, Issue 3, 2021 · pp. 11–18 Read article
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A Case Report on Metformin-induced Pancreatitis
Abstract: Metformin is a biguanide commonly used in type 2 diabetes mellitus. About 2% of acute pancreatitis is caused by drugs. Drug induced pancreatitis cases generally do not cause much harm but rarely results in fatality. Metformin is considered to be a safe drug with minimal side effects and only few papers suggest Metformin is associated with drug induced pancreatitis. Among the published case reports the mechanism postulated are drug overdose, …
Published in Research and Reviews: A Journal of Medicine · Vol. 9, Issue 1, 2019 · pp. 9–10 Read article
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Limitations to Therapeutic Approaches to T2DM in Light of Different HbA1C Values Suggested by Different Scientific Associations: A Review
Abstract: The present article provided a comprehensive review of international and national guidelines for managing Type-2 diabetes, with a focus on personalized treatment strategies. It discussed the recommended glycated haemoglobin targets and the initial treatment approach involving lifestyle modifications and the use of metformin. The present article underlined the necessity for treatment intensification due to the progressive nature of type-2 diabetes. It also emphasized the complexity of selecting additional antidiabetic medications, …
Published in Research and Reviews: A Journal of Medicine · Vol. 13, Issue 2, 2023 · pp. 13–26 Read article
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Madhu piramium in Siddha: Correlation with Chronic Glycosuria-Induced Urogenital Tract Infection in Male and its Clinical Characterization
Abstract: Urinary tract infection (UTI) is the most common bacterial infection encountered in clinical practice. Madhu piramiam is a syndrome described in Siddha system includes the symptoms of male urogenital infection in diabetes mellitus.To evaluate the correlation of madhu piramiam in Siddha with a syndrome of urogenital discharge of male patients with glycosuria in diabetes mellitus and to characterize the disease in the perception of Siddha. Clinical research was carried on …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 1, Issue 03, 2014 · pp. 24–34 Read article
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Insulin : Comprehensive review on its Crucial Role in Metabolism and Disease Management
Abstract: Insulin's pivotal function lies in meticulously regulating blood sugar levels, thus guaranteeing cells access to the necessary energy for optimal functionality. When there is a rise in blood sugar, after a meal, the releases insulin gets released from the pancreas to facilitate the uptake of glucose by cells. Insulin primarily acts on muscle, fat, and liver cells, promoting the uptake of glucose from the blood. Another way to store glucose …
Published in International Journal of Virus Studies · Vol. 1, Issue 1, 2024 · pp. 37–43 Read article