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1896 articles for “role”
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Gene Expression Profiling in Autism Spectrum Disorder: A Microarray Analysis Using Gse42133
Abstract: Autism Spectrum Disorder (ASD) is a diverse neurodevelopmental disorder characterized by difficulties in social interaction, communication impairments, and restricted or repetitive patterns of behavior. Despite its increasing prevalence, the underlying molecular mechanisms remain poorly understood. Advances in transcriptomics offer opportunities to investigate the gene expression changes that may contribute to ASD pathophysiology. In this study, the microarray dataset GSE42133 was analyzed, which comprises gene expression profiles from peripheral blood samples …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 13, Issue 1, 2026 · pp. 37–48 Read article
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Comprehending Ancient Wisdom of Ayurveda: Unveiling Phytochemistry and Molecular Mechanisms of Rasayana Medicine
Abstract: Rasayana medicine is an integral part of ancient medical system of India. In Sanskrit ‘rasayana’ refers to “path of essence” and serves as one of the eight clinical specialties of classical Ayurveda. Rasayana focuses on restoring health by replenishing vital fluids of human body. According to Ayurveda, our physical body constitutes of seven dhatus called ‘Sapthdhatu’, sapth-seven and dhatu-tissues or microchannels. These channels are the pathway through which vital nutrients …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 14, Issue 3, 2025 · pp. 59–67 Read article
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Exploration of Diverse Epoxy-Based Surface Coating Methods for Enhancing Anticorrosion Characteristics
Abstract: Epoxy-based polymers, commonly referred to as polyepoxides, constitute one of the most versatile and widely adopted categories of polymeric materials due to their exceptional structural, mechanical, and chemical characteristics. Their unique macromolecular framework enables strong interfacial bonding, high mechanical stability, and superior resistance to environmental and chemical degradation, positioning them as advanced alternatives to many traditional organic corrosion inhibitors that often fail under prolonged exposure to aggressive conditions When polyepoxides …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 167–177 Read article
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Impact of Hypoxia on Cardiopulmonary Adaptation in Canines: A Comprehensive Review
Abstract: Hypoxia triggers a series of cardiopulmonary responses that play an important role in oxygen delivery and the continuation of physiological activity in mammals. Canines are also a useful translational model of study to examine these adaptive responses because of their anatomical, physiological, and cardiopulmonary differences with humans. This review summarizes the experimental data of acute, subacute and chronic hypoxia in dogs with particular focus on the variations in cardiac functioning, …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 15, Issue 1, 2026 · pp. 13–24 Read article
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Machining-Induced Surface Integrity Optimization of High-Carbon Alloy Steel for Enhanced Polymer–Metal Composite Interface Performance
Abstract: The functional performance and structural reliability of polymer–metal hybrid composites are strongly influenced by the surface integrity of metallic substrates used for interfacial bonding and load transfer. In this context, machining-induced surface characteristics play a critical role in determining adhesion behavior, dimensional stability, and mechanical compatibility within composite architectures. The present study investigates the hard turning performance of a newly developed high-carbon alloy steel intended for composite-integrated structural applications, with …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 1531–1546 Read article
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Identification of Hub Genes and Enriched Gene Ontology & Pathways in Idiopathic Pulmonary Fibrosis Through Bioinformatics Approaches
Abstract: Idiopathic Pulmonary Fibrosis (IPF) is a progressive interstitial lung disease marked by aberrant remodeling of lung tissue and excessive extracellular matrix deposition, ultimately leading to respiratory failure. Despite ongoing research, the molecular mechanisms underlying IPF remain incompletely understood. This research aims to uncover differentially expressed genes (DEGs) and related biological pathways through an integrated analysis of microarray data. Two publicly available datasets, GSE110147 and GSE53845, were obtained from the Gene …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 13, Issue 1, 2026 · pp. 1–13 Read article
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Medically Important Hemiptera: Bed Bugs and Kissing Bugs in Human Health.
Abstract: Bed bugs (family Cimicidae) and kissing bugs (subfamily Triatominae) are hematophagous Hemiptera of major medical importance, yet they differ markedly in their public health impact. Bed bugs have resurged globally over the past three decades, with infestations reported from homes, multi-unit housing, hotels, transportation, and healthcare facilities in both high and low-income settings. They are not established biological vectors of human pathogens, but their bites cause pruritic papules, urticarial, and …
Published in International Journal of Insects · Vol. 3, Issue 1, 2026 · pp. 41–49 Read article
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The Mycobiome Frontier – Pre & Post 2020 Status: Integrating Fungal Bioactive Compounds, Probiotics, and Antimicrobial Peptides in Modern Therapeutics and Biotechnology.
Abstract: The fungal kingdom represents an indispensable resource in modern therapeutics and biotechnology, offering a diverse array of bioactive compounds, probiotics, and antimicrobial peptides (AMPs). Functional fungal polysaccharides (FFPs), such as beta-glucans, chitin, and mannans, are centrally involved in modulating the human gut microbiota, providing novel therapeutic avenues for chronic conditions including diabetes, neurodegenerative disorders, and cancer. These compounds act as prebiotics, nourishing beneficial bacteria and enhancing metabolic parameters such as …
Published in International Journal of Fungi · Vol. 3, Issue 1, 2026 · pp. 1–11 Read article
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Engineering Anti-Tau Monoclonal Antibodies for Alzheimer’s Disease and Parkinsonian Tauopathies: A Biotechnological Perspective
Abstract: Neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease are characterized by progressive neuronal loss associated with abnormal protein aggregation. Among these, tauopathies are defined by the accumulation of hyperphosphorylated tau protein, which plays a central role in disease progression. Advances in biotechnology have enabled the development of anti-tau monoclonal antibodies (mAbs) as promising therapeutic agents aimed at neutralizing pathological tau species and inhibiting their propagation. This review provides a …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 16, Issue 1, 2026 Read article
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Optimizing Smart Grids and Microgrids
Abstract: The widespread deployment of distributed energy resources, the integration of renewable energy sources, and the digitalization of the energy sector have, in a very short time, radically changed old power systems to more intelligent and resilient networks. The change is mainly about smart grids and microgrids that enable real-time monitoring, decentralized control, and improved power quality. The employment of smart meters, advanced communication platforms, and distributed generation elevates the operational …
Published in International Journal of Advanced Control and System Engineering · Vol. 4, Issue 1, 2026 · pp. 44–49 Read article
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Marine Fungi – An Expandable Source for Production of Novel Bioactive Metabolites: A Comprehensive Review
Abstract: The marine environment, representing the largest and most extreme biome on Earth, serves as an unparalleled reservoir of biodiversity. Within this vast ecosystem, marine fungi have emerged as a prolific source of structurally diverse and pharmacologically active secondary metabolites. Dwelling in habitats characterized by extreme high salinity, high hydrostatic pressure, and low temperatures, these microorganisms have evolved unique biochemical and metabolic pathways to synthesize novel compounds, including pyrrole-imidazole alkaloids, cyclic …
Published in International Journal of Fungi · Vol. 3, Issue 1, 2026 · pp. 30–37 Read article
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GLP-1 Receptor Agonists: A Dual Therapeutic Strategy for the Management of Type 2 Diabetes Mellitus and Obesity
Abstract: For the treatment of obesity and type 2 diabetes mellitus (T2DM), glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have become a revolutionary class of pharmaceutical drugs. These drugs were first created as glucose-lowering treatments, but they have now shown other advantages, such as notable weight loss, better cardiovascular results, and general metabolic control. The objective of this narrative review is to assess the pharmacological mechanisms, clinical efficacy, safety profile, and therapeutic …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 1, 2026 · pp. 69–75 Read article
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A Study to Assess the Impact of Safe Delivery app on Knowledge Regarding Modern Contraception Among Final Year B. Sc Nursing Students in Chittoor Dist., AP
Abstract: Background: Postpartum hemorrhage (PPH) remains a leading cause of maternal mortality, particularly in low-income countries, highlighting the importance of skilled healthcare providers. Mobile health innovations such as the Safe Delivery App (SDA) have demonstrated effectiveness in strengthening knowledge and skills in obstetric emergency management. However, limited evidence exists regarding its role in improving knowledge of modern contraception among nursing students, who represent the future maternal health workforce. This study aimed …
Published in International Journal of Women's Health Nursing And Practices · Vol. 4, Issue 1, 2026 · pp. 29–34 Read article
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Comparative Study of Time Slice Windows Analysis and Impacted As-Planned Analysis for Data Center Construction Projects Using Primavera P6 24.12 Version
Abstract: Data centers are IT infrastructure that needs to be precisely scheduled and coordinated. Significant financial losses and operational failures may result from building delays. Stakeholders can assign blame and comprehend the reasons behind delays with the aid of forensic delay analysis. Because of their unique approaches and legal acceptability, TSWA, and IAPA are commonly used among the many strategies. These methods provide various ways to analyze project schedules and pinpoint …
Published in Journal of Construction Engineering, Technology & Management · Vol. 16, Issue 1, 2026 · pp. 33–51 Read article
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Climate-Induced Drought, Food Insecurity, and Adaptation Governance: A Multiscale Review of Risks and Policy Responses in Africa and South Asia
Abstract: Drought is one of the most critical climate-induced hazards, severely affecting agricultural systems, water resources, and human well-being, particularly in Sub-Saharan Africa and South Asia. This review provides a comprehensive analysis of the multidimensional impacts of drought by examining its effects on food security, population displacement, and institutional adaptation across selected case studies from West Africa, South Africa, and coastal Bangladesh. The findings reveal that increasing climate variability and prolonged …
Published in International Journal of Environmental Planning and Development Architecture · Vol. 4, Issue 1, 2026 · pp. 1–8 Read article
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Integrating Social Perception and Economic Valuation for Riparian Zone Preservation: Evidence from Kiliti Watershed, Ethiopia
Abstract: Riparian zones play a crucial role in maintaining watershed health by providing ecosystem services such as water filtration, erosion control, biodiversity conservation, and aesthetic and cultural benefits to surrounding communities. Despite their importance, riparian areas in many developing countries are increasingly degraded due to agricultural expansion, grazing pressure, and settlement encroachment. This study integrates social perception analysis with economic valuation to assess riparian zone preservation in the Kiliti Watershed, Northwestern …
Published in International Journal of Environmental Planning and Development Architecture · Vol. 4, Issue 1, 2026 · pp. 49–55 Read article
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Nature-Integrated Day-Care Spaces: Fostering Early Childhood Growth in Lucknow
Abstract: The physical environment plays a vital role in shaping early childhood experiences, influencing cognitive, emotional, and social development. However, in rapidly urbanizing cities such as Lucknow, children’s exposure to natural environments has become increasingly limited, with most day-care centers confined within enclosed, concrete settings. This study investigates how the integration of natural elements within day-care interiors and outdoor spaces can foster holistic child development and enhance learning outcomes. Emphasizing the …
Published in International Journal of Architectural Design and Planning · Vol. 4, Issue 1, 2026 · pp. 7–18 Read article
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Assessing Utility of Parks: A Study of Parks in Raipur, India
Abstract: With the rapid growth of urbanization in India, urban parks are taking center stage as vital recreational spaces and community gathering spots. As cities continue to densify and open spaces shrink, public parks increasingly serve as essential infrastructure that supports physical health, social interaction, and environmental well-being. In addition to offering leisure and recreation, urban parks contribute to urban resilience by improving microclimatic conditions and enhancing the overall quality of …
Published in International Journal of Urban Design and Development · Vol. 4, Issue 1, 2026 · pp. 42–57 Read article
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Modulating Immune System of Mosquitoes with A Novel Salicylate Derivative: A Bioinformatics-Based Study
Abstract: The present study aims to compare the interactions of a novel derivative of salicylic acid, 5-(2-nitroethynl) salicylic acid (5-SANA, salicylic acid nitroalkene), and salicylic acid with the critical residues of mosquito’s juvenile hormone binding protein (mJHBP). Given the better water solubility of 5-SANA and salicylic acid, it is believed that they can interact quicker than the natural substrate, juvenile hormone (JH), with the cavity of mJHBP, a circulating protein in …
Published in Research and Reviews : A Journal of Immunology · Vol. 16, Issue 1, 2026 · pp. 1–5 Read article
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Divorced Women Attitudes Towards Remarriage: A Qualitative Approach
Abstract: The current study aimed to investigate the attitudes of divorced women regarding remarriage and to comprehend the diverse factors that shape their viewpoints. The research population comprised divorced women, and a purposive sampling method was employed to select participants. Data were collected from ten divorced women through semi-structured interviews, allowing for in-depth exploration of personal experiences and viewpoints. A qualitative research design was adopted to capture the complexity of individual …
Published in International Journal of Behavioral Sciences · Vol. 3, Issue 1, 2026 · pp. 1–14 Read article