Search
218 articles for “Drug toxicity”
-
Application of Graphene in Health and Medical Areas
Abstract: A comprehensive overview of the current state of graphene research in the health and biomedical field are presented here. The graphene and its derivatives hold immense potential for various applications in biotechnology, biomedicine, and bioengineering. The unique physicochemical properties of graphene, such as thermal conductivity and high-specific area, make it a promising material for advancements in drug delivery, bio-imaging, biosensors, and tissue engineering. However, there is an increasing anxiety surrounding …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 10, Issue 3, 2023 · pp. 1–9 Read article
-
An Overview of Gene Therapy
Abstract: Gene therapy is a revolutionary technique in medical science that seeks to cure or stop illnesses by means of introducing, altering, or quieting genes inside a patient's cells. Advancements in molecular biology, genetics, and biotechnology have propelled this field forward markedly changed over the last few decades. The underlying idea of gene therapy is to introduce genetic material into target cells via viral or non-viral vectors to rectify faulty genes, …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 89–105 Read article
-
A Review on Quantum Dots and Their Bioimaging Applications
Abstract: Quantum dots are nanoscale semiconductor crystals engineered to emit highly intense, photo-stable luminescence with quantum yields reaching 90%. Structurally, they are synthesized as single-substance core types, hetero-structured core-shell architectures for enhanced stability, or blended alloys. They are further categorized by synthesis and functional traits into colloidal, magnetic, and highly fluorescent varieties, alongside specialized silicon and eco-friendly carbon-based variants derived from organic waste. Due to their exceptional optoelectronic properties, they are …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 16, Issue 2, 2026 · pp. 41–60 Read article
-
Pathways in Drug Discovery and Development: From Molecular Targets to Market Approval
Abstract: A complicated, multidisciplinary, and resource-intensive process, the discovery and development of new pharmacological drugs is essential to the advancement of contemporary medicine. Finding and optimising lead chemicals comes after a disease-relevant biological target has been identified and validated. Through preclinical research in animal models, these leads are thoroughly assessed for toxicity, pharmacokinetics, safety, and efficacy. Clinical trials, which are carried out in several stages to evaluate safety, efficacy, ideal dosage, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 1, 2026 · pp. 01–04 Read article
-
Nanotechnology: Applications in Regenerative Medicine
Abstract: Nanotechnology presently has many uses in practically every one of the fields. The introduction of nanomedicine has benefitted many research areas in pharmaceutical industries. The usage of nanoparticles in drugs has shown great results that the other drugs did not. In the development of novel medicine, nanotechnology is playing an important role. It is because few medications cannot be used due to complications such as its toxicity, this can be …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 12, Issue 2, 2022 · pp. 1–5 Read article
-
Magnetic and Radioactive Nanoparticles for Improved Theranostics and AI Assisted Radiation Therapy
Abstract: Nanoparticles based therapeutic and theranostics technique is becoming an active area of research in nanomedicine. The sensitivity, biocompatibility, and stability of magnetic and radioactive nanoparticles determine their functionality. This research highlights the impacts of magnetic and radioactive nanoparticles on therapeutic techniques namely, cell therapy, gene therapy, and tissue regeneration. Then, it is intended to brief a principal role of these therapeutic techniques to envisage theranostics medicine and radiation therapy using …
Published in International Journal of Advance in Molecular Engineering · Vol. 3, Issue 2, 2025 · pp. 10–21 Read article
-
Graphene Oxide: A Potential Drug Carrier for Cancer Therapy—Review
Abstract: Graphene oxide (GO) is a single or few layer’s sheet derived from graphite using strong oxidizing agents. Graphene oxide possesses outstanding aqueous processability, amphiphilicity, functionalizability, surface enhanced area and fluorescence ability. Hydrophilicity is an important property for mixing the material with ceramic or polymer matrixes while trying to improve their electrical and mechanical properties. Acquiring a promising application in the biomedical area, graphene molecules undergo complex interactions with the biological …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 8, Issue 3, 2017 · pp. 21–31 Read article
-
Progress in Pharmacological Potential of Thione Substituted 1,3,4-Thiadiazoles: A Review
Abstract: Heterocyclic nucleus 1,3,4-thiadiazole constitutes an important class of compounds for new drug development. From the last decade, good research is going on the 1,3,4-thiadiazole ring, as a result of which, many research groups has developed novel clinically useful compounds. These compounds had shown its importance as anti-inflammatory, analgesic, antimicrobial, antitumor, antifungal, antimycobacterial, anticonvulsant, antidiabetic, antiviral agents etc. So far, the modifications of the 1,3,4-thiadiazole ring has proven highly effective way …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 3, Issue 2, 2012 · pp. 9–34 Read article
-
Nutraceutics: Opening the Debate for a Framework for the Safety and Efficacy of Nutraceuticals Formulations
Abstract: As of right now, there is no precise definition for nutraceuticals that distinguishes them from other food-based categories such herbal products, dietary supplements, pre- and probiotics, functional foods, and fortified foods. Several studies have shed light on the possible mechanisms of action of pharmaceutically active ingredients in food, emphasizing their ability to improve health, lower the risk of disease, and promote general wellbeing. However, Nutraceuticals confront difficulties in substantiating safety …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 1, 2024 · pp. 27–33 Read article
-
Recent Advances in Nanobiotechnology: Applications and Future Perspectives
Abstract: Nanobiotechnology is a rapidly growing field that combines the principles of nanotechnology with biology, medicine, and biotechnology. This review article provides an overview of recent advances in nanobiotechnology and their applications in various fields, including drug delivery, imaging, biosensors, tissue engineering, and nanomedicine. The article also discusses the challenges and future prospects of nanobiotechnology. This review article provides an overview of recent advances in nanobiotechnology and their applications in various …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 24, Issue 3, 2022 · pp. 43–47 Read article
-
Pylorus Ligation Induced Gastric Ulcer Protection by Sesamum Indicum Ethanolic Seed Extract
Abstract: The present study was performed in pylorus ligation induced ulcer model in Wister rats, in which ability to provide gastric protection was studied at two different doses 200 and 400 mg/kg calculated based on the acute toxicity study. Gastric protection was evaluated by assessing various parameters like gastric volume, pH, total acidity, free acidity, ulcer index and percentage inhibition of ulceration. Ranitidine at 50 mg/kg was used as the standard …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 6, Issue 3, 2015 · pp. 42–49 Read article
-
In-Silico Design and Study of Novel Tetrahydro-β-Carbolines as Inhibitor of HIV-1 Reverse Transcriptase
Abstract: In the present study, we have designed 50 novel tetrahydro-β-carboline derivatives as non-nucleoside inhibitors of HIV-1 reverse transcriptase. Docking studies of designed analogs were performed by molecular modeling software AutoDock 4.2 using HIV-1 reverse transcriptase (PDB ID: 1RT2) as receptor. Lipinski rule of five parameters and toxicity parameters were derived through online servers Molinspiration and Osiris property explorer respectively. Docking parameters such as binding free energy and predicted inhibitory constant …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 3, Issue 1, 2016 · pp. 19–30 Read article
-
Solanum viarum Dunal: Ethnomedicinal Importance, Phytochemical Profile and Pharmacological Potential — A Comprehensive Review
Abstract: Solanum viarum Dunal, commonly known as tropical soda apple or Sodom apple, is a medicinally important plant belonging to the family Solanaceae. The plant has been widely utilized in traditional medicine systems for the treatment of fever, cough, skin disorders, inflammation, gastrointestinal ailments, and microbial infections. The present review comprehensively summarizes the ethnomedicinal importance, phytochemical profile, pharmacological activities, and pharmaceutical significance of S. viarum. Literature reports indicate that the plant …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 13, Issue 3, 2026 Read article
-
Ethnomedicinal, Pharmacological and Phytochemical Screening of Supari (Areca catechu Linn.): A Review
Abstract: Supari (Areca catechu Linn.) is a tall tree about 10–20 m long. It is used both locally and internally. Local application is beneficial in various acute inflammatory conditions in the form of gargle, vaginal douche or abzan, decoction, juice and oil. Internally it act as muqavvie-qalb (cardiotonic) and muqavvi-e-ama (intestinal tonic), sozish meda (gastric irritation), dries the excessive secretions of mouth, used in vomiting and nausea, strengthen the teeth and …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 8, Issue 1, 2018 · pp. 6–20 Read article
-
Methodologies for in silico and in vitro Test of Biphenylalanine Compounds as Potential HIV-1 gp120 Attachment Inhibitors
Abstract: We postulate that biphenylalanine and its derivatives are propitious candidates to inhibit the binding of HIV-gp120 to CD4 T-cell. Many biphenylalanine derivatives are synthesized chemically and also prevailing in nature. We have proposed atom- and bond-based 2D TOMOCOMD-CARDD approach to identify the best derivative. Moreover, according to our proposition, the principal law simulated from in silico interaction of gp120 with CD4 can be tested by ELISA in vitro. Furthermore, the …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 2, Issue 3, 2015 · pp. 38–42 Read article
-
Engineering of PEG-b-PCL/Pluronic F127 Polymeric Composite Micelles for Controlled Co-Delivery of Docetaxel and Curcumin in Prostate Cancer Therapy
Abstract: Polymeric composite nanocarriers made from amphiphilic block copolymers are popular for their customisable architecture, self-assembly behaviour, and drug release control. A PEG-b-PCL/Pluronic F127 micellar composite was developed and tested as a multifunctional nanocarrier for docetaxel and curcumin administration.The amphiphilic block copolymers Pluronic® F127 and PEG-b-PCL were employed to generate polymeric micelles using solvent evaporation-assisted self-assembly. The optimised polymer composite showed good colloidal stability and uniform size distribution with a zeta …
Published in Journal of Polymer & Composites · Vol. 14, Issue 5, 2026 Read article
-
Samelisant, an H3 Receptor Agonist as an Anti-Alzheimer Potential – A Pilot Study on Molecular Docking
Abstract: Neurodegenerative diseases have become more prevalent and about 55 million of the population are affected by dementia globally. One of the most important neurodegenerative diseases is Alzheimer’s disease which is known for its effect on memory and cognitive impairment. Alzheimer’s disease (AD) is an area of intense scientific investigation due to its high prevalence and the lack of a definitive cure. Amyloid precursor protein plays a central role in Alzheimer’s …
Published in International Journal of Brain Sciences · Vol. 3, Issue 1, 2026 · pp. 15–26 Read article
-
Coronavirus – a Journey from Unknown to Known
Abstract: AbstractGlobally, a unique virus, novel coronavirus-19 affected the humanity in year of 2019. The virus resulted in a pandemic condition. The disease widespread affects the population of all age group. According to updated data, virus results in high mortality rate. Globally 4, 69,587 deaths and 8,993,659 confirmed cases were reported to WHO. The clinical manifestations includes respiratory symptoms and include fever, cough and shortness of breath. In criticalcondition, infection can …
Published in Research and Reviews: A Journal of Toxicology · Vol. 10, Issue 2, 2020 · pp. 32–39 Read article
-
In Silico Study of Histone Deacetylase Inhibitor as Anticancer Agents
Abstract: The clinical selective histone deacetylase inhibitor vorinostat is most commonly used for the treatment of lymphoma and solid tumor and has been preventing lives worldwide. Vorinostat is used in both treatment and prevention of lymphoma and other tumors. Based on these for current study some vorinostat derivatives with thiadiazole moiety containing derivatives have been designed for in silico study. For present work, the already selected study was against histone human …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 6, Issue 2, 2019 · pp. 6–23 Read article
-
Quality Control of Ayurvedic Drugs
Abstract: Ayurveda is the ancient most system of medicine and most of Indian population uses Ayurvedic drugs in some form [1]. Their high cultural acceptability is due to the experienced safety and efficiency over centuries of use. Because of their unique effects and relatively low side effects, this medicine has been gaining popularity all over the world. British physicians travelled to India to observe rhinoplasty being performed using native methods [2]. …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 3, Issue 3, 2016 · pp. 24–27 Read article