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1953 articles for “phosphoinositol-3-kinase pathway” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
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Visualization of genomic sequence in BRCA1 and BRCA2
Abstract: Heredity is the main reason of breast cancer in women and mutation or genetic variations also another reason for the spread of breast cancer. Heredity and genetic variations are responsible 5%-10%, 30%-50% respectively. There are 90% chances of developing neoplasm by the mutations. The effect of BRCA1 and BRCA2 may leads to the variations in DNA therefore it should be in limited amounts so that there will be minimum changes …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 1, 2025 · pp. 49–55 Read article
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Computational Identification of Antigenic Proteins and Epitopes in Hantavirus sp. for Drug Repurposing
Abstract: Hantavirus is an emerging virus that spreads from animals to humans and can cause serious illnesses like hantavirus pulmonary syndrome (HPS) and hemorrhagic fever with renal syndrome (HFRS). there are no FDA-approved treatments available for these diseases. This study explores in-silico drug repurposing as a strategy to identify potential therapeutic candidates. The physicochemical, secondary structure, antigenicity, and post-translational modification analysis of hantavirus proteins – specifically the glycoprotein precursor, N protein, …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 20–26 Read article
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Comparative Evaluation of the Pozzolanic Activity of Artificial Pozzolans: Steel Slag, Fly Ash, and GGBFS
Abstract: Evaluating the pozzolanic activity of specific industrial waste is crucial given the growing demand for cementitious materials. This research aims to expand the possibilities of incorporating pozzolanic waste such as Steel Slag (SS) as additives to cement. SS is a byproduct of the steel production process. A byproduct of the steelmaking process, slags have long been used as aggregates in building materials like concrete and roads. A closed-loop structure and …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 341–361 Read article
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Computational Investigation of Phytochemicals Targeting AKT1 for Major Depressive Disorder: A Molecular Docking and ADMET Study
Abstract: Major depressive disorder (MDD) is a prevalent neuropsychiatric condition affecting approximately 280 million individuals worldwide, with women exhibiting a 50% higher likelihood of diagnosis than men. Despite significant advancements in treatment, MDD remains a chronic and relapsing disorder, necessitating the exploration of novel therapeutic interventions. This study focuses on the AKT1 gene, a key player in neuropsychiatric disorders, and investigates its interactions with natural phytochemicals as potential alternatives to conventional …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 2, 2025 Read article
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Gesture-Based Cursor Control: A Comprehensive Review of Techniques and Applications
Abstract: Although hand gesture detection for man-machine interfaces has advanced recently, many systems still have issues with background and lighting. We have developed a rapid motion history image-based system to categorize dynamic hand motions and a face detection method to adaptively detect skin color. For the up, down, left-, and right-hand gesture classifiers, four sets of haar-like directional patterns were trained. To operate different household appliances, six hand gestures were defined, …
Published in International Journal of Electrical and Communication Engineering Technology · Vol. 3, Issue 1, 2025 · pp. 9–13 Read article
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Participatory Demonstration of Grass Strips as Biological Soil and Water Conservation Measures in Kamba Woreda, South Ethiopia
Abstract: Land degradation due to soil erosion and soil fertility depletion is a significant threat to the agricultural system, limiting food security and sustainable agricultural production. This study demonstrated Desho grass strips as biological soil and water conservation measures in Kamba woreda Gamo zone south Ethiopia. Six (6) nearby trial farmers who took part in the demonstration directly were chosen for the study using the purposive sample technique. Sole maize and …
Published in International Journal of Land · Vol. 1, Issue 1, 2024 · pp. 1–10 Read article
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Investigating the Dietary Flexibility and Feeding Behavior of Clarias anguillaris and Auchenoglanis biscutatus in a Tropical River Ecosystem
Abstract: Studies on food and feeding habits of fishes are required to guide the selection of fish species for culture. The current study determined the food and feeding habits of Clarias anguillaris and Auchenoglanis biscutatus in the Lower River Benue at Makurdi, Nigeria. Fish samples were collected biweekly from local fishermen at the Wadata landing site who fished with different gears like gillnets, cast nets, hook and line, traps and lift …
Published in International Journal of Marine Life · Vol. 2, Issue 1, 2025 · pp. 1–9 Read article
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Investigation of the Electrical Properties of a Forest and Its Impact on Radio Wave Propagations
Abstract: There are two important parameters that represent the forest electrical properties. They are permittivity, Ԑr and conductivity, δ of the forest. These parameters were observed to affect the radio wave propagation in forest. The study of radio wave propagation in forested environment becomes necessary since radio communication is propagated by electromagnetic wave (EMW) travelling through different environments, The main objective of this research was to investigate a simulated model for …
Published in Research & Reviews : Journal of Physics · Vol. 13, Issue 2, 2024 · pp. 18–25 Read article
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Effect of Different Doses of Phosphorus on the Growth and Yield of Mung Bean (Vigna radiata L.)
Abstract: Phosphatic fertilizers play a vital role in enhancing mung bean production by not only improving crop yield but also increasing the quality of the produce. A field trial was done at the Nepal Polytechnic Institute research field to determine the effect of different levels of phosphorus on yield of Mung bean at Bharatpur, Chitwan during the summer season 2024. The test was carried out as per Randomized Complete Block Design …
Published in Research & Reviews : Journal of Agricultural Science and Technology · Vol. 14, Issue 2, 2025 · pp. 1–7 Read article
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Health Risk and Evaluation of Atmospheric Pollutants in Owerri Metropolis and Sub-Urban Areas of Imo State, Nigeria Using Chemometric Models
Abstract: Concern about health risk from atmospheric pollutants; Particulate Matter (PM10), Sulphur dioxide (SO2), Nitrogen dioxide (NO2) and Carbon Monoxide (CO) prompted atmospheric monitoring and inhalation health risk assessment for residents of Owerri Metropolis and its Sub-urban areas. Field measurements were carried out in 35 select locations within Imo State. Monitoring was carried out using Chemometric methods as Matrix Laboratory (MATLAB) and Artificial Neural Network (ANN). According to the experiment results, …
Published in Research & Reviews : Journal of Statistics · Vol. 13, Issue 1, 2024 · pp. 47–79 Read article
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Modular and Prefabricated Design: Shaping the Future of Interior Spaces
Abstract: This paper explores the emerging trend of modular and prefabricated design in the interior design industry, highlighting its potential to revolutionize the creation of residential and commercial spaces. The study examines the advantages of these approaches, including cost efficiency, sustainability, and design flexibility, while also addressing the challenges such as design constraints and regulatory hurdles. Through the analysis of contemporary projects and innovative case studies, the research demonstrates how modular …
Published in Research & Reviews : Journal of Statistics · Vol. 13, Issue 1, 2024 · pp. 12–19 Read article
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Heat Transfer by Arc Welding for A Similar Material Joint
Abstract: Electric arc welding (EAW) is a traditional fabrication process used in wider domestic, commercial and industrial application. Welding is a joining of two materials with the application of heat at the molecular level with the application of heat and pressure. Many materials used for welding application for different joining process. Maraging steel is special steel used for production of different air-craft components. Maraging material is used for heavy tools, producing …
Published in Journal of Materials & Metallurgical Engineering · Vol. 15, Issue 2, 2025 · pp. 1–13 Read article
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Screening of Newer Phytoconstituents on Novel Enzymes for their Biological Activity
Abstract: Background: Hyperlipidemia and gout are prevalent metabolic disorders significantly impacting global health. The xanthine oxidase and HMG-CoA reductase pathways play pivotal roles in the pathophysiology of these conditions. This study explores the potential of natural phytoconstituents—daidzein, resveratrol, and genistein—as dual inhibitors for these enzymatic targets, offering insights into innovative therapeutic strategies. Aim: To evaluate the potential of natural phytoconstituents—daidzein, resveratrol, and genistein—as dual inhibitors of xanthine oxidase and HMG-CoA reductase …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 1, 2025 · pp. 81–86 Read article
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Au@Sio2@PVP-DCMD Membranes: A Breakthrough in Heavy Metal Removal and Antibacterial Defense
Abstract: This study investigates the development and characterization of multifunctional gold-doped silica (Au@SiO₂) membranes for water distillation and antibacterial applications. The manufacturing process integrated gold nanoparticles into silica matrices using sol-gel techniques. Structural analysis was conducted using SEM (showing uniform pore distribution with an average pore size of 40-50 nm), FTIR (confirming Si-O-Si and Si-Au-Si bonding peaks at 525 cm⁻¹ and 1310 cm⁻¹ respectively), EDX (revealing gold nanoparticle content of 1.5 …
Published in Journal of Polymer & Composites · Vol. 13, Issue 3, 2025 · pp. 13–27 Read article
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A Comprehensive Review on Neturaceuticals in Alzheimer's and Neurodegenerative Disease an Cognitive Enhancement
Abstract: Neurodegenerative diseases, including Alzheimers disease (AD), Parkinsons disease (PD), and related cognitive disorders, represent a significant and growing public health challenge, particularly in aging populations. Despite advances in pharmacological treatments, therapeutic options for cognitive decline and neurodegeneration remain limited. Recent interest has shifted towards nutraceuticals— bioactive compounds derived from food or natural sources—as promising adjuncts or alternatives in the management of these conditions. This review examines how nutraceuticals can help …
Published in International Journal of Brain Sciences · Vol. 2, Issue 1, 2025 · pp. 1–9 Read article
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Study on Chemical Insights into Alzheimer's Disease: Amyloid Beta and Tau Protein Interactions
Abstract: Background: Alzheimers disease (AD) is the most prevalent form of dementia, affecting millions of individuals worldwide and posing significant challenges to healthcare systems. The disease is characterized by a gradual decline in cognitive functions, particularly memory, reasoning, and the ability to perform daily activities. Aim & objective: To study chemical insights in alzheimers disease, especially amyloid beta and tau protein interactions Results & discussion: The results of this review highlight …
Published in International Journal of Brain Sciences · Vol. 2, Issue 1, 2025 · pp. 37–46 Read article
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Assessment of Differential Global Positioning System (DGPS Technology for Generating Accurate Topographic Maps and Controls: A Case Study of Farin-Lamba to Kwali College Area
Abstract: This study investigates the application of Differential Global Positioning System (DGPS) for topographic mapping and control point establishment in Farin-Lamba to Kwali College Area. The second order Survey controls extension are critical indices for ensuring structural and border control mechanisms in environmental development projects. However, creating these controls using traditional ways presents major obstacles. Most modern techniques are improvements on ancient approaches, which raises the possibility of environmental dangers and …
Published in International Journal of Land · Vol. 2, Issue 1, 2025 · pp. 11–23 Read article
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Effect of 4-Week Protocol of Kegel Exercise on Pelvic Floor Strength on a Patient with Ovarian Endometriosis—A Case Report
Abstract: Purpose: The purpose of this case study was to describe the effects of Kegel exercise in a 4-week protocol for a patient with endometriosis associated with urinary incontinence. Case description: A 23-year-old female patient presented with chronic low back pain and also complained of difficulty in holding urine and leakage while doing forceful activities like lifting heavy objects, coughing, and sneezing in the past 6 months. She also complained of …
Published in International Journal of Women's Health Nursing And Practices · Vol. 3, Issue 1, 2025 · pp. 9–14 Read article
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Influence of Nanomaterial on Biofuel Extracted from Lemon Seed Feedstock
Abstract: Biodiesel, which is a type of biofuel, offers a replacement to the traditional diesel fuel currently available on the market, which is derived from petroleum that is both more sustainable for the environment and more attractive from an economic standpoint. A plethora of environmental benefits can be obtained through the utilization of this technology, including a reduction in emissions of greenhouse gases and particulate matter, as well as the possibility …
Published in Journal of Polymer & Composites · Vol. 13, Issue 2, 2025 · pp. 200–210 Read article
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Preparation and Characterization of PVA-MgO Nanocomposite Films
Abstract: In this work, Magnesium Oxide Nanoparticles (MgO NPs) doped with 3 g of polyvinyl alcohol (PVA) at different weight percentages (0, 2, 4, 6, and 8 wt.%) using the solvent casting method, to fabricate thin PVA-MgO nanocomposite (NC) films. These films were characterized by (i) XRD, SEM, EDX, DLS, and Zeta Potential for morphological studies, (ii) FTIR spectra and UV-Visible techniques for spectroscopic studies and (iii) DSC for thermal studies. …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 27, Issue 2, 2025 · pp. 40–62 Read article