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245 articles for “sequencing”
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Antimicrobial Peptides in Fiddler Crabs: Structural Analysis and Potential Applications
Abstract: Crustaceans represent the largest and most ecologically and economically significant group of marine and aquatic arthropods. Their biomass and critical role in ecosystems highlight their importance. Among crustaceans, decapods are frequently used as model organisms in studies of immune responses due to their significant commercial value and the need to mitigate disease outbreaks in shellfish aquaculture. Antimicrobial host-defense peptides (AMPs) are pivotal in metazoan immunity, especially for invertebrates lacking adaptive …
Published in International Journal of Cheminformatics · Vol. 2, Issue 2, 2024 · pp. 26–32 Read article
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Screening of Newer Phytoconstituents on Novel Enzymes for their Biological Activity
Abstract: Background: Hyperlipidemia and gout are prevalent metabolic disorders significantly impacting global health. The xanthine oxidase and HMG-CoA reductase pathways play pivotal roles in the pathophysiology of these conditions. This study explores the potential of natural phytoconstituents—daidzein, resveratrol, and genistein—as dual inhibitors for these enzymatic targets, offering insights into innovative therapeutic strategies. Aim: To evaluate the potential of natural phytoconstituents—daidzein, resveratrol, and genistein—as dual inhibitors of xanthine oxidase and HMG-CoA reductase …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 1, 2025 · pp. 81–86 Read article
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Shell Scripting and Unix Programming: Foundations and Techniques
Abstract: Shell scripting and Unix programming are essential components of modern computing, enabling users to automate repetitive tasks, manage system operations, and optimize productivity. Unix, known for its robustness and multi-user capabilities, provides a powerful command-line interface (CLI) that allows efficient system interaction. Shell scripting enhances this functionality by enabling users to execute sequences of commands, making automation seamless and reducing manual effort. Different scripting paradigms: imperative, procedural, functional, and event-driven, …
Published in Journal of Advances in Shell Programming · Vol. 12, Issue 1, 2025 · pp. 10–16 Read article
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Molecular Mechanisms of Drug Metabolism in Anesthesia: A Pharmacogenomic Perspective
Abstract: Pharmacogenomics studies how a person’s genetic profile affects their reaction to drugs, which is vital in anesthesia. Anesthetic pharmacology depends significantly on drug metabolism, which involves complex biochemical processes that manage the absorption, distribution, metabolism, and excretion (ADME) of anesthetic drugs. The cytochrome P450 (CYP) enzyme family plays a critical role in the metabolism of various anesthetic drugs, with genetic polymorphisms leading to inter-individual variability in drug responses. Specific CYP …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 90–95 Read article
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Advancements in Plant Molecular Biology and Genetics: Insights into Genetic Engineering, Genomics, and Crop Improvement
Abstract: This comprehensive review explores the rapidly advancing fields of plant molecular biology and genetics, offering a thorough examination of contemporary research and innovative methodologies that contribute to a deeper understanding of plant development, improved crop productivity, and the mitigation of environmental challenges. Recent breakthroughs in genetic engineering, genomics, and transcriptomics are thoroughly analyzed to provide valuable insights into their practical applications for sustainable agriculture. The integration of cutting-edge tools and …
Published in International Journal of Trends in Horticulture · Vol. 2, Issue 1, 2025 · pp. 25–27 Read article
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Punjabi Text Sentiment Analysis Using Indic NLP
Abstract: Sentiment Analysis has become one of the challenging domains with the gaining popularity of Internet and social media platforms. Sentiment or opinion mining means to know people’s opinion, attitude, views and emotions towards anything. Sentiment analysis in English language has already been analyzing but there is a need of analyzing sentiments in other regional language in which Punjabi language is one of them. Users from the Punjab state of India …
Published in OmniScience: A Multi-disciplinary Journal · Vol. 15, Issue 1, 2025 · pp. 38–42 Read article
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Optimization of Type-4 Plastic Liner Composite Overwrapped Pressure Vessel Design
Abstract: Composite Overwrapped Pressure Vessels (COPVs) are prominently utilized for the storage of gases at high-pressure. Their widespread adoption is because they are significantly lighter weight compared to complete metal counterparts, but requires specialized design, and manufacturing process. This research employs finite element modelling to analyse the stress and failure assessments on a specific Type-IV COPV with plastic liner as core cylinder. This study aims to optimize COPV design by considering …
Published in Journal of Polymer & Composites · Vol. 13, Issue 3, 2025 · pp. 405–412 Read article
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Enhancing Production Line Efficiency: Simulating and Optimizing Single and Parallel Line Processes
Abstract: During a time of fast-paced industrial growth, increasing production line effectiveness is a core issue for manufacturers looking to maximize output, reduce waste, and stay competitive. This study explores the use of simulation-based optimization methods to enhance single and parallel production line designs. Stepping beyond traditional trial-and-error methods, the research utilizes Siemens Tecnomatix Plant Simulation to simulate actual manufacturing scenarios, considering intricacies like buffer capacities, machine sequencing, and event-driven scheduling. …
Published in Journal of Production Research & Management · Vol. 15, Issue 1, 2025 · pp. 22–32 Read article
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Synthesis and Characterization of Polymer-Based Benzamide Derivatives with Potential Biomedical Applications
Abstract: The present study explores the synthesis and characterization of polymer-supported benzamide derivatives, focusing on their potential biomedical applications. The use of polymer-supported synthesis offers several advantages, including improved reaction efficiency, ease of purification, and reusability of the support material, making it an environmentally friendly and cost-effective approach. The synthesis involved a stepwise reaction sequence, with polymeric supports facilitating controlled functionalization and ensuring high product purity. These materials have been widely …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 Read article
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Communication Pathways and Project Success: Analyzing Stakeholder Coordination Impacts on Construction Outcomes
Abstract: It is very critical to have effective communication and coordination among stakeholders for the successful delivery of the projects. Effective communication keeps stakeholders well-informed about project progress, promoting transparency, trust, and collaboration. Coordination ensures that responsibilities and resources are efficiently allocated, reducing the risk of misunderstandings and enhancing decision-making processes. Inadequate stakeholder engagement can lead to confusion, delays, rework, and the failure to meet key project milestones. The impact of …
Published in Journal of Construction Engineering, Technology & Management · Vol. 15, Issue 3, 2025 · pp. 104–126 Read article
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Clone-Specific Drug Delivery Systems: Targeted Approaches and Future Clinical Applications
Abstract: Clone-specific drug delivery systems represent a transformative frontier in personalized medicine, addressing the longstanding challenge of clonal heterogeneity within diseases such as cancer, infectious diseases, and autoimmune disorders. Traditional drug delivery platforms often fail to discriminate between pathogenic and healthy cells, leading to systemic toxicity and reduced therapeutic efficacy. In contrast, clone-specific systems aim to selectively target and eliminate disease-driving cellular clones based on unique molecular signatures, thereby improving treatment …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 21–29 Read article
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A Review on Parametric Optimization of WEDM Technique for OHNS Steel
Abstract: In this study, the Wire Electrical Discharge Machining (WEDM) process for OHNS (Oil Hardened Non-Shrinking) steel, a high-performance material frequently used in the production of dies, punches, and precision tooling components, is optimized parametrically and validated experimentally. A continuously moving wire electrode and a sequence of electrical discharges are used in WEDM, a non-traditional machining method, to erode material and produce intricate and precise profiles, particularly in materials that are …
Published in Trends in Mechanical Engineering & Technology · Vol. 15, Issue 2, 2025 · pp. 29–35 Read article
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COVID-19 Resurgence in 2025: India’s Continuing Public Health Challenge
Abstract: The year 2025 has witnessed the resurgence of COVID-19, reigniting concerns at both global and national levels regarding the persistent threat posed by SARS-CoV-2. In early 2025, India witnessed a moderate resurgence of COVID‑19, characterized by the emergence of Omicron sub-variants and a rise in mild-to-moderate infections. As of mid-June, active COVID‑19 cases in India totaled approximately 6,000–7,400, with hotspots in Kerala (~2,100 cases), Delhi (~600), Maharashtra (~500), and several …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 2, 2025 · pp. 16–23 Read article
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Comprehensive Review of Adenoid Cystic Carcinoma: Pathogenesis, Diagnosis, and Emerging Therapeutic Approaches
Abstract: Adenoid cystic carcinoma (ACC)is an infrequent neoplasm, highly malignant, that develops mainly in the salivary glands with the potential to exist in any secretory glandular sites, including the lacrimal glands, breast, and respiratory tract. ACC usually has a benign initial course, but conversely, it is notoriously aggressive in behavior with high incidence of perineural invasion, local recurrence, and distant metastasis, mostly to the lungs. The tumor’s molecular features are characterized …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 3, 2025 · pp. 1–17 Read article
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Adaptive E-Learning Algorithms and Heutagogy: A Systematic Analysis
Abstract: The proliferation of artificial intelligence (AI) and machine learning (ML) technologies has transformed the digital education landscape by enabling adaptive e-learning systems capable of personalizing content and optimizing learning paths. This study provides a systematic analysis of adaptive e-learning algorithms within the framework of heutagogy, an educational paradigm that emphasizes learner autonomy, self-direction, and capability development. The convergence of adaptive technologies with heutagogical principles offers new avenues for creating more …
Published in Journal of Computer Technology & Applications · Vol. 16, Issue 3, 2025 · pp. 33–38 Read article
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Timestamp Extraction and Log Classification Using Supervised Machine Learning: A Comparative Study
Abstract: In modern software systems, logs are vital for monitoring application behavior, diagnosing issues, and analyzing performance. Timestamps are especially important for sequencing events, identifying anomalies, and understanding system failures. However, detecting timestamps in logs is challenging due to inconsistent formatting across systems and the presence of timestamp-like strings in non-timestamp fields. Traditional rule-based methods often fail in such cases. This study proposes a supervised machine learning approach to accurately classify …
Published in Journal of Software Engineering Tools & Technology Trends · Vol. 12, Issue 3, 2025 · pp. 26–38 Read article
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Quasi-Sobol-Based Optimization and Sigmoid Fuzzy Logic for Efficient Task Clustering in Decentralized Edge-Cloud Architectures
Abstract: Decentralized edge-cloud systems face a lot of issues in efficient task clustering, resource allocation, and real-time decision-making. Conventional methods mostly fail to work well under dynamic workloads and uncertain conditions. This study intends to optimize task clustering through quasi-Sobol-based optimization and Sigmoid Fuzzy Logic for resource allocation, enhancing decision-making accuracy and achieving efficiency in the system at the edge-cloud environment. A hybrid technique that has incorporated optimization via Quasi-Sobol sequences …
Published in Trends in Machine design · Vol. 12, Issue 2, 2025 · pp. 9–18 Read article
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RFID Based Smart Trolley Billing System Using IoT
Abstract: Customers experience better retail interactions while operations become more efficient in the modernizing retail industry. Shopping through traditional methods requires lengthy manual scanning for products and billing operations leading retailers to require automation solutions for streamlining these processes. This system consists of RFID detection alongside 8051 microcontroller processing and load cells monitoring and uses IoT communications and relay controls to power an intelligent automated shopping cart. Real-time data tracking functions …
Published in Journal of Semiconductor Devices and Circuits · Vol. 12, Issue 3, 2025 · pp. 1–8 Read article
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Real-Time Air Quality Prediction Using IoT-Integrated Polymer Sensors and Recurrent Neural Networks
Abstract: Real-time air quality monitoring remains a critical challenge in urban environments, where traditional sensor infrastructures often suffer from limited responsiveness, poor scalability, and high deployment costs. The increasing prevalence of NO₂ pollution, a key contributor to respiratory and cardiovascular ailments, demands advanced sensing platforms capable of both accurate detection and predictive inference. Existing methods either rely on rigid electronic sensors lacking adaptability or on statistical forecasting models that fail to …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 332–347 Read article
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Dynamics of Prime Gap Sets: An Algorithmic and Set-Theoretic Approach
Abstract: In this paper, we present a theorem and an efficient algorithm for computing all prime numbers up to a given integer X. Our theorem establishes a relationship between the primes up to X and those up to (X+1)2, providing a theoretical foundation for the algorithm. The proposed method improves upon the traditional Sieve of Eratosthenes by dynamically eliminating multiples of primes using only the remaining numbers in the set, thereby …
Published in Research & Reviews: Discrete Mathematical Structures · Vol. 12, Issue 3, 2025 · pp. 20–25 Read article