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177 articles for “in-silico studies.”
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Performance Comparison of Noise-Tolerant, High- Performance CMOS Domino Logic Configurations
Abstract: In high-performance VLSI chip design, domino logic configuration is often preferred over static logic due to its faster operation and smaller area footprint, especially in deep submicron (DSM) technology. However, DSM noise has become a significant challenge in domino-based circuits, leading to compromises in the reliability and signal integrity of integrated circuits (ICs). The switching threshold of domino logic, defined as the input voltage level at which the gate output …
Published in Journal of Semiconductor Devices and Circuits · Vol. 12, Issue 2, 2025 · pp. 35–50 Read article
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Experimental Investigations on Aluminium Composites Materials Using Stir Casting Process
Abstract: In physical operations, accoutrements in motorcars and aeronautical machine factors, aluminium and its alloys are extensively used. In this study an effort is made to ameliorate the properties of aluminium essence matrix compound (A356) for manufacturing of machine rudiments taking High Tensile strength, Hardness, Wear resistance and low coefficient of friction, aluminium alloy (A356) reinforced with aluminium oxide, graphite and silicon carbide. In the current work, A356 as base metal …
Published in Journal of Polymer & Composites · Vol. 11, Issue 8, 2023 · pp. 302–323 Read article
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Influence of Aspect Ratio on the Mechanical and Tribological Properties of Vertical Centrifugal Cast Aluminium Silicon Alloy
Abstract: To get a sound cast of precise shape and size in the vertical centrifugal casting process, the flow behavior of the melt and process parameters such as aspect ratio of the mould, rotating speed, volume fraction, etc. must be optimized. The optimal parameters of the vertical centrifugal casting process derived from past cold modelling studies in casting of Al-12%Si alloy are investigated in this paper. Casts were obtained using 7 …
Published in Journal of Polymer & Composites · Vol. 11, Issue 13, 2023 · pp. 104–111 Read article
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Nanostructured Cr-WS2 Solid Lubricant Coating for Space Applications
Abstract: Abstract Tungsten disulphide (WS2) is one of the widely used intrinsic low friction materials, which is commonly used in the form of coating. WS2 offers very low coefficient of friction only in non humid conditions. Presence of humidity destroys this property and restricts its utility. Modifying the structure of WS2 by adding certain metals helps in overcoming this limitation and in addition improves the mechanical properties. Further, deposition technique and …
Published in Journal of Instrumentation Technology & Innovations · Vol. 9, Issue 1, 2019 · pp. 12–18 Read article
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Computational Software Assisted Multiple Therapeutic Targets Oriented Screening of Some Natural Alkaloid Compounds
Abstract: The current efforts endeavor towards the computational exploration of some interestingpharmacological potentials of some natural alkaloids by using the Schrodinger Maestro 9.1software. The excellence in therapeutics was screened against five most imperative targets:Cyclin-Dependent Kinase-5 (anti-cancer), Cycloxygenase-2 (anti-inflammatory), Proteinkinase C (anti-cancer), Dipeptidyl peptidase (anti-diabetic), and Angiotensin-1-ConvertingEnzyme (anti-hypertensive). The alkaloids which were previously reported to possessantibiotic activities against Bacillus subtilis, Staphylococcus aureus, and Mycobacteriumsmegmatis and anti-photo-oxidative, have now perceived to be multi-dimensional …
Published in Research and Reviews : Journal of Computational Biology · Vol. 8, Issue 2, 2019 · pp. 5–9 Read article
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Nanowire Photodetectors and Applications: A Review Study
Abstract: The utilization of nanowires and nanowire structures as photodetectors is an arising research subject. Novel gadget structures incorporated in single nanowire gadgets are additionally being effectively contemplated and created. Here, general NW-PD ideas are investigated, along with a point-by-point depiction of the actual phenomenon happening in nanowire photoconductors & phototransistors. Low dimensional frameworks like nanotubes and nanowires have intriguing, and technologically valuable, optical and electrical properties. Studies on these frameworks …
Published in Journal of Semiconductor Devices and Circuits · Vol. 10, Issue 2, 2024 · pp. 15–19 Read article
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Nanowire Photodetectors and Applications: A Review Study
Abstract: The utilization of nanowires and nanowire structures as photodetectors is an arising research subject. Novel gadget structures incorporated in single nanowire gadgets are additionally being effectively contemplated and created. Here, general NW-PD ideas are investigated, along with a point-by-point depiction of the actual phenomenon happening in nanowire photoconductors & phototransistors. Low dimensional frameworks like nanotubes and nanowires have intriguing, and technologically valuable, optical and electrical properties. Studies on these frameworks …
Published in Journal of Semiconductor Devices and Circuits · Vol. 10, Issue 2, 2024 · pp. 15–19 Read article
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Targeting PTPN22 in Arthritis: Molecular Docking and Pharmacokinetic Evaluation of Artemisia vestita Compounds
Abstract: Rheumatoid arthritis (RA) is a long-term autoimmune condition characterized by inflammation of the synovial membrane, commonly resulting in swelling, pain, stiffness, and overall fatigue. Protein tyrosine phosphatase non-receptor type 22 (PTPN22) has been identified as a risk factor linked to various autoimmune diseases, including RA. In the PTPN22 gene, two missense Single nucleotide polymorphisms (SNPs) are associated with autoimmune conditions. The R620W (C1858T, rs247660) variant in exon 14 has been …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 1, 2025 · pp. 20–31 Read article
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In Silico Prediction of Multitarget Mechanism of Quinoline and Its Analogs on Phosphoinositide-3-Kinase Pathway Proteins
Abstract: Objective: Phosphoinositide 3-kinases (PI3Ks), the target of rapamycin (PI3K/Akt/mTOR, PAM), are a family of enzymes that play a role in the growth, proliferation, differentiation, motility, survival, and intracellular trafficking of cells, all of which are essential for healthy cellular function and are also connected to cancer. In this study, quinoline and its derivatives were employed to analyze its inhibition activity on the phosphoinositide-3-kinase pathway. Methods: In this work, eight phytocompounds …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 57–76 Read article
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A Study On Mems Piezoresistive Pressure Sensor Design And Its Applications
Abstract: Easier and faster means of Pressure measurement is in utmost demand in Industries. MEMS piezoelectric pressure sensors can meet the claim due to its compactness and lightweight. The pressure measurement is purely application specific. The number of steps required to fabricate the MEMs sensor can be condensed if a proper selection of sensor is done. Based on the type of the piezoelectric materials used in the design, the shape of …
Published in Recent Trends in Electronics Communication Systems · Vol. 8, Issue 1, 2021 · pp. 18–23 Read article
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An innovative antibiotic "Abaucin": Instigated by Artificial Intelligence
Abstract: Nosocomial Gram-negative pathogen, Acinetobacter baumannii repeatedly demonstrates multidrug resistance. Discovering novel antibiotics against A. baumannii has proven thought-provoking through conventional screening tactics. Providentially, machine learning approaches allow for the speedy exploration of chemical space, snowballing the probability of determining new antibacterial molecules. In the following research era, a neural network is accomplished with growth reserve dataset and accomplished in silico predictions for structurally unconventional molecules with commotion in divergence to …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 13, Issue 3, 2023 · pp. 29–33 Read article
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Exploring Azadirachta indica’s Potential to Combat Visceral Leishmaniasis Through GP63 Inhibition
Abstract: Objectives: Millions of people worldwide suffer from the parasite disease visceral leishmaniasis. Determine the naturally occurring active ingredients in Azadirachta indica, which are employed as a disease-prevention agent and have several uses in medicine. To choose the best ligand to use as a medication, absorption, distribution, metabolism, and excretion (ADME) studies and molecular docking are employed. Methods: To obtain the GP63 protein, the Protein Data Bank (PDB) database was accessed. …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 2, 2024 · pp. 1–12 Read article
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Exploring the Influence of Rice Husk Ash on Compressive Strength: Experimental Investigations in Construction Materials
Abstract: This paper aims to know the effect of rice husk ash on compressive strength 6 molds were collected and laboratory tests were conducted in cooperation with private laboratories in Baghdad Governorate, Iraq. The tests were conducted for a period of 7 and 28 days, where the samples were divided into 1 control and 5 samples distributed on a different percentage from 5% to 25% of the rice husks. The compressive …
Published in Recent Trends in Civil Engineering & Technology · Vol. 13, Issue 1, 2023 · pp. 24–28 Read article
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Study of Stainless Steel’s Properties for Radiation Safety using Artificial Neural Networks
Abstract: Several general components of reactor are made from stainless steel. Most of the container used for storing nuclear waste is made from stainless steel. In this work, an artificial neural networks (ANNs) model is used to improve the properties of stainless steel during its manufacturing process. The main job of ANNs is determining the layer’s thickness and predicting the influence of different parameters on the growth kinetic of the process. …
Published in Journal of Nuclear Engineering & Technology · Vol. 8, Issue 3, 2018 · pp. 31–40 Read article
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Detailed Study of Working and Applications of FinFET Technology and Its Adaptability in Current Era
Abstract: The CMOS technology is following Moore’s law since almost 25 years. The scaling of CMOS transistor has increased packaging density, speed and decreased power dissipation in the integrated circuits. However, CMOS dimension when scaled to nanometer dimension, many physical barriers arise. In sub-100 nm scale, MOSFET has new variants as SOI implementation and double gate. Keywords: Silicon on insulator (SOI), short channel effect (SCE) [2], buried oxide (BOX)
Published in Journal of VLSI Design Tools and Technology · Vol. 2, Issue 1-2-3, 2012 · pp. 52–58 Read article
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Emerging Digital Trends in Virology Software: Optimizing Viral Discovery, Surveillance,and Patient Management.
Abstract: Virology and antiviral therapeutics are being reshaped by rapid advances in computational tools, automation platforms, and virus-focused digital health applications. Software systems now span the entire virology value chain, from in silico viral target identification and antigen design, to AI-supported clinical trial management for vaccines and antivirals, to post-marketing pharmacovigilance and patient-facing mobile tools. This review examines current and emerging software trends relevant to virus studies, emphasizing applications in viral …
Published in International Journal of Virus Studies · Vol. 3, Issue 1, 2026 · pp. 29–38 Read article
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Optimizing Parameters for Dry Sliding Wear Control in Stir-Cast AA7050/SiC Composites
Abstract: Using a pin-on-disc tribometer, this study examined the dry sliding wear behavior of AA7050/SiC composites. The production of this metal matrix composite was achieved through the stir-casting process, which involved an initial step of melting the AA7050 alloy, followed by the careful introduction of silicon carbide (SiC) particles, stirring to achieve uniform dispersion, and finally, casting the molten mixture. Wear rate (WR) was determined by three operational parameters: SiC reinforcement …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1624–1635 Read article
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In Silico Identification of Therapeutic Agents for Dengue Virus by Molecular Docking
Abstract: The dengue virus causes serious health issues and a loss of quality of life. Dengue poses a yearly threat to half of the world’s population. The drugs that are based on allopathy are expensive and also exhibit toxic effects on tissues and biological activities. It is also generally accepted that most pharmacologically active drugs, including those derived from medicinal plants, are isolated from natural sources. The present study is directed …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 · pp. 01–14 Read article
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Life Cycle Assessment of Solar Panels: Environmental Impacts from Production to Disposal
Abstract: LCA is a way to evaluate the full environmental impact of something—like a product, material, activity, or building—from start to finish. As solar energy adoption accelerates globally, understanding the full environmental implications of PV technology becomes crucial for informed decision-making and sustainable development. The study employs a cradle-to-grave approach, analyzing the environmental footprint of solar panels across multiple impact categories. These include global warming potential, energy payback time, water consumption, …
Published in International Journal of Environmental Planning and Development Architecture · Vol. 3, Issue 2, 2025 · pp. 33–38 Read article
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SU-8 Polymer as an Optical Waveguide for Integrated Optics
Abstract: Abstract: Optical integrated circuits analogous to electronic integration have many advantages over the latter technology. As information carriers are photons (bosons) in optical circuits rather than electrons (fermions), which maximize the speed as well as due to minimum mutual interaction between photons, losses are reduced whereas the band-width increases. Silicon is most dominant material in fabrication of Electronic Integrated Circits (EICs), Photonic Integrated Circuits (PICs) exploits the suitable optical properties …
Published in Journal of Electronic Design Technology · Vol. 10, Issue 1, 2019 · pp. 20–26 Read article