Search
1953 articles for “phosphoinositol-3-kinase pathway” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
Nothing matched all of your words, so these match any of them.
-
Innovative strategies in capsule formulation from concept to market
Abstract: Innovative strategies in capsule formulation have revolutionized drug delivery and nutraceutical development, offering advanced solutions from initial concept to market release. This report explores the transformative techniques at each stage of capsule formulation, detailing novel approaches in ingredient selection, encapsulation technology, and manufacturing processes. By leveraging advancements in artificial intelligence, encapsulation methods, such as liposomal and nanoparticle technologies, and materials science, formulators can optimize the bioavailability, stability, and targeted delivery …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 1, 2025 · pp. 1–8 Read article
-
Ethnopharmacological Insights: Uncovering Plant-Based Neuroprotective Treatments for Neurodegenerative Disorders
Abstract: The development of plant-based therapies for neurodegenerative diseases holds significant promise due to the therapeutic potential of natural compounds, such as Laurus nobilis, Aronia melanocarpa, and celastrol. This review identifies critical literature gaps in the current research, including inconsistent extraction methods, lack of clinical trials, insufficient documentation of long-term effects, limited mechanistic insights, and poor bioavailability. Addressing these gaps through standardization, rigorous clinical trials, advanced delivery systems, and comprehensive ethnopharmacological …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 13–18 Read article
-
Nutraceuticals as Adjunctive Treatment in Cancer Exploring Efficacy and Mechanism of Action
Abstract: Dietary habits are a critical factor in cancer prevention, with plant-based diets rich in vegetables and fruits associated with reduced cancer risk. Nutraceuticals—bioactive compounds derived from food and supplements—have gained attention for their potential in cancer prevention and therapy. Phytochemicals such as flavonoids, polyphenols, and alkaloids exhibit anti-cancer properties through mechanisms including antioxidant activity, anti-inflammatory effects, inhibition of tumor growth, and induction of apoptosis. Key nutraceuticals include alkaloids (e.g., caffeine, …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 1, 2025 · pp. 35–45 Read article
-
Strength Prediction and Optimization of Portland Limestone Cement Blended with Metakaolin and Rice Husk Ash
Abstract: This study explores the effects of Rice Husk Ash (RHA) and Metakaolin (MK) on the compressive strength of Portland Limestone Cement (PLC) mortar, aiming to promote sustainable construction materials. RHA and MK, derived from agricultural and industrial byproducts, serve as supplementary cementitious materials (SCMs) that offer environmental benefits and improve cement properties. Using response surface methodology (RSM) and central composite design (CCD), the research optimized the ternary blend of PLC, …
Published in International Journal of Minerals · Vol. 2, Issue 1, 2025 · pp. 1–14 Read article
-
A Descriptive Study to Assess Knowledge Regarding POSH Act Among Staff of Chirayu Medical College and Hospital, Bhopal, Madhya Pradesh
Abstract: Introduction: Sexual harassment is a significant health issue with severe effects on employees’ self-respect, physical mental health, and dignity. This descriptive study aimed to assess knowledge scores regarding the POSH (Prevention of Sexual Harassment) Act among staff of Chirayu Medical College and Hospital. A convenience sampling method was employed, and data were gathered using a self-designed knowledge questionnaire. The findings indicated that 41% of the staff had poor knowledge, while …
Published in International Journal of Community Health Nursing And Practices · Vol. 3, Issue 1, 2025 · pp. 1–10 Read article
-
Holistic Concept & Management of Male Sexual Disorders in Integrative Unani Medicine
Abstract: Sexual medicine or sexology is a multidimensional field that encompasses a wide variety of sexual dysfunctions and their management by counseling, sex therapy, and drugs. It is very difficult to know the actual prevalence of sexual problems in India. It is estimated that 5 –15% of persons of reproductive age group suffer from sexual disorders or have unsatisfactory sexual relationships. The most common sexual disorders include erectile dysfunction, ejaculatory disorders, …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 12, Issue 1, 2025 · pp. 18–24 Read article
-
Mobility for the Exceptionals: An Adaptable Electrified Transportation System for Manual Wheelchair
Abstract: The survey for the prevalence of handicapped people in India reveals that approximately 4.52% of India’s total population is physically challenged. Among the list, about 44% of people suffer from locomotor disability. Satisfaction of their primary need will be fulfilled when they get aid to move but the main problem is that about 31% of India’s population belongs to middle class or lower middle class. Their wish to buy an …
Published in International Journal of Robotics and Automation in Mechanics · Vol. 2, Issue 2, 2024 · pp. 21–25 Read article
-
Holistic Ayurvedic Approach to Managing Vicharchika (Eczema): Insights from a Case Study
Abstract: Background: Eczema is a common skin condition characterized by inflammatory reactions, manifesting as erythema, scaling, and itching. Nipple eczema is a localized dermatitis involving the nipple and areolar region, characterized by erythema and scaling. It may be itchy and painful and occasionally affect non-atopic breastfeeding women. Eczema has quite a resemblance with Vicharchika in Ayurveda. Vicharchika is characterized by skin manifestations having the symptoms Kandu (itching sensation), Pidika (papule), Shyava …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 14, Issue 1, 2025 · pp. 1–9 Read article
-
A Relationship Between Resilience and Mental Health Among Covid-19 Survivors
Abstract: In 2020, COVID-19 first appeared in Wuhan, China. Covid-19 affects the world at the global level. This pandemic disrupted lives and communities by having a significant negative impact on people's physical and mental health. Resilience helps individuals to bounce back from the crisis. The study examines the connection between COVID-19 survivors' mental health and resiliency. A sample of 100 people, 50 of whom were men and 50 of whom were …
Published in International Journal of Behavioral Sciences · Vol. 2, Issue 1, 2025 · pp. 28–33 Read article
-
Investigation of High reliable electric vehicles drive with fast charging system
Abstract: Per capita, India has the world's biggest battery electric vehicle market. For the last several years, there has been a lot of discussion about the challenges and prospects of integrating electric vehicles (EV) with an electric grid. A battery model of an EV should have suitable control mechanisms to interact with an electric grid. The growth of and accessibility of fast-charging technology is one of the many technological concerns being …
Published in Trends in Electrical Engineering · Vol. 15, Issue 1, 2025 · pp. 44–50 Read article
-
An Observational Study on Prevalence and Risk Factors for OA Knee Joint Among Adult Population Attending the SCSP Camps in Chennai, Tamil Nadu, India
Abstract: Background: Osteoarthritis (OA) is a prevalent degenerative condition affecting older individuals, particularly in developing nations. It is commonly linked to aging and various intricate underlying causes. The complex causes of osteoarthritis include confounding factors that significantly increase the risk of its development, many of which can be managed or prevented. Among all joints, knee osteoarthritis is particularly prevalent, especially in women. In rural India, the SC/ST population faces significant health …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 12, Issue 1, 2025 · pp. 9–17 Read article
-
The potential Role of Antidepressant Medications in DNA Oxidation of Depression Disorder Cases
Abstract: Oxidative stress and DNA oxidation is a main target of different medications side effect, the current work aims to evaluate the potential role of anti-depressed medications in DNA oxidation in depression disorder cases, reactive oxygen species (ROS), total antioxidant (TAO) and 8-oxo deoxyguanine (8-oxo-dG) were detected in depressed disorder cases that treated with different medications included clomipramine, tryptizol, fluxetin, olanzapine, tryptizol with fluxetin, tryptizol with olanzapine and other types of …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 15, Issue 1, 2025 · pp. 41–47 Read article
-
Computational Simulations in Drug Discovery: Modeling Protein Folding and Drug Binding
Abstract: Computational simulations have become essential tools in drug discovery, offering unprecedented insights into molecular behavior at the atomic level. These simulations, particularly in the domains of protein folding and drug binding, allow for the exploration of complex biological systems that are often difficult to study experimentally. Protein folding, a critical aspect of drug discovery, involves the transition of a polypeptide chain from an unfolded to a biologically active structure. Understanding …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 1, 2025 · pp. 23–29 Read article
-
Enhancing Patient Safety: A Study On Adr Monitoring In Tertiary Care Hospitals
Abstract: Background: Adverse drug reactions (ADRs) are a major concern in healthcare, causing patient morbidity and mortality. The objective of this study was to investigate the adverse drug reactions in a tertiary care hospital. Methods: From January to July 2024, an observational study was carried out at Bangalore's Akash Super Specialty Hospital. 51 individuals had their demographics, medications, and suspected adverse drug reactions (ADRs) gathered. The Naranjo scale was used to …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 1, 2025 · pp. 1–7 Read article
-
Analysis of Steel Chip Fiber Reinforced Composite Dual Pile Under Lateral Load Conditions on Sloping Terrain
Abstract: Pile foundations, in addition to supporting vertical loads from superstructures, are subjected to lateral stresses arising from seismic activities, wind gusts, water currents, and traffic impacts etc. Failure to account for these lateral forces can pose significant risks if the structure is expected to encounter any form of lateral pressure. Previous research has investigated the behavior of individual composite piles under horizontal forces, considering different soil properties, to determine the …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 210–220 Read article
-
Impact of the Roll Back Malaria Programme on the Knowledge of Malaria among Pregnant Women in Kaduna State, Nigeria
Abstract: Malaria remains a leading cause of maternal and neonatal morbidity and mortality in Nigeria, disproportionately affecting pregnant women. The Roll Back Malaria (RBM) programme, a global initiative to reduce malaria incidence, aims to improve malaria knowledge and preventive practices among high-risk groups, including pregnant women. This study investigates the impact of the RBM programme on malaria knowledge and prevention behaviours among pregnant women in Kaduna State, Nigeria. A cross-sectional survey …
Published in Research and Reviews: A Journal of Health Professions · Vol. 15, Issue 1, 2025 · pp. 10–21 Read article
-
Performance evaluation of MB plough with combination of different Tillage Implements
Abstract: This study evaluates the performance of tractor-drawn tillage implements in various combinations on clay loamy soil. The research aimed to assess performance parameters such as field capacity, efficiency, depth and width of cut, and energy requirements during seedbed preparation. The experiments were conducted on a 40 × 30 m² plot using multiple tillage combinations, including moldboard (MB) ploughing, MB ploughing combined with cultivating, MB ploughing followed by rotavating, single-pass rotavating, …
Published in Research & Reviews : Journal of Agricultural Science and Technology · Vol. 14, Issue 1, 2025 · pp. 20–26 Read article
-
The Impact of Climate Change on Jute Production in Gaibandha District, Bangladesh
Abstract: Jute plays a crucial role in Bangladesh’s agricultural economy, especially in Gaibandha District, where it is a key crop for rural livelihoods. However, climate change, characterized by rising temperatures and unpredictable rainfall, poses significant threats to jute production. While numerous studies have explored the broader impact of climate change on agriculture, there is a gap in understanding how localized climate conditions specifically affect jute farming in Gaibandha, with many existing …
Published in International Journal of Climate Conditions · Vol. 2, Issue 1, 2025 · pp. 1–17 Read article
-
Drug Design and Process Chemistry: Bridging the Gap between Discovery and Manufacturing
Abstract: This review explores how drug discovery connects with process chemistry to enable large- scale pharmaceutical manufacturing. While drug discovery identifies and optimizes therapeutic compounds, process chemistry adapts these compounds for mass production, addressing challenges in scalability, cost, and quality. The article examines the role of early collaboration between drug designers and process chemists, recent innovations in green chemistry and flow chemistry, and case studies that illustrate successful scale-up strategies. Emerging …
Published in Trends in Drug Delivery · Vol. 12, Issue 1, 2025 · pp. 09–21 Read article
-
Investigating the effect of Anodes workfunction on the Opto-electronics Performance of Organic Light Emitting Diode
Abstract: The research aims to assess the performance of organic light-emitting diodes (OLEDs) by exploring how various anode materials affect their optoelectronic properties. OLEDs are crucial for modern displays and lighting, and their efficiency and functionality are heavily influenced by the materials used in their design.This study examines four different anode materials: Indium Tin Oxide (ITO), Zinc Oxide (ZnO), Aluminum-doped Zinc Oxide (AZO), and Poly(3,4-ethylenedioxythiophene) Polystyrene Sulfonate (PEDOT: PSS). These materials …
Published in Research & Reviews : Journal of Physics · Vol. 13, Issue 2, 2024 · pp. 27–37 Read article