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Research & Reviews: A Journal of Pharmacognosy Review Article

Nutraceuticals as Adjunctive Treatment in Cancer Exploring Efficacy and Mechanism of Action

  1. Mohd. Wasiullah Dept. of Pharmacy, Prasad Institute of Technology
  2. Piyush Yadav Department of Pharmaceutical Chemistry, Prasad Institute of Technology, Jaunpur
  3. Mohit Vishwakarma Dept. of Pharmacy, Prasad Institute of Technology, Jaunpur
  4. Nitesh Maurya Dept. of Pharmacy, Prasad Institute of Technology, Jaunpur

Abstract

Dietary habits are a critical factor in cancer prevention, with plant-based diets rich in vegetables and fruits associated with reduced cancer risk. Nutraceuticals—bioactive compounds derived from food and supplements—have gained attention for their potential in cancer prevention and therapy. Phytochemicals such as flavonoids, polyphenols, and alkaloids exhibit anti-cancer properties through mechanisms including antioxidant activity, anti-inflammatory effects, inhibition of tumor growth, and induction of apoptosis. Key nutraceuticals include alkaloids (e.g., caffeine, taxol), polyphenols (e.g., curcumin, quercetin), and omega-3 fatty acids (e.g., DHA, EPA), all of which influence cancer cell signaling, DNA repair, and immune response. Additionally, traditional herbal remedies, such as those in Traditional Chinese Medicine (e.g., Yangzheng Xiaoji), and marine-derived compounds (e.g., Trabectedin, Kahalalide F) show promise in inhibiting cancer cell adhesion, inducing apoptosis, and blocking angiogenesis. These natural compounds, with their diverse mechanisms, present potential alternatives or adjuncts to conventional cancer treatments, offering a pathway to less toxic, more effective therapies.

Keywords

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