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Trends in Drug Delivery Review Article

Drug Design and Process Chemistry: Bridging the Gap between Discovery and Manufacturing

  1. Mohd. Wasiullah Dept.of Pharmacy, Prasad Institute Technology, Jaunpur
  2. Piyush Yadav Department of Pharmaceutical Chemistry, Prasad Institute of Technology
  3. Amit Kumar Department of Pharmacy, Prasad Institute of Technology, Jaunpur

Abstract

This review explores how drug discovery connects with process chemistry to enable large- scale pharmaceutical manufacturing. While drug discovery identifies and optimizes therapeutic compounds, process chemistry adapts these compounds for mass production, addressing challenges in scalability, cost, and quality. The article examines the role of early collaboration between drug designers and process chemists, recent innovations in green chemistry and flow chemistry, and case studies that illustrate successful scale-up strategies. Emerging technologies like AI, automated synthesis, and bioengineering are also discussed as transformative tools. By integrating design and process, the pharmaceutical industry can more efficiently bridge the gap between lab discoveries and market-ready drugs.This review examines how drug discovery transitions to scalable manufacturing, focusing on process chemistry's role in overcoming challenges from lab synthesis to industrial production. Highlights include emerging technologies and collaborative strategies that streamline this pathway.

Keywords

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