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225 articles for “Controlled Release”
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Polymer Chemistry and Composite Materials in Biomedical Applications
Abstract: The integration of polymer chemistry and composite materials has revolutionized biomedical applications. Recent advancements in polymer synthesis, functionalization, and nanotechnology have further expanded their applications, leading to significant improvements in biocompatibility, biodegradability, and mechanical performance. These polymeric carriers protect bioactive compounds from enzymatic degradation, enable controlled drug release, and improve therapeutic efficacy. The integration of polymer chemistry with nanotechnology has enabled the development of highly efficient, targeted therapeutic systems that …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 413–419 Read article
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Polymer-Based Film Coatings for Enhancing Drug Stability and Shelf-Life
Abstract: Pharmaceutical stability is a crucial factor in ensuring drug efficacy and safety throughout its shelf-life. Polymer-based film coatings have emerged as an effective strategy to enhance drug stability by protecting active pharmaceutical ingredients (APIs) from environmental stressors such as moisture, oxygen, temperature fluctuations, and light exposure. These coatings act as physical barriers that prevent degradation, improve mechanical integrity, and enable controlled drug release. Various types of polymers are employed for …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 558–570 Read article
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Preparation and Characterization of Clay-Based Hybrid Membranes for Antibacterial Biodegradable Polymer Wound Dressings
Abstract: Recent developments in the field of polymer chemistry have resulted in many new forms of Hybrid polymer. This has further revolutionized the application of polymer chemistry in numerous fields. In this research, we manufactured clay-based hybrid membrane by adding clay to the biodegradable matrix of chitosan polymer. It is widely known that microbial and pathogenic organisms are responsible for wound hampering infections such as impetigo. They can spread in bodily …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 13–20 Read article
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Polymeric Nanocomposite Aided Bioaugmentation for Marine Oil Spills – A Review
Abstract: Bioaugmentation is a promising, cost-effective bioremediation technique that enhances the degradation of marine pollutants by introducing hydrocarbon-degrading microorganisms. This review explores recent advancements in the use of bioaugmentation for petroleum biodegradation in marine environments, emphasizing the integration of microbial systems with polymeric and composite materials. Innovative methods, such as the immobilization of microbial cells within biodegradable polymeric matrices (e.g., alginate, chitosan, polyvinyl alcohol), have significantly improved microbial viability, metabolic efficiency, …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 1049–1061 Read article
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Strategies for the Development and Optimization of Orally Disintegrating Tablets (ODTs) to Improve Bioavailability and Patient Compliance
Abstract: Background: Pharmaceutical scientists have developed Orally Disintegrating Tablets (ODTs) to advance patient drug acceptance and biological system availability through simplified medi-cation delivery especially for children and senior citizens and people who cannot swallow pills regularly. The oral disintegrating tablets dissolve in the mouth within thirty seconds or less (USP 701) while needing no additional liquid thus making them suitable for both emergency treatments. Objective: The research examines ODT development strategies …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 · pp. 50–64 Read article
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Toxicological Profiling and Safety Assessment of NASAT 2.0: A Conceptual Framework for Adaptive Nanoparticle Therapy in Rabies
Abstract: Rabies, caused by the highly neurotropic Rabies lyssavirus, remains one of the most enigmatic and universally lethal infectious diseases known to modern medicine. Once clinical symptoms manifest following successful neuroinvasion, the fatality rate approaches absolute certainty (approximately 99.9%), a staggering statistic that has remained largely unchallenged despite massive, concurrent advances in modern virology, critical care medicine, and cellular immunology. Current late-stage therapeutic protocols, most notably the widely debated Milwaukee Protocol, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 2, 2026 · pp. 1–19 Read article
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Integration of Green-Synthesized Calcium Nanoparticles in Natural Polymer Matrices by Bio-Nanocomposite Approach to Calcium Fortification
Abstract: Calcium deficiency continues to pose a widespread nutritional challenge, particularly in vulnerable populations. In this study, a bio-nanocomposite-based fortification strategy was developed using calcium nanoparticles (CaNPs) synthesized via green chemistry from Sesbania grandiflora (Agathi keerai) leaf extract. The nanoparticles, ranging between 50–150 nm in size, were characterized by SEM and embedded into buckwheat flour a naturally polymer-rich food matrix containing proteins, starch, and dietary fibers. The resulting system mimicked polymer …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 Read article
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Chitosan-Based Polymer Coatings for Antimicrobial Catheter Surfaces
Abstract: Catheter-associated infections (CAIs) remain a major clinical challenge. Microbial adhesion and subsequent biofilm formation on catheter surfaces significantly reduce the effectiveness of antimicrobial therapy, resulting in prolonged hospitalization, increased healthcare costs, and higher patient morbidity. Consequently, the development of antimicrobial polymer coatings has emerged as an effective strategy for minimizing catheter-associated infections while improving device performance. Among the various biomaterials investigated, chitosan has attracted considerable attention owing to its intrinsic …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 Read article
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Formulation and Evaluation of Microballoons of Ramipril
Abstract: The present study was an attempt to develop microballoons of Ramipril to prolong gastric residence time in stomach and to control drug release in therapeutic range. Ramipril is ACE inhibitor having short half-life of 2–4 h and bioavailability 28%. Microballoon was formulated using Eudragit E100 and HPMC K4M in different ratios by emulsion solvent evaporation technique using methanol as evaporating solvent and liquid paraffin as a processing medium. Microballoons were …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 5, Issue 2, 2018 · pp. 13–30 Read article
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Microemulsion: Novel Carrier for Drug Delivery
Abstract: Since the discovery of much novel formulation belongs to the lipid based drug delivery system, the handicapped property of drug molecule reverted to the fittest, doable and easily delivered with strategies of improving bioavailability and depleting dose of the same. Microemulsion system is clear, stable, isotropic mixture of oil, water and Smix (Surfactant and co-surfactant mixture), frequently in combination with a co-solvents. To date microemulsions have been shown to be …
Published in Trends in Drug Delivery · Vol. 3, Issue 1, 2016 · pp. 1–18 Read article
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Development and Assessment of Levetiracetam Microspheres Utilizing Synthetic and Natural Polymers: A Biomedical Engineering Perspective
Abstract: In the present study, comparative study of Levetiracetam loaded microspheres using Ethyl cellulose as synthetic and Sodium alginate as natural polymers was done. Solvent evaporation and ionic gelation technique has been successfully employed to produce Levetiracetam loaded ethyl cellulose and sodium alginate microspheres with optimal drug encapsulation that sustained the drug release over a period of time. Based on the pre-formulation studies E1 to E4 and S1 to S4 batches …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 1, 2024 · pp. 1–18 Read article
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Chlorine Leakage from Control Valve in Charging Station Pipeline: A Case Study
Abstract: This paper describes accidental release of chlorine gas from control valve through a chlorine charging system in a green color pigment manufacturing chemical industry. The chlorine gas dispersed over the entire reactor floor and nearby area at night time shift work. This paper presents root cause analysis of the incident. Corrective and preventive measures are also discussed. Finally, conclusions reached with recommendations are drawn for industrial facilities for handling and …
Published in Journal of Industrial Safety Engineering · Vol. 1, Issue 2, 2014 · pp. 1–6 Read article
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Review on Sustained Released Matrix Tablet
Abstract: Pharmaceuticals often use sustained release dose forms to prolong the therapeutic agent’s presence in the bloodstream and maintain a consistent plasma profile. The matrix governs the drug’s release rate. Hydroxypropyl methyl cellulose, a release retardant, is a key excipient in formulations due to its ability to promote sustained release. Techniques that include wet granulation, direct compression, or the dispersion of solid particles within a porous matrix, integrating polymers, like polymethyl …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 60–69 Read article
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Accelerating Drug Discovery with AI: Transforming the Pharmaceutical Pipeline
Abstract: The revolutionary potential of artificial intelligence (AI) is examined in this essay the pharmaceutical industry, highlighting its application across the drug development lifecycle. Artificial Intelligence, specifically via deep learning models and machine learning (ML) such as GANs, RNNs, and transformers, enhances drug discovery, formulation, toxicity prediction, and clinical trials. It streamlines processes like identification of targets, virtual screening, modelling of structure-activity relationships, and medication repurposing. AI is also employed in …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 77–84 Read article
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Nanotechnology In Herbal Medicine
Abstract: Herbal medicine has been widely used for centuries as a natural and holistic approach to health care. However, many herbal compounds face challenges such as low solubility, low bioavailability, instability, and the lack of targeted delivery, which affect their efficacy. The integration of nanotechnology into herbal medicine has emerged as a promising strategy to overcome these challenges and enhance the pharmacological potential of plant-derived compounds. Nanocarriers such as liposomes, solid …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 28, Issue 1, 2025 · pp. 50–69 Read article
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Floating In-Situ Gel for Gastric Retention Delivery
Abstract: When taken orally, medications with a limited window of absorption in the gastrointestinal tract (GIT) are typically accessible to the extremities due to the partial release of the active component and the brief residence period at the absorption site. Because they prolong the duration of the drug's presence in the stomach, they are made with high density and have the capacity to swell. Because oral fluids go more quickly through …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 11, Issue 2, 2024 · pp. 24–32 Read article
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Novel Synthesis of Encapsulated Super Paramagnetic Iron Nanoparticles (Fe3O4) and its Evaluation in Drug Delivery System
Abstract: Nanoparticles can be defined as solid, submicron, colloidal particles ranging in size from 10–100 nm in diameter, generally but not necessarily made of natural or synthetic polymers, in which drugs can be adsorbed, entrapped, that exhibit new or enhanced size-dependent properties as compared to microparticles. Iron oxide nanoparticles are often magnetic by nature, which means that they obey Coulomb’s law, and can be manipulated by an external magnetic field gradient. …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 7, Issue 2, 2016 · pp. 11–24 Read article
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Advances in Polymeric In Situ Drug Delivery and Soft Biosensors: Innovations in Biochemical Sensing and Personalized Healthcare
Abstract: Advanced healthcare and personalized medicine are undergoing a transformation thanks to in situ medication delivery systems and biochemical sensor technology. Polymeric in situ drug delivery systems form gels upon administration, releasing medications in a controlled manner and providing benefits such as ease of administration and enhanced patient compliance. Similarly, advancements in soft electronics, including flexible and stretchable biosensors, enable continuous, in situ biochemical monitoring, conforming to complex biological environments like …
Published in International Journal of Cheminformatics · Vol. 2, Issue 1, 2024 · pp. 27–32 Read article
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Nanoformulation Strategies: Emerging Innovations in Drug Delivery Systems
Abstract: Nanotechnology is significantly advancing the pharmaceutical industry by introducing nanosystems that improve drug delivery, therapeutic efficacy, and patient outcomes. Various nanosystems-such as liposomes, dendrimers, polymeric nanoparticles, solid lipid nanoparticles, carbon nanotubes, and metallic nanoparticles-offer benefits like enhanced bioavailability, targeted delivery, improved stability, and reduced side effects. Innovative formulation strategies, including surface functionalization, particle size optimization, and use of biodegradable carriers, support controlled and sustained drug release. Additionally, production in non-aqueous …
Published in International Journal of Toxins and Toxics · Vol. 3, Issue 1, 2026 · pp. 54–67 Read article
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AWARENESS REGARDING PROTON THERAPY AMONG NURSES
Abstract: Background: Cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths in 2020, or nearly one in six deaths. The most common cancers are breast, lung, colon and rectum and prostate cancers. [1] Proton beam therapy, is a type of radiation treatment that uses a beam of protons to deliver radiation directly to the tumor. The advantage of proton therapy is that the physician can control …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 12, Issue 3, 2023 · pp. 19–23 Read article