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282 articles for “treatment strategy”
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Deciphering the Roles of Estrogen Receptors and 27-Hydroxycholesterol in BC Progression
Abstract: Breast cancer (BC) ranks among the top causes of cancer-related deaths in women worldwide. Many risk factors of BC are linked to estrogen. Experiments of Beatson in 1896 show the role of steroid hormones as major determinant in BC. Action of steroid hormones is mediated by their receptors including Estrogen receptors (ERs). ERs are part of a subfamily of ligand-regulated transcription factors. Their primary role is to translate hormone signals …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 2, 2024 · pp. 18–26 Read article
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The Function of Diuretics in Current Medical Practice and Prospective Advancements
Abstract: Diuretics have a rich history that spans several centuries, and this review aims to highlight their progression and clinical uses. We start by exploring kidney physiology, followed by a description of how diuretics function through symporters in the renal tubules. Different categories of diuretics are outlined, along with details of their specific actions. Next, we investigate the clinical use of diuretics in conditions, such as congestive heart failure and hypertension, …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 1, 2025 · pp. 70–75 Read article
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Sustainable Polymer Composites Reinforced with Natural Fibers: Processing, Properties, and Applications
Abstract: The environmental footprint of synthetic plastics has led to extensive studies of sustainable polymer composites reinforced with natural fibers like jute, sisal, hemp, flax, and coir. These biocomposites offer a greener solution to the conventional petroleum-based materials, which blends biodegradability and competitive mechanical characteristics. The present paper focuses on the processing methods, mechanical and thermal characteristics, and the possible application of natural fiber-reinforced polymer composites (NFRPCs). A survey of 50 …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1663–1670 Read article
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Tensile and Microstructural Behaviour of Friction Stir Welded AL7050 Hybrid Composites Reinforced with Multani Mitti and Cow Dung Ash
Abstract: The study examines Al7050 aluminum alloy composites made by stir casting and bonded by friction stir welding (FSW), supplemented with environmentally friendly Multani Mitti (MM) and cow dung ash (CDA). The study assesses the effects of different hybrid reinforcement contents (0–8 vol%) on the microstructural properties, hardness, and tensile behavior of the base alloy and its FSW joints. Tensile testing reveals an initial decline at 2% reinforcement but a notable …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 78–89 Read article
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Circular Economy Approach in Wastewater Treatment: Recycling and Recovery
Abstract: The demand for freshwater resources has been greatly raised by the exponential expansion of urbanization, industrialization, and population, therefore causing water scarcity in many different countries. Concerning the safe disposal of sewage to safeguard public health and the environment, traditional wastewater treatment methods have mostly concentrated. These linear solutions, however, sometimes ignore the possibilities of wastewater as a useful resource. Focused on resource recovery and recycling, the circular economy (CE) …
Published in Journal of Water Pollution & Purification Research · Vol. 12, Issue 3, 2025 · pp. 1–8 Read article
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The Effects of HIV/AIDS Worldwide
Abstract: The Human Immunodeficiency Virus (HIV), which targets immune system conductors (CD4 cells), has infected millions throughout the world. HIV lowers the body's defences by infecting certain bodily fluids (blood, sperm, vaginal fluids, and breast milk) through unprotected sex, contaminated needles, or mother-to-child transmission. Early flu-like symptoms may go unrecognised, but if not treated, HIV advances to AIDS, which is characterised by severe immune system impairment. However, advances in antiretroviral therapy …
Published in International Journal of Virus Studies · Vol. 1, Issue 1, 2024 · pp. 26–31 Read article
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Nanomedicine in the Tumor Microenvironment: Physiological Modulation Through Tissue Engineering Approaches
Abstract: The integration of nanomedicine and tissue engineering offers transformative strategies for cancer therapy by directly modulating the physiological processes within the tumor microenvironment (TME). This review emphasizes recent advances in nanomedicine that enable precise drug delivery, controlled release, and real-time monitoring of key physiological parameters influencing tumor progression, angiogenesis, and immune evasion. Tissue-engineered 3D tumor models provide physiologically relevant platforms that better mimic in vivo conditions than traditional 2D cultures, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 1, 2026 · pp. 19–31 Read article
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Assessing the Impact of Topical Steroids on Tinea Infections: An Epidemiological Investigation
Abstract: This retrospective epidemiological study investigates the prevalence and characteristics of modified tinea infections resulting from the use of topical steroids. Analyzing patient records from October 2022 at ‘District General Hospital, Amravati, the study reveals a significant association between topical steroid use and altered clinical features in 89% of cases. Factors such as steroid potency, duration of use, and specific tinea subtypes affected contribute to understanding the epidemiology of modified tinea …
Published in International Journal of Vaccines · Vol. 1, Issue 1, 2024 · pp. 10–18 Read article
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Clinicians’ role in the prevention and management of neonatal candidiasis in Punjab: challenges and opportunities.
Abstract: Background: Neonatal candidiasis is a growing concern in Punjab, particularly among newborns in neonatal intensive care units. The increasing prevalence poses significant risks to neonatal health, highlighting the need for effective management and prevention strategies. Objective: This study aims to explore the role of clinicians in preventing and managing neonatal candidiasis in Punjab while identifying the key challenges they face in clinical practice. Methods: A structured questionnaire was distributed to …
Published in Recent Trends in Infectious Diseases · Vol. 2, Issue 2, 2025 · pp. 26–33 Read article
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Personalised Cancer Vaccination Strategies: Bridging Genomics, Bioinformatics, and Immunotherapy
Abstract: Immunotherapy has revolutionized cancer treatment by harnessing the body’s immune system to detect and destroy cancer cells. Personalised cancer vaccines are one of the most promising options because they could allow treatment to be based on the specific tumour profile of each person. The goal of these vaccines is to make the immune system recognise and fight cancer-specific antigens, which will lead to strong and long-lasting anti-tumor responses. However, moving …
Published in Research and Reviews : A Journal of Immunology · Vol. 15, Issue 3, 2025 Read article
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Strategies to Improve Drug Compliance Among Patients with Mental Disorders: A Systematic Review
Abstract: Background: Mental disorders constitute a public health concern, accounting for 13% of the global disease burden. Pharmacotherapy along with psycho education is primary line of treatment and maintaining drug compliance is crucial. Aim: The aim of this systematic review was to summarize the strategies to improve drug compliance among patients with mental disorders, identify which tools are most frequently used to measure strategies to improve drug compliance among patients with …
Published in International Journal of Evidence Based Nursing And Practices · Vol. 3, Issue 1, 2025 · pp. 74–81 Read article
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Strategies in the Battle against Recurrent UTIs: A Brief Overview
Abstract: Recurrent urinary tract infections (UTIs) present a serious medical issue, and such conditions can disappoint those affected. They are uncomfortable, but a difficulty arises because treating such conditions with antibiotics comes with the risk of antibiotic overuse. This summary will evaluate the measures incorporated in treating frequent UTIs in the contemporary world. These measures include taking antibiotics regularly to prevent infections and alternatives to antibiotics such as probiotics, cranberry extract, …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 68–73 Read article
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GLP-1 Receptor Agonists: A Dual Therapeutic Strategy for the Management of Type 2 Diabetes Mellitus and Obesity
Abstract: For the treatment of obesity and type 2 diabetes mellitus (T2DM), glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have become a revolutionary class of pharmaceutical drugs. These drugs were first created as glucose-lowering treatments, but they have now shown other advantages, such as notable weight loss, better cardiovascular results, and general metabolic control. The objective of this narrative review is to assess the pharmacological mechanisms, clinical efficacy, safety profile, and therapeutic …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 1, 2026 · pp. 69–75 Read article
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Menopausal Health Concerns in Women Residing in Urban Areas
Abstract: Menopause is a natural biological transition in a woman’s life marked by the permanent cessation of menstruation and significant hormonal changes. This stage is often accompanied by a variety of physical, psychological, and social challenges that can affect overall well-being. Women residing in urban areas may experience menopausal health concerns differently due to lifestyle patterns, occupational stress, environmental factors, and changing social structures. The present article explores the common health …
Published in International Journal of Women's Health Nursing And Practices · Vol. 4, Issue 1, 2026 · pp. 35–40 Read article
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The Curious Case of the Sphered Blood Cells: Unveiling Hereditary Spherocytosis
Abstract: Hereditary spherocytosis (HS) is an inherited blood disorder that disrupts the shape and flexibility of red blood cells (RBCs) due to genetic mutations. These abnormal, sphere-shaped RBCs, called spherocytes, are prematurely destroyed in the spleen, leading to hemolytic anemia. Symptoms range from mild fatigue to chronic weakness and shortness of breath. While incurable, Hereditary spherocytosis can be effectively managed. Regular monitoring, folic acid supplementation, and in severe cases, splenectomy (surgical …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 13, Issue 1, 2024 · pp. 49–57 Read article
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Restoring Swallowing Freedom: A Triumph Over Achalasia Cardia Type III- A Case Report
Abstract: This case report explores the rare occurrence of achalasia cardia in a 24-year-old male in India, highlighting the unique challenges in diagnosis and treatment. The atypical demographic and the efficacy of laparoscopic Heller's myotomy with Dor's fundoplication underscore the importance of reporting such cases. The background reveals an unusual presentation of achalasia cardia in a 24-year-old male at Ahmedabad, Gujarat, India, justifying its documentation due to the infrequency of this …
Published in Research and Reviews : Journal of Surgery · Vol. 13, Issue 3, 2024 · pp. 1–5 Read article
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Smart and Circular Lakshadweep: Innovating Solid Waste Management for Sustainable Tourism Development
Abstract: Urban growth necessitates effective resource management, especially for resource-constrained island communities. This study focuses on the Lakshadweep Islands, examining the shift towards a circular economy through the perspective of solid waste management, with an emphasis on enhancing tourism and circular economy principles. The circular economy aims to eliminate waste and continually use resources by creating closed-loop systems where products, materials, and resources are reused, repaired, refurbished, and recycled. This study …
Published in Journal of Geotechnical Engineering · Vol. 11, Issue 2, 2024 · pp. 32–37 Read article
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Progeria Syndrome Unveiled: A Scientific Odyssey into Premature Aging Mechanisms and Therapeutic Frontiers
Abstract: Progeria, or Hutchinson-Gilford Progeria Syndrome (HGPS), is a rare and fatal genetic disorder in childhood, exhibiting features akin to premature aging. Despite normal appearances in infancy, affected children face accelerated aging with distinct facial characteristics, including micrognathia, dental malformations, lower body weight, early hair loss, decreased joint mobility, lipodystrophy, etc. The cause of HGPS is a point mutation that occurs at the exon 11 of the LMNA gene which normally …
Published in Research and Reviews: A Journal of Health Professions · Vol. 14, Issue 2, 2024 · pp. 52–68 Read article
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Strategies for the Development and Optimization of Orally Disintegrating Tablets (ODTs) to Improve Bioavailability and Patient Compliance
Abstract: Background: Pharmaceutical scientists have developed Orally Disintegrating Tablets (ODTs) to advance patient drug acceptance and biological system availability through simplified medi-cation delivery especially for children and senior citizens and people who cannot swallow pills regularly. The oral disintegrating tablets dissolve in the mouth within thirty seconds or less (USP 701) while needing no additional liquid thus making them suitable for both emergency treatments. Objective: The research examines ODT development strategies …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 Read article
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Postbiotics Unveiled: Mechanistic Insights and Therapeutic Implications in Obesity.
Abstract: The burgeoning global obesity epidemic necessitates innovative therapeutic approaches, and postbiotics, bioactive compounds arising from microbial fermentation, have emerged as promising contenders in reshaping obesity management. This comprehensive review explores the multifaceted mechanisms by which postbiotics impact obesity, from modulating gut microbiota composition to influencing metabolic pathways and enhancing energy expenditure. The exploration of postbiotics is rooted in a deeper understanding of the gut–brain axis and bidirectional communication between gut …
Published in Emerging Trends in Metabolites · Vol. 3, Issue 1, 2026 · pp. 11–28 Read article