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136 articles for “Metabolic Response”
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Limitations to Therapeutic Approaches to T2DM in Light of Different HbA1C Values Suggested by Different Scientific Associations: A Review
Abstract: The present article provided a comprehensive review of international and national guidelines for managing Type-2 diabetes, with a focus on personalized treatment strategies. It discussed the recommended glycated haemoglobin targets and the initial treatment approach involving lifestyle modifications and the use of metformin. The present article underlined the necessity for treatment intensification due to the progressive nature of type-2 diabetes. It also emphasized the complexity of selecting additional antidiabetic medications, …
Published in Research and Reviews: A Journal of Medicine · Vol. 13, Issue 2, 2023 · pp. 13–26 Read article
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REVIEW OF PHARMACOEPIGENETICS: BRIDGING EPIGENETICS AND PERSONALIZED MEDICINE
Abstract: Pharmacoepigenetics is an emerging field that explores how alterations in gene expression, independent of DNA sequence changes, influence individual responses to drugs. Unlike pharmacogenetics, which focuses primarily on genetic variation, pharmacoepigenetics integrates genetic, environmental, and lifestyle factors to explain interindividual differences in drug efficacy, toxicity, and resistance. Key epigenetic mechanisms including DNA methylation, histone modifications, non-coding RNAs, and RNA methylation play critical roles in regulating drug metabolism and therapeutic outcomes. …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 · pp. 33–40 Read article
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Exploring the Thyroid Gland Physiology in Relation to Thyroid Hormones: An Overview through the Lens of 3D Computational Biology
Abstract: The endocrine system plays a pivotal role in orchestrating and sustaining diverse physiological functions by manufacturing and releasing hormones, which function as vital chemical messengers within the body. Among the prominent endocrine glands, the thyroid gland holds a central position. Situated in the lower part of the neck, this gland adopts a butterfly-shaped structure. Its significance lies in the synthesis of three key hormones: thyroxine (T4), tri-iodothyronine (T3), and calcitonin.The …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 11, Issue 1, 2024 · pp. 46–54 Read article
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The Renaissance and Resilience of CB1 Reverse Agonists: From Central Liabilities to Peripheral Promise
Abstract: Building upon these foundational insights, current research has increasingly focused on refining the pharmacological profile of CB1 reverse agonists to maximize therapeutic benefit while minimizing central adverse effects. The adverse neuropsychiatric outcomes associated with first-generation agents such as Rimonabant including anxiety, depression, and suicidal ideation highlighted the critical role of central CB1 receptors in mood regulation. Consequently, drug development strategies have shifted toward peripherally restricted CB1 reverse agonists that exhibit …
Published in International Journal of Cheminformatics · Vol. 4, Issue 1, 2026 · pp. 30–35 Read article
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A Review on Advances in Personalized Medicine: from Genomics to Clinical Applications
Abstract: Personalised medicine, also known as precision medicine, is a revolutionary approach to healthcare that customises medical interventions and treatments for individual patients according to their distinct genetic, environmental, and lifestyle properties. The basic pillar of personalised medicine is genomics, and the area has seen an explosion of genetic information with the advent of high-throughput sequencing tools. Genomic data now provide unprecedented insights into the underlying genetic variations, mutations, and genetic …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 10, Issue 2, 2023 · pp. 13–17 Read article
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Effect of Caffeic Acid on Glutathione Metabolism of MCF-7 and MDA MB-231 Breast Cancer Cells
Abstract: Increasing incidences of breast cancer at alarming rates with treatment strategies having an overall detrimental effect on the patients led to investigating the potential of phytochemicals as anti-tumorigenic agents. Caffeic acid, an antioxidant and anti-tumorigenic phytochemical, has been tested on MCF-7(hormone responsive) and MDA MB-231(hormone-independent) breast cancer cell lines. Alterations in the levels of intracellular glutathione (GSH) in both cell lines due to exposure to the drug are the primary …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 12, Issue 1, 2022 · pp. 14–22 Read article
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Identification of Secondary Metabolites from Zingiber officinale as Inhibitors for Keap 1-Nrf2 small Molecules through Molecular Docking Techniques
Abstract: Objective: Therapeutic plants aid in treating cancer-based cell signaling pathways and preventing certain risk factors. Zingiber officinale has a variety of anti-inflammatory characteristics also contributing to enhanced immunity, reducing cancer risk and used to target the KEAP NRF2. When overexpressed in response to oxidative stress and DNA damage, elevates the risk of developing multiple cancers. NRF2 cellular sensors, which also control and coordinate their expression aid in defending healthy cells …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 2, 2023 · pp. 35–48 Read article
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Human Milk and Infant Growth: A Systematic Review of Nutritional Outcomes
Abstract: Human milk is recognized as the optimal source of nutrition for infants, playing a critical role in their growth and development. This systematic review explores the evidence linking human milk consumption to various growth parameters in infants, including weight gain, length, and head circumference while considering the influencing factors of prematurity and health status. The composition of human milk, rich in essential macronutrients (proteins, fats, carbohydrates) and micronutrients (vitamins and …
Published in Research and Reviews : Journal of Dairy Science and Technology · Vol. 13, Issue 3, 2024 · pp. 1–6 Read article
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Study of Polycystic Ovary Syndrome (PCOS) with Special Reference to Candidate Genes
Abstract: The PCOS (polycystic ovary syndrome) has become a worldwide concern as progression of PCOS in the age group of adolescence to postmenopausal women is increasing. In India, sudden rapid growth in PCOS is observed in the range of 3.7–22.5%. Effects of PCOS are not only on the reproductive and metabolic systems, but the whole body’s metabolism gets affected; ultimately, it leads to different life- style diseases like type 2 diabetes …
Published in Research and Reviews: A Journal of Health Professions · Vol. 13, Issue 1, 2023 · pp. 49–55 Read article
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Phytochemical Screening of Leaves of Peltophorum pterocarpum (DC.) Baker ex Heyne
Abstract: AbstractPhytochemicals are responsible for medicinal activity of plant species. Hence in the present study preliminary phytochemical screening of medicinal plant Peltophorum pterocarpum was carried out. Qualitative phytochemical analysis of the plant confirm the presence of various secondary metabolites like saponins, terpenoids, steroids, tannins, phenols, alkaloids, coumarins etc. Phytochemical have ability for curing various ailments and possess otential anti-inflammatory, antimicrobial and antioxidant activities. The presence of various bioactive compounds confirms the …
Published in Research & Reviews : Journal of Botany · Vol. 4, Issue 2, 2015 · pp. 16–20 Read article
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Conceptual Study of Pachaka Pitta—A Review
Abstract: Pachaka Pitta is responsible for digestion of food, Vibhajan of Sara and Kitta and it nourishes the Agneya part of Pitta located in different parts of body. Ancient texts provide a clear description about its Sthan, Swaroop and Karma. Acharya Sushruta, quotes “By dispensation which is unseen and hidden (a cause which cannot be perceived or explained in terms of known facts) the Pitta that is located in the area …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 6, Issue 3, 2017 · pp. 1–7 Read article
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Evaluation of the antioxidants potential and total phenolic contents of the Albbizia siris a drug plant
Abstract: Free radicals are the major problems of the world today. They are formed endogenously as well as exogenously by different kinds of metabolic processes in the body. Some of them are highly toxic process causing considerable damage to the system and produce several kindsof disorders. Antioxidants are the substance which reduces the formation of free radicals inthe body and are responsible for degradation of free radical and reactive oxygen species …
Published in Research and Reviews: A Journal of Toxicology · Vol. 9, Issue 1, 2019 · pp. 21–25 Read article
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Modulation of Receptor Proteins: A Recent Paradigm in Drug Discovery and Target
Abstract: The main aim in drug discovery is to design different ligands those work on specific drug targets. However, various effective drugs work through the modulation of many proteins than single target. Advancement in system biology are establishing a phenotypic strength and a network structure, which suggests that, the excellent selective compounds may be performed less than desired clinical efficacy in comparison to multi-target drugs. In this new appreciation of the …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 1, 2018 · pp. 14–24 Read article
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Pharmacodynamics and Drug–Receptor Interactions: Integrating PK/PD Modeling with Modern Drug Development
Abstract: Understanding drug action requires an integrated perspective of pharmacodynamics and pharmacokinetics, which together determine therapeutic efficacy and safety. This review provides a comprehensive overview of the mechanisms underlying drug action, with particular emphasis on drug–receptor interactions and their role in modulating physiological responses. Drugs exert their effects primarily through interactions with specific biological targets, including receptors, enzymes, ion channels, and transporters, resulting in a spectrum of desired and adverse outcomes. …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 · pp. 33–47 Read article
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Exploring the Therapeutic Potential of Phytochemicals in Aloe Barbadensis Miller Through Molecular Docking for Ulcerative Colitis Management
Abstract: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by mucosal inflammation of the colon, often associated with immune dysregulation and oxidative stress. Natural compounds have gained significant attention as alternative therapeutic agents due to their efficacy and minimal side effects. Quercetin, a flavonoid abundantly found in Allium cepa (onion), has demonstrated potent anti-inflammatory and antioxidant properties. This study employs an in silico approach to evaluate the therapeutic potential …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 13, Issue 1, 2026 · pp. 06–12 Read article
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A Review on Wound Healing: Pathophysiology, Animal Model and Role of Biomarkers
Abstract: AbstractBlood cells, extracellular matrix, parenchyma cells, and soluble mediators are all involved in the physiological process of wound healing, which is highly complex, dynamic, interactive, and well-regulated. The 4 stages of wound healing are separated out. Hemostasis b. Inflammation c. Proliferation d. Remodeling. Many animal models are employed in the examination of wound healing activities because a large variety of models have been produced for examining different components of the …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 9, Issue 3, 2022 · pp. 29–39 Read article
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Polymeric Nanocomposite Aided Bioaugmentation for Marine Oil Spills – A Review
Abstract: Bioaugmentation is a promising, cost-effective bioremediation technique that enhances the degradation of marine pollutants by introducing hydrocarbon-degrading microorganisms. This review explores recent advancements in the use of bioaugmentation for petroleum biodegradation in marine environments, emphasizing the integration of microbial systems with polymeric and composite materials. Innovative methods, such as the immobilization of microbial cells within biodegradable polymeric matrices (e.g., alginate, chitosan, polyvinyl alcohol), have significantly improved microbial viability, metabolic efficiency, …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 1049–1061 Read article
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Extracellular Vesicle-Based Liquid Biopsies: Decoding the Tumor Microenvironment for Precision Oncology
Abstract: The tumor microenvironment (TME) plays a pivotal role in cancer initiation, progression, and therapeutic response. Decoding the TME is, therefore, essential for advancing precision oncology. Extracellular vesicles (EVs), including exosomes and microvesicles, are nanoscale lipid bilayer particles secreted by tumor and stromal cells. They transport a wide range of bioactive molecules, such as DNA, RNA, proteins, lipids, and metabolites, which reflect the dynamic state of the TME. Recent advances in …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 15, Issue 1, 2026 · pp. 43–62 Read article
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Pharmacogenomics in Anesthesia: Case Studies and Clinical Applications for Personalized Care
Abstract: Pharmacogenomics, the study of how genetic variability influences individual responses to medications, is transforming anesthetic practice by enabling personalized care. This case study collection explores the integration of pharmacogenomic insights into anesthesia management, highlighting its impact on safety, efficacy, and patient outcomes. Adverse reactions to anesthetics often arise from genetic polymorphisms that alter drug metabolism or sensitivity. For instance, patients with RYR1 mutations are susceptible to malignant hyperthermia (MH) when …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 2, 2025 · pp. 85–91 Read article
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Toxicokinetics of Herbicide Residues in Green Forages: Implications for Fertility, Health, and Welfare of Dairy Cows
Abstract: Herbicide residues in green roughages have emerged as a significant concern in dairy production due to their potential toxicokinetic interactions and detrimental effects on reproductive health. While herbicides are widely used to control weeds and enhance fodder yield, their persistence in forage poses a latent risk to dairy cattle fertility. This review explores the absorption, distribution, metabolism, and excretion of herbicide residues in dairy cows, emphasizing their bioaccumulation and systemic …
Published in Research and Reviews : Journal of Dairy Science and Technology · Vol. 14, Issue 3, 2025 · pp. 48–64 Read article