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1680 articles for “BCS Class II/IV drugs”
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Targeting Homogentisate Dioxygenase Dysfunction in Alkaptonuria: Investigating Curcuma longa’s Therapeutic Potential
Abstract: Objectives: Alkaptonuria is known to have a faulty gene HGO in the metabolic process. In the present research work, the focus is towards investigating the therapeutic capabilities of the Curcuma longa upon the faulty Homogentisate dioxygenase gene using ligand-protein binding, which would assist in the corrective tyrosine metabolism. Methods: This study is based on the computational approach using different phytochemicals for evaluation of the potency against the abnormal Homogentisate dioxygenase …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 2, 2024 · pp. 1–11 Read article
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Exploring Azadirachta indica’s Potential to Combat Visceral Leishmaniasis Through GP63 Inhibition
Abstract: Objectives: Millions of people worldwide suffer from the parasite disease visceral leishmaniasis. Determine the naturally occurring active ingredients in Azadirachta indica, which are employed as a disease-prevention agent and have several uses in medicine. To choose the best ligand to use as a medication, absorption, distribution, metabolism, and excretion (ADME) studies and molecular docking are employed. Methods: To obtain the GP63 protein, the Protein Data Bank (PDB) database was accessed. …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 2, 2024 · pp. 1–12 Read article
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Exploring Malaria Fever (Vishama Jwara) Through an Ayurvedic Lens: A Comprehensive Review
Abstract: Malaria fever, known as Vishama Jwara in Ayurveda, is a significant global health challenge caused by the Plasmodium species transmitted via Anopheles mosquitoes. While conventional medicine has advanced in diagnosing and treating malaria, exploring it through the Ayurvedic perspective offers valuable insights into its holistic understanding and management. Ayurveda describes Vishama Jwara as a fever with irregular patterns, aligning with the cyclical febrile episodes seen in malaria. This review delves …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 13, Issue 3, 2024 · pp. 47–53 Read article
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Impact of Suriyanamaskar with Sky Maharasana and Suriyanamaskar without Sky Maharasana on Strengthening the Spine
Abstract: Purpose: The human body's entire work runs through the spinal cord. Spine strength helps to achieve blissful health and a sound mind. The purpose of this study is to evaluate the effects of Suriyanamaskar with and without SKY Maharasana on strengthening the spine and improving mental clarity. Method: The schoolgirls from in and around Chennai were selected as subjects for study. The total number of subjects is 75 and they …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 13, Issue 3, 2024 · pp. 58–62 Read article
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The Heart of Charani Poetry: An AI Interpretation of Emotional Resonance
Abstract: Poetry has long been a means of expressing emotions and ideas, yet understanding the emotional depth within poems can be challenging using traditional computer-based tools. This study explores the emotions embedded in Charani poems, an important genre in Indian literature, through the lens of their distinctive poetic style. The primary objective is to develop a novel method of analyzing emotions in Charani poetry, contributing to the broader field of emotion …
Published in Journal of Artificial Intelligence Research & Advances · Vol. 12, Issue 1, 2025 · pp. 34–39 Read article
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Detection of Phishing Website URLs and Email/SMS Using Random Forest and Multinomial Naive Bayes
Abstract: Currently, phishing attacks via SMS/email and URL have become significant threat to cybersecurity, posing risks to both individuals and organizations alike. Phishing attacks typically involve the creation of fraudulent websites or the dissemination of deceptive emails and SMS messages to trick users into disclosing sensitive information such as passwords, credit card numbers or personal details. To respond to these attacks, we develop a robust system for the detection of phishing …
Published in Journal of Computer Technology & Applications · Vol. 16, Issue 1, 2025 · pp. 22–30 Read article
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Fake News Detection System Using MultinomialNB and Django Framework
Abstract: The emergence of the World Wide Web and the rapid growth of online platforms have transformed the landscape of news dissemination. However, the rise of social media has also led to an overwhelming influx of potentially unreliable information, making it increasingly challenging to verify the truthfulness of articles. This verification process has become a daunting task, necessitating a thorough examination of various domain-specific aspects to ascertain the credibility of news …
Published in Current Trends in Information Technology · Vol. 15, Issue 1, 2025 · pp. 23–32 Read article
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Assessing the Clinical Efficacy and Safety of Semaglutide: A Comprehensive Study
Abstract: Semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), has emerged as a versatile therapeutic agent with significant potential in managing a range of diseases. Extensive research has demonstrated its efficacy in treating obesity, type 1 and type 2 diabetes, and even neurodegenerative disorders like Parkinson’s disease. This comprehensive review examines the principal outcomes derived from clinical trials that incorporate semaglutide alongside other GLP-1 agonists, with particular emphasis on the mechanisms underlying …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 96–104 Read article
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A Review Article on Nutraceuticals – An Impact on Conventional Health Care
Abstract: Nutraceuticals, combining nutrition and pharmaceuticals, have transformed healthcare. This review explores their classification, scope, benefits, and challenges. Nutraceuticals, including dietary supplements, functional foods, herbal products, and fortified foods, promote health and prevent diseases. The global market, valued at $117 billion, is expanding rapidly, fueled by the growing focus on health. Key benefits are boosted health benefits, fewer side effects, natural options improved nutrition. Classification is traditional (conventional) nutraceuticals (e.g., lycopene, …
Published in International Journal of Nutritions · Vol. 2, Issue 1, 2025 · pp. 9–23 Read article
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Advanced Ointment Formulation: An Insightful Review of Innovation and Efficacy
Abstract: This review provides an in-depth exploration of the evolution of ointment formulations, particularly considering the increasing prevalence of fungal infections and the growing demand for effective antifungal treatments. Traditional ointment formulations, while useful, often face significant challenges, such as inadequate penetration into the skin, poor bioavailability, and undesirable textures that limit their efficacy. As a result, there has been a shift toward more advanced, innovative formulations that aim to address …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 27, Issue 1, 2025 · pp. 14–23 Read article
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Enhancing Energy Efficiency in Air Handling Units Through AI Driven Optimization
Abstract: This research explores the implementation of artificial intelligence (AI) in enhancing the energy efficiency of Air Handling Units (AHUs) in manufacturing facilities. The study proposes a comprehensive solution architecture that incorporates temperature and humidity sensors within AHUs, utilizing RS485 for data communication. The collected data undergoes exploratory analysis, which informs the training of a decision tree algorithm, chosen for its accuracy and compatibility with edge gateways. The algorithm's predictions enable …
Published in International Journal of Industrial and Product Design Engineering · Vol. 2, Issue 2, 2024 · pp. 19–28 Read article
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E – Learning The Indian Way: Design and Implications, Challenges and Remedies
Abstract: The Indian higher education system and the entire realm of academics were radically altered with the global pandemic and its ensuing changes witnessed in the year 2020. Everything has transformed from physical to online. The idea of the classroom as a dominant learning space was altered. A new definition for the word ‘space’ emerged. The closing down of various educational institutions like schools, colleges, and universities transformed the e-learning system …
Published in Journal of Multimedia Technology & Recent Advancements · Vol. 12, Issue 1, 2025 · pp. 1–7 Read article
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RTL to GDSII Implementation UART using Verilog and Cadence tools
Abstract: The paper outlines a thorough design flow for Universal Asynchronous Receiver and Transmitter (UART) utilizing Register Transfer Level (RTL) to Graphic Data System II (GDS II) Implementation using Verilog and Cadence tools. The process involves RTL design, logic synthesis with Genus and physical design using Innovus, followed by verification steps including formal verification, static timing analysis and power optimization. The results demonstrate an efficient workflow, highlighting the effectiveness of Cadence’s …
Published in Journal of VLSI Design Tools and Technology · Vol. 15, Issue 1, 2025 · pp. 1–7 Read article
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A Comprehensive Review of Therapeutic and Pharmacological Potential of Karafs (Apium graveolens)
Abstract: The history of the medicinal properties of plants and their use in various ailments is as old as the history of mankind. Karafs (Apium graveolens) is one of the important plants among them, belonging to the family Apiaceae/Umbelliferae. Its use in various ailments has been documented in Unani classical literature in detail. Every part of Karafs possesses wonderful medicinal properties. A series of studies conducted to evaluate its medicinal uses …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 12, Issue 1, 2025 · pp. 1–8 Read article
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Pothole Detection utilising Machine Learning: A Review
Abstract: Potholes must be found and fixed quickly in order to maintain infrastructure, maximize transportation systems, and guarantee road safety. Using the Sequential API and the Keras library, this study presents a neural network model for pothole detection. Convolutional layers with ReLU activation, global average pooling, dense layers with dropout, and softmax activation for binary classification make up the model architecture. Image loading, resizing, array conversion, labeling, shuffling, normalization, and one-hot …
Published in Journal of Control & Instrumentation · Vol. 16, Issue 1, 2025 · pp. 35–43 Read article
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Holistic Concept & Management of Male Sexual Disorders in Integrative Unani Medicine
Abstract: Sexual medicine or sexology is a multidimensional field that encompasses a wide variety of sexual dysfunctions and their management by counseling, sex therapy, and drugs. It is very difficult to know the actual prevalence of sexual problems in India. It is estimated that 5 –15% of persons of reproductive age group suffer from sexual disorders or have unsatisfactory sexual relationships. The most common sexual disorders include erectile dysfunction, ejaculatory disorders, …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 12, Issue 1, 2025 · pp. 18–24 Read article
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Mobility for the Exceptionals: An Adaptable Electrified Transportation System for Manual Wheelchair
Abstract: The survey for the prevalence of handicapped people in India reveals that approximately 4.52% of India’s total population is physically challenged. Among the list, about 44% of people suffer from locomotor disability. Satisfaction of their primary need will be fulfilled when they get aid to move but the main problem is that about 31% of India’s population belongs to middle class or lower middle class. Their wish to buy an …
Published in International Journal of Robotics and Automation in Mechanics · Vol. 2, Issue 2, 2024 · pp. 21–25 Read article
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Evaluating the therapeutic effects of Asystasia gangetica (Chinese violet) on the chronic respiratory condition- Asthma
Abstract: Asthma is a chronic condition affecting the respiratory system. Its symptoms affect the immune pathways via helper T-cells. The plant Asystasia gangetica is prevalent throughout tropical regions around the world. It has been used in some herbal remedies to relieve symptoms of asthma. This study used computational techniques to assess the effectiveness of several phytocompounds present in A. gangetica in relieving symptoms of Asthma. Three proteins associated with asthma, namely …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 1, 2025 · pp. 15–21 Read article
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Effect of Radiation Dose, Dose Rate and Annealing Temperature on Edible Potato Starch by Spectroscopic Methods
Abstract: Potato starch (PS) is a favorite food choice in different forms. During its storage and applications the PS is exposed to different radiations. In the present study the authors attempt to compare radiation effects (gamma and Electron beam of same radiation dose) in PS by Electron spin resonance (ESR) and Fourier transform infrared (FTIR) methods. ESR spectra of gamma irradiated PS appeared to have resolved shapes than the electron beam …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 198–209 Read article
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Signal Feature Extraction and Machine Learning Techniques for Human Activity Recognition
Abstract: Human Activity Recognition (HAR) has emerged as a critical field of study with diverse applications in healthcare, fitness tracking, smart homes, and human-computer interaction. The aim of this research is to create an efficient HAR system through advanced techniques characterized by signal feature extraction and machine learning algorithms. The MEMS sensors are used appropriately during data mining to extract time-domain, frequency-domain, and statistical features, which are subsequently passed to the …
Published in Journal of Mobile Computing, Communications & Mobile Networks · Vol. 12, Issue 1, 2025 · pp. 24–41 Read article