Search
106 articles for “mediation”
-
A Review on Kaempferol Eye Drops for the Glaucoma Treatment
Abstract: One of the main causes of permanent blindness, glaucoma is defined by gradual damage to the optic nerve, mostly brought on by oxidative stress, neuroinflammation, and high intraocular pressure (IOP). The investigation of herbal alternatives is necessary since current synthetic therapies, such as beta-blockers and prostaglandin analogs, frequently result in ocular discomfort, systemic toxicity, and poor patient compliance. Clitoria ternatea contains kaempferol, a bioactive flavonoid that has shown anti-inflammatory, antioxidant, …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 110–121 Read article
-
Effect of Adverse Childhood Experiences on Adult Attachment Styles and Help Seeking Behaviour Among Youth
Abstract: Psychological development is deeply influenced by early environments, where personal experiences, cultural norms, and structural factors intersect. Beyond individual adversity, societal conditions shape cognitive, emotional, and social functioning, ultimately influencing attachment patterns and help-seeking behaviour in adulthood. The current study explores the influence of adverse childhood experiences on adult attachment styles and help-seeking behaviour among youth. 140 participants (70= males, 70= females) aged 18-25 years were involved in the study. …
Published in International Journal of Children · Vol. 2, Issue 2, 2025 · pp. 25–34 Read article
-
Comprehensive Analysis of Advanced Methods, Materials and Technologies for Portable Water Purifier in Domestic and Industrial Applications
Abstract: Safe drinking water is still a major problem in developing countries, especially in areas with water scarcity, pollution or poor infrastructure. Portable water purifiers have come to the fore as solutions that are realistic to narrow this gap providing flexibility and accessibility in household and industrial environments as well. In this study, promising techniques, materials and technologies used in portable water treatment equipment design have been reviewed. We review important …
Published in Trends in Mechanical Engineering & Technology · Vol. 15, Issue 2, 2025 · pp. 8–19 Read article
-
Magnetic and Radioactive Nanoparticles for Improved Theranostics and AI Assisted Radiation Therapy
Abstract: Nanoparticles based therapeutic and theranostics technique is becoming an active area of research in nanomedicine. The sensitivity, biocompatibility, and stability of magnetic and radioactive nanoparticles determine their functionality. This research highlights the impacts of magnetic and radioactive nanoparticles on therapeutic techniques namely, cell therapy, gene therapy, and tissue regeneration. Then, it is intended to brief a principal role of these therapeutic techniques to envisage theranostics medicine and radiation therapy using …
Published in International Journal of Advance in Molecular Engineering · Vol. 3, Issue 2, 2025 · pp. 10–21 Read article
-
A Comprehensive Review of Guillain-Barré Syndrome (GBS)
Abstract: The rare but potentially life-threatening immune-mediated condition dubbed Guillain-Barré syndrome (GBS) impacts the peripheral nerves and nerve roots and is generally brought on by infections. As was the scenario during the Zika virus outbreaks in Latin America (2015) and French Polynesia (2013), the incidence of GBS may consequently escalate during influenza outbreaks. Considering GBS’s clinical features and ailments course are multiple and there are currently no global clinical guidelines, the …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 15, Issue 3, 2025 · pp. 1–5 Read article
-
Carbon Dioxide as a Fundamental Component in Sustainable Organic Synthesis
Abstract: A lot of people are interested in carbon dioxide (CO₂) as a cheap, plentiful, and safe source of carbon for making chemical processes more sustainable. Using it as a C1 building block in organic synthesis is a promising way to make products with added value while having less of an impact on the environment. This article examines current advancements in CO₂ fixation into organic compounds, emphasising the creation of effective …
Published in International Journal of Advance in Molecular Engineering · Vol. 3, Issue 2, 2025 · pp. 22–34 Read article
-
Ocular Films as a Drug Delivery System Against Fungal Infections: Current Insights and Future Directions
Abstract: Fungal infections of the eye, including keratitis, endophthalmitis, and blepharitis, represent a challenging class of ocular diseases due to their potential for vision loss and the limited efficacy of existing treatments. These infections are caused by a range of pathogenic fungi, such as Aspergillus, Candida, and Fusarium species, and often require long-term therapeutic intervention. Conventional topical antifungal therapies, such as eye drops and ointments, suffer from poor ocular bioavailability due …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 101–109 Read article
-
Graphene-Derived Reinforced Polymer Composites for Self-Healing and Durability Enhancement in Concrete Structures
Abstract: This study presents a matrix-centric polymer-composite repair binder: an epoxy–polyamide network reinforced with graphene derivatives (GO/rGO, 0.1–1.0 wt%). The polymer drives function via segmental mobility that closes microcracks, while 2D-filler topology densifies the interphase, improves load transfer, and enforces tortuous moisture pathways. Adhesion was high: pull-off (ASTM D4541) reached 13.5 MPa at 2.0 mm displacement; slant-shear (ASTM C882) reached 12.1 MPa at 2.8 mm, with greater deformation capacity (zero stress …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 77–91 Read article
-
Intelligent Management of Construction Projects: The Nexus of Human and Artificail Expertise
Abstract: Conversations about digitalization and artificial intelligence (AI) have continued to gain traction in the project management discourse. Although human expertise remains the hallmark of professionalism in the construction industry, AI has emerged as the newest wave of digital technological innovation, which can significantly elevate human productivity in the performance of project management functions. However, for project management professionals in the Nigerian construction industry, the potential of AI is both thrilling …
Published in Journal of Production Research & Management · Vol. 15, Issue 3, 2025 · pp. 16–24 Read article
-
Experimental Study on the Effect of Membranous Milkvetch and Ledebouriella divaricate Immunomodulatory Tablets on cytokine production in allergic rhinitis model mice
Abstract: We have established allergic rhinitis models for use in the treatment of allergic rhinitis with the help of the traditionall Koryo medicine administration, lade-screen Powder-extracted Membranous Milkvetch and Ledebouriella divaricate immunomodulatory tablet and the effect of lade-screen Powder on cytokine production in allergic rhinitis model mice. In the allergic rhinitis model, the administration of Membranous Milkvetch and Ledebouriella divaricate immunomodulatory tablets, along with Lade-screen Powder, demonstrated significant therapeutic effects. These …
Published in Research and Reviews : A Journal of Immunology · Vol. 15, Issue 3, 2025 Read article
-
In Silico Screening of Terminalia chebula Phytocompounds as Potential Inhibitors of NTCP and DDB1 in Hepatitis B Virus Infection
Abstract: Hepatitis B virus (HBV) infection is a major global health concern, and chronic carriers are at risk of developing cirrhosis, hepatocellular carcinoma (HCC), and even death. Existing treatments can effectively inhibit viral replication, but they achieve little eradication of the virus because of covalently closed circular DNA (cccDNA) retention. In this investigation, bioactive compounds of Terminalia chebula, a plant known for its hepatoprotective and antiviral properties in traditional medicine, were …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 1, 2026 · pp. 33–44 Read article
-
Sustainable Waste Management Using AI and Robotics
Abstract: The fast increment in squander era around the world has driven to noteworthy natural and open wellbeing concerns. Conventional squander administration strategies, which depend intensely on manual labor and obsolete forms, are battling to keep up with the developing volume, driving to wasteful aspects and environmental harm. AI and Mechanical autonomy give inventive arrangements by improving effectiveness in squander collection, sorting, reusing, and transfer. AI-driven squander sorting frameworks optimize exactness, …
Published in International Journal of Advanced Robotics and Automation Technology · Vol. 3, Issue 2, 2025 · pp. 42–48 Read article
-
Immune Dysregulation and Cytokine Circuitry in Genital Endometriosis: Mechanistic Insights and Next-Generation Immunotherapeutic Strategies
Abstract: Genital endometriosis is increasingly recognized as an immune-mediated inflammatory disorder driven by complex interactions between dysregulated immune cells, cytokine hubs, and microbiome-derived modulators. This review introduces a novel “immune–cytokine circuitry” framework that unifies innate and adaptive immune abnormalities with key cytokine loops sustaining chronic inflammation, angiogenesis, neuroinflammation, and immune tolerance. Within this circuitry, macrophage polarization, dendritic cell immaturity, NK-cell anergy, Treg expansion, Th17 amplification, and B-cell–mediated autoimmunity converge to establish …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 1, 2026 · pp. 06–16 Read article
-
An Overview of Microbial Diversity in the Functions of Wetland Ecosystems
Abstract: Wetlands serve as abundant reservoirs of biodiversity, crucial for the well-being of both humanity and the natural world. They represent the most critical and fertile ecosystem, where water predominantly dictates the environment and the plant and animal species that inhabit it. Wetlands have diverse microbial flora and fauna, which play essential roles in ecosystems. Soil and aquatic microorganisms mediate many processes, such as biogeochemical cycles, waste decomposition, symbiotic relationships, and …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 15, Issue 3, 2025 · pp. 1–14 Read article
-
Forage Bioactive Compounds and Rumen Microbiota: Exploring Colonization, Density, and Diversity Dynamics in Dairy Cows
Abstract: The rumen microbiota plays a pivotal role in the health, productivity, and sustainability of dairy cows, with forage serving as a fundamental dietary component influencing microbial dynamics. This review explores the intricate interactions between forage bioactive compounds – such as tannins, saponins, alkaloids, and flavonoids – and the rumen microbiota, focusing on their effects on colonization, microbial density, and diversity. Forage bioactives modulate microbial adhesion, biofilm formation, and growth patterns, …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 15, Issue 3, 2025 · pp. 15–26 Read article
-
Unlocking Novel Drug Targets and Therapeutic Advancements Against RNA Viruses: Insights from HMPV and SARS-CoV-2
Abstract: Re-emerging RNA viruses pose a significant epidemiological welfare threat due to their high mutation rates, potential for zoonotic transmission, and capacity to cause widespread outbreaks such as Human Metapneumovirus (HMPV), Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Influenza, etc. The rapid evolution and re-emergence of these viruses necessitate the development of novel drug targets and therapeutic strategies to combat existing and future outbreaks. This study focuses on structural as well …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 15, Issue 3, 2025 · pp. 54–86 Read article
-
Drug-Induced Liver Injury: Hepatotoxicity and Treatment - A Literature Review
Abstract: Drug-induced liver injury (DILI) is a major clinical and regulatory challenge, posing risks to patient safety and drug development worldwide. As the primary organ responsible for xenobiotic metabolism, the liver is particularly susceptible to toxic injury from prescription drugs, over-the-counter medications, herbal products, and dietary supplements. Drug-induced liver injury (DILI) accounts for a substantial proportion of acute liver failure cases and remains a leading cause of post-marketing drug withdrawal. Its …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 1, 2026 · pp. 1–17 Read article
-
The Impact of Nutrition on Sports Performance and Academic Success: A Study Among University Athletes – Eastern Technical University of Sierra Leone
Abstract: University athletes operate within dual-performance environments that require simultaneous academic and athletic excellence. Nutrition plays a critical role in supporting both physiological performance and cognitive functioning; however, limited empirical work has examined its combined influence on athletic and academic outcomes within university athlete populations, particularly in low-resource contexts. This study aimed to investigate the relationship between nutritional practices, sports performance, and academic achievement among university athletes at the Eastern Technical …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 15, Issue 1, 2026 · pp. 16–27 Read article
-
Integrating Livestock for Enhancing Sustainability of Soil, Water and Agroecosystem: Implications from a One Health Perspective
Abstract: Livestock systems play a pivotal role in sustaining environmental health, enhancing ecosystem services, and supporting agricultural productivity. Well-managed integration of livestock into agroecosystems contributes to soil fertility through organic matter deposition, microbial stimulation, and nutrient cycling, while improving soil structure and long-term productivity. Grazing and pasture management regulate water infiltration, retention, and hydrological balance, mitigating soil erosion and enhancing water-use efficiency. Livestock also promote biodiversity by maintaining habitat heterogeneity, facilitating …
Published in International Journal of Sustainability · Vol. 3, Issue 1, 2026 · pp. 1–11 Read article
-
Diet-Gene Interactions in Farm Animals: Molecular Dynamics, Gene Expressions, Signalling Pathways and Precision Nutrition for Sustainable Productivity
Abstract: Diet-gene interactions represent a central mechanism through which nutrition influences growth, health, and productivity in farm animals. Recent advances in molecular biology and genetics have revealed that nutrients act not only as metabolic substrates but also as signalling molecules capable of modulating gene expression, cellular pathways, and epigenetic regulation. This review synthesizes current knowledge on the molecular dynamics of nutrient utilization in farm animals, with emphasis on nutrigenomic responses, nutrient …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 4, Issue 1, 2026 Read article