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257 articles for “inflammatory”
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Synthesis and Characterization of Pyrazole Heterocyclic Derivatives via Vilsmeier-Haack-Reaction and its Schiff`s Bases.
Abstract: The synthesis of New Schiff bases (2; and 3a-c) is reported in this study. These bases were created by reacting -chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde (1) with various amines that contained various pharmacophore atoms or groups, such as derivatives of benzothiazole and aniline, in the hopes of having antimicrobial and antifungal properties. Using mild reaction conditions and a good yield percentage, mono-pyrazole Schiff bases (2 and 3a–c) were designed and synthesized by reacting 5-chloro--3-methyl-1-phenyl-pyrazole-4-carbaldehyde …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 15, Issue 3, 2024 · pp. 34–48 Read article
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Development of a Polymeric Detection System for Salivary Annexin-1: A Potential Tool for Point-of-Care Diagnostics in Periodontal Disease
Abstract: Salivary annexin-1, a protein with anti-inflammatory properties, has emerged as a potential biomarker for periodontal disease. However, current detection methods, like ELISA, are often complex and require laboratory settings. This study explores the development of a novel polymeric detection system for the rapid and sensitive identification of salivary annexin-1. This system could leverage the unique properties of polymers to create a point-of-care diagnostic tool for: (1) early detection and monitoring …
Published in Journal of Polymer & Composites · Vol. 12, Issue 5, 2024 · pp. 101–110 Read article
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Evaluation of Chemical Constituents of Terminalia Arjuna Bark: As a Cardio-Protective Agent
Abstract: In the past, the primary source of medicinal agents was herbal remedies. One such medicinal plant that is well known for its many therapeutic benefits, particularly its cardiovascular effects, is Terminalia arjuna (TA). The therapeutic effects of these substances are due to a wide range of natural chemical compounds, such as flavonoids, polyphenols, triterpenoids, tannins, glycosides, minerals, proteins, and others. These compounds work together to provide the health benefits associated …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 1, 2025 · pp. 1–6 Read article
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Erythrodermic Psoriasis: A Case Report Highlighting Clinical Features and Management
Abstract: Background: Erythrodermic psoriasis (EP) is a rare and severe variant of psoriasis that presents as widespread erythema, scaling, and systemic complications such as fever, dehydration, and electrolyte imbalances. It requires urgent medical attention due to the risk of life-threatening complications, including sepsis and multi-organ failure. The condition can arise de novo or as an exacerbation of pre-existing psoriasis, often triggered by medication withdrawal, infections, or systemic inflammation. Case Presentation: We …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 2, 2025 · pp. 01–05 Read article
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Therapeutic Potential of Terminalia arjuna Bark in the Management of Hemorrhoids: A Comprehensive Review
Abstract: Background: Hemorrhoids appear frequently among anorectal disorders since they create vascular swelling together with pain symptoms, while leading to bleeding and mucosal tissue tending to slide out. Though effective therapy exists, traditional treatments produce various adverse effects and lead to recurrence and inconsistent patient following of medical recommendations over the long term. Plantbased therapeutic medicines have gained rising demand, which leads experts to investigate medicinal plants with established pharmacological effects. …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 2, 2025 · pp. 22–32 Read article
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Fermented Foods: Functional and Regulatory Insights
Abstract: Traditional fermented edible products have been in the food industry since ancient times. Today, the fermentation process has become most common in the health food industry. Due to the microorganisms present in fermented food products, the health benefits have been helpful in many ways. Fermentation helps in enhancing gut health, blood sugar, blood pressure, and brain health. These food products also play a major role in lowering cancer risk and …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 15, Issue 3, 2025 · pp. 1–10 Read article
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Clinical Evaluation of Efficacy of a Polyherbal Unani Formulation (Mentioned in Makhzan-Ul-Ilaj) in the Management of Warm-e-Lauzatain-Haad (Acute Tonsillitis)
Abstract: Background: Warm-e-Lauzatain-Haad (Acute Tonsillitis) is an inflammatory condition of the palatine tonsils characterized by throat pain, fever, odynophagia and general discomfort. It is particularly common among adolescents and young adults and contributes substantially to outpatient visits and missed academic or workdays. In Unani medicine Warm-e-Lauzatain is described as a hot inflammatory swelling arising from deranged humors, exposure to irritants or descending catarrhal matter. Classical Unani texts including Makhzan-ul-Ilaj, advocate the …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 15, Issue 1, 2026 · pp. 13–22 Read article
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The Evolution of Asthma Management: A Comprehensive Analysis of GINA 2024 Guidelines, Endotype-Driven Diagnosis, and Targeted Biologic Intervention
Abstract: Asthma remains a substantial global public health challenge, characterized by heterogeneous airway inflammation leading to variable airflow obstruction. Recent advances in personalized medicine and guideline revisions, notably the Global Initiative for Asthma (GINA) 2024 update, mandate a profound paradigm shift from reliance on short-acting beta2-agonists (SABA) to antiinflammatory reliever (AIR) strategies utilizing inhaled corticosteroid (ICS)-formoterol. This report provides an exhaustive analysis of current asthma epidemiology, molecular pathogenesis distinguishing between Type …
Published in Recent Trends in Infectious Diseases · Vol. 3, Issue 2, 2026 Read article
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Advancing Asthma Management: The Synergy of Systems Biology, Artificial Intelligence, and Next-Generation Therapeutics
Abstract: Asthma is an inflammatory disorder of the respiratory tract that is chronic and heterogeneous in nature and has various effects on millions of people. Being a chronic inflammatory disease, asthma remains incurable and the major conventional treatments offer limited success due to the mask nature of its pathophysiology. Systems biology/(AI), and next-generation has greatly enhanced knowledge and the management of asthma. The approaches based on gene, transcript, protein, and metabolite …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 14, Issue 2, 2024 · pp. 1–12 Read article
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Preparation and Evaluation of Herbal Gel Containing Multiple Plant Extracts for Acne Treatment
Abstract: A persistent inflammatory condition affecting the pilosebaceous unit, acne is caused by an increase in sebum production by sebaceous glands and an incorrect desquamation of hair follicles in response to rising testosterone levels throughout teenage years. Follicular obstruction results in follicular distention, which frequently triggers an inflammatory reaction and the growth of the Propionibacterium acnes bacteria. This project mainly focused on the formulation of a herbal gels for acne. These …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 2, 2025 · pp. 18–30 Read article
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Ilaj bil-Ma’ (Hydrotherapy) as a Regimenal Modality in Pain Management: Conceptual Foundations in Unani Medicine and Modern Correlation
Abstract: Waja‘ (pain) is one of the most common clinical complaints encountered worldwide and remains a leading cause of disability, impaired functional capacity, and diminished quality of life. In the Unani system of medicine, pain is not considered merely a symptom but a significant manifestation of disturbed physiological balance. Classical Unani scholars describe pain as arising from derangement in Mizāj (temperament), imbalance of Akhlāṭ (humours), Sudad (obstruction within bodily channels), Waram …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 13, Issue 2, 2026 · pp. 12–19 Read article
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Development of Zinc Gluconate Vitamin C Effervescent Tablet for Immunity Improvement and Management of Corona Virus Disease (COVID-19)
Abstract: The global pandemic of coronavirus disease- 2019 (COVID-19) continues to pose a threat to people, societies, and economic and healthcare systems. COVID-19s progression and lethality are determine by the host immune system, as is the case with many other diseases. revolutionary idea that has been used to treat other diseases is the control of inflammatory response and cytokine production based on immunonutrition. Some COVID-19 clinical trials are now using zinc, …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 1, 2024 Read article
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Multiple Sclerosis: A Systematic Review of a Neurological Disorder
Abstract: The inflammatory illness known as multiple sclerosis (MS) is brought on by outside influences that affect a biologically vulnerable host. It has 3 separate diagnostic phases: the pre-clinical phase, which can only be discovered by MRI; the relapsing-remitting (RRMS) phase, which again is defined by bouts of neurological malfunction accompanied by remission; and the progressing phase, which often develops from either the relapse phase. Unfortunately, the majority of relapse MS …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 1, 2023 · pp. 53–71 Read article
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DMARDs, Biologic Agents and Novel Experimental Strategies in The Treatment of Rheumatoid Arthritis
Abstract: An inflammatory and autoimmune disease, rheumatoid arthritis (RA) causes severe pain and inflammation in affected areas of the body. According to the report, there is no known cure for RA. Therefore, reducing discomfort and halting future harm must be the goals of present therapy. For the purpose of prevention and to reduce disease activity in RA patients, significant success has been achieved with the continued development of disease-modifying antirheumatic drugs …
Published in Emerging Trends in Personalized Medicines · Vol. 1, Issue 1, 2024 · pp. 14–24 Read article
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Deciphering Th-Related Gene Interactions in Chronic Spontaneous Urticaria: Bioinformatics Insights and Drug Affinity Exploration
Abstract: Objective: There has been a great deal of interest in how inflammatory dermatosis and The cell interact, but the etiopathogenesis of chronic spontaneous urticaria (CSU) is still inadequately comprehended. Through bioinformatics techniques, the purpose of this work is to elucdate the molecular mechanism underlying Th-related genes in CSU and seeks to find the highest affinity drug. Methods: The CSU RNA expression profiling dataset provided the basis for the investigation. The …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 1–15 Read article
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Harnessing the Healing Potential of Khamira Abresham Hakim Arshad Wala in the Management of Different Health Conditions
Abstract: Khamira Abresham Hakim Arshad Wala (KAHAW) is a potent Unani remedy that plays a vital role in fortifying the body's vital organs and efficiently reducing free radicals by enhancing levels of antioxidant enzymes. The term 'Khamira' originated from the Unani system of medicine and was first introduced by the esteemed Hakeem during the Mughal period. This preparation involves incorporating herbal drugs into a base (Qiwam) containing sugar or honey, resulting …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 11, Issue 1, 2024 · pp. 7–13 Read article
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Concern for Public Health: Periodontitis
Abstract: Periodontitis, a severe form of gum disease, erodes the bone that supports teeth and results in tooth loss. It is caused by bacterial infection and inflammation of the soft tissues around the teeth. About 70% of people 65 years of age and older are affected, on average. Red, bleeding, sensitive gums, foul breath, and receding gums are hallmark indications. Depending on the severity, a full dental examination, the insertion of …
Published in Research and Reviews: A Journal of Dentistry · Vol. 15, Issue 1, 2024 · pp. 22–26 Read article
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Computational Screening of Vitex negundo Compounds for Potential Arthritis Therapies in India
Abstract: Objective: Arthritis is a pervasive medical condition that manifests as inflammation and discomfort within the joints. As of September 2021, arthritis has affected an estimated 180 million people in India, making it a substantial public health concern with a considerable impact on individuals' quality of life and healthcare systems. Therefore, using molecular docking, drug-likeness prediction, and ADME analysis, an effort was made to identify natural compounds from Vitex negundo, which …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 01–18 Read article
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Global Burden of Major Depressive Disorder: Prevalence, Diagnosis, and Impact: A Comprehensive review
Abstract: In this review, we will discuss about the major depressive disorders on the basis of neurobiological changes. MDD, a prevalent psychiatric condition, manifests as a complex interplay of genetic, environmental, and physiological factors with a substantial impact on individuals and societies globally. Here the clinical assessment is fully based on diagnosis and the statistical manual for mental disorder, 5th edition (DSM-5). The pathophysiology involves Diagnosis alterations in neurotransmitter systems, dysregulation …
Published in Emerging Trends in Metabolites · Vol. 1, Issue 1, 2024 · pp. 54–62 Read article
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Phytochemical Profile & Therapeutic Potential of Clematis Terniflora: A Comprehensive Review
Abstract: Clematis terniflora is a plant comes under the family Ranunculaceae, which is folk medicinal plant which is found widely in China, according to the Chinese medical system, Clematis terniflora is a widely distributed folk remedy that is used to cure rheumatoid arthritis, asthma, syphilis, gout, malaria, dysentery and used as analgesic, antitumor, anti-inflammatory, diuretic, antibacterial, antioxidants and anti-inflammatory etc. It is distributed around the world like China, Japan, Korea, Mongolia, …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 11, Issue 2, 2024 · pp. 16–24 Read article