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Research and Reviews: A Journal of Pharmaceutical Science Review Article

Evaluation of Chemical Constituents of Terminalia Arjuna Bark: As a Cardio-Protective Agent

  1. Mohd. Wasiullah Dept. Principal, Dept.of Pharmacy, Prasad Institute Technology, Jaunpur
  2. Piyush Yadav Dept. of Pharmaceutical Chemistry, Dept.of Pharmacy, Prasad Institute ofTechnology, Jaunpur
  3. Shashikant Maury Department of pharmacy, Prasad Polytechnic Jaunpur
  4. Mohd .Altamash Dept.of Pharmacy, Prasad Institute of Technology, Jaunpur

Abstract

In the past, the primary source of medicinal agents was herbal remedies. One such medicinal plant that is well known for its many therapeutic benefits, particularly its cardiovascular effects, is Terminalia arjuna (TA). The therapeutic effects of these substances are due to a wide range of natural chemical compounds, such as flavonoids, polyphenols, triterpenoids, tannins, glycosides, minerals, proteins, and others. These compounds work together to provide the health benefits associated with the plants or substances in question. To effectively extract pertinent phytochemicals from TA extracts, we have first described the several procedures and their parameters in this review. This review, in our opinion, may aid researchers in comprehending the significance of TA, a well-known cardioprotective medicinal plant, its biomedical qualities, its use in green nanotechnology, and the different formulations that have been investigated for encapsulating them. In addition to improving formulations to increase the stability and bioavailability of TA extracts, this review will assist researchers in creating better and more environmentally friendly nano-medicines.

Keywords

References (23)

  1. Premila MS. Ayurvedic herbs: a clinical guide to the healing plants of traditional Indian medicine. Psychology Press; 2006.
  2. Jain S, Yadav PP, Gill V, Vasudeva N, Singla N. Terminalia arjuna a sacred medicinal plant: phytochemical and pharmacological profile. Phytochemistry Reviews. 2009;8(2):491-502. doi:10.1007/s11101-009-9134-8
  3. Warrier PK, Nambiar VP, Ramankutty C. Indian Medicinal Plants: A Compendium of 500 Species. Orient Blackswan; 1993.
  4. Wang W, Ali Z, Li XC, Shen Y, Khan I. Triterpenoids from TwoTerminaliaSpecies. Planta Medica. 2010;76(15):1751-1754. doi:10.1055/s-0030-1249809
  5. Dhingra V, Dhingra S, Singla A. Forensic and pharmacognostic studies of the Terminalia Arjuna Bark. Egyptian Journal of Forensic Sciences. 2013;3(1):15-19. doi:10.1016/j.ejfs.2012.10.001
  6. Paarakh PM. Terminalia arjuna (Roxb.) Wt. and Arn.: A review. Int J Pharmacol. 2010;6;(5)515–34.
  7. Trivedi PC. Medicinal plants: traditional knowledge. IK International Pvt Ltd; 2006.
  8. Dwivedi S. Terminalia arjuna Wight & Arn.—A useful drug for cardiovascular disorders. Journal of Ethnopharmacology. 2007;114(2):114-129. doi:10.1016/j.jep.2007.08.003
  9. Wang W, Ali Z, Li XC, Bharani A, Ganguli A, Mathur LK, Jamra Y, Raman PG. Efficacy of Terminalia arjuna in chronic stable angina: a double-blind, placebo-controlled, crossover study comparing Terminalia arjuna with isosorbide mononitrate. Indian Heart J. 2002 Mar-Apr;54(2):170-5.
  10. Wang W, Ali Z, Li XC, Shen Y, Khan I. 18,19-Secooleanane Type Triterpene Glycosyl Esters from the Bark ofTerminalia arjuna. Planta Medica. 2010;76(09):903-908. doi:10.1055/s-0029-1240841
  11. Wang W, Ali Z, Shen Y, Li XC, Khan IA. Ursane triterpenoids from the bark of Terminalia arjuna. Fitoterapia. 2010;81(6):480-484. doi:10.1016/j.fitote.2010.01.006
  12. Nema R, Jain P, Khare S, Pradhan A, Gupta A, Singh D. Preliminary phytochemical evaluation and flavanoids quantification of Terminalia arjuna leaves extract. Int. J. Pharm. Phytopharmacol. Res. 2012;1(5):283-286.
  13. Yadava RN, Rathore K. A New Cardenolide from the Seeds ofTerminalia arjuna(W&A;). Journal of Asian Natural Products Research. 2000;2(2):97-101. doi:10.1080/10286020008039898
  14. Maulik SK, Talwar KK. Therapeutic Potential of Terminalia Arjuna in Cardiovascular Disorders. American Journal Cardiovascular Drugs. 2012;12(3):157-163. doi:10.2165/11598990-000000000-00000
  15. Swain RK, Tripathy SN, Rana R, Patro SK, Behera S. A Study on Phytochemical and Pharmacological activity of Terminalia arjuna: A Review. Research Journal of Pharmacognosy and Phytochemistry. 2023;15(2):111-7. 52711/0975-4385.2023.00017
  16. Manna P, Sinha M, Sil PC. Phytomedicinal activity of Terminalia arjuna against carbon tetrachloride induced cardiac oxidative stress. Pathophysiology. 2007;14(2):71-78. doi:10.1016/j.pathophys.2007.05.002
  17. Sinha M, Manna P, Sil PC. Terminalia arjuna Protects Mouse Hearts Against Sodium Fluoride-Induced Oxidative Stress. Journal of Medicinal Food. 2008;11(4):733-740. doi:10.1089/jmf.2007.0130
  18. Shahriar M, Akhter S, Hossain MI, Haque MA, Bhuiyan MA. Evaluation of in vitro antioxidant activity of bark extracts of Terminalia arjuna. Journal of Medicinal Plants Research. 2012 Oct 10;6(39):5286-98.
  19. Tiwari AK, Gode JD, Dubey GP. Effect of Terminalia Arjuna on Lipid Profiles of Rabbits Fed Hypercholesterolemic Diet. International Journal of Crude Drug Research. 1990;28(1):43-47. doi:10.3109/13880209009082773
  20. Verma SK, Bordia A. Effect of Terminalia arjuna bark (arjun chhal) in patients of congestive heart failure and hypertension. J Res Educ Indian Med. 1988;7(31):e6.
  21. Bhawani G, Kumar A, Murthy KSN, Kumari N, Ganapati Swami C. A retrospective study of effect of Terminalia arjuna and evidence based standard therapy on echocardiographic parameters in patients of dilated cardiomyopathy. Journal of Pharmacy Research. 2013;6(5):493-498. doi:10.1016/j.jopr.2013.05.006
  22. Dwivedi S, CHANSOURIA JN, Somani PN, Udupa KN. Effect of Terminalia arjuna on ischaemic heart disease. Alternative medicine. 1989;3(2):115-22.
  23. Dwivedi S, Agarwal MP. Antianginal and cardioprotective effects of Terminalia arjuna, an indigenous drug, in coronary artery disease. J Assoc Physicians India. 1994 Apr;42(4):287-9.
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