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84 articles for “conventional therapy”
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Global Burden of Major Depressive Disorder: Prevalence, Diagnosis, and Impact: A Comprehensive review
Abstract: In this review, we will discuss about the major depressive disorders on the basis of neurobiological changes. MDD, a prevalent psychiatric condition, manifests as a complex interplay of genetic, environmental, and physiological factors with a substantial impact on individuals and societies globally. Here the clinical assessment is fully based on diagnosis and the statistical manual for mental disorder, 5th edition (DSM-5). The pathophysiology involves Diagnosis alterations in neurotransmitter systems, dysregulation …
Published in Emerging Trends in Metabolites · Vol. 1, Issue 1, 2024 · pp. 54–62 Read article
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Ethnopharmacological Insights: Uncovering Plant-Based Neuroprotective Treatments for Neurodegenerative Disorders
Abstract: The development of plant-based therapies for neurodegenerative diseases holds significant promise due to the therapeutic potential of natural compounds, such as Laurus nobilis, Aronia melanocarpa, and celastrol. This review identifies critical literature gaps in the current research, including inconsistent extraction methods, lack of clinical trials, insufficient documentation of long-term effects, limited mechanistic insights, and poor bioavailability. Addressing these gaps through standardization, rigorous clinical trials, advanced delivery systems, and comprehensive ethnopharmacological …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 13–18 Read article
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Plant-Derived Antimicrobials as Next-Generation Solutions to Multidrug Resistance
Abstract: The steady rise of multidrug-resistant (MDR) pathogens is reshaping how clinicians, researchers, and policymakers think about infection control. When bacteria acquire the ability to survive exposure to three or more antibiotic classes at once—whether through efflux pumps, enzyme-mediated drug destruction, target modifications, or reduced membrane permeability—treatment options narrow dramatically, hospital stays lengthen, and mortality climbs. Conventional pharmaceutical pipelines have struggled to keep pace with this biological arms race, pushing the …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 2, 2026 Read article
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Drug Induced Immune Mediated Nephritis: Molecular Mechanism , Pathways and Clinical Implications
Abstract: Drug-induced immune-mediated nephritis (DI-IMN) has become a more widely known cause of acute kidney injury (AKI), with the potential for development to chronic kidney disease if not detected and treated promptly. T-cell hypersensitivity to pharmaceuticals, such as antibiotics, proton pump inhibitors, nonsteroidal anti-inflammatory drugs, and immunological drugs, are the major causes for it. Beyond clinical burden, DI-IMN reflectsintricate molecular interactions that sustain interstitial inflammation and tubular injury. These interactions include …
Published in International Journal of Toxins and Toxics · Vol. 3, Issue 1, 2026 · pp. 13–29 Read article
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The Therapeutic Potential of Nutraceutical in Diabetes Management: A Comprehensive Review
Abstract: Diabetes is a long-term and complex condition characterized by high blood sugar levels resulting from inadequate insulin production, ineffective insulin function, or a combination of both. Various nutraceuticals used in clinical settings have shown beneficial impacts on a range of biochemical and clinical markers related to diabetes. In many traditional medical systems, hypoglycemic agents derived from plants are used to treat, manage, and prevent diabetes mellitus. These plant extracts have …
Published in Emerging Trends in Metabolites · Vol. 2, Issue 1, 2025 · pp. 20–27 Read article
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Polymer Chemistry in Shoulder Orthotics
Abstract: The design of effective shoulder orthotic devices has increasingly made use of polymeric materials because of their versatility, durability, and biocompatibility. This review illustrates polymer chemistry role in constructing an orthotic device for shoulder subluxation, which is a commonly occurring post stroke or injury condition. Proprietary design elements such as polypropylene are rigid yet moldable which help in anatomical formulating for joint stabilization. On the other hand, rubber elastomers, medicinal …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 21–28 Read article
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Drug Screening Using Stem Cell Technology
Abstract: Stem cell technology in drug screening has transformed the research and development sector of pharmaceuticals. Although stem cells imitate their human counterparts in terms of both safety and potential, it is a new paradigm for mimicking diseases of humans and scale measuring for toxicity. These tissues will, therefore, be more predictive of what will happen in humans during clinical situations, compared to conventional cell lines or animal models, since they …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 3, 2025 · pp. 42–51 Read article
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Malaria Diagnosis through Conventional Methods: A Comprehensive Review
Abstract: The incidence of drug-resistant parasite strains is rising, there is an apparent increase in the number of cases of malaria worldwide, and in a small number of cases and there has been a dramatic rise in international migration and travel. Over 1 million people die from malaria every year; 90% of these deaths are in African children, who live in tropical and subtropical regions. Although there are now efficient techniques …
Published in International Journal of Pathogens · Vol. 1, Issue 2, 2024 · pp. 8–14 Read article
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An AAV Vector for Inducible Gene Expression Preferentially in Muscles
Abstract: Adeno associated viral (AAV) vectors has been used widely in gene therapy and efforts have been made to improve their utility by adding genetic elements that would enable targeting transgene expression to particular cells or tissues of interest and permitting on/off regulation of expression. In this study, we designed a recombinant AAV9 variant PHP.eB vector with muscle creatine kinase (Mck)-derived enhancers, a synthetic muscle-expression promoter, in combination with a third-generation …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 2, 2023 · pp. 46–61 Read article
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Ayurveda as a Medium of Healing: A Critical Review of Classical Concepts and Modern Evidence
Abstract: Ayurveda, recognized as one of the world’s oldest holistic healing systems, has its origins in India over 5,000 years ago. Rooted in a philosophy that views health as a harmonious balance of body, mind, and spirit, Ayurveda offers a comprehensive and individualized approach to wellness. This traditional system of medicine is grounded in the concept of the Tridosha Vata, Pitta, and Kapha representing the fundamental bio-energetic forces governing physiological and …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 14, Issue 3, 2025 · pp. 40–44 Read article
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Phytomedicine in 21st century: challenges, innovations & future directions
Abstract: Phytomedicine, the use of plant-derived substances for therapeutic purposes, has experienced significant advancements and challenges in the 21st century. This review explores the current state of phytomedicine, highlighting its advantages, such as natural ingredients, fewer side effects, and cultural acceptance, as well as its disadvantages, including variable quality, lack of standardization, and limited research. The challenges faced by phytomedicine are discussed, focusing on issues of standardization, regulatory discrepancies, scientific evidence …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 1, 2025 · pp. 86–95 Read article
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Advanced Polymer Nanocomposite EEG Electrodes for Enhanced Epileptic Seizure Detection: A Comparative Analysis
Abstract: Electroencephalography (EEG) has been very important in the detection of epileptic seizures so as to enable successful diagnosis, surveillance and therapy of epilepsy. Nevertheless, EEG electrodes based on traditional metals may be limited due to high or high contact impedance, lack of biocompatibility, discomfort to patients and prone to motion artifacts, which interfere with signal quality and diagnostic adequacy. The recent progress in material science has resulted in coming up …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 Read article
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Psoriasis: Causes, Symptoms, Treatment, Effect on Quality of Life and Future Therapeutic Prospects: A Detailed Review
Abstract: Objective: This review’s objective is to provide an outline of how psoriasis is caused, what are its symptoms, what are the conventional methods being employed for treatment, and how future prospects can take over the conventional methods. We also aim to put light on how psoriasis is having a huge impact on people’s life quality in various fields of life and how this effect can be measured using instruments or …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 · pp. 31–49 Read article
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AI in Healthcare: Drug Delivery in Tuberculosis
Abstract: Tuberculosis (TB) , mainly caused by Mycobacterium tuberculosis, remains a major global health burden, accounting for millions of new infections and deaths each year. Although progress has been made in diagnosis and treatment, the growing threat of multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB makes disease control increasingly difficult. Conventional diagnostic approaches such as chest X-rays, sputum smear microscopy, and culture methods continue to play an important role, but they …
Published in Trends in Drug Delivery · Vol. 13, Issue 1, 2026 · pp. 9–17 Read article
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Nanotechnology-Based Cosmeceuticals for Anti-Aging and Skin Regeneration
Abstract: Nanotechnology has transformed the cosmetic industry of the cosmeceuticals by allowing the production of sophisticated delivery systems that improve the stability, penetration, bioavailability, and therapeutic efficacy of active ingredients in cosmetics. The present review identifies the value of nanotechnology-based cosmeceuticals in anti-aging and skin regeneration, with special focus on the recent developments in nanocarrier technologies and their use in dermatology. Many nanocarriers have exhibited great potentials in enhancing delivery of …
Published in Recent Trends in Cosmetics · Vol. 3, Issue 2, 2026 · pp. 33–45 Read article
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Antimicrobial Peptides and Bacteriophages as Next-Generation Alternatives to Conventional Antibiotics
Abstract: The growing threat of antibiotic-resistant bacteria has underscored the urgent need for innovative alternatives to conventional antibiotics. Antimicrobial peptides (AMPs) and bacteriophages are gaining recognition as next-generation therapeutics due to their distinct mechanisms of action and ability to target resistant pathogens effectively. AMPs, which can be natural or synthetic, disrupt microbial membranes and offer broad-spectrum antimicrobial activity with a reduced likelihood of resistance development. Bacteriophages, as bacteria-specific viruses, provide precise …
Published in International Journal of Antibiotics · Vol. 2, Issue 1, 2025 · pp. 9–27 Read article
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Integrating Ayurveda in Infertility Management: A Case Study on Fimbrial Blockage
Abstract: Infertility significantly impacts a woman’s psychological and physical health, as well as that of her family. Fallopian tube blockage is one of the leading causes of female infertility, accounting for a substantial number of cases globally. Conventional medical approaches, including in vitro fertilization (IVF) and surgical procedures, often present barriers due to their high cost, invasive nature, and limited accessibility. Additionally, cultural, financial, and personal considerations can further restrict their …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 12, Issue 3, 2025 · pp. 12–19 Read article
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Gastro Retentive Drug Target System: Its Needs, Advantages, Limitation and Approaches
Abstract: Background: Gastro retentive drug delivery systems (GRDDS) address limitations of oral therapy for drugs with poor solubility, instability at intestinal pH, or narrow absorption windows by prolonging gastric residence and increasing contact with the gastric mucosa. Objectives: To review GRDDS approaches—floating systems, mucoadhesive systems, and super porous hydrogels—with emphasis on formulation strategies and polymer–excipient selection to enhance gastric retention, modulate buoyancy/swelling/adhesion, and ultimately improve oral bioavailability and therapeutic outcomes for …
Published in Trends in Drug Delivery · Vol. 13, Issue 2, 2026 Read article
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Scaling of Machine Learning Techniques in Medical Imagining and Biomedical Applications Concerning Healthcare
Abstract: Machine learning refers to a field within computer science enabling computers to learn without explicit programming. Stemming from artificial intelligence's study of pattern recognition and computational learning theory, machine learning develops algorithms capable of learning from vast datasets and making predictions. Its applications span diverse computing tasks like email filtering, network intrusion detection, optical character recognition, and computer vision, where conventional algorithm design proves challenging. Notably, in computer vision, a …
Published in Journal of Computer Technology & Applications · Vol. 15, Issue 1, 2024 · pp. 41–44 Read article
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Recent Advances & Prospects of Transferosomes for Transdermal Delivery: Trends in Drug Delivery
Abstract: There have been several non-invasive administrations that have emerged recently to replace conventional needle injections. With its minimal rejection rate, remarkable ease of administration, and remarkable patient comfort and perseverance, the transdermal drug delivery system (TDDS) is the most attractive of them all. The skincare industry, which includes cosmetics, may also find use for TDDS in addition to the pharmaceutical industry. As this strategy mainly entails local drug administration, it …
Published in Trends in Drug Delivery · Vol. 11, Issue 3, 2024 · pp. 01–21 Read article