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Trends in Drug Delivery Review Article

Recent Advances & Prospects of Transferosomes for Transdermal Delivery: Trends in Drug Delivery

  1. Sakshi Chauhan Department of Pharmacy, I.T.S. College of Pharmacy, Murad Nagar, Ghaziabad
  2. Moumita Barman Department of Pharmaceutics, I.T.S. College of Pharmacy, Murad Nagar, Ghaziabad
  3. Monika Singh Department of Pharmacology, I.T.S. College of Pharmacy, Murad Nagar, Ghaziabad

Abstract

There have been several non-invasive administrations that have emerged recently to replace conventional needle injections. With its minimal rejection rate, remarkable ease of administration, and remarkable patient comfort and perseverance, the transdermal drug delivery system (TDDS) is the most attractive of them all. The skincare industry, which includes cosmetics, may also find use for TDDS in addition to the pharmaceutical industry. As this strategy mainly entails local drug administration, it can prevent untargeted drug delivery to tissues not intended for the treatment and buildup of localized drug concentrations. Transdermal delivery is hampered by several physicochemical characteristics of the skin, which have led to a great deal of research into ways to get over these barriers. Most transdermal medicines that have proved effective, do so by using smaller lipophilic compounds, which have a molecular weight of a few 100 Daltons. Transferosomes have proven to be an effective method for transdermal distribution of a range of therapies, including hydrophilic actives, bigger molecules, peptides, proteins, and nucleic acids, to get around the medications’ size and lipophilicity limits. Because of their flexible form and increased surface hydrophilicity, transferosomes are essential for the delivery of medicines and other solutes through and into the skin by exploiting hydration gradients a source of energy. As a result, the medication is released into the skin layers under regulated conditions and has improved overall penetration. This review outlines the development of transferosomes from liposomes and solid lipid nanoparticles, as well as their subsequent advancements as commercially available dosage forms, physical-chemical characteristics, and cutaneous kinetics.

Keywords

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