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1344 articles for “Target”
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Computer Simulations on Magnetic Particles Capturing in an Implant Assisted Channel for Targeted Drug Delivery
Abstract: In this paper, we studied the effect of magnetic field, inlet velocity and particle size on capture efficiency of magnetic particles transported in an implant assisted uniform channel through computational simulations. The dominant magnetic and drag forces are included in the simulations. The couple nonlinear Navier-Stokes equation for fluid flow and Newton’s second law equation for particle transport are solved using finite element based COMSOL multiphysics software. It is found …
Published in Trends in Drug Delivery · Vol. 2, Issue 2, 2015 · pp. 1–7 Read article
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Targeting Dystrophin Restoration and Neuroprotection in Duchenne Muscular Dystrophy: Insights from Withania somnifera
Abstract: Duchenne muscular dystrophy is a genetic disorder. This disease affects men more common than women. Main objective of the present study was to identify the naturally active phytocompounds from Withania somnifera (Ashwagandha). Ashwagandha has a great value in the field of Ayurveda and Indian medicine and is used for treating muscular and neurological disorders. Toxicity prediction, molecular docking, statistical information, drug illness prediction, and Absorption, distribution, metabolism, excretion, and toxicity …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 64–84 Read article
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Screening Phytocompounds of Tinospora cordifolia to Find Potential Drug Targets for Cystic Fibrosis
Abstract: This study aimed to evaluate the therapeutic potential of phytocompounds derived from Tinospora cordifolia in treating cystic fibrosis (CF), a genetic disorder caused by mutations in the CFTR gene that lead to severe respiratory and digestive complications. Phytocompounds were retrieved from the IMPPAT database and subjected to molecular docking simulations using PyRx to assess their binding affinity to the CFTR protein. The top-scoring compounds – sterol, magnoflorine, tembetarine, kaempferol, and …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 1, 2025 · pp. 16–24 Read article
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Repurposing Approved Immunomodulatory Drugs for Target Proteins in the Pancreas of European eel: A Molecular Docking Approach
Abstract: Leishmaniasis is a disease caused by tiny parasites called Leishmania, which spread to humans through the bite of an infected female sand fly. The disease manifests in three different forms, and the protein calcitonin promotes the disease’s spread. By reducing blood calcium levels, inhibiting osteoclast activity, increasing calcium excretion, and possibly playing a role in neurotransmitter modulation, calcitonin, a hormone released by vertebrates, promotes the progression of pathogenesis and lessens …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 12–19 Read article
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Therapeutic Potential of Plant-Derived Phytochemicals in Targeting Receptor Pathways Related to Non-Enzymatic Glycation: A Meta-Analysis
Abstract: Background: Non-enzymatic glycation, where reducing sugars react with proteins, lipids, and nucleic acids, contributes to various pathological conditions, such as diabetic complications and cardiovascular diseases. This process is facilitated by the receptor for advanced glycation end-products (RAGE), which is pivotal in driving inflammation and causing tissue damage. Objective: This meta-analysis evaluates the effects of plant-derived phytochemicals on RAGE expression and associated signaling pathways, assessing their therapeutic potential in glycation-related diseases. …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 1, 2025 · pp. 60–73 Read article
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Enhancing Puberty in Dairy Heifers: Targeted Management Practices For Sustainable Development.
Abstract: Early attainment of puberty in dairy heifers is critical for improving reproductive efficiency and ensuring sustainable dairy production systems. This study explores targeted management practices that can accelerate puberty onset, contributing to enhanced productivity and economic viability in dairy farming. Key factors influencing puberty in heifers include nutritional management, genetic potential, health care, environmental factors, and behavioral interventions. Adequate nutrient supply, especially energy and protein, along with balanced mineral and …
Published in Research & Reviews : Journal of Ecology · Vol. 14, Issue 2, 2025 · pp. 28–35 Read article
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Pharmacokinetic Profiling and Molecular Docking of Carvacrol and Structural Analogs: Targeting Quorum Sensing Proteins to Disrupt Biofilm-Mediated Antimicrobial Resistance in Multidrug-Resistant Bacterial Pathogen
Abstract: Antibiotic resistance, particularly in Pseudomonas aeruginosa, has become a major global health threat, exacerbated by the organism's ability to form biofilms and regulate virulence through quorum sensing (QS). The LuxR and LasR receptors are key regulators in this process, influencing both pathogenicity and antibiotic resistance. This study investigates potential QS inhibitors targeting these receptors as a strategy to mitigate antibiotic resistance. The primary objective was to identify novel ligands that …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 2, 2025 · pp. 43–61 Read article
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In silico Molecular Docking Analysis of Stephania glabra phytocompounds Targeting Thymidylate Kinase for potential Antituberculosis Activity
Abstract: Tuberculosis (TB) is an infectious disease caused by the bacteria Mycobacterium tuberculosis. It mainly affects the lungs and spreads through the air when a person with active TB in their lungs coughs, sneezes, or spits. This study investigates several bioactive compounds derived from plants to forecast how effective plant-based ligands will be at preventing tuberculosis. The purpose of the study was to use computational techniques to assess the effectiveness of …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 2, 2025 · pp. 25–37 Read article
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Exploring Abies grandis phytocompounds potential by in silico analysis targeting on the 5P9J Protein
Abstract: Blood Cancer, also popular with name ‘Hematologic cancer’ have variety of types: Leukaemia, Lymphoma, Myeloma, uncontrolled multiplication of blood cells mainly affecting to bone marrow and blood cells (White Blood Cells). Lymphoma, originating from lymphatic system resulted in uncontrolled growth and instead of normal apoptosis development of tumor. Myeloma, uncontrolled formation of malignant plasma cells leads disrupting production of healthy blood cells. This situation creates variety of diseases like anaemia, …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 2, 2025 · pp. 1–12 Read article
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Design and Implementation of Lightweight Polymer-Based Drone System for Targeted Agricultural Spraying
Abstract: Agriculture has entered a new era of innovation, with drone technology emerging as a key tool in pesticide and fertilizer application. Unlike conventional methods that expose farmers to hazardous chemicals resulting in health issues such as skin disorders, neurological impairments, and in extreme cases, fatal illnesses drone-based spraying offers a safer and more efficient alternative. In India, the adoption of this technology is accelerating due to its ability to reduce …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 476–486 Read article
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In-Silico Repurposing of Antipsychotic Drugs Against Novel Protein Targets in Multidrug-Resistant Mycobacterium tuberculosis
Abstract: Multidrug-resistant TB is a growing worldwide health concern, particularly in high-burden areas. Resistance to frontline drugs like isoniazid and rifampicin is caused by mutations in key Mycobacterium tuberculosis proteins. Given the difficulty of developing new antibiotics, medication repurposing offers a good alternative. The potential use of molecular docking to target resistance-associated TB proteins with FDA-approved antipsychotic drugs is investigated in this work. Three proteins were selected: InhA (PDB ID: 5W07), …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 1, 2026 · pp. 49–63 Read article
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Zebrafish in Drug Research: Decoding Biological Mechanisms and Finding Novel Therapeutic Targets
Abstract: The zebrafish, scientifically known as Danio rerio, is a powerful model organism in biological research because of its favorable traits, which include rapid development, genetic tractability, and transparent embryos. Zebrafish were first identified for their use in studies of vertebrate development, but they have since spread to a variety of disciplines, such as pharmacology, clinical research as a disease model, and most notably, drug development. Zebrafish have emerged as a …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 3, 2025 · pp. 1–8 Read article
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The Evolution of Asthma Management: A Comprehensive Analysis of GINA 2024 Guidelines, Endotype-Driven Diagnosis, and Targeted Biologic Intervention
Abstract: Asthma remains a substantial global public health challenge, characterized by heterogeneous airway inflammation leading to variable airflow obstruction. Recent advances in personalized medicine and guideline revisions, notably the Global Initiative for Asthma (GINA) 2024 update, mandate a profound paradigm shift from reliance on short-acting beta2-agonists (SABA) to antiinflammatory reliever (AIR) strategies utilizing inhaled corticosteroid (ICS)-formoterol. This report provides an exhaustive analysis of current asthma epidemiology, molecular pathogenesis distinguishing between Type …
Published in Recent Trends in Infectious Diseases · Vol. 3, Issue 2, 2026 Read article
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A Combined Molecular Docking Analysis of The Phytochemicals of Ginkgo biloba against The Parkin Protein Target (Autoinhibited Parkin Catalytic Domain)
Abstract: This study's goal is to evaluate the specific therapeutic targets for Parkinson's disease (PDB ID: 4BM9) using molecular docking simulation and ADME analysis against bilobalide, quercetin, ginkgolide B, and protocatechuic acid (3,4-Dihydroxybenzoic acid). The Protein Data Base was used to extract theprotein's three-dimensional structure, and the PubChem database was used to retrieve the ligands. Using Auto-Dock Tools-1.5.7, a molecular docking simulation of the compounds was carried out. Since none of …
Published in Journal of Catalyst & Catalysis · Vol. 10, Issue 1, 2023 · pp. 1–9 Read article
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Worker Radiation Exposure during Transportation of Irradiated LEU Targets in a Typical MTR Reactor
Abstract: The paper estimates the radiation dose exposure for the worker in the second Egyptian research reactor ETRR-2 during the process of transporting the irradiated low enriched uranium LEU plates from the core to the hot cell. The aim of estimating the radiation doses distribution is determining the exposure dose for the worker during the transportation process as a safety point of view. In order to estimate irradiated LEU plates radiation …
Published in Journal of Nuclear Engineering & Technology · Vol. 10, Issue 3, 2020 · pp. 48–51 Read article
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In Silico Molecular Docking Studies of Phytoconstituents Identified in Curcuma zedoaria Rosc. on Acetylcholinesterase: An Enzyme Target for Anti Alzheimer’s Activity
Abstract: Alzheimer’s disease (AD) is a chronic, progressive and disabling organic brain disorder characterized by disturbances of multiple cortical functions. Acetylcholinesterase (AChE) inhibition is thought to be a promising approach towards the treatment of AD. The aim and objective of the present study is to perform in-silico docking analysis of the major active constituents identified in Curcuma zedoaria Rosc. against AChE for anti-Alzheimer’s activity. In this perspective, phytoconstituents like bisdemethoxy curcumin, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 8, Issue 3, 2019 · pp. 9–14 Read article
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Renin-Angiotensin System as a Therapeutic Target for Colorectal Cancer Liver Metastasis
Abstract: Classically, renin-angiotensin system (RAS), for a long time, has been perceived as the main regulator of cardiovascular homeostasis, due to its effect on blood vessels contraction or cardiac hypertrophy and is known to maintain blood pressure and body fluids. Hence, its pharmacological regulation is mainly associated with the management of hypertension. Currently, it was found that the RAS is involved in a broad range of physiological processes and diseases. RAS …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 7, Issue 2, 2018 · pp. 1–14 Read article
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Developed Nano-technological Production of Chemotherapeutic Drugs for Targeted Destruction of a Cancerous Tumor
Abstract: Existing chemotherapeutic drugs do not have the ability to act on a cancerous tumor with a calculated dose and time, corresponding to the cancer cell mitosis, which leads to the unpredictability of the resultof the drug application, and, consequently, to the ineffectiveness of its use in treatment. An indirect effect of a chemotherapeutic drug on cancerous tumor cells leads to damage of normal cells of the patient's body, causing a …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 13, Issue 1, 2023 · pp. 39–45 Read article
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A Molecular Docking Approach for Unlocking the Potential of Bryophyllum peltatum Phytochemicals for Targeting Multiple Proteins in Mumps Treatment
Abstract: Objective: The Mumps virus is the source of the infectious illness mumps. It affects the parotid glands that make saliva. Swelling of this gland can cause severe pain in an individual. Finding the ADME qualities of several B. peltatum phytochemicals and determining which of these compounds may have the ability to prevent the mumps disease are the main objective of this investigation. Methods: The structure of Hemagglutinin-neuraminidase (HN) protein, was …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 13, Issue 1, 2023 · pp. 18–27 Read article
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Superoxide Dismutase: An Emerging Target for Human Therapeutic
Abstract: Superoxide dismutases (SODs) represent a very essential antioxidant guard beside oxidative stress in the body. The enzyme does something as an excellent restorative mediator next to reactive oxygen species (ROSs)-mediated multiple sicknesses. The current review portrays the curative property of SOD in diverse physiological and pathological circumstances such as cancer, inflammatory diseases, gene mutation, cardio therapy, aging, neurodegenerative diseases, and diabetes. However, the enzyme has positive boundaries in experimental applications. …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 9, Issue 1, 2019 · pp. 165–172 Read article