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109 articles for “Candidate gene”
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Screening Phytocompounds of Tinospora cordifolia to Find Potential Drug Targets for Cystic Fibrosis
Abstract: This study aimed to evaluate the therapeutic potential of phytocompounds derived from Tinospora cordifolia in treating cystic fibrosis (CF), a genetic disorder caused by mutations in the CFTR gene that lead to severe respiratory and digestive complications. Phytocompounds were retrieved from the IMPPAT database and subjected to molecular docking simulations using PyRx to assess their binding affinity to the CFTR protein. The top-scoring compounds – sterol, magnoflorine, tembetarine, kaempferol, and …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 1, 2025 · pp. 16–24 Read article
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Structural Modification of Sugarcane Bagasse using Alkaline, Acid, and Bleaching Pretreatments for Enhanced Yield of Poly (1→4)-β-D-glucopyranose (Cellulose) and Hemicellulose for Utilization as Biocomposites
Abstract: Sugarcane bagasse, a lignocellulosic byproduct generated in substantial quantities by the sugar industry, represents a promising feedstock for the sustainable production of enzymes and bio-based chemicals. Its high (1→4)-β-D-glucopyranose (cellulose) content, abundant availability, and low cost make it an ideal candidate for bioconversion processes. However, the inherent recalcitrance of bagasse, primarily due to its lignin-rich matrix, necessitates effective pretreatment strategies to enhance enzymatic digestibility. This study presents a comparative investigation …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 983–992 Read article
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Computer-aided Drug Design Method for Anti-hepatitis C Drug Design
Abstract: Hepatitis C is a disease caused by the hepatitis C virus and can cause serious liver damage. There is currently no vaccine for this disease and the number of infections continues to increase worldwide. Currently used antiviral drugs are interferon alfa-2a and ribavirin, but about half of patients do not respond to therapy. Therefore, new drugs that protect against hepatitis C need to be investigated. Computational drug methods have been …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 2, 2024 · pp. 1–8 Read article
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Insightful Innovations: A Review of Eye-controlled Mouse Hardware Development
Abstract: Many people who suffer from neurological disorders or those who have been rendered paralyzed by an accident find it difficult to use computers for everyday chores like sending and receiving messages, browsing the internet, or watching their favorite TV series or films. A recent study focused on the topic and discovered that eyeballs are an excellent candidate for eye tracking because they move properly when working with hardware. By using …
Published in Trends in Opto-electro & Optical Communication · Vol. 13, Issue 3, 2023 · pp. 28–32 Read article
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Heuristic Application on Energy Storage System Allocation in Wind Integrated Power System
Abstract: Increasing penetration of renewable energy significantly alters the network power flow in terms of direction as well as magnitude. The intermittent and uncertain nature of renewable inputs is a major concern since the power flow in the system is affected considerably. Hence to support bulk integration of renewable energy in the power system, bulk or distributed energy storage systems can be implemented. The energy storage system is utilized to absorb …
Published in Journal of Power Electronics and Power Systems · Vol. 12, Issue 2, 2022 · pp. 21–31 Read article
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Unveiling the Role of Lead Molecules in CADD: A Systematic Review
Abstract: The word "medicate plan" alludes to the objective creation of modern drugs. Arbitrary screening of engineered compounds, engineered of organically dynamic compounds based on actually happening drugs, amalgamation of basic analogs of actually happening lead particles, and usage of the bioisosteric hypothesis are a few of the strategies that have been utilized. As a result, the most recent drift in medicate plan is to either completely enhance a lead or …
Published in International Journal of Membranes · Vol. 1, Issue 1, 2024 · pp. 37–43 Read article
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Recent Update on Advanced Drug Delivery System
Abstract: Over the past decade, there has been a growing interest in the use of artificial intelligence (AI) technology for analysing and interpreting biological or genetic data, accelerating drug discovery, and identifying selective small-molecule modulators or rare molecules in addition to predicting their behaviour. The use of artificial neural networks (ANNs) for the rapid analysis of massive amounts of data, the development of novel hypotheses and treatment plans, the prediction of …
Published in International Journal of Advance in Molecular Engineering · Vol. 1, Issue 1, 2023 · pp. 22–30 Read article
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Evaluation of Thermal Damage in Pipe by Nonlinear Guided Wave
Abstract: This work investigates the evaluation of thermal damage in aluminum pipe by using nonlinear guided wave. Thermal loading was imposed on the specimens to cause thermal degradation. Flexible Polyvinylidene Fluoride (PVDF) comb transducers are used to generate and receive the ultrasonic waves. The second harmonic wave generation technique was used to check the material nonlinearity change after different heat loading. Conventional linear ultrasonic approach based on the acoustic attenuation was …
Published in Journal of Nuclear Engineering & Technology · Vol. 3, Issue 1, 2013 · pp. 22–27 Read article
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Performance Analysis of Single Band PIFA for 4G/LTE Mobile Communication Networks
Abstract: This paper presents a Planer Inverted F Antenna (PIFA) for Fourth Generation (4G) Long Term Evaluation (LTE). The proposed antenna is designed on FR4 substrate and the dimension is 22.5 mm x 18.5 mm x 2.8 mm. The Antenna covers the LTE 40 frequency band application from 2.3–2.4 GHz (resonance at 2.35 GHz). Different performance parameters: return loss, VSWR, radiation pattern, current distribution, gain and efficiency are analyzed. The proposed …
Published in Journal of Microwave Engineering and Technologies · Vol. 3, Issue 3, 2016 · pp. 1–7 Read article
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Exploring Composite Materials for Energy Harvesting in Electric Vehicles: A Comprehensive Review
Abstract: Energy harvesting, an increasingly dynamic field, holds promise for powering various devices by extracting energy from surrounding sources. Composite materials, blending mechanical and electrical properties, emerge as ideal candidates for energy harvesting applications. Despite their burgeoning utilization in electric vehicle (EV) energy capture, the full realization of their potential remains subject to ongoing evaluation. This editorial comprehensively examines composite materials' mechanical properties, electrical conduction, thermal stability, and affordability concerning EV …
Published in Journal of Polymer & Composites · Vol. 12, Issue 3, 2024 · pp. 1–15 Read article
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Salient Region Guided Deep Network for Violence Detection in Surveillance Systems
Abstract: Abstract: It is significant to detect violent actions in video surveillance systems automatically, for example, bus stands, malls and railway stations. Though, the earlier detection techniques generally extract statistic features around the spatiotemporal interest points or extract descriptor in the regions where movement takes place, leading to limited abilities to successfully detect violence activities in video surveillance systems. To solve this problem, a new approach for the automatic detection of …
Published in Journal of Computer Technology & Applications · Vol. 10, Issue 3, 2019 · pp. 19–28 Read article
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Parallelizing Apriori Algorithm using Open MP
Abstract: An Association rule mining used for finding frequent item sets thus generating rules from the frequent item sets. Finding frequent itemsets is more expensive in terms of CPU power and computing resources utilization. Apriori Algorithm is used for high dimensionality on massively large data sets. Parallelism reduces the time required for serial processing. Parallel computing can be applied for mining of association rules. Parallel apriori algorithm focus on parallelizing the …
Published in Recent Trends in Parallel Computing · Vol. 1, Issue 1, 2014 · pp. 1–5 Read article
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Inhibition of PI3K/Akt/mTOR Signaling Pathway by Vitis Vinifera Phytocompounds: A Promising Strategy for Supressing Colorectal Cancer Growth and Metastasis
Abstract: Objectives: Colorectal cancer was not typically identified a few decades ago. Today, with almost 900 000 fatalities each year, it is the fourth most dangerous cancer in the world. Colorectal cancer is responsible for about 10% of all cancer diagnoses annually and cancer-related deaths worldwide. It is the second most common type of cancer in women and the third most common type in men. Incidence and death are roughly 25% …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 · pp. 64–75 Read article
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Future Prospects of AI in Pharmaceutical Industry and its Limitation
Abstract: The pharmaceutical industry is facing significant challenges, including prolonged drug development timelines, high costs, and low success rates in clinical trials. Traditional methods often result in inefficiencies, with new drug development taking over a decade and billions of dollars, yet most candidates fail in clinical trials due to issues like inefficacy or safety concerns. Artificial Intelligence (AI) has become a groundbreaking technology with the potential to tackle these issues effectively. …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 2, 2025 · pp. 6–13 Read article
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Magnetic and Radioactive Nanoparticles for Improved Theranostics and AI Assisted Radiation Therapy
Abstract: Nanoparticles based therapeutic and theranostics technique is becoming an active area of research in nanomedicine. The sensitivity, biocompatibility, and stability of magnetic and radioactive nanoparticles determine their functionality. This research highlights the impacts of magnetic and radioactive nanoparticles on therapeutic techniques namely, cell therapy, gene therapy, and tissue regeneration. Then, it is intended to brief a principal role of these therapeutic techniques to envisage theranostics medicine and radiation therapy using …
Published in International Journal of Advance in Molecular Engineering · Vol. 3, Issue 2, 2025 · pp. 10–21 Read article
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Screening and Isolation of Bacterial Isolates for Polyhydroxyalkanoates Production from Oil-Contaminated sites
Abstract: Synthetic polymers are generally manufactured from petroleum and chemical-based sources. These polymers are employed in day-to-day life basic needs which leads to the production of huge number of synthetic polymers that accumulate in nature for thousands of years. There are limitations associated with synthetic polymers apart from their non-biodegradability, non-compatibility their mechanical and physical properties that cannot be easily altered narrows their few applications. PHAs (polyhydroxyalkanoates) are biopolymers that can …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 14, Issue 1, 2024 · pp. 1–6 Read article
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Isolation and Characterization of Glucuronide Compound from Luffa Tuberosa (Roxb.) for Potential Applications in Polymer Chemistry
Abstract: This study explores the isolation process of glucuronide compounds from Luffa tuberosa (Roxb.) using an efficient and cost-effective method. The extracted compound, Gypsogenin-3β-O-β-D-Methyl glucuronide, is characterized using spectroscopic techniques such as IR, NMR, and Mass Spectrometry. The polymeric nature of glucuronide-based compounds and their potential applications in polymer and composite materials are discussed. The findings highlight the suitability of glucuronide derivatives in biomedical, pharmaceutical, and polymeric drug delivery systems. Additionally, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 566–572 Read article
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AI-News 4.0: Most Suitable LLM for UPSC Aspirants
Abstract: In recent years, the domain of interactive artificial intelligence (AI) has experienced a significant surge with large language models (LLMs) at the forefront of this evolution. AI systems, including those based on the GPT-3.5 framework, have been engineered to address various tasks such as responding to intricate inquiries, participating in conversations, and executing sophisticated natural language processing (NLP) operations. A prominent LLM, known for its adaptability, prompts an essential inquiry: …
Published in International Journal of Computer Science Languages · Vol. 2, Issue 2, 2024 · pp. 47–53 Read article
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CRISPR, Recombinant DNA, and LAMP-Based Platforms for Monkeypox: Emerging Tools for Diagnosis and Therapeutic Development
Abstract: Monkeypox, a zoonotic viral infection caused by the Monkeypox virus of the Orthopoxvirus genus, has recurred as a worldwide public health concern after recent outbreaks outside of its classical endemic areas in Central and West Africa. The resurgence has demanded a thorough reassessment of its epidemiology, mode of transmission, and clinical presentation. In light of these challenges, recombinant DNA technology (rDNA) has emerged as a candidate for developing vaccines, diagnostics, …
Published in International Journal of Virus Studies · Vol. 3, Issue 1, 2026 · pp. 7–28 Read article
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The Mycobiome Frontier – Pre & Post 2020 Status: Integrating Fungal Bioactive Compounds, Probiotics, and Antimicrobial Peptides in Modern Therapeutics and Biotechnology.
Abstract: The fungal kingdom represents an indispensable resource in modern therapeutics and biotechnology, offering a diverse array of bioactive compounds, probiotics, and antimicrobial peptides (AMPs). Functional fungal polysaccharides (FFPs), such as beta-glucans, chitin, and mannans, are centrally involved in modulating the human gut microbiota, providing novel therapeutic avenues for chronic conditions including diabetes, neurodegenerative disorders, and cancer. These compounds act as prebiotics, nourishing beneficial bacteria and enhancing metabolic parameters such as …
Published in International Journal of Fungi · Vol. 3, Issue 1, 2026 · pp. 1–11 Read article